• 한국산업정보학회논문지
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• 제14권5호
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• pp.11-18
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• 2009

자바스크립트 기반의 Ajax는 ActiveX 기술의 대안으로 주목받고 있는데, 대부분의 웹 브라우저에서 기본으로 지원되고, 비동기 상호작용을 통한 빠른 속도와 뛰어난 트래픽 절감 효과, 그리고 화려한 인터페이스 등의 장점들로 인해, 현재 국내 대형 포털 사이트들에서도 이 기술을 접목시켜 기존의 서비스를 재오픈 하는 추세이기도 하다. 본 연구에서는 이러한 Ajax 기술과 국내외 주요 사이트에서 제공하는 오픈 API들을 이용하여 다국어 메타검색 시스템을 모델링하고 구현하였다. 사용자로부터 입력받은 한국어 질의어를 구글 번역 API를 이용하여 저 세계 54개국 언어 중 하나의 언어로 번역한 후, 대표적인 소셜 웹 사이트(Flickr, Youtube, Daum, Naver 등)의 정보를 통합 검색한다. 검색된 결과는 Ajax 기술을 통해 화면의 일부분만 동적 로딩하여 빠른 속도로 출력해주는 동시에, 불필요한 정보의 중복 전송을 방지하여 서버의 트래픽과 패킷당 통신 요금을 절감하는 효과를 가져왔다.

• 정보처리학회논문지D
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• 제9D권5호
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• pp.945-954
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• 2002

인터넷을 통한 비즈니스에 수익 모델에 대한 관심이 높아지면서 방문자별로 개인화된 서비스를 제공하려는 노력이 커지고 있다. 개인화(Personalization)란 고객 한 명을 대상으로 하여 그 고객 한 사람을 위한 정보나 제품을 제공해주는 작업을 말한다. 개인화 서비스를 위해서 전 처리과정인 사용자 프로파일 생성과정이 필요하며, 적극적인 개인화 서비스를 제공하기 위해서는 충분한 고객 데이터가 필요하다. 본 논문에서는 웹사이트 상에서 사용자 행위 패턴을 파악할 수 있는 클릭스트림 정보를 모듈화 하였으며, 이를 이용하여 확장된 웹 로그 시스템을 구현하였다. 클릭스트림 정보를 웹 로그정보에 포함시켜 사용자의 행위 패턴을 파악할 수 있도록 웹 서버 시스템을 설계하고 구현하였다. 그리고 이 웹 서버는 웹사이트로부터 얻은 클릭스트림 정보를 분류하고 저장하여 관리자가 쉽게 분석할 수 있다. 이때 데이터베이스 저장 기술로 OLE DB Provider상에서 수행되는 ADO(ActiveX Data Object)기술을 사용함으로써 확장된 웹 로그 처리 시스템을 설계하였다. 확장된 웹 로그 DB를 패턴분석, 군집분석 등의 마이닝(Mining) 기법을 통하여 맞춤서비스에 대한 사용자 프로파일을 구축할 수 있다.

• Journal of Microbiology
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• 제35권4호
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• pp.300-308
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• 1997

The catechol 2,3-dioxygenase (C23O) encoded by the Pseudomonas putida xylE gene was over-produced in Escherichia coli and purified to homogeneity. The activity of the C23O required the reduced form of the Fe(II) ion since the enzyme was highly susceptible to inactivation with hydrogen perocide but reactivated with the addition of ferrous sulfate in conjunction with ascorbic acid. The C23O activity was abolished by treatment with the chemical reagents, diethyl-pyrocarbonate (DEPC), tetranitromethane (TNM), and 1-cyclohexy1-3-(2-morpholinoethyl) car-bodiimidemetho-ρ-toluenesulfontate (CMC), which are modifying reagents of histidine, tyrosine and glutamic acid, respectively. These results suggest that histidine, tyrosine and glutamic acid residues may be good active sites for the enzyme activity. These amino acid residues are conserved residues may be good active sites for the enzyme activity. These amino acid residues are conserved residues among several extradion dioxygenases and have the chemical potential to serveas ligands for Fe(II) coordination. Analysis of random point mutants in the C23O gene derived by PCR technique revealed that the mutated positions of two mutants, T179S and S211R, were located near the conserved His165 amd Hos217 residues, respectively. This finding indicates that these two positions, along with the conserved histidine residues, are specially effective regions for the enzyme function.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2015년도 제49회 하계 정기학술대회 초록집
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• pp.60-60
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• 2015

