• Archives of Pharmacal Research
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• 제12권2호
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• pp.143-147
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• 1989

The urea effect on skin permeation of clonidine was investigated to reduce a log time and to increase a permeability. ICR mouse skin and human skin were used and were assumed to be a two-layer membrane consisted of stratum corneum and viable epidermis. The urea acted as a skin denaturant and humectant in the whole epidermis. Also it enhanced the skin permeability of clonidine about 3.5 times. On the other hand, it enhanced the skin permeability by acting as a humectant in the viable epidermis. But the urea effect on the whole epidermis was shown to be greater than that on the viable epidermis. Therefore, it was found that the effect of urea was greater on the stratum corneum than the viable epidermis. Variation of enhancing effect according to the concentration of urea was not found in the range of 1% to 20%.

• Wind and Structures
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• 제17권6호
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• pp.589-608
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• 2013

A model is proposed to analyse the along-wind dynamic response of upwind turbines with horizontal axis under service wind conditions. The model takes into account the dynamic coupling effect between rotor blades and supporting tower. The wind speed field is decomposed into a mean component, accounting for the well-known wind shear effect, and a fluctuating component, treated through a spectral approach. Accordingly, the so-called rotationally sampled spectra are introduced for the blades to account for the effect of their rotating motion. Wind forces acting on the rotor blades are calculated according to the blade element momentum model. The tower shadow effect is also included in the present model. Two examples of a large and medium size wind turbines are modelled, and their dynamic response is analysed and compared with the results of a conventional static analysis.

• International journal of advanced smart convergence
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• 제10권4호
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• pp.14-21
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• 2021

The purpose of this study is to investigate the effect of consumers' engagement through SNS sports advertisements on purchase intention through advertising attitudes and product trust for the disabled. In other words, it was intended to investigate how the disabled people's intention to purchase products is formed by acting on various sports product advertisements that are seen during SNS activities. Accordingly, a survey was conducted on 300 people with disabilities participating in sports for the disabled. As a result, it was found that functional engagement had a positive effect on both advertising attitude and product trust, and advertising attitude and product trust had a positive effect on purchase intention. However, emotion engineering and communal engineering were found to have a negative effect on advertising attitudes and not on product trust.

• 약학회지
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• 제39권4호
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• pp.444-449
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• 1995

Primary cultures of rat cortical and chicken embryonic brain cells were employed to establish a reliable screening method for natural products blocldng or enhancing glutamate-induced neurotoxicity. Exposure of primary cultured rat cortical cells or chicken embryonic brain cells to high dose of glutamate resulted in the fragmentation of neutites and consequent neuronal death. The level of cytoplasmic lactate dehydrogenase(LDH), indicator for cell survival in cultures, was significantly reduced at exposure to glutamate. For the practical application of the methods, series of concentrations of plants extracts and positive control were applied prior to the glutamate insult on primary cultures of rat cortical and chicken embryonic, brain cells. Relative LDH level in cells was measured for the estimation of the effect of the test materials on the glutamatergic neurons. The validity of the present screening method for natural products acting on glutamatergic neurons was examined with dextromethorphan, a known glutamatergic antagonist. The treatment of 100 $\mu{M}$ dextromethorphan prevented the reduction of LDH in rat cortical and chicken embryonic brain cells caused by glutamate insult keeping 60% and 90% of LDH level in normal control, respectively. Above results indicate that primary cultures of rat cortical and chicken embryonic brain cells could be proper systems for the screening of potential natural agents acting on glutamatergic, neurons. Between the two types of cultures, primary culture of chicken embryonic brain cells seemed to be a better system for the primary screening, since it is technically easier and economical compared to that of rat cortical cells.

• 제어로봇시스템학회논문지
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• 제18권10호
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• pp.921-927
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• 2012

In this paper we deal with a hydraulic tilting actuator to make a diagnosis of load characteristic acting on the tilting actuator of the tilting train. Tilting actuator in the tilting train plays a role of making tilt of the train when the train runs a curve section to make the train run without deceleration. However in the process of tilt the tilting actuator is affected by the load acting on the actuator, which has a possibility to make bogie vibration. In order to figure out the effect of the load on the tilting actuator a hydraulic tilting devices that are capable of tilting the train is proposed. The proposed devices are installed in the front bogie and in the rear bogie to make tilting of the train. The devices are consist of sensors that measure the load capacity of the actuator and displacement of the hydraulic cylinder stroke, control blocks to make synchronization of the two actuators, user interface block to monitor the status of the actuators. The effectiveness of the proposed hydraulic tilting actuators is presented by the experimental evaluation using actual tilting train.

• Gut and Liver
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• 제12권6호
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• pp.694-703
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• 2018

Background/Aims: Limited data exist comparing the safety and efficacy of direct-acting antivirals (DAAs) in hepatitis C virus (HCV) monoinfected and HCV/human immunodeficiency virus (HIV) coinfected patients in the real-world clinic practice setting. Methods: All HCV monoinfected and HCV/HIV coinfected patients treated with DAAs between January 2014 and October 2017 in community clinic settings were retrospectively analyzed. Pretreatment baseline patient characteristics, treatment efficacy, factors affecting sustained virologic response at 12 weeks (SVR12) after treatment, and adverse reactions were compared between the groups. Results: A total of 327 patients were included in the study, of which 253 were HCV monoinfected, and 74 were HCV/HIV coinfected. There was a statistically significant difference observed in SVR12 when comparing HCV monoinfection and HCV/HIV coinfection (94% and 84%, respectively, p=0.005). However, there were no significant factors identified as a predictor of a reduced response. The most common adverse effect was fatigue (27%). No significant drug interaction was observed between DAA and antiretroviral therapy. None of the patients discontinued the treatment due to adverse events. Conclusions: In a real-world setting, DAA regimens have lower SVR12 in HCV/HIV coinfection than in HCV monoinfection. Further studies involving a higher number of HCV/HIV coinfected patients are needed to identify real predictors of a reduced response.

