• Archives of Pharmacal Research
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• 제29권1호
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• pp.50-58
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• 2006

Translationally controlled tumor protein (TCTP), also known as histamine releasing factor (HRF), is found abundantly in different eukaryotic cell types. The sequence homology of TCTP between different species is very high, belonging to the MSS4/DSS4 superfamily of proteins. TCTP is involved in both cell growth and human late allergy reaction, as well as having a calcium binding property; however, its primary biological functions remain to be clearly elucidated. In regard to many possible functions, the TCTP of Plasmodium falciparum (Pf) is known to bind with an antimalarial agent, artemisinin, which is activated by heme. It is assumed that the endoperoxide-bridge of artemisinin is opened up by heme to form a free radical, which then eventually alkylates, probably to the Cys14 of PfTCTP. Study of the docking of artemisinin with heme, and subsequently with PfTCTP, was carried out to verify the above hypothesis on the basis of structural interactions. The three dimensional (3D) structure of PfTCTP was built by homology modeling, using the NMR structure of the TCTP of Schizosaccharomyces pombe as a template. The quality of the model was examined based on its secondary structure and biological function, as well as with the use of structure evaluating programs. The interactions between artemisinin, heme and PfTCTP were then studied using the docking program, FlexiDock. The center of the peroxide bond of artemisinin and the Fe of heme were docked within a short distance of $2.6{\AA}$, implying the strong possibility of an interaction between the two molecules, as proposed. When the activated form of artemisinin was docked on the PfTCTP, the C4-radical of the drug faced towards the sulfur of Cys14 within a distance of $2.48{\AA}$, again suggesting the possibility of alkylation having occurred. These results confirm the proposed mechanism of the antimalarial effect of artemisinin, which will provide a reliable method for establishing the mechanism of its biological activity using a molecular modeling study.

• 한국전자거래학회지
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• 제18권1호
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• pp.165-189
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• 2013

개념적 모델링은 성공적인 비즈니스 정보 시스템을 개발하기 위한 중요한 활동이다. 본 연구의 목적은 개념적 모델링 활동에 있어서 근거연구로부터 도입한 지속비교 방법을 적용하는 것에 관한 가능성을 평가하는 것이다. 이를 알아보기 위해, 우리는 초심 모델러를 훈련시키고 두 그룹으로 나누어 사후 평가를 실시했다. 실험 결과는 지속비교 방법을 훈련받고 이를 적용한 그룹이 그렇지 않은 그룹보다 경험이 많은 모델러에게 더 호의적인 평가를 받는다는 점을 보여주었다. 더욱이, 통제 그룹은 도메인 지식에 대해 덜 친숙할수록 문제해결에 어려움을 겪었지만, 실험 그룹은 어려움에 더 잘 대처했다. 또한 지속비교 방법의 적용은 개념적 모델링의 분석 시간을 단축시켰다.

• 방사성폐기물학회지
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• 제6권2호
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• pp.73-100
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• 2008

고준위 방사성폐기물 처분장으로부터 유출된 핵종에 의한 선량률을 계산하기 위한 생태계평가 코드 ACBIO를 일반적인 구획모델링도구인 AMBER를 이용하여 BIOMASS 방법론을 적용하여 개발하였다. ACBIO의 유용성을 보이고, 구획의 변화나 일부 파라미터값의 변화에 따른 구획 내 농도와 방사능, 그리고 구획간의 플럭스의 민감도도 검토하였다. 지하매질-생태계 경계(GBI)를 통해 넘어오는 핵종의 유출플럭스에 따른 선량환산인자를 각 핵종별로 구하여 결정집단내 개인의 최대피폭선량율을 선량환산인자로 얻는 계산을 수행하였다. 또한 생태계 요소의 구획모델링이나 가능한 피폭집단의 설정, 그리고 GBI의 인지 등이 생태계평가에 중요한 요소가 되는 것을 확인하였다.

• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4367-4381
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• 2023

Nuclear power plants are increasingly being equipped with digital I&C systems. Although some probabilistic safety assessment (PSA) models for the digital I&C of nuclear power plants have been constructed, there is currently no specific internationally agreed guidance for their modeling. This paper presents an initiative by the OECD Nuclear Energy Agency called "Digital I&C PSA - Comparative application of DIGital I&C Modelling Approaches for PSA (DIGMAP)", which aimed to advance the field towards practical and defendable modeling principles. The task, carried out in 2017-2021, used a simplified description of a plant focusing on the digital I&C systems important to safety, for which the participating organizations independently developed their own PSA models. Through comparison of the PSA models, sensitivity analyses as well as observations throughout the whole activity, both qualitative and quantitative lessons were learned. These include insights on failure behavior of digital I&C systems, experience from models with different levels of abstraction, benefits from benchmarking as well as major contributors to the core damage frequency and those with minor effect. The study also highlighted the challenges with modeling of large common cause component groups and the difficulties associated with estimation of key software and common cause failure parameters.

