• Journal of Acupuncture Research
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• v.23 no.2
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• pp.61-72
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• 2006

Objectives : Human chondrocytes co-treated with Buthus martensi Karsch herbal acupuncture solution(BMK-HAS) extract produced significantly less NO compared with chondrocytes stimulated with $IL-1{\beta}$ alone Methods : Activation and translocation of and NF-kB DNA binding activity were determined by Western blotting and specific enzyme-linked immunosorbent assay. Results : The inhibition of NO production correlated with the suppression of induction and expression of nuclear factor-kB (NF-kB) and activation protein-1 (AP-1)-dependent gene. BMK-HAS inhibited the activation and translocation of NF-kB to the nucleus, indicating that BMK-HAS inhibits the $IL-1{\beta}-induced$ production of NO in human chondrocytes by interfering with the activation of NF-kB through a novel mechanism. In addition, BMK-HAS reduced prostaglandin E2 (PGE2)production in mouse peritoneal macrophages stimulated with lipopolysaccharide, whereas no influence on the activity of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) or cyclooxygenase-1 (COX-1) was observed. My data, therefore, suggest that BMK-HAS may be a therapeutically effective inhibitor of $IL-1{\beta}-induced$ inflammatory effects that are dependent on NF-kB activation in human OA chondrocytes. Conclusion : The results indicate that BMK-HAS exerts anti-inflammatory effects related to the inhibition of neutrophil functions and of NO and PGE2 production, which could be due to a decreased expression of iNOS and COX-2 through the transcription factors NF-kB and AP-1.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.5
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• pp.357-366
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• 2019

$G{\alpha}_q$-coupled receptor stimulation was implied in the activation process of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heterotetrameric channels. The inactivation occurs due to phosphatidylinositol 4,5-biphosphate ($PI(4,5)P_2$) depletion. When $PI(4,5)P_2$ depletion was induced by muscarinic stimulation or inositol polyphosphate 5-phosphatase (Inp54p), however, the inactivation by muscarinic stimulation was greater compared to that by Inp54p. The aim of this study was to investigate the complete inactivation mechanism of the heteromeric channels upon $G{\alpha}_q$-phospholipase $C{\beta}$ ($G{\alpha}_q-PLC{\beta}$) activation. We evaluated the activity of heteromeric channels with electrophysiological recording in HEK293 cells expressing TRPC channels. TRPC1/4 and TRPC1/5 heteromers undergo further inhibition in $PLC{\beta}$ activation and calcium/protein kinase C (PKC) signaling. Nevertheless, the key factors differ. For TRPC1/4, the inactivation process was facilitated by $Ca^{2+}$ release from the endoplasmic reticulum, and for TRPC1/5, activation of PKC was concerned mostly. We conclude that the subsequent increase in cytoplasmic $Ca^{2+}$ due to $Ca^{2+}$ release from the endoplasmic reticulum and activation of PKC resulted in a second phase of channel inhibition following $PI(4,5)P_2$ depletion.

• International Commerce and Information Review
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• v.6 no.1
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• pp.25-50
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• 2004

This study attempts to find out what kind of service quality is considered important by customers in using the Internet shopping mall and suggests the way to activate the customer relationship. The findings based on empirical analysis are shown here. First, empirical analysis of the contextual factors such as gender, education, and experience levels, shows that what customers perceive as most important in the product purchase is security in terms of the payment and personal information service. The second important service quality factor perceived by customers is responsiveness, particularly the rapidity and accuracy of response to their needs and wants. The customers also considered price, quality and diversity of the product as being important. Furthermore, there is no big difference among other service quality factors. Second, in the different gender context, there is no significant difference between the genders. However, the male group shows an even distribution of factors valued in the service quality, whereas female respondents placed stronger emphases on particular aspects of service, such as security, response, reliability and product quality. Third, in the context of different education level, the payment method between graduates and non-graduates has a significant difference. That is, the non-graduates prefer the credit card and saving through ATM, while the graduates use dual payment method using credit card and another payment method together. Therefore, the various payment methods should be considered according to the customer type, namely graduates or non-graduates. Fourth, in the context of different experience level, the result of the empirical analysis of the factors of the service quality shows no great difference between experienced and inexperienced customers. Both types of customer perceive security as the most important. To sum up, the service quality perceived by the customers of Internet shopping malls is empirically analyzed in different contexts such as gender, education, and experience. Then, the device for the customer relationship activation is suggested. It can be utilized as a guideline for the continuing diffusion of the Internet shopping mall, giving it a competitive advantage against other companies.

