• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 1995년도 추계 학술발표회
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• pp.126-126
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• 1995

• Bulletin of the Korean Chemical Society
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• 제20권5호
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• pp.621-623
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• 1999

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.323-323
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• 1994

Allyl alcohol은 간에서 두 단계의 효소 반응을 거쳐 대사되는데, 먼저, alcohol dehydrogenase (ADH)에 의해 독성 활성체인 acrolein으로 바뀌고, 이후 계속하여 aldehyde dehydrogenase (ALDH)에 의해 acrylic acid로 무독화되어 배설된다. Ethanol 역시 간에서 대사되는데 있어 같은 효소들을 공유하므로 allyl alcohol과 경쟁적으로 반응할 것이다. 따라서, 본 실험에서는 ethanol에 의한 대사 효소 경쟁반응에 의해 allyl alcohol 의 간독성이 어떻게 변화하는지를 연구하였다. 우선 ethanol과 allyl alcohol을 동시 투여할 경우 5시간째에 allyl alcohol에 의해 증가된 ALT level을 낮춘다는 보고를 확인하고자 ethanol 2 g/kg과 allyl alcohol 40 mg/kg을 동시투여했으나 오히려 치사율이 증가했고, ethanol을 2시간 전처리한 군에서도 역시 치사율이 증가되고, 간의 glutathione 양은 allyl alcohol 단독 처리군에 비해 현저히 감소되는 양상을 보였다.

• 약학회지
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• 제38권2호
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• pp.107-113
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• 1994

Ally alcohol is metabolized in the liver through two steps, first to reactive acrolein by alcohol dehydrogenase(ADH), subsequently to acrylic acid by aldehyde dehydrogenase(ALDH). Since ethanol could compete the same enzymes to be metabolized in the liver, we have studied the interaction between allyl alcohol and ethanol on liver toxicity. Simultaneous treatment of 2 g/kg ethanol by ip administration with 40 mg/kg allyl alcohol to rats increased the lethality significantly, accompanied by potentiation of the loss of hepatic glutathione. Collectively, these findings suggested that ethanol potentiated the hepatotoxicity and lethality induced by allyl alcohol probably through competing two metabolizing enzymes, ADH and ALDH.

• 한국자동차공학회논문집
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• 제3권6호
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• pp.162-175
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• 1995

Exhaust emissions in diesel engine are affected by fuel properties, but the reason for this is not clear. Especially, the recent strong interest in using low-grade fuel such as used vegetable oil as alternative diesel fuel demands extensive investigation in order to clarify the exhaust emissions. The purpose of this study is to evaluate the feasibility of a used vegetable oil as an alternative fuel in a diesel engine in terms of exhaust emissions. The emission concentration of used vegetable oil such as formaldehyde and acrolein is two times than that of diesel fuel. However, since that of alcohol is ten times than that of used vegetable oil and that concentration is very low, it is not a problem for human health.

• 한국식품과학회지
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• 제22권3호
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• pp.261-265
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• 1990

두충엽의 휘발성 성분을 SDE 장치로 추출한 후 GC 및 GC/MS에 의해서 비교 분석하였다. 확인된 성분은 35개 성분이며 alcohol류 7종, aldehyde류 3종, ketone류 4종, ester류 2종. hydrocarbon류 18종, phenol 1종이 확인되었다. 이 중에서 가장 많이 함유된 성분은 2-ethyl furyl acrolein으로 추정되었는데 전체 휘발성 성분의 31.4%를 차지하였다.

• 대한화학회지
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• 제45권3호
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• pp.207-212
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• 2001

1.4-Diaza-1,3-butadiene(1,4-DAB)과 acrolein 과의 Diels-Alder 반응의 반응성을 조사하기 위해 1,4-DAB의 말단 두 질소에 전자를 끌거나 주는 기들을 치환시킨 여러 치환 1,4-DAB들에 대해 DFT계산을 수행하였다. 최적화된 구조들에 대해 계산된 FMO(Frontier Mole cular Orbital) 에너지로서 상대적인 반응성을 설명할 수 있었다. 즉, 전자를 주는 기가 치환될 경우에는 normal electron demand 반응이 유리하며, 전자를 끄는 기가 치환될 경우에는 inverse electron demand 반응 메카니즘으로 진행됨을 알 수 있었다.

• 한국연초학회지
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• 제6권1호
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• pp.51-62
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• 1984

The chemical components of non-blended and blended cigarettes and their smoke have been analyzed to investigate the correlation between them. Some regression of linear equations were obtained based on the simple correlation data(r), for the various smoke components such as tar, nicotine, nitrogen dioxide, steam volatile phenols, formaldehyde, acetaldehyde, acrolein and hydrogen cyanide. Chi-square tests were carried out to observe the probabilities of the values estimated by the regression of linear equations. The probabilities of the greater values were 0.900-0.999 to tar, nicotine, formaldehyde, acetal dehyde, acrolein, steam volatile phenols, nitrogen dioxide and hydrogen cyanide of the non-blended cigarettes, and 0.900-0.999 to tar, nicotine, nitrogen dioxide, steam volatile phenols and static burning rate (SBR) of the blended cigarettes.

• Toxicological Research
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• 제14권4호
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• pp.557-562
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• 1998

Allyl alcohol is metabolized in the liver through two steps, first to reactive acrolein by alcohol dehydrogenase (ADH), subsequently to acrylic acid by aldehyde dehydrogenase (ALDH). Since ethanol could compete the same enzymes to be metabolized in the liver, we have determined the plasma concentrations of allyl alcohol and ethanol followed by combined treatment. Pretreatment of rats with 2g/kg ethanol followed by ip administration of 40mg/kg allyl alcohol increased the lethality significantly. Determination of in vivo blood concentrations revealed that ethanol pretreatment caused the apparent decrease in allyl alcohol clearance, whereas acetaldehyde level in blood increased significantly by allyl alcohol treatment, as determined by head space GC analysis. Treatment of 4-methylpyrazole, an inhibitor of ADH, delayed allyl alcohol elimination significantly and reduced its lethality. Collectively, these findings suggested that reduction of allyl alcohol clearance in the presence oj ethanol was mediated through ADH competitive inhibition.

• 대한화학회지
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• 제18권3호
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• pp.180-188
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• 1974

Layer silicate 에 지지된 陽이온상에서의 일어난 acetaldehyde, acrolein, 그리고 crotonaldehyde의 吸着機構에 對하여 IR과 X-ray로서 硏究하였다. $1720∼1580㎝^{-1}$의 범위에서 일어난 4個의 특성적인 吸捉 band를 分析한 結果 $130㎝^{-1}$程度로 shift한 carbonyl band 는 >C=O${\cdots}$M형 complex 形成에 基因하는 것이었고, acetaldehyde는 $1722㎝^{-1}$에서, 다른 알데히드는 $1690㎝^{-1}$에서 sharp하게 나타난 carbonyl band는 >C=O와 surface -O-H와의 interaction에서 일어난 것이었다. 그리고 1710∼1660㎝-1에서 나타난 broad한 band는 >C=O와 陽이온 -O-H와의 사이에 일어난 水素結合에 依한 것이었다. 그리고 $1640∼1660㎝^{-1}$사이에 나타난 弱한 band는 carbonyl group 의 强한 吸着에 依하여 誤起된 >C=C< 二重結合에 依한 것이었다. 이 사실들은 X-ray 廻折에 依하여 다시 確認하였다.