• Journal of Pharmaceutical Investigation
• /
• 제23권3호spc1호
• /
• pp.19-30
• /
• 1993

The influence of emulsion type of tegafur, an oral anticancer agent, on lymphatic transport was studied in rats. The water-in-oil-type of emulsion and the oil-in-water-type emulsion of tegafur each in 50 mg, calculated in terms of tegafur, were prepared by adding tegafur aqueous solution to sesame oil containing hydrogenated castor oil following ultrasonic treatment, and then the prepared emulsions and aqueous solution as a comparative formulation were administered orally to rats (50 mg/5 ml/kg). The concentration levels of tegafur in plasma of femoral artery and lymph from thoracic duct cannula were measured simultaneously along a time course after administration and the pharmacokinetic parameters were investigated. At the same time, we examined the above described factors of 5-FU which is known as an active metabolite of tegafur. In comparison with tegafur solution, AUC and mean residence time of plasma tegafur were significantly increased in w/o-emulsion but significantly decreased in o/w-emulsion. Lymph flow rates were similar in both solution and w/o-emulsion but half in o/w-emulsion. Ratios between area under the lymph and plasma concentration time curves were always less than 1 reflecting the passive lymphatic delivery after oral administration of the prepared tegafur emulsions, but those to the 5-FU in the case of w/o-emulsion were more than 1. These results suggested that lymphatic delivery of tegafur by w/o-emulsion was more effective than that by o/w-emulsion due to its differences of formation ability of chylomicrons.

• The Journal of Asian Finance, Economics and Business
• /
• 제7권1호
• /
• pp.249-257
• /
• 2020

This paper focused on the level of managerial centralization on chief executive officer (CEO) as a factor to affect the shared growth activities of corporate. As service corporations are becoming active in shared growth activities recently, this paper thus used CEO. Pay Slice (CPS) information to measure the level of managerial centralization on CEO of service corporation and tested the influence of the level of managerial centralization on whether shared growth activities are executed and the level of such activities respectively. The result of test shows that companies with high managerial centralization on CEO are more passive toward shared growth activities than those without such centralization. This can be interpreted that a CEO with more powerful influence may consider shared growth activities as to be negative and take a passive attitude to them. On the other hand, such result was supported by additional analysis with companies committing shared growth activities as well. This paper is expected to contribute to bring about interest on shared growth activities as the gap between major companies and small and medium sized companies is currently expanding in terms of operating profit ratio and even salary of employees.

• Asian Journal of Innovation and Policy
• /
• 제9권1호
• /
• pp.56-78
• /
• 2020

Changes in our lives due to Artificial Intelligence (AI) are currently ongoing, and there is little refutation of the effectiveness of AI. However, there have been active discussions to minimize the side effects of AI and use it responsibly, and publishing the AI Charter of Ethics (AICE) is one result of it. This study examines how our society is responding to threats from AI that may emerge in the future by examining various AIECs in the Republic of Korea. First, we summarize seven AI threats and classify these into three categories: AI's value judgment, malicious use of AI, and human alienation. Second, from Korea's seven AICEs, we draw fourteen topics based on three categories: protection of social values, AI control, and fostering digital citizenship. Finally, we review them based on the seven AI threats to evaluate any gaps between the threats and our responses. The analysis indicates that Korea has not yet been able to properly respond to the threat of AI's usurpation of human occupations (jobs). In addition, although Korea's AICEs present appropriate responses to lethal AI weapons, these provisions will be difficult to realize because the competition for AI weapons among military powers is intensifying.