• Journal of the Korean Society for Library and Information Science
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• v.51 no.1
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• pp.49-67
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• 2017

An archives collects and manages a variety of records and archives including information reflecting the phases of the times and has a role in society as archive information center. Also, archives support that users can efficiently search and use records. Although archives has a variety of records and archives, users and non-users has low recognition on it. This study aims to find factors why people don't use archives and analyzes requirements to utilize archives activation for users and non-users. To perform the goals, questionnaires were used to collect data from 148 domestic people. Also, this study used descriptive statistics and independent t-test to analyze the collected data. With the analyzed results, this study proposed suggestions to improve user's perception and factors for activation of archives.

• Journal of Family Resource Management and Policy Review
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• v.25 no.3
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• pp.69-85
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• 2021

The purpose of this study was to explore ways to revitalize the community-based child care community by identifying the factors that are hindering and activating the operation and use of this community by elementary school students. To this end, an in-depth interview survey was conducted of operators of child care communities in Jeollabuk-do and users of caring communities. Detailed themes, sub-ranges and upper ranges were determined through a qualitative research method. As a result of the study, it was determined that the basic environmental weakness of the caring community and its lack of power are the things hindering the operation and use of rhe communities the most. On the other hand, the main activation factors for community-based child care community activities were the stabilization of the environment and the strengthening of the internal capacity of the care community. This study is meaningful as basic data for the safe establishment and activation of a community-based child care community, which is emerging as an alternative to the child care gap due to the prolonged effects of COVID-19.

• Journal of Korea Trade
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• v.23 no.7
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• pp.34-44
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• 2019

Purpose - The purpose of this study is to present what the port of Pyeongtaek, the hub of Korean trade with China, should improve in the current situation, wherein the e-commerce trade volume between Korea and China is increasing due to the development of online technology. Design/methodology - In this study, through prior research and expert interviews on e-commerce and port activation between borders, we derived the main improvement factors for 1) Administration and Systems, 2) Facilities, 3) Transport, and 4) Manpower, and selected 12 detailed variables for the major improvement factors. To identify the relative importance of the major improvement factors, the Analytic Hierarchy Process (AHP) method was applied, and a survey was conducted among 15 related experts. Findings - As a result, among the 12 detailed variables, Composition of Association (0.267) was the first factor to be improved, followed by Incentive Support (0.143) and E-Commerce Cluster (0.131). Based on these analyses, the main implications of this study are, first, in the current situation where the cross-border e-commerce market is growing, Pyeongtaek Port needs to form a consultative body among the government, local governments, and related businesses in connection with cross-border e-commerce and develop various support policies for the e-commerce market. Second, it will have to be able to provide differentiated services from competing ports by establishing e-commerce market-oriented clusters. Originality/value - In existing related studies, various improvements were presented to revitalize trade in line with the growth of the cross-border e-commerce market. However, with regard to most cross-border e-commerce businesses, one-dimensional improvement measures, such as improvement of payment systems, improvement of customs clearance services, and promotion of human resources, are presented in a piecemeal manner. In other words, none of the studies have proposed the importance and priority of each measure in terms of both the forward-looking and efficient allocation of resources, which is the purpose of this study. Therefore, this study contributed politically, practically, and academically by presenting countermeasures for ports to revitalize cross-border e-commerce and presenting strategic priorities using quantitative analysis methods.

