• Journal of Pharmaceutical Investigation
• /
• 제40권4호
• /
• pp.231-236
• /
• 2010

This study was to fabricate the porous poly(lactide-co-glycolide) (PLGA) microparticles with anthocyanin (as a model antioxidant) for pulmonary drug delivery. The highly porous PLGA microparticles were prepared by the waterin-oil-in-water ($W_1/O/W_2$) multi-emulsion method, followed by the decomposition of ammonium bicarbonate (AB) in $W_1$ phase to the base of ammonia, carbon dioxide and water vapor at $50^{\circ}C$, making a porous structure in PLGA microparticles. Herein, hyaluronate (HA), a viscous polysaccharide, was incorporated in the porous microparticles for sustained anthocyanin release. In in vitro release studies, the anthocyanin release from the porous microparticles with HA continued up to 24 hours, while the porous microparticles without HA released 80 wt.% of encapsulated anthocyanin within 2 hours. In addition, these microparticle are expected to be effectively deposited at a lung epithelium due to its high porosity (low density) and avoid alveolar macrophage's uptake in the lung due to its large particle size. We believe that this system has a great pharmaceutical potential as a long acting antioxidant for relieving the oxidative stress in chronic obstructive pulmonary disease (COPD).

• 한국농업기계학회:학술대회논문집
• /
• 한국농업기계학회 2000년도 THE THIRD INTERNATIONAL CONFERENCE ON AGRICULTURAL MACHINERY ENGINEERING. V.II
• /
• pp.287-294
• /
• 2000

Calculation of the flexural rigidity value (EI) is indispensable for prescription of deflection characteristics of crop stalks in harvesting□Conventionally□EI has been determined by either average EI of the whole stalk or average EI of each stems divided into node through the calculation method of cantilever with homogeneous section□However□deflection characteristics of crop stalks caused by mechanical operation such as combine harvester were not exactly presumed by these conventional EI through the experiment by authors. Further, actual EI of a stalk changes in company with a change of moisture contents as time passes during the experiment. Finally, efficient calculation method for determining EI is needed in order to improve these problems. In this study, mechanical model based on actual structure of the crop stalk with variety sectional area was proposed. This mechanical model is calculated by the theory of cantilever with continuous stages. Therefore, improvement of both calculating accuracy on EI and efficiency of measuring system was tried. At first, this calculation method was applied to piano wire of which EI was recognized in advance. As a result, EI calculated from this new method coincided approximately with piano wire's EI. Next, applying to crop stalks as same as piano wire, relationship between loads acting on crop stalks and deflection values calculated by EI using this new calculation method was exactly presumed in comparison with conventional method. Further, measuring time of deflection test was greatly reduced. Finally, new calculation method of EI will be available for estimating mechanical characteristics of so many kinds of crop stalks in harvesting operation. Further, in this study, new deflection test using image-processing apparatus by computer will be introduced.

• Tribology and Lubricants
• /
• 제33권1호
• /
• pp.23-30
• /
• 2017

The electric controlled marine diesel engine has fuel pump generating the high pressurized fuel for fuel injection to combustion chamber via a common rail. Fuel pump consists of a cam-roller system. Journal bearing installed between a roller and a cam-roller pin is subjected to fluctuating heavy and instant loads by cam lift. First, Kinematic analysis is carried out to predict bearing loads during one cycle acting on the journal bearing. Second, flexible multi-body dynamic analysis and transient elasto-hydrodynamic(EHD) lubrication analysis for journal bearing considering elastic deformation of cam-roller pin, roller and bearing are conducted using AVL EXCITE/PU software to predict lubrication performance. The clearance ratio and journal groove shape providing lubrication oil are important parameter in bearing design having good performance and can be changed easier than other design parameters such as diameter, width, oil supply pressure and bearing material grade. Generally, journal bearing performance is represented by the minimum oil film thickness(MOFT) and peak oil film pressure(POFP). As well as the traditional design parameters(MOFT, POFP), in this study, temperature rise of lubrication oil is also evaluated through the side leakage flow of supplied oil. By the evaluating MOFT, POFP and temperature rise, the optimum bearing clearance ratio is decided.

