• 제목/요약/키워드: Active Senior

검색결과 175건 처리시간 0.02초

다양한 암세포 주와 MSCs에 대한 Saccharin의 항증식성 평가 (Estimation of Anti-proliferative Activity of Saccharin against Various Cancer Cell Lines and MSCs)

  • 최정수;박상용;양만길;이동범;이태복;허지혜;이민우;김성욱
    • 대한임상검사과학회지
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    • 제48권3호
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    • pp.169-175
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    • 2016
  • Saccharin (o-benzoic sulfimide)은 1879년에 최초로 합성된 열량이 없는 인공감미료이다. 본 연구에서, 우리는 다양한 인간 암세포주와 인간 골수에서 유래한 중간엽 줄기세포에 대한 saccharin의 생물학적 활성을 실험해보고자 한다. 4가지 인간 암세포주(H460, H157, A549, SKOV3)와 쥐암세포(Raw264.7) 그리고 인간 골수 유래 중간엽 줄기세포에 대한 세포 viability assay는 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)의 변환을 기초하여 세포독성을 실험하였다. Saccharin을 처리하지 않은 세포와 대조적으로 saccharin을 처리한 세포에서 발현 양상이 달라지는 gene을 찾기 위해, 우리는 ACP를 기초로 한 DDRT-PCR을 시행하였다. 모든 실험에 사용된 세포들은 각기 다양한 saccharin 농도로(0.0, 4.8, 7.2, 9.6, 12.0, 14.4 mg/mL) 48시간 동안 처리되었다. 그 결과, 48시간 동안 다양한 saccharin 농도로 처리되면서 saccharin 처리를 하지 않은 암세포보다 saccharin 처리를 한 암세포에서 대사활성을 지닌 세포의 수가 감소하는 것을 확인할 수 있었고, 이런 세포 증식의 감소는 농도가 증가함에 따라 더욱 두드러졌다. 그리고 saccharin에 대한 반응으로 MSCs에 다른 양상으로 발현이 되는 주목할만한 gene 후보군이 2% agarose gel 상에 16개 밴드로 나타났고, 7개는 발현이 증가, 9개는 발현이 감소한 gene으로 보였다. 이 후보군중 하나는 FK506 binding protein gene이다. 이 단백질이 줄기세포의 생장활성에 어떠한 역할을 하고 있는지는 명확하지 않고 saccharin의 줄기세포 증식 활성 증가에 대한 FK506 binding protein의 자세한 기능은 추후 더 연구가 필요하다.

일개 상급종합병원 의사들의 환자안전문화에 대한 인식 분석 (Analysis of doctors' cognition of patient safety at general hospitals)

  • 유은영;정상진
    • 한국산학기술학회논문지
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    • 제13권6호
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    • pp.2607-2616
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    • 2012
  • 본 연구에서는 의료기관의 환자안전문화를 이해하고, 의사들의 환자안전문화에 대한 인식분석을 위한 기초자료로 활용하고자 시도하였다. G시에 소재한 상급종합병원 의사를 대상으로 2011년 8월 1일 부터 9월 5일까지 설문조사하여 194부를 최종분석 하였다. 연구결과는 첫째, 대상자와 병동 및 병원안전문화 간의 관계는 직원배치가 성별, 연령별, 병원 근무년수, 환자 접촉여부, 1주 근무시간에 따라 인식의 차이가 있으며, 조직학습과 병동내 팀워크는 1주 근무시간에 따라, 병동 안전문화 모든 하부영역은 진료과별로 유의하게 나타났다. 둘째, 대상자와 의료사고보고체계, 환자 안전도 평가 및 전반적 의식수준과의 관계에서는 사고에 대한 피드백과 의사소통, 사고빈도보고, 전반적 안전의식이 진료과별로 유의하였으며, 전반적 안전의식은 환자접촉과 1주 근무시간에 따라 유의한 결과를 나타냈다. 셋째, 병동 및 병원 안전문화 인식 하부영역과 전반적 인식, 환자안전도 평가는 모두 정의 상관관계가 있는 것으로 나타났다. 의료사고 보고체계와는 직속상관/관리자의 태도와 병원경영진의 태도를 제외한 모든 영역에서 정의 상관관계가 있는 것으로 나타났다. 넷째, 환자안전도 영향을 미치는 환자안전문화 하부영역은 조직학습, 의사소통의 개방성, 전반적 안전인식, 부서간의 협조체계, 피드백과 의사소통, 비처벌적 대응에서 유의한 결과를 나타냈다. 결론적으로, 의사들의 병동 및 병원 환자안전문화 수준을 높이고 의료사고보고체계를 충실하게 하기 위해서는 적절한 직원배치와 근무시간을 바탕으로 병동 내 조직적 학습을 통한 팀워크을 활성화 시키고, 부서간 팀원간의 개방적 의사소통과 사고에 대한 피드백을 제공하여 환자 안전에 대한 병원경영진의 적극적인 지원과 진료과별 협조체계 구축이 필요하다.

