• 한국터널지하공간학회 논문집
• /
• 제20권2호
• /
• pp.527-539
• /
• 2018

다수의 승객들이 이용하는 지하철은 안전과 공간의 쾌적한 환경관리가 필수적이며, 2003년 이후 기준 강화로 승강장 내에 스크린도어(PSD)를 반드시 설치해야 한다. 선행연구에 따르면 지하철 화재 시에 화재연기의 배연을 위해 배연설비의 설비용량 최적설계가 필요하다. 따라서 본 연구에서는 선행연구의 실험 결과를 바탕으로 3차원 수치해석기법을 이용하여 PSD가 설치된 승강장 내에서 화재발생 시 배연시스템 별로 CO가스와 Smoke의 유동을 분석하였다. 본 연구의 결과 비상시 상부 배연설비만 가동한 경우에는 CO 가스와 Smoke 농도는 653.8 ppm과 $768.4mg/m^3$로 피난 시 승객들의 위험이 큰 것으로 분석되었으며, 모든 배연설비를 가동하고 화재측 PSD만을 개방한 경우 CO 가스와 Smoke 농도 36.0 ppm 및 $26.2mg/m^3$를 보이며 화재연기의 전파범위가 줄어드는 것으로 분석되었다. 모든 배연설비를 가동하고 화재측 PSD를 미개방한 경우에는 화재연기 유입이 발생하지 않아서 대피환경에 있어 가장 효과적인 배연모드로 분석되었다.

• Experimental and Molecular Medicine
• /
• 제50권11호
• /
• pp.5.1-5.14
• /
• 2018

Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of intervertebral disc degeneration (IVDD). Sirtuin 3 (SIRT3), a sirtuin family protein located in mitochondria, is essential for mitochondrial homeostasis; however, the role of SIRT3 in the process of IVDD has remained elusive. Here, we explored the expression of SIRT3 in IVDD in vivo and in vitro; we also explored the role of SIRT3 in senescence, apoptosis, and mitochondrial homeostasis under oxidative stress. We subsequently activated SIRT3 using honokiol to evaluate its therapeutic potential for IVDD. We assessed SIRT3 expression in degenerative nucleus pulposus (NP) tissues and oxidative stress-induced nucleus pulposus cells (NPCs). SIRT3 was knocked down by lentivirus and activated by honokiol to determine its role in oxidative stress-induced NPCs. The mechanism by which honokiol affected SIRT3 regulation was investigated in vitro, and the therapeutic potential of honokiol was assessed in vitro and in vivo. We found that the expression of SIRT3 decreased with IVDD, and SIRT3 knockdown reduced the tolerance of NPCs to oxidative stress. Honokiol ($10{\mu}M$) improved the viability of NPCs under oxidative stress and promoted their properties of anti-oxidation, mitochondrial dynamics and mitophagy in a SIRT3-dependent manner. Furthermore, honokiol activated SIRT3 through the AMPK-PGC-$1{\alpha}$ signaling pathway. Moreover, honokiol treatment ameliorated IVDD in rats. Our study indicated that SIRT3 is involved in IVDD and showed the potential of the SIRT3 agonist honokiol for the treatment of IVDD.

