• Journal of Institute of Control, Robotics and Systems
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• v.9 no.4
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• pp.296-303
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• 2003

A personal portable type electronic dosimeter using silicon PIN photodiode and small GM tube is recently attracting much attention due to its advantages such as an immediate indication function of dose and dose rate, alerting function, and efficient management of radiation exposure history and dose data. We designed and manufactured a semiconductor radiation detector aimed to directly measure X-ray and v-ray irradiated in silicon PIN photodiode, without using high-priced scintillation materials. Using this semiconductor radiation detector, we developed an active electronic dosimeter, which measures the exposure dose using pulse counting method. In this case, it has a shortcoming of over-evaluating the dose that shows the difference between the dose measured with electronic dosimeter and the dose exposed to the human body in a low energy area. We proposed an energy compensation filter and developed a dose conversion algorithm to make both doses indicated on the detector and exposed to the human body proportional to each other, thus enabling a high-precision dose measurement. In order to prove its reliability in conducting personal dose measurement, crucial for protecting against radiation, the implemented electronic dosimeter was evaluated to successfully meet the IEC's criteria, as the KAERI (Korea Atomic Energy Research Institute) conducted test on dose indication accuracy, and linearity, energy and angular dependences.

• Journal of Institute of Control, Robotics and Systems
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• v.14 no.6
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• pp.608-614
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• 2008

This paper describes a location tracking system to guide landing process of an Unmanned Helicopter(UMH) exploiting MIT Cricket nodes. For automatic landing of a UMH, a precise positioning system is indispensable. However, GPS(Global Positioning System) is inadequate for tracking the three dimensional position of a UMH because of large positioning errors. The Cricket systems use Time-Difference-of-Arrival(TDoA) method with ultrasonic and RF(Radio Frequency) signals to measure distances. They operate in passive mode in that a listener attached to a moving device receives distance signals from several beacons located at fixed points on ground. Inevitably, this passive type of implementation causes large disturbances in measuring distances between beacons and the listener due to wind blow from propeller and turbulence of UMH body. To cope with this problem, we proposed active type of implementation for positioning a UMH. In this implementation, a beacon is set up at UMH body and four listeners are located at ground area at least where the UMH will land. A pair of Ultrasonic and RF signals from the beacon arrives at several listeners to calculate the position of the UMH. The distance signals among listeners are synchronized with a counter value appended to each distance signals from the beacon.

• Journal of Microbiology and Biotechnology
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• v.30 no.12
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• pp.1927-1936
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• 2020

Tunicates are known to contain biologically active materials and one species in particular, the sea peach (Halocynthia aurantium), has not been thoroughly studied. In this study we aimed to analyze the fatty acids profile of the H. aurantium body wall and its immunomodulatory effects on RAW264.7 macrophage-like cells. The fatty acids were classified into three categories: saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and polyunsaturated fatty acids (PUFAs). Omega-3 fatty acid content, including EPA and DHA, was higher than omega-6 fatty acids. H. aurantium body wall fatty acids exhibited enhanced immune response and anti-inflammatory effects on RAW264.7 macrophage-like cells. Under normal conditions, fatty acids significantly increase nitric oxide (NO) and PGE2 production in a dose-dependent manner, thereby improving the immune response. On the other hand, in LPS-treated RAW264.7 cells, fatty acids significantly decreased nitric oxide (NO) and PGE2 production in a dose-dependent manner, thereby enhancing anti-inflammatory effects. Fatty acids transcriptionally control the expression of the immune-associated genes, iNOS, IL-1β, IL-6, COX-2, and TNF-α, via the MAPK and NF-κB signaling cascades in RAW264.7 cells. However, in LPS-stimulated RAW264.7 cells, H. aurantium body wall fatty acids significantly inhibited expression of inflammatory cytokine; similarly, production of COX-2 and PGE2 was inhibited. The results of our present study provide insight into the immune-improving and anti-inflammatory effects of H. aurantium body wall fatty acids on macrophages. In addition, our study demonstrates that H. aurantium body wall is a potential source of immune regulatory components.