연희지역 아파트주부의 건강관리실천의 결정요인분석에 관한 조사연구 (A Study on the Decisive Factors in Personal Health Maintenance Practice of Housewives Living in Younhi Area Apartments)

  • 김인숙
    • 대한간호학회지
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    • 제8권2호
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    • pp.89-102
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    • 1978
  • Owing to the development of modern science, prolonging man's life, the sudden increase of population and betterment of the standard of living has increased health needs. In order to fulfill these health needs, more active plans for developing health should be made. Health education is one of the methods at hand that can improve the health behavior of the community and the individual through the contact of individuals with their groups. Proper understanding of the characteristics of the sampled group and participation of individuals within the community for the development of their health plan are needed for efficient health education. This study was attempted for the purpose of presenting some data helpful for pre-paring the fundamentals of a health education plan that can improve personal health maintenance practice of a community through efficient health education by investigating the relationship between the response of subjects to personal health maintenance practice and selected decisive factors in personal health maintenance practice. The subjects for this study were a systematic sample of 120 housewives selected from 600 housewives from B Zone Apt. Younhi-3-Dong in Seoul. Data was collected for 4 days from May 16th to May 19th, 1578 through personal interviews with questionnaires by well trained interviewers. Percentage, t-test and stepwise multiple regression analysis by use of EDPS were employed for statistical analysis. Results of this study can be summarized : 1. General characteristics of subjects Subjects over 20 and below 40 years of age formed 62.5% of the toed and the rest were subjects of 40 years and upward. 76.7% of the subjects have less than 4 children. 51.3% of the subjects had completed at least the senior high school course. 2. The response of subjects to personal health maintenance practice. Ratios of personal health maintenance practice to the maximum score for each category are as follows; 84.1% in the category of population and family planning, which was the highest ratio; 82.4% in the prevention of accidents; 68.0% in control of communicable disease; 67.8% in personal health care and habits of daily life, 64.3% in mental health and 52.5% in control of parasites, which was the lowest. 3. The response of subjects to selected decisive factors. in personal health maintenance practice. The arithmetic mean of the score for each decisive factor was as follows: the mutual relation between family members marked 18.33, which is under 73,3% of the maximum score; the degree of interest in health marked 34.48, 70.0% of the maximum score: the degree of utilization and demand for health care facilities marked 25.79 or 64.5% of the maximum score and health maintenance of the family marked 11.58, 43.6% of the maximum score. 4. The relationship between personal health maintenance practice and general characteristics of subjects. 1) There was a significant difference in the numbers of children. (t = 1.83, d.f. =117, p< 0.1) 2) There was a significant difference in the contact rates with mass-media, (t = 5.02, d.f. = 118, p< 0,05) 5. The multiple correlation between personal health maintenance practice and their selected decisive factors. 1) The factor“the degree of interest in health”could account for personal health maintenance practice in 43.6% of the sample. (R = 0.6602, R²= 0,4359, F = 91.1678, p< 0.001) 2) When the factor,“health maintenance of family”is added to this, it accounts for 51.2% of personal health maintenance practice. (R = 0.7158, R²= 0.5124, F = 61.4653, p< 0.001) 3) When the factor,“mutual relations between family members”is also included, it accounts for 53.7% of personal health maintenance practice. (R = 0.7324, R²= 0.5365, F = 44.7509, p< 0.001) 4) When the factor, “the degree of utilization and demand for health care facilities”is included, it accounts for 55.1% of personal health maintenance practice. (R = 0.7421, R²= 0.5507, F = 35.2430, p< 0.001).