• 한국과학교육학회지
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• 제34권5호
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• pp.479-490
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• 2014

이 연구는 과학교육에서 의사소통을 위해 글쓰기와 논의를 활용한 논의-기반 모델링 전략의 개발을 목적으로 하였다. 논의-기반 모델링 전략은 모델링의 목적인 의사소통을 위해 자신이 만든 모델을 논의와 글쓰기를 통해 과학적 언어를 사용하여 스스로 정리하거나 표현하고, 다른 사람의 의견을 듣고 교환하는 과정을 통해 모델을 평가하고 수정하는 일련의 과정을 의미한다. 이 전략은 과학교육에서 모델링에 어려움을 느끼는 학생과 교사를 지원하기 위한 것으로 다음 네 가지 요소의 발달에 초점을 맞추었다. 첫째 여러 문제 상황을 관찰하여 문제를 연관지어 인식하는 문제인식이다. 둘째는 과학적 설명을 위해 충분한 과학개념을 구조화하여 제시하는 과학개념 구조화이며, 셋째는 주장에 대해 적절한 표상을 증거로 제시하는 주장-증거 적절성이다. 마지막은 증거제시에서 다양한 표상의 사용과 이 표상들을 전환하고 통합하는 다중표상 지수이다. 이 네 가지 요소의 발달을 위해 세 가지 stage를 구성하였다. '인지 과정'은 다중표상에 대한 이해를 위한 것이고, '해석 과정'은 다중표상 활동을 통해 증거 제시의 중요성을 인식하는 것이며, '적용 과정'은 학생들이 논의-기반 모델링을 직접 접해보는 것이다. 이 적용 과정에서는 질문 또는 문제 만들기-실험 설계 및 수행하기-관찰 통한 조사하기-자료의 분석 및 해석하기-임시 모델 설계하기-논의하기-되돌아보기-모델 평가하기-모델 수정하기의 아홉 개의 단계로 이루어진다. 논의-기반 모델링 전략은 학생들이 자신이 설계한 임시모델을 다른 사람과 공유하기 위해 증거를 바탕으로 발표하고 반박하는 논의과정을 통해 증거 제시의 필요성을 인식할 수 있다. 논의과정 후 학생들은 주장과 증거를 다중표상으로 나타내는 것에 대해 되돌아보는 과정을 거치면서 주장-증거 적절성을 높이게 된다. 또한 모델을 평가하기 위한 기준을 만들고, 이를 바탕으로 자신의 모둠이나 다른 모둠의 모델을 평가하고 그 결과를 피드백 받으면서 수정하게 된다. 이러한 일련의 과정을 거치면서 관찰한 자연세계의 현상에 대한 자신의 설명체계를 만듦으로써 과학적 지식을 형성할 수 있는 기회를 제공받을 수 있다.

• 한국프랜차이즈경영연구
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• 제8권2호
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• pp.25-36
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• 2017

Purpose - Recently, entrepreneurship education has been revitalized with interest in entrepreneurship. Entrepreneurship education is an educational service activity that is provided for entrepreneurship and individual start-up success within a certain period of time. According to previous studies on entrepreneurship and entrepreneurship, the satisfaction of entrepreneurship education affects entrepreneurship and as a result increases entrepreneurship. In recent years, the number of female entrepreneurs has also increased as the number of entrepreneurial issues has increased. Based on previous studies, this research proposed the theoretical framework about the structural relationships among mentoring quality (career development, psychological social, role modeling), education satisfaction, recommendation intention and entrepreneurial intention. This study is to find out the possibility of attempting to create a theoretical basis for entrepreneurial mentoring education in entrepreneurship education program. Research design, data, and methodology - In this model, mentoring quality consists of three sub-dimensions such as career development, psychological social, and role modeling. In order to test research model and hypotheses, the data were collected from 203 female college students who participated in entrepreneurial education. The data were analyzed using frequency analysis, confirmatory factor analysis, correlation analysis, and structural equational modeling with SPSS 24.0 and SmartPLS 3.0 statistical program. Result - The results of the study are as follows. First, role modeling has a positive effect on recommendation intention and entrepreneurial intention. Second, career development has a strong negative effect on the entrepreneurial intention. Third, career development and role modeling had a positive effect on educational satisfaction, and educational satisfaction had positive influence on recommendation intention and entrepreneurial intention. Conclusions - As women's social advancement becomes more active, start-up support programs including entrepreneurship mentoring are increasing. The results of this study suggest how to use the mentoring program mix and how to allocate the resources for the education program when the entrepreneurial education manager plans and executes the mentoring education program. For example, this study shows that career development and role modeling enhance educational satisfaction, and in turn increase recommendation intention and entrepreneurial intention. This means that entrepreneurship education should consist of contents that include career development functions such as sponsorship, guidance, protection, and provision of challenging work. In addition, the findings of this study indicate that mentors should perform the function of allowing the participants to have confidence and professional thinking ability at the time of start up based on their experiences.