• 한국항해항만학회지
• /
• 제40권4호
• /
• pp.173-181
• /
• 2016

2016년부터 배출통제지역(ECA : Emission Control Atea)을 운항하는 선박에 대하여 배출되는 NOx(질소산화물) 및 SOx(황산화물)의 배기량 감소규제가 강화되었다. 상기의 규제 물질 중 NOx를 제거하는 탈질장비 중 선택적 촉매 환원(SCR : Selectivity Catalytic Reduction) 시스템은 효율이 높고 상업적으로 많이 활용되고 있으나, 높은 온도에서 요소수가 활성화되는 단점이 있다. 이에 초미세기포를 이용하여 낮은 온도에서도 반응할 수 있는 요소수 및 요소수 활성화 기기를 개발하여 상기의 문제점들을 최소화 할 수 있도록 하였다. 또한 SCR 시스템의 효율성을 향상시키는 방안을 마련하기 위하여, ANSYS-CFX package를 이용한 전산유체역학(CFD : Computational fluid dynamics)기법을 사용하였다. Navier-Stokes 방정식을 해석의 지배방정식으로 적용하여 SCR 시스템의 점성유동해석 시뮬레이션을 수행하였다. SCR 시스템의 형상은 CATIA V5를 사용하여 3D 모델링을 하였고, SCR 시스템의 효율성을 비교하기 위해 요소수 분사 노즐의 위치를 요소수 분사 노즐은 배기관의 입구로부터 1/3, 1/2, 2/3로 변경하며 확인하였다. 또한, 노즐의 분사구 수가 SCR 시스템의 효율에 미치는 영향을 확인하기 위하여 분사구 수가 4, 6, 8개일 경우를 시뮬레이션 하여 비교 분석하였다. 시뮬레이션 결과 배기관 입구에 가까울수록, 분사구 수가 많을수록 효율이 향상됨을 확인하였다.

• 한국전산유체공학회지
• /
• 제13권4호
• /
• pp.8-12
• /
• 2008

Heat/smoke detectors are installed in most subway platforms in Korea to detect fire. Subway platform is divided by smoke-control zones for efficient smoke-control. Once the detectors detect heat or smoke, the smoke-control ventilation system in the platform and concourse is activated according to the smoke-control ventilation mode. Smoke-control mode during fires in Korean subway platforms is that the smoke zones operate by exhausting smoke while other zones in the platform and in the concourse which is the upper floor of the platform operate by supplying air or stopping any ventilation. This study is conducted to evaluate performance of passengers' evacuation for various smoke control modes in the subway station. Distribution of smoke and heat due to fire on the platform is analyzed by using Fire Dynamics Simulator(FDS V 4.06) of NIST. Various smoke-control ventilation modes and locations of fire are considered. Evacuation and movement of passengers within the platform is simulated by building EXODUS V.4.0.

• 제어로봇시스템학회논문지
• /
• 제10권12호
• /
• pp.1155-1163
• /
• 2004

Extracellular signal-regulated kinase (ERK) signaling pathway is one of the mitogen-activated protein kinase (MAPK) signal transduction pathways. This pathway is known as pivotal in many signaling networks that govern proliferation, differentiation and cell survival. The ERK signaling pathway comprises positive and negative feedback loops, depending on whether the terminal kinase stimulates or inhibits the activation of the initial level. In this paper, we attempt to model the ERK pathway by considering both of the positive and negative feedback mechanisms based on Michaelis-Menten kinetics. In addition, we propose a fraction ratio model based on the mass action law. We first develop a mathematical model of the ERK pathway with fraction ratios. Secondly, we analyze the dynamical properties of the fraction ratio model based on simulation studies. Furthermore, we propose a concept of an inhibitor, catalyst, and substrate (ICS) controller which regulates the inhibitor, catalyst, and substrate concentrations of the ERK signal transduction pathway. The ICS controller can be designed through dynamical analysis of the ERK signaling transduction pathway within limited concentration ranges.

• Journal of Electrical Engineering and Technology
• /
• 제10권6호
• /
• pp.2413-2419
• /
• 2015

Core spinal muscles are related to trunk stability and assume the main role of stabilizing the spine during daily activities; strengthening of core muscles around the spine can therefore reduce the chance of back pain. The objective of the study was to investigate the effect of core muscle strengthening in the spine during spine stabilization exercise using a whole body tilt device. To achieve this, a validated musculoskeletal (MS) model of the whole body was used to replicate the input motion from the whole body tilting exercise. An inverse dynamics analysis was executed to estimate spine loads and muscle forces depending on the tilting angles of the exercise device. The activation of long and superficial back muscles such as the erector spinae (iliocostalis and longissimus) were mainly affected by the forward direction (-40°) of the tilt, while the front muscles (psoas major, quadratus lumborum, and external and internal obliques) were mainly affected by the backward tilting direction (40°). Deep muscles such as the multifidi and short muscles were activated in most directions of the rotation and tilt. The backward directions of the tilt using this device could be carefully applied for the elderly and for rehabilitation patients who are expected to have less muscle strength. In this study, it was shown that the spine stabilization exercise device can provide considerable muscle exercise effect.