• 대한안전경영과학회지
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• 제17권3호
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• pp.247-263
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• 2015

This study seeks to identify effects derived from emotional labor in the distribution industry, and draw ways to systematically manage the employees by exploring effects of the emotion work on performance. For the purpose, literature reviews and empirical experiments were conducted to find out effects of emotional labor and false face acting on emotion work and organizational performance and effects of social support and job autonomy on the relationship between emotion work and organizational performance. To verify the hypothesis, we conducted a hierarchical regression analysis and structural equation model analysis using SPSS 20 and AMOS19. The result of the verification in this study is as follows: First, effects of emotional labor on burnout was found to be statistically significant, second, as for the path-coefficient for "emotional labor ${\rightarrow}$ emotion work" and "emotional labor ${\rightarrow}$ job satisfaction" was not statistically significant, while the path-coefficient for "emotional labor ${\rightarrow}$ service level" was found to be statistically significant. Third, effects of emotion work on job satisfaction was found statistically significant, fourth, emotion work on the service level was found statistically significant, fifth, effects of false face acting on emotion work was found statistically significant, sixth, effects of false face acting on burnout was statistically significant, seventh, moderating were found statistically significant and lastly, moderating effects of the relationship between emotion work from job autonomy and organization performance was not verified in job satisfaction, while emotion work, job autonomy, and interaction variable in service level were statistically significant.

• 한국화재소방학회논문지
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• 제32권6호
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• pp.69-73
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• 2018

본 연구에서는 볼록한 바닥면을 가진 이동형 소방용수 저장탱크의 수직 벽면에 작용하는 동수력을 계산하고 그 결과를 바탕으로 볼록한 바닥면 설계를 통한 동수력의 감소 효과를 확인하고자 하였다. 수치 모의 실험하기 위해 바닥의 형태를 볼록하게 한 수치 해석 영역을 구성하였으며, 특정 위치와 높이에 용수 공급 노즐을 위치시켜 용수를 낙하시켰다. 용수 낙하에 의한 자유 수면의 출렁임과 수직 벽면에서의 유체 벽 오름을 선형 Peregrine 방정식을 이용하여 수치 모사하고 동수력을 계산하였으며, 그 결과를 오목한 바닥면 및 동일한 해석 조건에서 얻은 동수력과 서로 비교 분석하였다. 결과적으로 오목한 바닥면 설계에 비해 볼록한 바닥면 설계를 통해 수직 벽면에서의 동수력이 더 작아짐을 확인할 수 있었다. 본 연구 결과는 이동형 소방용수 저장탱크의 안정적인 구조 설계 및 운용에 기여할 수 있을 것으로 사료된다.

• 한국항해항만학회지
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• 제46권2호
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• pp.73-81
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• 2022

Currently, shipping by sea is becoming common because of the low price and the safety of goods. The ship is designed as a larger vessel to meet the need of this development. In the design stage, the investigation of hydrodynamic forces acting on the ship hull is very important in predicting the ship's maneuverability. Given that the ship docks at various ports for loading or discharging goods, the ship usually operates in various loading conditions, depending on the site condition and other various factors. Hence, it is necessary to investigate the effect of the loading condition on the hydrodynamic forces acting on the ship, to most accurately determine the maneuverability of the ship. In this study, an experiment of Korea Autonomous Surface Ship (KASS) was conducted at the towing tank of Changwon National University to measure the hydrodynamic forces acting on the KASS. The loading condition considered in this experiment is determined based on the draft, which was decreased by 5% for each loading condition. The smallest draft is 85% of the design draft. The static test as Oblique Towing Test (OTT), Circular Motion Test (CMT), Circular Motion Test with Drift (CMTD) is performed in the various loading conditions. First, the hydrodynamic forces in the Oblique Towing test (OTT) are compared with the result of other institutes. Second, the hydrodynamic forces in various drift angle, yaw rate and loading conditions are measured. Finally, the influence of the loading conditions on the hydrodynamic coefficient is discussed.

• 대한조선학회논문집
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• 제48권5호
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• pp.381-389
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• 2011

In this study, we are focusing our attention on lift characteristics of the low aspect wings for Wing-In Ground effect crafts (WIG). Experimental measurements at an open-type wind tunnel are carried out and results are comparatively presented. In order to simulate the realistic ground condition in where the WIG craft is flying, moving ground is implemented by a conveyor belt rotating with the same velocity of the inflow. We consider two different wings (NACA0012 and DHMTU section) which have four different aspect ratios (0.5, 1.0, 1.5 and 2.0). Forces acting on the wings are measured and lift characteristics are elaborately investigated for various different conditions. In addition, end-plate effects are estimated. Results are validated by comparing with theoretic solutions of the symmetric airfoil. Present results show that ground effects are differently generated in moving or fixed ground conditions, and hence left characteristics are affected by the ground condition. Consequently, accurate aerodynamic forces acting on the WIG craft are guaranteed in a realistic moving ground condition.