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65세 이상 인구의 고용형태와 의료요구 미충족 경험률의 관련성 (Correlation of Unmet Healthcare Needs and Employment Status for a Population over 65 Years of Age)

  • 강정희;김철웅;서남규
    • 한국노년학
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    • 제37권2호
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    • pp.281-291
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    • 2017
  • 본 연구의 목적은 한국의 65세 이상 노인의 의료요구 미충족 경험률을 알아보고, 고용형태와 의료요구 미충족 경험률 및 경제적 이유로 인한 의료요구 미충족 경험률의 관련성을 분석하는 것이다. 연구방법은 2013년 한국의료패널자료를 이용하여 65세 이상인구 5,528명을 대상으로 고용형태에 따른 의료요구 미충족 경험률과 경제적 이유로 인한 의료요구 미충족 경험률의 관련성을 알아보기 위해 로지스틱 회귀분석을 실시하였다. 연구결과, 65세 이상 노인의 의료요구 미충족 경험률은 18.9%로 유렵연합국 노인인구집단보다 의료요구 미충족 경험률이 2-3배 높았다. 그리고, 의료요구 미충족을 경험한 노인 중 의료요구 미충족을 경험한 이유가 경제적 이유라고 응답한 노인은 42.8%였으므로 경제적 이유로 인한 의료요구 미충족 경험률은 8.1%이다. 임시직으로 경제활동을 하는 노인은 은퇴로 경제활동을 하지 않는 노인보다 의료요구 미충족 경험률이 높았고(ORs=1.75), 일용직으로 경제활동을 하는 노인은 경제적 이유로 인한 의료요구 미충족 경험률이 높았다(ORs=1.92). 경제활동 상태에 따른 의료요구 미충족 경험률의 차이는 '질병과 손상'을 가진 노인을 제외하고는 종사상의 지위에 따른 차이가 크지 않았다. 의료요구 미충족 경험 이유가 높은 의료비 부담이라고 응답한 경우에도 경제활동 상태에 따른 의료요구 미충족 경험률의 차이는 '질병과 손상'을 가진 노인을 제외하고는 종사상 지위에 따른 차이가 크지 않았다. 다만, 경제활동자 중에서는 '일용직' 노인의 경제적 이유로 의료요구 미충족 경험률이 가장 높았다. 또한, 소득이 적을수록 의료요구 미충족을 경험할 가능성이 높았다. 결론적으로 한국 노인의 의료요구 미충족을 해결하기 위해서는 노후소득보장제도의 개선뿐만 아니라 평균수명 증가에 따른 경제활동에 참여하는 노인의 일자리 형태 및 임금수준에 대한 개선방안이 필요할 것으로 보이며, 더불어 의료비를 해결할 수 있는 건강보험의 보장성이 강화되어야 할 것으로 보인다.

농촌(農村) 주민(住民)들의 의료필요도(醫療必要度)에 관(關)한 연구(硏究) (A Study Concerning Health Needs in Rural Korea)

