• Biomolecules & Therapeutics
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• v.21 no.3
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• pp.181-189
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• 2013

Motilitone$^{(R)}$ (DA-9701) is a new herbal drug that was launched for the treatment of functional dyspepsia in December 2011 in Korea. The heterogeneous symptom pattern and multiple causes of functional dyspepsia have resulted in multiple drug target strategies for its treatment. DA-9701, a compound consisting of a combination of Corydalis Tuber and Pharbitidis Semen, has being developed for treatment of functional dyspepsia. It has multiple mechanisms of action such as fundus relaxation, visceral analgesia, and prokinetic effects. Furthermore, it was found to significantly enhance meal-induced gastric accommodation and increase gastric compliance in dogs. DA-9701 also showed an analgesic effect in rats with colorectal distension induced visceral hypersensitivity and an antinociceptive effect in beagle dogs with gastric distension-induced nociception. The pharmacological effects of DA-9701 also include conventional effects, such as enhanced gastric emptying and gastrointestinal transit. The safety profile of DA-9701 is also preferable to that of other treatments.

• Journal of Environmental Impact Assessment
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• v.22 no.1
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• pp.109-116
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• 2013

By IPCC climate change scenario, the socioeconomic actions such as the land use change are closely associated with the climate change as an up zoning action of urban development to increase green gas emission to atmosphere. Prediction of the land use change with rational quality can provide better data for understanding of the climate change in future. This study aims to predict land use change of Cheongju in future and SLEUTH model is used to anticipate with the status quo condition, in which the pattern of land use change in future follows the chronical tendency of land use change during last 25 years. From 40 years prediction since 2000 year, the area urbanized compared with 2000 year increases up to 87.8% in 2040 year. The ratios of the area urbanized from agricultural area and natural area in 2040 are decreased to 53.1% and 15.3%, respectively.

• Journal of Information Display
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• v.9 no.1
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• pp.14-19
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• 2008

We demonstrated the capillary force lithography (CFL) method for controlling the azimuthal anchoring energy of a liquid crystal (LC) alignment layer. When a thermoplastic polymer film is heated to over the glass transition temperature, the melted polymer is filled into the mold structure by the capillary action and the aspect ratio of the pattern is determined by the dewetting time of the CFL process. Here, the proposed method showed that the azimuthal anchoring energy of the LC alignment layer could be simply controlled by the surface relief patterns which were determined by the dewetting times during the CFL patterning.

• Proceedings of the KIEE Conference
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• 2000.11c
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• pp.583-585
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• 2000

This study reports the fluidic handling method using hydrophobic patterns inside PDMS microchannels. In order to obtain hydrophobic patterns, we pattern fluorcarbon(FC) film surfaces by lift-off process. FC films are deposited by spin coating method and plasma polymerization method. Hydrophobic surfaces are used as the barriers to control fluid flow. Injected liquid is spontaneously filled up inside PDMS-microchannels by the capillary action. Liquid flow stops when it meets hydrophobic regions which can be the barrier against fluid flow. Then, again, when liquid is pressurized externally, liquid can move toward another hydrophilic region by external air pressure. Contact angle analyses are performed on fluorocarbon films to estimate the wettability of film surfaces.

• The Korean Journal of Zoology
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• v.38 no.2
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• pp.220-229
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• 1995

uftraspirocle (usa) gene product (Uspl is a member of the superfamilv of steroid hormone receptors in Drosophila melonogaster which mediate the hormone action by heteromerization with ecdvsone receptor (EcR). Based on the genetic and molecular characterization of usp, it has been proposed that Usp funtions in at least three significant developmental pathway: embrvogenesis, eve morphogenesis, and female reproduction. In this study, the expression patterns of Usp were investigated by immunohistochemistrv in individual tissues from diHernt developmental stases of Drosophila. Usp is localized in the nucleus with ubiquitous distribution throughout development. Usp expression is detected throughout embrvogenesis. Usp is expressed in imaginal and lanral tissues from late third instar 18nra. The expression pattern of Usp is overlapped by those of EcR. Also Usp is expressed in differentiating adult reproductive organs. This result suggests that Usp is not a transcriptional regulatory factor modulating hormonal response during development, but also play some roles in female and male reproduction of Drosophila.