Nanosheets of graphene and related 2D materials have attracted much attention due to excellent physical, chemical and mechanical properties. Single-layer graphene (SLG) was first synthesized by Blakely et al in 1974 [1]. Following his achievements, we initiated the growth and characterization of graphene and h-BN on metal substrates using surface segregation and precipitation in 1980s [2,3]. There are three important steps for nanosheet growth; surface segregation of dopants, surface reaction for monolayer phase, and subsequent 3-D growth (surface precipitation). Surface phase transition was clearly demonstrated on C-doped Ni(111) by in situ XPS at elevated temperatures [4]. The growth mode was clarified by inelastic background analysis [5]. The surface segregation approach has been applied to C-doped Pt(111) and Pd(111), and controllable growth of SLG has been demonstrated successfully [6]. Recently we proposed a promising method for producing SLG fully covering an entire substrate using Ni films deposited on graphite substrates [7]. A universal method for layer counting has been proposed [8]. In this paper, we will focus on the effect of competitive surface-site occupation between carbon and other surface-active impurities on the graphene growth. It is known that S is a typical impurity of metals and the most surface-active element. The surface sites shall be occupied by S through surface segregation. In the case of Ni(110), it is confirmed by AES and STM that the available surface sites is nearly occupied by S with a centered $2{\times}2$ arrangement. When Ni(110) is doped with C, surface segregation of C may be interfered by surface active elements like S. In this case, nanoscopic characterization has discovered a preferred directional growth of SLG, exhibiting a square-like shape (Fig. 1). Also the detailed characterization methodologies for graphene and h-BN nanosheets, including AFM, STM, KPFM, AES, HIM and XPS shall be discussed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권6호
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• pp.431-436
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• 2009

There are five principal causes for excessive bleeding in the immediate postextraction phase ; (1) Vascular wall alteration (wound infection, scurvy, chemicals, allergy) (2) Disorders of platelet function (genetic defect, drug-aspirin, autoimmune disease) (3) Thrombocytopenic purpuras (radiation, leukemia), (4) Inherited disorders of coagulation (hemophilia, Christmas disease, vitamin deficiency, anticoagulation drug-heparin, coumarin). If the hemorrhage from postextraction wound is unusually aggressive, and then dehydration and airway problem are occurred, the socket must be packed with gelatine sponge(Gelfoam) that was moistened with thrombin and wound closure & pressure dressing are applied. The thrombin clots fibrinogen to produce rapid hemostasis. Gelatine sponges moistened with thrombin provide effective coagulation of hemorrhage from small veins and capillaries. But, in dental alveoli, gelatine sponges may absorb oral microorganisms and cause alveolar osteitis (infection). This is a case report of bleeding control by continuous rubber strip & iodoform gauze drainage (without gelfoam packing) of active bleeding infection sites of three teeth extraction wounds in a 46-years-old female patient with advanced liver cirrhosis.

• 한국안전학회지
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• 제35권2호
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• pp.55-60
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• 2020

The purpose of this study is to analyze the influence of the economic and workforce factors on the annual number of occupational accident fatalities occurring at the construction sites. The considered variables of the economic factor are the amount of economic losses caused by industrial accidents, the GDP, and the total monthly wage for each economically active population. And, the variables related to the workforce factor are the number of economically active population, the number of female economically active population, and the number of labor union members. The multiple regression analysis was conducted to determine the effect of two factors on the total number of occupational fatalities in the construction industry. The results show that GDP among considered variables in the economic factor had a statistically significant negative relationship with the number of the construction accident fatalities in the construction industry. Among variables related to the workforce factor, economically active population showed a statistically significant negative relationship with the number of the construction accident fatalities.

• 천문학회지
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• 제33권1호
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• pp.47-55
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• 2000

Nonpotential characteristics of magnetic fields in AR 5747 are examined using Mees Solar Observatory magnetograms taken on Oct. 20, 1989 to Oct. 22, 1989. The active region showed such violent flaring activities during the observational span that strong X-ray flares took place including a 2B/X3 flare. The magnetogram data were obtained by the Haleakala Stokes Polarimeter which provides simultaneous Stokes profiles of the Fe I doublet 6301.5 and 6302.5. A nonlinear least square method was adopted to derive the magnetic field vectors from the observed Stokes profiles and a multi-step ambiguity solution method was employed to resolve the $180^{\circ}$ ambiguity. From the ambiguity-resolved vector magnetograms, we have derived a set of physical quantities characterizing the field configuration, which are magnetic flux, vertical current density, magnetic shear angle, angular shear, magnetic free energy density, a measure of magnetic field discontinuity MAD and linear force-free coefficient. Our results show that (1) magnetic nonpotentiality is concentrated near the inversion line in the flaring sites, (2) all the physical parameters decreased with time, which may imply that the active region was in a relaxation stage of its evolution, (3) 2-D MAD has similar patterns with other nonpotential parameters, demonstrating that it can be utilized as an useful parameter of flare producing active region, and (4) the linear force-free coefficient could be a evolutionary indicator with a merit as a global nonpotential parameter.