• 인터넷정보학회논문지
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• 제6권6호
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• pp.57-69
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• 2005

본 논문에서는 워크플로우 프로세스 재발견 문제를 해결하기 위한 적절한 해결책으로 워크플로우 최적 축소 모델을 제안한다. 워크플로우 최적 축소 모델은 워크플로우 최적 축소 넷으로 표현할 수 있다. ICN(Information Control Net) 모델링 기법으로 표현되는 프로세스 모델은 ICN을 구성하고 있는 액티비티 사이의 액티비티 의존성에 따라 적절한 알고리즘의 적용으로 액티비티 의존 넷을 구성할 수 있다. 워크플로우 최적 넷 또한 액티비티 의존 넷의 몇 가지 속성에 대한 알고리즘 적용으로 찾아낼 수 있으며, 찾아낸 워크플로우 최적 넷을 프로세스 재발견 문제를 해결하기 위한 방안으로 제안하며, 프로세스 개선에도 의미를 둘 수 있다.

• Bulletin of the Korean Chemical Society
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• 제27권7호
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• pp.1025-1030
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• 2006

A 3D-CoMFA model with pranlukast analogues was constructed, which could be applied to predict the antagonistic activity of aryl benzyl ether analogues against LTD4. Molecular modeling and 3D-CoMFA studies were performed on 78 pranlukast analogues and 14 aryl benzyl ethers to evaluate the antagonistic behavior of aryl benzyl ethers and provide information for further modification of this kind of compounds. The aryl benzyl ether core was found to be in excellent three dimensional match with the central planar moiety of pranlukast analogues, and the pranlukast 3D-CoMFA model could be successfully applied to predict the biological activity of aryl benzyl ether analogues.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권11호
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• pp.2839-2852
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• 2013

Context-awareness is an essential part of ubiquitous computing, and over the past decade video based activity recognition (VAR) has emerged as an important component to identify user's context for automatic service delivery in context-aware applications. The accuracy of VAR significantly depends on the performance of the employed human body segmentation algorithm. Previous human body segmentation algorithms often engage modeling of the human body that normally requires bulky amount of training data and cannot competently handle changes over time. Recently, active contours have emerged as a successful segmentation technique in still images. In this paper, an active contour model with the integration of Chan Vese (CV) energy and Bhattacharya distance functions are adapted for automatic human body segmentation using depth cameras for VAR. The proposed technique not only outperforms existing segmentation methods in normal scenarios but it is also more robust to noise. Moreover, it is unsupervised, i.e., no prior human body model is needed. The performance of the proposed segmentation technique is compared against conventional CV Active Contour (AC) model using a depth-camera and obtained much better performance over it.

• Journal of Microbiology and Biotechnology
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• 제16권8호
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• pp.1325-1329
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• 2006

Structural modeling of $\beta$-galactosidase from L. lactis ssp. lactis 7962 has shown that the residues Cys-472 and His-509 are located in the wall of the active-site cavity. To examine the functions of Cys-472 and His-509, we generated five site-specific mutants: Cys-472-Ser, Cys-472-Thr, Cys-472-Met, His-509-Asn, and His-509-Phe. $\beta$-Galactosidase substituted at Cys-472 with Met or His-509 with Phe had <3% of the activity of the native enzyme when assayed using ONPG as substrate. The other mutants Cys-472-Ser, Cys-472-Thr, and His-509-Asn had ca. 10-15% of the native enzyme activity. The V$_max$ values of the five mutated enzymes were lower (60-7,000-fold) than that of native enzyme. These results show that the catalytic ability of $\beta$-galactosidase is significantly affected by mutations at Cys-472 or His-509.