  • 이성관;김두희;정종학;정극수;박상빈;최정헌;홍순호;라진훈
    • Journal of Preventive Medicine and Public Health
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    • 제7권1호
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    • pp.29-94
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    • 1974
  • Today most developed countries provide modern medical care for most of the population. The rural area is the more neglected area in the medical and health field. In public health, the philosophy is that medical care for in maintenance of health is a basic right of man; it should not be discriminated against racial, environmental or financial situations. The deficiency of the medical care system, cultural bias, economic development, and ignorance of the residents about health care brought about the shortage of medical personnel and facilities on the rural areas. Moreover, medical students and physicians have been taught less about rural health care than about urban health care. Medical care, therefore, is insufficient in terms of health care personnel/and facilities in rural areas. Under such a situation, there is growing concern about the health problems among the rural population. The findings presented in this report are useful measures of the major health problems and even more important, as a guide to planning for improved medical care systems. It is hoped that findings from this study will be useful to those responsible for improving the delivery of health service for the rural population. Objectives: -to determine the health status of the residents in the rural areas. -to assess the rural population's needs in terms of health and medical care. -to make recommendations concerning improvement in the delivery of health and medical care for the rural population. Procedures: For the sampling design, the ideal would be to sample according to the proportion of the composition age-groups. As the health problems would be different by group, the sample was divided into 10 different age-groups. If the sample were allocated by proportion of composition of each age group, some age groups would be too small to estimate the health problem. The sample size of each age-group population was 100 people/age-groups. Personal interviews were conducted by specially trained medical students. The interviews dealt at length with current health status, medical care problems, utilization of medical services, medical cost paid for medical care and attitudes toward health. In addition, more information was gained from the public health field, including environmental sanitation, maternal and child health, family planning, tuberculosis control, and dental health. The sample Sample size was one fourth of total population: 1,438 The aged 10-14 years showed the largest number of 254 and the aged under one year was the smallest number of 81. Participation in examination Examination sessions usually were held in the morning every Tuesday, Wenesday, and Thursday for 3 hours at each session at the Namchun Health station. In general, the rate of participation in medical examination was low especially in ages between 10-19 years old. The highest rate of participation among are groups was the under one year age-group by 100 percent. The lowest use rate as low as 3% of those in the age-groups 10-19 years who are attending junior and senior high school in Taegu city so the time was not convenient for them to recieve examinations. Among the over 20 years old group, the rate of participation of female was higher than that of males. The results are as follows: A. Publie health problems Population: The number of pre-school age group who required child health was 724, among them infants numbered 96. Number of eligible women aged 15-44 years was 1,279, and women with husband who need maternal health numbered 700. The age-group of 65 years or older was 201 needed more health care and 65 of them had disabilities. (Table 2). Environmental sanitation: Seventy-nine percent of the residents relied upon well water as a primary source of dringking water. Ninety-three percent of the drinking water supply was rated as unfited quality for drinking. More than 90% of latrines were unhygienic, in structure design and sanitation (Table 15). Maternal and child health: Maternal health Average number of pregnancies of eligible women was 4 times. There was almost no pre- and post-natal care. Pregnancy wastage Still births was 33 per 1,000 live births. Spontaneous abortion was 156 per 1,000 live births. Induced abortion was 137 per 1,000 live births. Delivery condition More than 90 percent of deliveries were conducted at home. Attendants at last delivery were laymen by 76% and delivery without attendants was 14%. The rate of non-sterilized scissors as an instrument used to cut the umbilical cord was as high as 54% and of sickles was 14%. The rate of difficult delivery counted for 3%. Maternal death rate estimates about 35 per 10,000 live births. Child health Consultation rate for child health was almost non existant. In general, vaccination rate of children was low; vaccination rates for children aged 0-5 years with BCG and small pox were 34 and 28 percent respectively. The rate of vaccination with DPT and Polio were 23 and 25% respectively but the rate of the complete three injections were as low as 5 and 3% respectively. The number of dead children was 280 per 1,000 living children. Infants death rate was 45 per 1,000 live births (Table 16), Family planning: Approval rate of married women for family planning was as high as 86%. The rate of experiences of contraception in the past was 51%. The