• 공업화학
• /
• 제1권2호
• /
• pp.107-115
• /
• 1990

Glucose의 redox 반응에 의한 새로운 인슐린 방출계를 5, 5'-dithiobis(2-nitrobcnzoic acid)의 disulfide 결합을 이용해 인슐린을 pmma 막과 glucose oxidase에 고정화시켜 합성하였다. glucose와 glucose dehydrogenase 및 glucose oxidise와의 산화반응에 의해 disulfide 결합이 파괴되어 막과 효소로부터 인슐린이 방출된다. enzyme cofact들(nicotinamide adenin dinucleotide와 flavin adenin dinucleotide)을 coimmobilization 시켜 membrane device에 대해 electron mediator로 작용하도록 하여 glucose의 농도 민감성을 향상시켰고 protein device에 대해서는 glucose oxidase에 인슐린을 직접 고정화시켜 민감성을 더욱 향상시켰다. 이 두 가지 계들은 glucose 특이성을 나타내며 방출된 인슐린은 생체인슐린과 구분되지 않았다. 방출인슐린의 생리활성은 생체인슐린의 81%였다.

• 한국항공우주학회지
• /
• 제40권8호
• /
• pp.711-717
• /
• 2012

스포츠급 경항공기 개념 설계 단계에서 항공기의 정적 안정성 분석을 위해 1/5 축소모델로 풍동시험을 수행하였다. 제안된 경항공기의 동체 단독 및 동체에 주익, 수평꼬리날개, 수직꼬리날개 등을 조합한 6개 형상에 작용하는 공력을 내장형 밸런스를 이용하여 측정하고 정안정 미계수를 도출하여 기본 양항력 공력특성 및 각 요소가 세로 방향 가로 정안정 특성에 미치는 효과를 분석하였다. 풍동시험 결과로부터 특히, 수평꼬리날개와 수직꼬리날개 그리고 고익형태와 상반각을 갖는 주익 등이 각각 세로, 방향, 가로 정안정성에 미치는 기여정도를 정량적으로 파악하였으며, 본 시험결과는 항공기 각 형상 구성품 조합의 정안정 특성에 관한 유용한 실험자료로 활용될 수 있을 것이다.

• 한국분말재료학회지
• /
• 제14권2호
• /
• pp.123-126
• /
• 2007

In this work, the dispersion behavior of $Y_2O_3$ particles in binary aluminum (Al)-copper (Cu) cast alloy was investigated with respect to Cu contents of 20 (hypoeutertic), 33 (eutectic) and 40 (hypereutectic) wt.%. In cases of hypo and hypereutectic compositions, SEM images revealed that the primary Al and ${\theta}$ phases were grown up at the beginning, respectively, and thereafter the eutectic phase was solidified. In addition, it was found that some of $Y_2O_3$ particles can be dispersed into the primary Al phase, but none of them are is observed inside the primary 6 phase. This different dispersion behavior of $Y_2O_3$ particles is probably due to the difference in the val- ues of specific gravity between $Y_2O_3$ particles and primary phases. At eutectic composition, $Y_2O_3$ particles were well dispersed in the matrix since there is few primary phases acting as an impediment site for particle dispersion during solidification. Based on the experimental results, it is concluded that $Y_2O_3$ particles are mostly dispersed into the eutectic phase in binary Al-Cu alloy system.

• 지질공학
• /
• 제16권3호
• /
• pp.283-291
• /
• 2006

기존의 NATM 터널에서는 숏크리트가 임시적인 지보재로 사용되었으나 싱글쉘에서는 영구적인 구조물의 역할을 담당하게 된다. 따라서 숏크리트에 작용하는 하중과 변위를 신뢰성 있게 예측하는 것이 터널의 안정성을 확보하기 위한 필수조건이므로 지반정수 산정의 정확성이 매우 중요하다. 특히, 국내의 지질상태는 외국과 다르므로 싱글쉘 공법을 국내에 적용하기 위해서는 국내 지질상태를 고려한 지반정수 산정기법의 기술 개발이 필수적이다. 본 연구에서는 국내 25개 터널 현장에서의 암반분류 사례 및 지반정수 사례를 조사하였다. 국내 싱글쉘 터널공법을 위한 지보 패턴안을, Q분류에서 수정된 NMT방법과 국내 암반상태를 고려하여 제안하였다. 또한 사례연구를 통한 Q시스템과 RMR값의 상관성을 이용하여 RMR을 이용한 지보량을 제시하였다.