• Journal of Web Engineering
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• v.14 no.17
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• pp.3604-3622
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• 2022

The fruit of Hippophae rhamnoides has been widely used for medicinal purposes because of its anti-inflammatory, antioxidant, antiplatelet, and antimicrobial effects. Since there are no clear reports on the therapeutic efficacy of H. rhamnoides in osteoporosis, this study aimed to confirm the potential use of H. rhamnoides for the treatment of osteoporosis through its osteogenic differentiation-promoting effect in ovariectomized mice. Through an in vitro study, we compared the effects of the EtOH extract of H. rhamnoides fruits (EHRF) on the differentiation of C3H10T1/2, a mouse mesenchymal stem cell line, into osteoblasts based on alkaline phosphatase (ALP) staining and the relative expression of osteogenesis-related mRNAs. The EHRF significantly stimulated the differentiation of mesenchymal stem cells into osteoblasts and showed 7.5 times (^* p < 0.05) higher osteogenesis than in the untreated control. A solvent fractionation process of EHRF showed that the hexane-soluble fraction (HRH) showed 10.4 times (^** p < 0.01) higher osteogenesis than in the untreated control. Among the subfractions derived from the active HRH by preparative HPLC fractionation, HRHF4 showed 7.5 times (^* p < 0.05) higher osteogenesis than in the untreated naïve cells, and HRH and HRHF4 fractions showed 22.6 times (^*** p < 0.001) stronger osteogenesis activity than in the negative control. Osteoporosis was induced by excision of both ovaries in 9-week-old female ICR mice for in vivo analysis, and two active fractions, HRH and HRHF4, were administered orally for three months. During the oral administration period, body weight was measured weekly, and bone mineral density (BMD) and body fat density were measured simultaneously using a DEXA machine once a month. In particular, during the in vivo study, the average BMD of the ovariectomized group decreased by 0.0009 g/cm², whereas the average BMD of the HRH intake group increased by 0.0033 g/cm² (^* p < 0.05) and that of the HRHF4 intake group increased by 0.0059 g/cm² (^** p < 0.01). The HRH and HRHF4 intake groups significantly recovered the mRNA and protein expression of osteogenic genes, including ALP, Osteopontin, Runx2, and Osterix, in the osteoporosis mouse tibia. These findings suggest that the active fractions of H. rhamnoides fruit significantly promoted osteoblast differentiation in mesenchymal stem cells and increased osteogenic gene expression, resulting in an improvement in bone mineral density in the osteoporosis mouse model. Taken together, H. rhamnoides fruits are promising candidates for the prevention and treatment of osteoporosis.

• Journal of Nutrition and Health
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• v.30 no.3
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• pp.277-285
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• 1997

The purpose of this study was to investigate the relationship among nutrient intake, life style, and serum lipids level in 108 healthy middle-aged men in Taegu. A convenient method was to assess nutritional intake. Anthropometric measuement of body weight and hight were measured and average energy expenditure was calculated. The mean body mass index(BMI) was 22.8$\pm$2.4 and it was in the middle of the mean BMI of Korean men. Obesity rate of study subject were 13.2%. Daily energy intake was not sufficient as 88.4% of recommended dietary allowances and the energy percentage of carboydrate, fat protein was 65 : 21 : 14. Mean intake of vitamin A, B1, C and Ca were lower than RDA. There was a highly significant negative correlation between the systolic blood pressure and calcium intake(r=-0.28, p<0.05). Smokers showed significantly higher blood glucose than non-smokers. Skipping meals and uneven diurnal distribution(no breakfast and large evening meals) are associated with high triglyceride level in this population. There was a highly significant correlation between body weight and plasma lipids. Energy expenditure was negatively correlated with plasma triglyceride level. Especially, atherogenic index was significantly lower in job-time physically active worker than that in sedentary worker. Above data provides valuable imformation to the community for program planning as well as to health providers who work individual male adults to meet their nutrition needs and to control blood lipids.

