• 한국콘텐츠학회논문지
• /
• 제13권11호
• /
• pp.477-491
• /
• 2013

각 대학은 사회적 책무성에 근거하여 핵심역량을 고루 갖춘 인재양성에 주력하고 있다. 특히 세분화된 특정분야의 첨단지식의 지속시간이 짧아지는 시대적 특성을 고려하여 교양교육 과정을 개편 운영하고, 교수학습 방법을 개선하고 있다. 본 연구는 대학생들의 핵심역량 육성을 위해 적용된 Action Learning에서의 경험과정을 탐색하는 것을 목적으로 한다. 이를 위해 근거이론 접근방법을 사용하였다. 따라서 핵심역량 교과 영역 수강자들을 고루 포함할 수 있도록 하면서 다양한 범주, 속성 및 차원에 속하는 참여자를 모집하기 위해 이론적 표본추출을 하였다. 결과 총 15명을 연구 참여자로 선정하였고, 수집된 심층면담자료는 Strauss와 corbin의 근거이론 접근방법에 따라 분석하였다. 분석결과는 첫째, 액션러닝의 운영단계에 따라 러닝코치의 역할이 달라야 하고, 둘째, 효과적인 액션러닝 운영을 위해서 개인성찰의 기회도 충분히 가져야 한다. 셋째, 학습자들이 학습과정에서 도출되는 문제를 직접 해결해보는 것이 중요하고, 넷째, 핵심역량 교과목의 목적에 대한 숙지도 중요 한 것으로 나타났다.

• 한국영양학회:학술대회논문집
• /
• 한국영양학회 1995년도 추계학술대회 초록
• /
• pp.11-34
• /
• 1995

Growth hormone (GH) plays a key role in regulating postnatal growth and can stimulate growth of animals by acting directly on specific receptors on the plasma membrane of tissues or indirectly through stimulating insulin-like growth factor (IGF)-I synthesis and secretion by the liver and other tissues. IGF-I and IGF-Ⅱ are polypeptides with structural similarity with proinsulin that stimulate cell proliferation by endocrine, paracrine and autocrine mechanisms. The initial event in the metabolic action of IGFs on target cells appears to be their binding to specific receptors on the plasma membrane. Current evidence indicates that the mitogenic actions of both IGFs are mediated primarily by binding to the type I IGF receptors, and that IGF action is also mediated by interactions with IGF-binding proteins (IGFBPs). Six distinct IGFBPs have been identified that are characterized by cell-specific interaction, transcriptional and post-translational regulation by many different effectors, and the ability to either potentiate or inhibit IGF actions. Nutritional deficiencies can have their devastating consequence during growth. Although IGF-I is the major mediator of GH's action on somatic growth, nutritional status of an organism is a critical regulator of IGF-I and IGFBPs. Various nutrient deficiencies result in decreased serum IGF-I levels and altered IGFBP levels, but the blood levels of GH are generally unchanged or elevated in malnutrition. Effects of protein, energy, vitamin C and D, and zinc on serum IGF and IGFBP levels and tissue mRNA levels were reviewed in the text. Multiple factors are involved in the regulation of intestinal epithelial cell growth and differentiation. Among these factors the nutritional status of individuals is the most important. The intestinal epithelium is an important site for mitogenic action of the IGFs in vivo, with exogenous IGF-I stimulating mucosal hyperplasia. Therefore, the IGF system appears to provide and important mechanism linking nutrition and the proliferation of intestinal epithelial cells. In order to study the detailed mechanisms by which intestinal mucosa is regulated, we have utilized IEC-6 cells, an intestinal epithelial cell line and Caco-2 cells, a human colon adenocarcinoma cell line. Like intestinal crypt cells analyzed in vivo or freshly isolated intestinal epithelial cells, IEC-6 cells and Caco-2 cells possess abundant quatities of both type Ⅰ and type Ⅱ IGF receptors. Exogenous IGFs stimulate, whereas addition of IGFBP-2 inhibits IEC-6 cell proliferation. To investigate whether endogenously secreted IGFBP-2 inhibit proliferation, IEC-6 cells were transfected with a full-length rat IGFBP-2 cDNA anti-sense expression construct. IEC-6 cells transfected with anti-sense IGFBP-2 protein in medium. These cells grew at a rate faster than the control cells indicating that endogenous IGFBP-2 inhibits proliferation of IEC-6 cells, probably by sequestering IGFs. IEC-6 cells express many characteristics of enterocyte, but do not undergo differentiation. On the other hand, Caco-2 cells undergo a spontaneous enterocyte differentiation. On the other hand, Caco-2 cells undergo a spontaneous enterocyte differentiation after reaching confluency. We have demonstrated that Caco-2 cells produce IGF-Ⅱ, IGFBP-2, IGFBP-3, and an as yet unidentified 31,000 Mr IGFBP, and that both mRNA and peptide secretion of IGFBP-2 and IGFBP-3 increased, but IGFBP-4 mRNA and protein secretion decreased after the cells reached confluency. These changes occurred in parallel to and were coincident with differentiation of the cells, as measured by expression of sucrase-isomaltase. In addition, Caco-2 cell clones forced to overexpress IGFBP-4 by transfection with a rat IGFBP-4 cDNA construct exhibited a significantly slower growth rate under serum-free conditions and had increased expression of sucrase-isomaltase compared with vector control cells. These results indicate that IGFBP-4 inhibits proliferation and stimulates differentiation of Caco-2 cells, probably by inhibiting the mitogenic actions of IGFs.