current rate of contraception was 37%. Willingness to use contraception in the future was as high as 86% (Table 17). Tuberculosis control: Number of registration patients at the health center currently was 25. The number indicates one eighth of estimate number of tuberculosis in the area. Number of discharged cases in the past accounted for 79 which showed 50% of active cases when discharged time. Rate of complete treatment among reasons of discharge in the past as low as 28%. There needs to be a follow up observation of the discharged cases (Table 18). Dental problems: More than 50% of the total population have at least one or more dental problems. (Table 19) B. Medical care problems Incidence rate: 1. In one month Incidence rate of medical care problems during one month was 19.6 percent. Among these health problems which required rest at home were 11.8 percent. The estimated number of patients in the total population is 1,206. The health problems reported most frequently in interviews during one month are: GI trouble, respiratory disease, neuralgia, skin disease, and communicable disease-in that order, The rate of health problems by age groups was highest in the 1-4 age group and in the 60 years or over age group, the lowest rate was the 10-14 year age group. In general, 0-29 year age group except the 1-4 year age group was low incidence rate. After 30 years old the rate of health problems increases gradually with aging. Eighty-three percent of health problems that occured during one month were solved by primary medical care procedures. Seventeen percent of health problems needed secondary care. Days rested at home because of illness during one month were 0.7 days per interviewee and 8days per patient and it accounts for 2,161 days for the total productive population in the area. (Table 20) 2. In a year The incidence rate of medical care problems during a year was 74.8%, among them health problems which required rest at home was 37 percent. Estimated number of patients in the total population during a year was 4,600. The health problems that occured most frequently among the interviewees during a year were: Cold (30%), GI trouble (18), respiratory disease (11), anemia (10), diarrhea (10), neuralgia (10), parasite disease (9), ENT (7), skin (7), headache (7), trauma (4), communicable disease (3), and circulatory disease (3) -in that order. The rate of health problems by age groups was highest in the infants group, thereafter the rate decreased gradually until the age 15-19 year age group which showed the lowest, and then the rate increased gradually with aging. Eighty-seven percent of health problems during a year were solved by primary medical care. Thirteen percent of them needed secondary medical care procedures. Days rested at home because of illness during a year were 16 days per interviewee and 44 days per patient and it accounted for 57,335 days lost among productive age group in the area (Table 21). Among those given medical examination, the conditions observed most frequently were respiratory disease, GI trouble, parasite disease, neuralgia, skin disease, trauma, tuberculosis, anemia, chronic obstructive lung disease, eye disorders-in that order (Table 22). The main health problems required secondary medical care are as fellows: (previous page). Utilization of medical care (treatment) The rate of treatment by various medical facilities for all health problems during one month was 73 percent. The rate of receiving of medical care of those who have health problems which required rest at home was 52% while the rate of those who have health problems which did not required rest was 61 percent (Table 23). The rate of receiving of medical care for all health problems during a year was 67 percent. The rate of receiving of medical care of those who have health problems which required rest at home was 82 percent while the rate of those who have health problems which did not required rest was as low as 53 percent (Table 24). Types of medical facilitied used were as follows: Hospital and clinics: 32-35% Herb clinics: 9-10% Drugstore: 53-58% Hospitalization Rate of hospitalization was 1.7% and the estimate number of hospitalizations among the total population during a year will be 107 persons (Table 25). Medical cost: Average medical cost per person during one month and a year were 171 and 2,800 won respectively. Average medical cost per patient during one month and a year were 1,109 and 3,740 won respectively. Average cost per household during a year was 15,800 won (Table 26, 27). Solution measures for health and medical care problems in rural area: A. Health problems which could be solved by paramedical workers such as nurses, midwives and aid nurses etc. are as follows: 1. Improvement of environmental sanitation 2. MCH except medical care problems 3. Family planning except surgical intervention 4. Tuberculosis control except diagnosis and prescription 5. Dental care except operational intervention 6. Health education for residents for improvement of utilization of medical facilities and early diagnosis etc. B. Medical care problems 1. Eighty-five percent of health problems could be solved by primary care procedures by general practitioners. 2. Fifteen percent of health problems need secondary medical procedures by a specialist. C. Medical cost Concidering the economic situation in rural area the amount of 2,062 won per residents during a year will be burdensome, so financial assistance is needed gorvernment to solve health and medical care problems for rural people.

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