• Biomolecules & Therapeutics
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• 제2권1호
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• pp.34-38
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• 1994

In order to investigate the structure-activity relationships of the stereoisomers of angiotensin converting enzyme inhibitors, captopril and its derivatives were selected as model compounds. In vitro enzymatic activities of them depend on the symmetry at the asymmetric carbons. Especially, the alanyl carbon should have the S configuration to be biologically active. But the demethylated captopril having the achiral carbon also shows the activity although it is less active than captopril. Seven stereoisomers of captopril and its derivatives were chosen and their acidic and ionic forms were used for molecular dynamics simulations. Four computer simulations were practiced for each model compound in order to obtain the good condition for simulation to explain the experimental structure-activity relationships. From the computer simulation results, relativistic movements of three well-known pharmacophoric sites, carboxylate carbon, carbonyl oxygen, and sulfur atoms, were analyzed. Good results were obtained from the aqueous solution molecular dynamics simulation with ionic forms of model compounds. Active model compounds have the pharmacophoric areas of 6.08 to 6.38 $\AA$$^2$and the similarity in the geometrical data. But inactive ones have the largely deviated values of 4.51 to 4.87 $\AA$$^2$from those of active ones.

• 헤리티지:역사와 과학
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• 제55권2호
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• pp.232-249
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• 2022

본 글은 우리나라 선사시대 사적의 지정·보존·관리의 전반적 현황을 점검하고 향후 선사시대 사적의 활용 방향을 모색하기 위한 목적으로 작성되었다. 본격적인 논의에 앞서 한국의 선사시대 사적에 대한 전반적인 현황을 파악하기 위해 시대 및 유구 성격에 따른 선사시대 사적의 지정 현황을 비롯하여 선사시대 사적의 지정 면적, 지역별 분포 양상 등을 자세히 살펴보았다. 아울러 현 선사시대 사적의 보존·정비·관리 현황에 대한 전반적 상황을 파악하였다. 다음으로 우리나라 선사시대 사적의 보존·관리 실태를 확인하기 위해 현지답사를 통해 울주 검단리 유적, 부여 송국리 유적, 홍성 석택리 유적 등 몇몇 유적의 현황을 점검하고 선사시대 사적의 보존·정비·관리 방안에 대한 몇 가지 의견을 개진하였다. 울주 검단리 유적은 유적의 성격을 고려하여 유구 관련 시설물을 설치할 필요가 있는데, 복토현장보존 뿐만 아니라 노출현장보존이나 이전보존을 병행하는 방안이 요구된다. 부여 송국리 유적은 유적의 전체적인 범위와 유구 분포를 파악하기 위한 정밀지표조사와 시굴조사가 선결되어야 하며, 무엇보다 뚜렷한 목적을 가진 학술발굴이 계획적이고 지속적으로 실시되어야 한다. 홍성 석택리 유적과 같이 획기적이고 학술적 가치가 높은 고고 자료가 확인되고 역사적 가치와 고고학적 중요성이 인정되는 보존조치 유적의 경우, 보존 현황과 관리 상태를 우선 점검하여 국가지정문화재의 지정을 적극적으로 검토할 필요가 있다. 마지막으로 미국 국가사적의 문화유산 보호보전 및 운영관리 체계, 학술조사연구 프로젝트 사례를 들어, 우리나라 선사시대 사적을 보다 효과적으로 보존·관리하고 활용하기 위해서는 문화유산의 교육·연구적 측면과 사회·경제적 측면 모두를 고려한 활용 방향성이 요구된다는 점을 강조하였다. 문화유산의 적극적 활용이 유적의 지속적인 보존·관리로 이어지는 방안이 될 수 있으며 궁극적으로 선사시대 사적의 가치를 증대시키는 지름길이 될 수 있을 것으로 보았다.

• Bulletin of the Korean Chemical Society
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• 제27권5호
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• pp.657-662
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• 2006

Identification of accessible sites in targeted RNAs is a major limitation to the effectiveness of antisense oligonucleotides. A class of antisense oligodeoxynucleotides, known as the “10-23” DNA enzyme or DNAzyme, which is a small catalytic DNA, has been shown to efficiently cleave target RNA at purine-pyrimidine junctions in vitro. We have designed a strategy to identify accessible cleavage sites in the target RNA, which is hepatitis C virus nonstructural gene 3 (HCV NS3) RNA that encodes viral helicase and protease, from a pool of random DNAzyme library. A pool of DNAzymes of 58 nucleotides-length that possess randomized annealing arms, catalytic core sequence, and fixed 5'/3'-end flanking sequences was designed and screened for their ability to cleave the target RNA. The screening procedure, which includes binding of DNAzyme pool to the target RNA under inactive condition, selection and amplification of active DNAzymes, incubation of the selected DNAzymes with the target RNA, and target site identification on sequencing gels, identified 16 potential cleavage sites in the target RNA. Corresponding DNAzymes were constructed for the selected target sites and were tested for RNA-cleavage in terms of kinetics and accessibility. These selected DNAzymes were effective in cleaving the target RNA in the presence of $Mg^{2+}$. This strategy can be applicable to identify accessible sites in any target RNA for antisense oligonucleotides-based gene inactivation methods.