• Biomolecules & Therapeutics
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• 제1권1호
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• pp.37-43
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• 1993

Electrical or chemical stimulation of many areas in the brainstem modulates activity of dorsal horn neurons (DHN). This is known to be mediated by a population of bulbospinal neurons. Yet, little is known about responses of DHNs to stimulation of the caudal ventrolateral medulla (CVLM). Thus, the purpose of the present study is to see if there is any change in activity of DHNs when CVLM is stimulated electrically. Thirty-one DHNs were recorded from dorsal horn of the spinal cord. Fourteen DHNs (45%) were classified as wide dynamic range neurons and 9 (19%) were high threshold cells, and 4 (13%) and 4 (13%) were deep and low threshold neurons, respectively. Among 31 neurons tested for responses to stimulation of CVLM, 21 DHNs (68%) were inhibited by the electrical stimulation of CVLM ($200{\mu}A,\;100{\mu}s$ duration, 100 Hz), and 9 cells (39%) did not show any change in neuronal activity. One neuron was excited by the stimulation. The electrical stimulation of CVLM not only inhibited spontaneous activity of DHNs but also inhibited evoked responses of DHNs to somatic stimulation in the receptive field. These data suggest that CVLM is one of the pain-modulatory areas that control transmission of ascending information of noxious input to the brain from the spinal cord.

• 한국작물학회지
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• 제45권5호
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• pp.277-281
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• 2000

Fifty-four Korean native and 28 foreign varieties harvested in 1998 and 1999 were examined for superoxide dismutase (SOD) and peroxidase (POD) activities. The SOD and POD activities of leaves extracts in Korean native and foreign rice varieties showed variation at the heading stage. The activities of SOD and POD changed with growth stage. In comparison of storage duration, the SOD and POD activities of the extract from three months stored seeds in Korean native (CV=53.3%) and foreign rice (CV=57.9%) varieties were higher than that of stored rices for a year in seed extracts although the activities among varieties did not show significant variation. Also, the averaged activity of foreign rice varieties (SOD=12.9%) was relatively higher than that of korean native rice varieties (SOD=10.7%). The test of activity at the enzymatic level related to antioxidative activity suggests that the rice varieties with higher antioxidative potentials can be developed and also may provide information with rice breeder to breed rice variety with a high antioxidative activity.

• Journal of Information Science Theory and Practice
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• 제8권3호
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• pp.47-63
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• 2020

This study focuses on users of activity tracking technologies and their related information behavior. How useful is the provided information by the trackers? Do users understand all information and explanations? We conducted a web-based survey. All in all, 631 users of a tracking device filled out the survey. From the perspective of information science, this investigation aims to analyze information needs considering different types of the provided information by activity tracking technologies. Are users satisfied by using the information on their steps, heart rates, and sleep duration? How do users assess readability about heart rate zones and sleep stages? Additionally, we investigated if users understand how to reflect on and adapt their health behavior based on the received explanations. According to the results, users mainly agree that the received information (raw data as well as - to a lesser extent - aggregated data in the form of corresponding diagrams) is useful, that the explanations are easy to understand, and that they know how to use this obtained information. This investigation enables an in-depth insight into how users are applying the self-quantifying activity and health information and which information needs are satisfied.

• 지역사회간호학회지
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• 제31권spc호
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• pp.563-576
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• 2020

Purpose: The purpose of this study is to identify personal factors, social factors, and environmental factors related to physical activity in older adults in urban and non-urban areas. Methods: We used source data from the 2017 Community Health Survey. The subjects of this study included some older adults aged 65 and over, and analyzed the data of 23,043 older adults living in the urban and 34,063 older adults living in the non-urban area. Results: The common factors influencing physical activity in older adults by region include current smoking and drinking, BMI, sleep duration, and subjective health status, help with neighbors, frequency of meeting with neighbors and friends, participation in social and leisure activities, and falls experience (p<.001). However, the living environment, public transport satisfaction, and medical service use significantly associated with physical activity for only older adults living in the urban area (p<.001). Conclusion: In order to improve physical activity in older adults in the community, it is necessary to consider not only the improvement of individual factors that practice health behaviors but also health promotion strategies that take into account social and environmental factors because there are environmental differences among regions.