• KSCI Review
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• v.15 no.1
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• pp.125-129
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• 2007

지능형 홈 네트워크 서비스의 일반적 보급화로 사용자의 필요와 욕구에 밀착한 개인화 서비스를 위한 사용자의 프로파일 및 다양한 상태 정보, 센서 및 기타 환경정보를 통한 동적 상황인지가 가능토록 하는 상황인지(context-aware) 서비스에 대한 필요성이 증대되고 있다. 사용자 행위 학습에 따른 지능적 자동 제어 시스템 구축에서 먼저 고려해야 할 사항은 사용자 행위 학습에 따른 지능적 자동 제어에 대한 기준을 마련하는 것이다. 홈 네트워크 내의 정보가전기기들 환경에 대한 정보를 지속적으로 수집하고 학습 알고리즘을 통하여 분석하며, 분석되어진 정보를 바탕으로 사용자의 성향을 파악하는 것을 주요인으로 간주해야 할 것이다. 이에 따라 본 논문에서는 사용자 능동적 행위에 따른 지능형 홈 제어 시스템을 제안하였다. 또한 지속적인 모니터링을 통하여 사용자의 성향이 파악되면 상황에 따른 최적의 환경을 제공할 수 있도록 홈 네트워크 제어 시스템을 구축하는 것으로 목적으로 하였다. 사용자의 행동 패턴을 분석하고 이를 기반으로 지능적인 서비스를 제공함으로써 사용자 중심의 능동적 서비스 효과들을 얻을 수 있을 것으로 기대한다.

• Journal of the Korean Chemical Society
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• v.35 no.1
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• pp.78-84
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• 1991

In an effort to increase effective action of enkephalins, several peptide inhibitors of enkephalin aminopeptidase have been synthesized. The peptides contain 3-amino-2-hydroxy amino acid as a zinc binding site and side chains of substrate pattern. The peptides were synthesized in solution by chain elongation from C-terminal end using DCC/HOBt as coupling reagent. The peptides are shown to have very strong inhibitory activity against enkephalin aminopeptidase.

• Journal of the Korean Society of Marine Environment & Safety
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• v.2 no.1
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• pp.143-143
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• 1996

Recent Class requirements and IMO recommendations concerning Hull Strength Monitoring (HSM) have prompted an increasing number of shipowner to adopt monitoring systems on bulk carriers and tanker. Such systems are designed to give warning when stress levels and the frequency and magnitude of ship motions approach levels which require corrective action. When fitted these systems provide enhanced operational safety and efficiency. This paper describes a development beyond the standard BMT HSM system through the integration of stress, motion and radar-based sea state monitoring with powerful, on-board, artificial intelligence (AI) tools. The latter utilises conceptual clustering techniques as an aid to pattern recognition in stress, fatigue. motion and sea state data clusters. This, in turn, provides additional operational guidance for ship's staff. Feedback from applications of the standard BMT HSM and extended HSM systems on board the British Steel Bulk Shipping fleet is described.

• The Korean Journal of Physiology
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• v.29 no.1
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• pp.103-111
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• 1995

Intracellular recordings were obtained from Purkinje cells in rat cerebellar slices maintained in vitro. Adding tetrodotoxin to the superfusion solution produced a typical pattern of repetitive burst firing consisting of a cluster of action potentials followed by a long hyperpolarization. TTX-induced oscillatory activity was not due to modulation of membrane potential although underlying mechanisms for maintenance of oscillatory activity were influenced by membrane voltage. The mechanism of TTX-induced oscillation was not related to the presence or amplitude of $I_h$ and could still induce the oscillatory activity after blockade of $I_h$ by cesium. The result from an experiment in which QX-314 was injected intracellularly strongly suggested that TTX-induced oscillatory firing activity was due to blockade of post-synaptic $Na^{+}$ currents intrinsic to PCs.

• Journal of Korea Game Society
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• v.4 no.3
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• pp.43-47
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• 2004

Fast games such as first person shooting games and action games gives notiming surplus to analyze both states of enemys and my status normally. Behavioral of enemy characters in these games are generally produced by patterns. However It was weekpoints of exposure of patterns when gamers try many times. In this paper, we study the new patterns of enemy characters after analysing patterns of gamers