• 한국항공우주학회지
• /
• 제30권6호
• /
• pp.124-129
• /
• 2002

한국과학기술원 인공위성연구센터는 우리별 1, 2, 3호의 성공적인 개발 및 발사에 이어 2003년 발사예정으로 과학위성 1호를 개발하고 있다. 과학위성 1호는 주탑재체로 원자외선분광기와 우주플라즈마 관측시스템을 탑재하고 있으며, 우리별 1, 2, 3호의 기술적 유산인 박스형태의 적층식 기계수조로 설계되어 있다. 현재 과학위성 1호는 인증모델의 설계 및 제작과 인증수준의 열진공시험 및 발사환경시험을 성공적으로 마친 상태이다. 본 논문에서는 과학위성 1호 인증모델을 기계구조시스템을 중심으로 소개하고, 발사환경시험 결과를 보고한다.

• 한국수산과학회지
• /
• 제41권2호
• /
• pp.140-149
• /
• 2008

This study evaluated the efficiency of an oil fence and spreading devices for one vessel in a towing tank. A series of model experiments and numerical calculations were conducted using an existing oil fence for two vessels and a new method for one vessel. Models of the oil fence and spreading devices were constructed on $1/20^{th}$ scale from waterproofed nylon fabric and canvas. The tensions acting on the model of the oil fences and the horizontal distance between the spreading devices were calculated numerically while the oil fences were being towed. The results were extremely close to the results of the model experiments. The ratio of the opening width to the total length of the oil fence, which shows the efficiency of the oil fence for one vessel, was 49.7% in 0.4 m/sec. Therefore, the proposed oil fence system should be very useful for oil containment at sea. As the opening width of the oil fence is not proportional to the length of the towing rope, it may be reasonable to maintain the towing rope at approximately 100 m. Furthermore, a reasonable towing speed, when operating the oil fence for one vessel equipped with spreading devices, was within 0.4 m/sec.

• Animal cells and systems
• /
• 제15권3호
• /
• pp.227-233
• /
• 2011

The Nramp1/Slc11a1 locus encodes a proton-coupled divalent cation transporter, expressed in late endosomes/lysosomes of macrophages, that constitutes a component of the innate immune response to combat intracellular pathogens and it was shown to play an important role in regulating inherent immunity. The previously identified Z-DNA forming polymorphic repeat(GT)n in the promoter region of the human Nramp1 gene does act as a functional polymorphism influencing gene expression. Research has shown that INF-${\gamma}$, TNF-${\alpha}$, IL-$1{\beta}$ and bacteria LPS increase the level of Nramp1 expression. However, the molecular mechanism for Nramp1 gene regulation is unclear. In this research, bovine Nramp1 5'-flanking region (-1748~+769) was cloned and analyzed by bioinformatics. Then to find the core promoter and the cis-acting elements, deletion analysis of promoter was performed using a set of luciferase reporter gene constructs containing successive deletions of the bovine Nramp1 5'-flanking regions. Promoter activity analysis by the dual luciferase reporter assay system showed that the core promoter of Nramp1 was located at +58~-89 bp. Some positive regulatory elements are located at -89~-205 bp and -278~-1495 bp. And the repressor elements were in region -205~-278 bp, intron1 and -1495~-1748 bp. LPS-responsive regions were located at -1495~-1748 bp and -278~-205 bp. The present study provides an initial effort to explore the molecular mechanism of transcriptional activation of the bovine Nramp1 gene and should facilitate further studies to decode the complex regulatory process and for molecular breeding for disease resistance in bovines.