• 간호행정학회지
• /
• 제15권4호
• /
• pp.581-592
• /
• 2009

Purpose: This study was designed to describe the nurses' knowledge and attitude about incidence reporting according to nursing organizational culture and organizational characteristics. Methods: The subjects of this study were 783 clinical nurses who were in A university hospital in Gyeonggi-Do. The data were collected from May, 20, 2009 to June, 2, 2009. The collected data were analyzed through descriptive methods, Pearson correlation coefficient, multiple regression in SPSS win(12.0). Results: Nurses' knowledge and attitude about incidence reporting were positively correlated with innovation oriented culture, relation oriented culture, and culture of patient safety. And among characteristics of nursing organization, communication, decision making, centralization were positively correlated with nurses' knowledge and attitude about incidence reporting. But the most correlated factor with nurses' knowledge and attitude about incidence reporting was culture of patient safety. Conclusions: The findings of this study suggest that to encourage reporting incidence, there must be a organizational approach, such as creating a culture of patient safety, active participating decision making, and communication.

• 수산경영론집
• /
• 제28권1호
• /
• pp.51-70
• /
• 1997

The fishing industry of Korea is now i a critical transitional stage. That is, broadly speaking, there are two dominant factors that constrain the further development of Korea fishey and effective competition in the international fishing industry. First of all, the global fishing industry has experienced many significant changes due to the execution of U.N, maritime law, the establishment of EEZ(the Exclusive Economic Zones), the increased roles of WTO(the World Trade Organization) as well as Korea being a member of OECD(the Organization for Economic Co-operation and Development). Second, the fishing industry of Korea is faced with the following domestic troubles, such as the icreasing fishing expenses, insufficient labor supply, and the collapse of traditional local co-operative organizations of fishing villages, etc. However, the demand for aquatic products of home consumers not only continues to increase but also is shifting to select more valuable species, completely ignoring the above-mentioned serious pressures incurred by the Korean fishery. To solve these problems and keep developing steadily, it is necessary for the fishing industry of Korea to adopt a more active and flexible development pattern in order to reset up the regional economic base in fishing villages nation-wide and make the exploitation of fishing resources balance. The paper gives an reconsideration to the primary alternatives facing the Korean fishery and its prospective roles in a realistic and far-sighted attitude. It may serve as an endeavour in seeking an outlet for the fishing industry of korea to advance forwardly and lastingly.

• STI Policy Review
• /
• 제4권2호
• /
• pp.96-112
• /
• 2013

The need for designing and implementing integrated policy was further emphasized in tandem with the increase in interest concerning policy coordination and interactions. An active discussion is taking place in the field of innovation policy concerning "integrated innovation policy," which considers innovation along with financial, regional development, social, and environmental policies together in a holistic manner. In Korea since the beginning of the 2000s, there were many attempts at implementing integrated innovation policy through the restructuring of the overall S&T administration system. For the purposes of taking an integrated approach to S&T policies as well as to S&T-related human resources, industrial, and regional development policies, the Roh Administration (February 2003~February 2008) elevated the S&T Minister to the level of Deputy Prime Minister as well as launching the Office of Science, Technology, and Innovation (OSTI) (October 2004 ~ February 2008) under the Ministry of Science and Technology. This study investigates the policy coordination activities of the OSTI from the perspective of policy integration. It deals with the background of the OSTI, its roles and responsibilities, the coordination process, and its achievements and limitations while discussing the important implications for developing effective policy measures with the hope of contributing to the development of theories of integrated innovation policy.

• 동아시아경상학회지
• /
• 제7권1호
• /
• pp.1-16
• /
• 2019

Purpose - For the development of fresh food shopping malls, consumers should continue to experience loyalty and favorability for the company's products or brands, and this should lead directly to purchase so that active word-ofmouth and recommendation should be encouraged. Therefore, the purpose of this study is to investigate the effect of e-service quality and e-ERM on e-loyalty with customer satisfaction and commitment as mediators. Research design, data, and methodology - This study was conducted by sample survey method on 320 online customers who have experience in using major online fresh food shopping malls for more than one year. Data analysis methods were frequency analysis, confirmatory factor analysis, reliability analysis, correlation analysis, and structural equation model analysis. Result - Hypothesis 1 through Hypothesis 7 were all supported. The results of this study suggest that e-service quality and e-CRM of online fresh food shopping malls have a significant effect on satisfaction and commitment. Therefore, the conclusion has been derived that the focus of this study, that such satisfaction and commitment have a significant effect on e-customer loyalty. has been supported theoretically and empirically. Conclusion - This study suggests that studies on customer loyalty based on activation commerce factors related to fresh food in online shopping malls will be an index that can reflect on customer's needs corresponding with future trends of not only online shopping malls but also offline shopping malls.