• The Korean Journal of Pain
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• 제34권1호
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• pp.114-123
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• 2021

Background: Evaluation of the effectiveness of caudal epidural injection on pain, spine mobility, disease activity, and activity of daily living in axial spondyloarthritis (SpA) patients. Methods: A total sample of 47 patients were registered in this study. They were randomly assigned into 2 groups; Group I received caudal epidural injections, ultrasound-guided, with 1% lidocaine hydrochloride mixed with triamcinolone, whereas Group II did not receive any injections. All participants fulfilled the ASAS criteria for axial SpA. Outcome measures were as follows: visual analogue scale, Oswestry disability index (ODI), modified Schober test, lateral lumbar flexion, and Ankylosing Spondylitis Disease Activity Score (ASDAS) with assessment at baseline, 2 weeks, and 8 weeks post-treatment. This clinical trial was registered on clinicaltrials.gov under the number NCT04143165. Results: There was a significant difference between both groups regarding pain, ODI, spine mobility and ASDAS scores in favor of group I. This effect was at its maximum after 2 weeks. Despite the decline of this effect after 2 months, the difference between the groups remained significant. Higher disease activity, younger age, and shorter disease duration were associated with better outcomes. Conclusions: Epidural injection of lidocaine and triamcinolone is a cost effective and a practical technique for controlling pain, as well as improving the function of the spine and disease activity scores in axial SpA patients with acceptable complications and relatively sustained effect.

• 근관절건강학회지
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• 제19권1호
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• pp.57-70
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• 2012

Purpose: This study aimed to investigate the level of physical activity and to identify factors related with physical activity for the elderly with Diabetes Mellitus (DM). Methods: The subjects were 154 diabetic outpatient at 3 hospitals located in J city. Data were collected from February 1 to 17 in 2012. Data were analysed using Chi-square test, ANOVA, and logistic regression by SPSS/WIN 18.0. Results: Mean physical activity level per week measured by International Physical Activity Questionnaire (IPAQ) was $2247.01{\pm}2533.73$ MET-minutes (minimally active). There were significant differences in the level of physical activity by age, spouse, education, job, admission, duration of DM, and DM therapy. There were significant differences in subjective health status, objective and subjective obesity, satisfaction with physical body, perception of aging, self-efficacy, perceived benefits, perceived barriers, and social support among the inactive, minimally active, and health enhancing physical activity groups. Factors influencing the level of health enhancing physical activity were spouse (OR=10.192), self-efficacy (OR=5.351), subjective obesity (OR=.114), and perceived barriers (OR=.069). Conclusions: The level of physical activity of elderly patients with DM was minimally inactive. Physical activity program enhancing self-efficacy and decreasing perceived barriers, as well as improving the correct perception of subjective obesity is recommended as a nursing intervention.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.203-216
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• 1995

The effects of ${\alpha}_1-adrenergic$ receptor stimulation on membrane potential, intracellular $Na^+$ activity, and twitch force were investigated in ventricular muscles from guinea-pig hearts. Action potentials, intracellular $Na^+$ activity, and twitch force of ventricular papillary muscles were measured simultaneously under various experimental conditions. Stimulation of the ${\alpha}_1-adrenergic$ receptor by phenylephrine produced variable changes in action potential duration, a slight hyperpolarization of the diastolic membrane potential, a decrease in intracellular $Na^+$ activity, and a biphasic inotropic response in which a transient negative inotropic response was followed by a sustained positive inotropic response. These changes were blocked by prazosin, an antagonist of the ${\alpha}_1-adrenergic$ receptor, but not by atenolol, an antagonist of the ${\beta}-adrenergic$ receptor. This indicates that the changes in membrane potential, intracellular $Na^+$ activity, and twitch force are mediated by stimulation of the ${\alpha}_1-adrenergic$ receptor, but not by stimulation of ${\beta}-adrenergic$ receptor. The decrease in intracellular $Na^+$ activity was not observed in quiescent muscles, depending on the rate of the action pontentials in beating muscles. The intracellular $Na^+$ activity decrease was substantially inhibited by tetrodotoxin. However, the decrease in intracellular $Na^+$ activity was not affected by an inhibition of the $Na^+-K^+$ pump. Therefore, the decrease in intracellular $Na^+$ activity mediated by the ${\alpha}_1-adrenergic$ receptor appears to be due to a reduction of $Na^+$ influx during the action potential, perhaps through tetrodotoxin sensitive $Na^+$ channels. Our study also revealed that the decrease in intracellular $Na^+$ activity might be related to the transient negative inotropic response. The intracellular $Na^+$ activity decrease could lower intracellular $Ca^{2+}$ through the $Na^+-Ca^{2+}$ exchanger and thereby produce a decline in twitch force.