• KIEAE Journal
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• v.7 no.5
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• pp.59-64
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• 2007

Using air conditioner has been increased in home or office buildings in summer. Also various problems related to air conditioning such as disease induction happened by using air conditioner excessively and operating long. Active operation control is needed for occupant's health when air conditioner operates long. We should think ahead to acquire thermal comfort of occupants which represents psychological and physiological reaction for this operation. Research has been progressed to observe activity of autonomic nervous system by trying to quantitate change of thermal comfort. In this study, questions of the subject and change of body's autonomic nervous system were chosen to evaluate thermal comfort during operation of air conditioner for a long time. Electrocardiogram and questions of the subject which is the progress of changing TSV and CSV by occupants indoor were measured when room air conditioner is operated for a long time, and an air-conditioned adaptability of human body was evaluated by acquiring the change rate of autonomic nervous system through analyzing HRV. As a result of the evaluation, change rate of body's autonomic nervous system corresponded to votes of the subject's question generally, but was distinguished from analysis result of warm-cold sensation in a low temperature area.

• The Journal of Korea Robotics Society
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• v.12 no.2
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• pp.124-131
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• 2017

This paper present a novel approach to control the lower body power assistive exoskeleton system of a HEXAR-CR35 aimed at improving a muscular strength. More specifically the control of based on the human intention is crucial of importance to ensure intuitive and dexterous motion with the human. In this contribution, we proposed the detection algorithm of the human intention using the MCRS which are developed to measure the contraction of the muscle with variation of the circumference. The proposed algorithm provides a joint motion of exoskeleton corresponding the relate muscles. The main advantages of the algorithm are its simplicity, computational efficiency to control one joint of the HEXAR-CR35 which are consisted knee-active type exoskeleton (the other joints are consisted with the passive or quasi-passive joints that can be arranged by analyzing of the human joint functions). As a consequence, the motion of exoskeleton is generated according to the gait phase: swing and stance phase which are determined by the foot insole sensors. The experimental evaluation of the proposed algorithm is achieved in walking with the exoskeleton while carrying the external mass in the back side.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.11 no.1
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• pp.29-36
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• 2005

The purpose of this study was to evaluate change of path length center of body on sacroiliac joint mobilization. The subjects were consisted of sixty healthy adult two decade(28 females. 32 males; mean aged 22.2) from 20 to 29. All subjects randomly assigned to the control group, sacroiliac joint mobilization group. sacroiliac joint mobilization group received sacroiliac joint mobilization for 2-3 minutes per day and three times a week during 3 weeks period. The study carried out to determine the change of path length center of body on sacroiliiac joint mobilization from July 1, 2004 through september 30, 2004. Active balancer(SAKAI EAB-100) was used to measure equilibrium ability. All measurements of each subjects were measured at pre-experiment and post-experiment. The results of this study were summarized as follows: 1. The WPL of control group, sacroiliac joint mobilization group was no significantly differences at pre-experiment but significantly reduced post-experiment(p<.05). The results of analyzed effects of WPL was significantly reduced between experiment type of control group, sacroiliac joint mobilization group according to pre-experiment and post-experiment(p<.05). 2. The UPL of control group, sacroiliac joint mobilization group was no significantly differences at pre-experiment but significantly reduced post-experiment(p<.05). The results of analyzed effects of UPL was significantly reduced between experiment type of control group, sacroiliac joint mobilization group according to pre-experiment and post-experiment(p<.05). Conclusionally these data suggest that a 3-week S-I joint mobilization improved equilibrium. Additional randomized controlled trials to more fully investigate treatment effects and factors that may mediate these effects are needed.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.1648-1652
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• 2004

An advanced training machine designed for elderly people is proposed. The training machine allows users to have a safe and effective training through exercise close to ordinal motion appears in daily life such as standing up/down motion. The activation level of user's muscle is real timely monitored during the exercise and the training load is adjusted based on the body information. The training load is exerted and continuously controlled by actuation of an air cylinder.

• International Journal of Automotive Technology
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• v.6 no.6
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• pp.599-604
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• 2005

A functional suspension model is proposed as a kinematic describing function of the suspension, that represents the relative wheel displacement in polynomial form in terms of the vertical displacement of the wheel center and steering rack displacement. The relative velocity and acceleration of the wheel is represented in terms of first and second derivatives of the kinematic describing function. The system equations of motion for the full vehicle dynamic model are systematically derived by using velocity transformation method of multi-body dynamics. The comparison of test and simulation results demonstrates the validity of the proposed functional suspension modeling method. The model is computationally very efficient to achieve real-time simulation on TMS 320C6711 150 MHz DSP board of HILS (hardware-in-the-loop simulation) system for ECU (electronic control unit) evaluation of semi-active suspension.