• Archives of Pharmacal Research
• /
• 제12권3호
• /
• pp.154-159
• /
• 1989

Pharmacokinetics and urinary excretion of sulfamethoxazole were investigated in healthy sheep. From the plasma disappearance curves after intravenous bolus injection (50 mg/kg), the half-life and volume of distribution were found to be 76 $\PM$14 min and 0.41 $\PM$ 0.18 lit/kg respectively. Body clearance was 4.06 $\PM$ 1.03 ml/kg/min. Very low Concentration of ddrug was present in plasma after 3 hours of administration and plasma level at 6 hour was only 4.4 $\PM$ 2.0 $\mu$g/ml. The renal clearance of sulfamethoxazole (22 $\PM$ 2.17 ml/min/10 kg) exeeded the creatinine clearance (9.78 $\PM$ 1, 57 ml/min/ 10 kg) which may be due to involvement of active tubular secretion and pH dependent back diffusion. Half of the dose of sulfamethoxazole was excreted as unchanged free drug while acetylated amine comprised of 20 percent within the first 6 hours of drug administration.

• Archives of Pharmacal Research
• /
• 제29권3호
• /
• pp.235-240
• /
• 2006

The oral administration of extracts of young radishes cultivated with sulfur after intravenous tumor cell injection achieved a marked reduction of pulmonary colonization in mice. Treatment of the mice with extracts of young radish cultivated with sulfur did not show any increase in the number of CD8+ or NK T cells in the spleen, indicating no influence on host immunity. Sulforaphane, which could be a candidate for an active compound from young radishes cultivated with sulfur, inhibited cell growth of B16-F10 melanoma cells. In addition, extracts of the young radish cultivated with sulfur-fed group showed enhanced quinine reductase (QR) activities in the liver and lung and a slight increase of glutathione S-transferase (GST) activity in the liver. These results suggested that the administration of extracts of young radishes cultivated with sulfur suppressed pulmonary tumorigenesis, possibly due to increased activity of detoxification enzymes in the liver and lung, and partly due to cell cytotoxicity.

• BMB Reports
• /
• 제29권5호
• /
• pp.436-441
• /
• 1996

The palmitoyl acyl carrier protein (ACP) specific thioesterase (EC 3.1.2.14) from Iris pseudoacorus was purified and characterized. The thioesterase which was very unstable in relatively high salt concentrations was eluted using a co-gradient of Triton X-100 and low concentration of KCl or Na-phosphate from Q-Sepharose, DEAE-Sepharose, and hydroxyapatite chromatography. SDS-PAGE analysis showed a single band with a molecular weight of 35,000. The native molecular weight of approximately 37,000 was estimated by Sephacryl S-200 chromatography, indicating that the enzyme is a monomer. The thioesterase activity was inhibited about 75% and 50% by N-ethylmaleimide (2 mM) and phenylmethylsulfonyl fluoride (2 mM). respectively. The N-ethylmaleimide-inactivation was protected by sodium palmitate but the inactivation with phenylmethylsulfonyl fluoride was not protected. Oxidation of thiols by 2 mM 5.5'-dithio-bis-(2-nitrobenzoic acid) resulted in 65% inactivation of the enzyme. These results suggest that a cysteinyl residue is essential to the catalytic reaction of the enzyme. The enzyme activity was increased by sodium citrate and also by $Cu^{2+}$