• Journal of Acupuncture Research
• /
• 제24권1호
• /
• pp.165-177
• /
• 2007

Objectives : This study anus to investigate the effects of Rosa Rugosae Radix (RU) herbal acupuncture on the metabolic syndrome in high-fat diet-fed mice. Methods : The experimental groups were fed with high-fat diet (HFD) for 8 weeks to induce metabolic syndrome. During the induction of metabolic syndrome, RU herbal acupuncture at a dosage of 50 mg/kg was carried out on the point of Sinsu(BL23) every day to measure the body weight, feed efficiency, blood glucose levels, insulin resistance index, lipid levels, blood pressure, and weight of liver and adipose tissues (brown adipose tissue from interscapular fat and white adipose tissue from epididymal fat). And after five weeks' induction of metabolic syndrome, RU herbal acupuncture was also performed for 6 weeks to measure the body weight and blood glucose levels. Results: 1. RU herbal acupuncture inhibited increasing body weight and blood glucose levels, with improved insulin resistance. 2. RU herbal acupuncture inhibited increasing levels of total cholesterol, LDL-cholesterol and free fatty acid, while increased HDL-cholesterol levels. 3. RU herbal acupuncture activated anti-hypertensive action. 4. RU herbal acupuncture inhibited increasing weight of white adipose tissues, but not in brown adipose tissues and liver. 5. RU herbal acupuncture lowered blood glucose levels and inhibited increasing body weight in metabolic syndrome-induced ICR mice. Conclusion : Rosa Rugosae Radix (RU) herbal acupuncture showed effectiveeness in prevention and management of metabolic syndrome in clinical application.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2002년도 가을 학술발표회 논문집
• /
• pp.123-128
• /
• 2002

In this paper, an averaged constitutive model of concrete and reinforcing bars for RC structure and path-dependent Ohsaki's model for soil are applied, and an elasto-plastic interface model having thickness is preposed for seismic analysis of underground RC subway station structure. A finite element analysis technique is developed by applying aforementioned constitutive equations and verified through seismic analysis of underground RC subway station. Then, failure mechanisms of the RC subway station structure under seismic action are numerically derived. Then, failure modes and damage levels of the station are also analytically evaluated for the cases of several designs of the underground RC station.