• 한국약용작물학회지
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• 제28권5호
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• pp.331-338
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• 2020

Background: The aim of this study was to analyze the total phenol and total flavonoid contents and antioxidant activity of steam-treated leaves and rhizomes of Polygonatum sibiricum Redoute. In addition, we aimed to confirm their potential use as cosmetic materials by investigating their anti-aging and skin-whitening activity. Methods and Results: The leaves and rhizomes of P. sibiricum were treated with steam at different temperatures for different durations, and the antioxidant activity (DPPH and ABTS radical scavenging activity) and total phenol and total flavonoid contents of each sample were tested. The steam temperature and treatment duration siginificantly affected the antioxidant activity and, total phenol and total flavonoid content of the leaves and rhizome of P. sibiricum. Treating the P. sibiricum samples with steam at 120℃ for 12 h, yielded higher total phenol and total flavonoid contents. Comparatively, the samples treated with steam at 120℃ for 12 to 24 h showed significantly higher antioxidant activity. Further, the steamed samples of P. sibiricum demonstrated collagenase and tyrosinase inhibition activity, which indicated their anti-aging and skin-whitening properties. The samples steamed at 120℃ for 12 h, exhibited higher collagenase and tyrosinase inhibition activity. Conclusions: Leaves and rhizomes of P. sibiricum steamed at 120℃ for 12 h, showed highest antioxidant activity and, total phenol and total flavonoid contents than all other samples. Our results indicate the potential of using P. sibiricum as a cosmetic material by confirming its excellent anti-aging and whitening activity.

• 한국의학물리학회지:의학물리
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• 제17권3호
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• pp.159-166
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• 2006

기능성 자기공명영상을 이용하여 진동자극에 대한 감각피질의 비선형성에 대하여 연구하였다. 진동자극은 25 Hz의 주파수로 5개의 각기 다른 진동 자극 기간, 2초, 4초, 8초, 12초 그리고 16초와 함께 20초의 무자극 주기와 pseudo-random순서로 구성되었다. 감각피질에 대한 자극 기간의 변화에 따른 선형성을 이해하기 위하여 두 다른 방법(시스템의 선형성 조사법과 gamma-variate 함수를 적용하여 impulse response함수를 구하는 방법)을 사용하여 혈류반응 함수를 분석하였는데, 그 결과는 거의 비슷하였다. 감각피질에서의 BOLD 반응은 8초보다 작은 자극 기간 동안에는 비선형이고 8초 이상일 때는 선형성을 보였다. 자극 기간의 함수로 Impulse response 함수의 진폭, 면적, 피크까지의 시간, FWHM을 계산하였고 진폭과 면적의 크기는 자극 기간이 증가할 때 감소함을 보여줌으로써 자극 기간 8초에서 BOLD 반응이 비선형성에서 선형성으로 변함을 뒷받침해 주었다.

• 한국학교보건학회지
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• 제29권2호
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• pp.90-97
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• 2016

Purpose: The purpose of this study was to investigate the relationship between sleep timing and depressive mood in Korean adolescents. Methods: The study analyzed the data from the 2007~2015 Korea Youth Risk Behavior Web-based Survey. A total of 541,693 students in grades 7~12 were included in the final analysis. Multivariable logistic regression was used to examine their sleep timing and depressive mood, adjusted for sex, grade, region, socioeconomic status, academic performance, alcohol, smoking and physical activity. Sleep duration and sleep quality were also included in our model to identify whether or not the effect of sleep timing on depression is mediated by sleep duration or sleep quality. Results: The prevalence of depressive mood was 32.7% and the mean sleep timing was 12:13 AM. After adjustment for eligible covariates, the association between sleep timing and depressive mood showed a J-shaped curve. Adolescents who slept at 8 pm~10 pm were 39% more likely to be depressive (OR = 1.39, 95% CI 1.30~1.40) and at 3 am~ 4 am were 67% more likely to be depressive (OR=1.67, 95% CI 1.64~1.70) than adolescents who slept at 11 pm~12 am. These associations persisted after being adjusted for sleep duration and sleep quality. Conclusion: Sleep timing was related to depression in adolescents, independent of sleep duration and sleep quality. It appears that there is a certain sleep timing beneficial to mental health of adolescents.