• Journal of the Korea institute for structural maintenance and inspection
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• v.9 no.4
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• pp.261-269
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• 2005

The object of this research is to produce alkali activated fly ash-cement using low calcium fly ash as substitute for portland cement. The experimental program included activation of fly ash by a strong base(NaOH) at different concentration, temperature, and liquid-to-fly ash ratios. To achieve for higher compressive strength of the hardened product, sodium meta silicate is added to the alkaline solution. From the factors considered on strength development, the ratio of liquid/fly ash, the activator concentration and temperature always result to be significative factors. The optimization studied show that the alkaline solution concentration of $NaOH(210g)+Na_2SiO_3{\cdot}9H_2O(30g)+H_2O=1L$ at $50^{\circ}C$ produces the best alkali activation effect for the low calcium fly ash. SEM and XRD patterns showed that the components of alkali-activated fly ash consist mainly of mullite, quartz and amorphous aluminosilicate.

• Analytical Science and Technology
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• v.14 no.4
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• pp.1075-1081
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• 2001

Instrumental Neutron Activation Analysis as a representative method of nuclear analytical technique, has advantages of non-destructive, simultaneous multi-element analysis with the characteristics of absolute measurement method. Up to date, $k_0$-quantitative method which is accurate, convenient and user-friendly, has been generalized world-widely. In this study, it is intented to introduce the general concept of $k_0$-method and to measure $k_0$-parameters for the future implementation to our NAA system. For this objectives, the definition of relevant factors for the quantitative analysis and the equation for the experimental determination of parameters such as $Q_0$(${\alpha}$) and f were summarized. Furthermore, a foundation for the $k_0$-standardization method was prepared through the measurement of ${\alpha}$ and f-value which depend on the specific character of irradiation hole at NAA#1-hole of HANARO research reactor.

• Korean Institute of Interior Design Journal
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• v.25 no.1
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• pp.3-12
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• 2016

This study analyses characteristics of space to facilitate community centering on cases of collective houses in Japan and uses the results as basic data to activate collective houses as an alternative form of housing in our country. To identify the characteristics of space for active communities with collective living space, this study conducted a theoretical examination on collective houses and housing, derived territoriality, accessibility, comfort and safety as factors of community activation and analysed various cases, and the results are presented as follows: First, territoriality is a necessary condition for formation of community, and a confined and physical space. It indicates the proper size of a space and diverse spacial areas which meet the needs of residents with the proper size and amount of space (space which can accommodate diverse generations including women, the aged and the young, flexible space which changes according to the purposes and program, space which supports leisure and hobby activities, and space which can accommodate outsiders). Second, accessibility indicates an environment which supports residents' easy use of space. As the more accessible it is, the higher the frequency of its use, spatial factors (piloti, backyards, benches and tables) should be provided, community space should be arranged in a central or decentralized way and community living space should be made for each floor. As for exits, accessibility should be considered in every way; entrances connected with community spaces, open entrances and entrances accessible from outside or individual living spaces. Third, comfort satisfies the physical and mental needs of residents through separation of floors and flows between the community and individual spaces for privacy and formation of eco-friendly spaces including vegetable gardens, gardens and plant arrangements. Fourth, safety should be considered for a higher quality environment with psychological stability and comfort, for which the following are recommended: installation of hand-rails, removal of thresholds, spacial design for the socially weak, duplex and open type structures for community space, open stages and halls, as well as indoor and outdoor openness through the use of windows.

• Journal of Digital Convergence
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• v.13 no.12
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• pp.13-21
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• 2015

Ongoing advances in wireless broadband technologies can affect all of industrial society. As new wireless broadband technologies emerge, they will improve competition between established industries and their current services and produce new industries and new converged services. This paper analyzes the trend of next-generation wireless broadband and suggests ways of activating the industry further. To this end, we analyze the trend for previous wireless broadband industries and find out three influential factors (content, wireless network technology, and service) that will produce the continued growth of wireless broadband. Using these three factors, we propose a network technology-driven growth model. Based on that model, we offer activation plans for next-generation wireless broadband industries. This study thus provides an insightful perspective for next-generation wireless broadband industries by establishing additional useful guidelines for developing wireless broadband industries in the future.