• 한국시뮬레이션학회논문지
• /
• 제8권1호
• /
• pp.89-99
• /
• 1999

The major objective of this research is to propose a design architecture for autonomous defense systems for supporting highly intelligent behavior by combining decision, perception, and action components. Systems with such high levels of autonomy are critical for advanced battlefield missions. By integrating a plenty of advanced modeling concepts such as system entity structure, endomorphic modeling, engine-based modeling, and hierarchical encapsulation & abstraction principle, we have proposed four layered design methodology for autonomous defense systems that can support an intelligent behavior under the complicated and unstable warfare. Proposed methodology has been successfully applied to a design of autonomous tank systems capable of supporting the autonomous planning, sensing, control, and diagnosis.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
• /
• pp.157.1-157.1
• /
• 2003

This study was carried out to evaluate the cytotoxicity and anti-inflammatory effects of Resina Pini on cultured human gingival fibloblasts. We carried out a study of cytotoxic effects of Resina Pini on cultured cells by MTT assay. Various treatments on Resina Pini reduced its toxicity on cultured cells in order of natural Resina Pini, water extracted mixture of Resina Pini and Ramus Mori Albae and recrystalized Resina Pini. However, Resina Pini showed harmless levels of cytotoxicity to cultured human gingival fibroblast. (omitted)

• Food Science and Biotechnology
• /
• 제17권3호
• /
• pp.457-463
• /
• 2008

The effects of dietary supplementation of the unrefined rice bran oil from 'Suwon 415' pigmented black rice (BRBO) on cholesterol metabolism and cellular antioxidant status were investigated in hypercholesterolemic rats. The significant reduction of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) concentrations was observed in the plasma of rats fed BRBO. BRBO also decreased plasma and hepatic oxidative stress as a result of increased levels of hepatic thiobarbituric acid reactive substances (TBARS) levels associated with the elevations of hepatic superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities together with increased plasma level of tocopherol. This study indicates that dietary BRBO supplement can leads to the improvement of overall cholesterol metabolism and antioxidant status even more effectively than 'Chuchung' white rice (WRBO). Consumption of BRBO may also protect the liver from oxidative damage caused by lipid peroxidation.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권9호
• /
• pp.4221-4227
• /
• 2012

Cancer of the uterine cervix is a worldwide menace taking innumerable womens' lives. The literature is vast and a large number of studies have been conducted in this field. Analyses have shown significant differences exist in terms of screening and HPV testing facilities among high income and low to middle income countries. In addition, acute lack of awareness and knowledge among the concerned population is particularly noted in rural areas of the low income countries. A detailed review of Indian case studies revealed that early age of marriage and childbirth, multiparity, poor personal hygiene and low socio-economic status among others are the principal risk factors for this disease. This review concludes that a two pronged strategy involving strong government and NGO action is necessary to minimize the occurrence of cervical cancer especially in low and medium income countries.

• 한국경영과학회지
• /
• 제23권1호
• /
• pp.109-141
• /
• 1998

Many processes in the industrial realm exhibit sstochastic and nonlinear behavior. Consequently, an intelligent system must be able to nonlinear production processes as well as probabilistic phenomena. In order for a knowledge based system to control a manufacturing processes as well as probabilistic phenomena. In order for a knowledge based system to control manufacturing process, an important capability is that of prediction : forecasting the future trajectory of a process as well as the consequences of the control action. This paper examines the robustness of data mining tools under varying levels of noise while predicting nonlinear processes, includinb chaotic behavior. The evaluated models include the perceptron neural network using backpropagation (BPN), the recurrent neural network (RNN) and case based reasoning (CBR). The concepts are crystallized through a case study in predicting a chaotic process in the presence of various patterns of noise.

• Computers and Concrete
• /
• 제6권5호
• /
• pp.421-435
• /
• 2009

Chloride induced corrosion is a concern that governs the durability of concrete structures in marine environments, especially in tidal environments. During the service lives of concrete structures, internal cracks in the concrete cover may appear due to imposed loads, accelerating chloride penetration because of the simultaneous action of environmental and service structural loads. This paper investigated the effects of cyclic flexural loads on chloride diffusion characteristics of plain concretes, and proposed a model to predict the chloride penetration into plain concretes subjected to both tidal environments and different cyclic flexural load levels. Further, a new experiment was performed to verify the model. Results of the model using Finite Difference Method (FDM) showed that the durability of concretes in tidal environments was reduced as cyclic flexural load levels, SR, increased, and the modeling results fitted well with the experimental results.