• 한국산학기술학회논문지
• /
• 제13권4호
• /
• pp.1814-1821
• /
• 2012

본 논문은 국내에서 설비용량 20MW 이상의 신재생발전기에 대해 계통연계 유지조건을 의무화하는 송배전용 전기설비 이용규정이 2012년부터 적용됨에 따라 이를 모의해석 기반의 풍력발전기 계통연계 검토 시에 고려하기 위한 풍력발전기의 LVRT(Low Voltage Ride Through) 전사모형을 개발하고 이를 풍력발전기가 연계된 전력계통의 성능평가에 적용하여 전사모델의 유용성을 검증한 후 전력계통의 대표적인 상정고장에 적용하여 국내 풍력발전기 계통연계 유지조건의 적용효과를 분석하였다.

• 한국수소및신에너지학회논문집
• /
• 제20권4호
• /
• pp.352-359
• /
• 2009

KEPRI is developing a Korean type coal-gasification system and the scale is 20 ton/day. Prior to this pilot plant, a 1 ton/day class gasification system will be used for pre-testing of several coal types. This paper introduces the configuration and design conditions of this 1 ton/day class system, presenting the gas/coal ratio, oxygen/coal ratio, cold gas efficiency, CFD analysis of gasifier, and others. The existing combustion furnace for residual oil was retrofitted as a coal gasifier and a vertical and down-flow type burner was manufactured. Ash removal is carried out through a water quencher and a scrubber following the quencher, and the sulfur is removed by adsorption in the activated carbon tower. The gas produced from the gasifier is burned at the flare stack. In this paper, the results of design conditions and initial operation conditions of I ton/day gasification system are compared together.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2002년도 학술대회지
• /
• pp.705-706
• /
• 2002

Hemodynamics of the TPLS(Twin Pulse Life Support System) is numerically investigated to delineate the possibility of hemolysis in blood. Computational method employing finite element algorithm is utilized to solve the blood flow of the sac squeezed by moving actuator. We assume that the blood flow interacts with the sac material which is activated by the rigid body motion of the actuator. Valve dynamics at the ends of the sac is simplified as on/off type motion. We compute the transient viscous flow in the two-dimensional geometry of the blood sac. Incompressible laminar flow is simulated on the assumption of Newtonian fluid. Blood velocity has a step gradient near the throat of the sac formed by the moving actuator. According to the decrease of the gap size of blood passage, the magnitude of shear stress in the blood is dramatically increased. Numerical solutions show that the maximum value of shear stress in the blood flow in TPLS is relatively smaller than that of the roller type ECLS.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2008년도 춘계학술대회논문집
• /
• pp.641-646
• /
• 2008

Long and slender body with or without flexible supports under severe operating condition can be unstabilized even by the small cross flow. Turbulent flow mixer, which actually increases thermal-hydraulic performance of the nuclear fuel by boosting turbulence, disturbs the flow field around the fuel rod and affects dynamic behavior of the nuclear fuel rods. Few studies on this problem can be found in the literature because these effects depend on the specific natures of the support and the design of the system. This work shows how the dynamics of a multi-span fuel rod can be affected by the turbulent flow, which is discretely activated by a flow mixer. By solving a state-space form of the eigenvalue equation for a multi-span fuel rod system, the critical velocity at which a fuel rod becomes unstable was established. Based on the simulation results, we evaluated how stability of a multi-spanned nuclear fuel rod with mixing vanes can be affected by the coolant flow in an operating reactor core.