• 보건교육건강증진학회지
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• 제16권2호
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• pp.1-17
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• 1999

AIDS (Acquired Immunodeficiency Syndrome) known as 20th century's pest is spreading rapidly internationally, and the number of patients are increasing. Since the prevention vaccine has not been developed yet, the only available effective method for preventing AIDS is the health education. Most of the AIDS-infected persons are males, and especially over twenties of age. Therefore, it is necessary to measure the knowledge and attitudes on AIDS of male workers. The purpose of this study is to examine the knowledge, attitudes and education-needs of male workers on AIDS. The data were collected by a questionnaire survey of 977 workers who work in Seoul and Kyungki areas from September 1 thru October 4, 1997. The results were as follows: 1. We examined the level of knowledge on AIDS transmission, symptoms, diagnoses, and prevention methods. Even though respondents had a moderate level of AIDS-related knowledge, still sizable numbers believed that AIDS could be transmitted through casual contact. White-collar workers, higher education groups, higher income groups or those with age thirties showed respectively higher level of knowledge than the other comparison groups. 2. 85％ of the respondents recognized AIDS as a serious problem. Statistical analysis revealed that white-collar workers, higher education groups or those with age twenties had more positive attitudes towards a AIDS patient than their counterparts. 3. Over 80％ of the respondents replied that AIDS education in schools, work places, social agencies or by mass-media was necessary. 62.8％ of the respondents mentioned that government should play the major role in developing AIDS education program. 4. The prediction model of AIDS-education needs was examined with using the multiple logistic regression method. The education level and AIDS-related knowledge were turned to be statistically significant factors influencing positively the perceived needs of AIDS education.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제43권1호
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• pp.29-36
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• 2017

Objectives: Acquired immunodeficiency syndrome (AIDS) is a disease of the human immune system caused by the human immunodeficiency virus (HIV). People with AIDS are much more vulnerable to infections, including opportunistic infections and tumors, than people with a healthy immune system. The objective of this study was to correlate oral lesions associated with HIV/AIDS and immunosuppression levels by measuring clusters of differentiation 4 (CD4) cell counts among patients living in the middle western regions of Ghana. Materials and Methods: A total of 120 patients who visited the HIV clinic at the Komfo Anokye Teaching Hospital and the Regional Hospital Sunyani of Ghana were consecutively enrolled in this prospective and cross-sectional study. Referred patients' baseline CD4 counts were obtained from medical records and each patient received an initial physician assessment. Intraoral diagnoses were based on the classification and diagnostic criteria of the EEC Clearinghouse, 1993. After the initial assessment, extra- and intraoral tissues from each enrolled patient were examined. Data analyses were carried out using simple proportions, frequencies and chi-square tests of significance. Results: Our study included 120 patients, and was comprised of 42 (35.0%) males and 78 (65.0%) females, ranging in age from 21 to 67 years with sex-specific mean ages of 39.31 years (males) and 39.28 years (females). Patient CD4 count values ranged from 3 to 985 cells/mL with a mean baseline CD4 count of 291.29 cells/mL for males and 325.92 cells/mL for females. The mean baseline CD4 count for the entire sample was 313.80 cells/mL. Of the 120 patients we examined, 99 (82.5%) were observed to have at least one HIV-associated intraoral lesion while 21 (17.5%) had no intraoral lesions. Oral candidiasis, periodontitis, melanotic hyperpigmentation, gingivitis and xerostomia were the most common oral lesions. Conclusion: From a total of nine oral lesions, six lesions that included oral candidiasis, periodontitis, melanotic hyperpigmentation, gingivitis, xerostomia and oral hairy leukoplakia were significantly correlated with declining CD4 counts.

• Tuberculosis and Respiratory Diseases
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• 제46권4호
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• pp.574-579
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• 1999

저자들은 신증후군에 동반된 거대세포바이러스 폐렴 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 디지털융복합연구
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• 제13권11호
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• pp.255-265
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• 2015

본 연구는 의학전문대학원 학생의 HIV/AIDS에 대한 지식과 태도를 조사하기 위해 시행된 횡단적 서술적 조사연구이다. 연구대상은 J도의 일 대학 의학전문대학원 3학년 학생 97명으로 2014년 8월 4일부터 12월 8일까지 자료수집이 실시되었으며, 수집된 자료는 SPSS WIN 19.0 프로그램을 이용하여 분석하였다. 연구결과 의학전문대학원 학생들의 HIV/AIDS 관련 지식과 태도는 각각 15점 만점에 평균 8.91, 7.00으로 나타났으며, 지식과 태도는 대상자들의 특성에 따라 통계적으로 유의한 차이가 없었다. 대상자들의 HIV/AIDS 관련 지식과 태도 간에는 통계적으로 유의한 양적 상관관계(r=.34, p<.01)를 보여 지식이 높을수록 태도 또한 긍정적인 경향을 보임이 확인되었다. 본 연구결과는 예비의료인 및 의료인의 HIV/AIDS 관련 지식을 증진시키고 부정적인 태도를 감소시키는 것을 목적으로 하는 효과적인 교육제공을 위한 구체적인 실행전략 개발에 유용하게 이용될 수 있다.

• Journal of Korean Neurosurgical Society
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• 제46권4호
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• pp.413-416
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• 2009

Since the start of the antibiotic era, syphilis has become rare. However, in recent times, it has tended to be prevalent concomitantly with human immunodeficiency virus (HIV) infection and coinfection in North America and Europe. Now, such cases are expected to increase in elsewhere including Korea. A 40-year-old male patient visited hospital complaining of a headache for about one month. Brain computed tomography and magnetic resonance imaging, showed leptomeninged enhancing mass with edema an right porisylvian region, which was suspected to be glioma. Patient underwent a blood test and was diagnosed with syphilis and acquired immune deficiency syndrome. Partial cortical and subcortical resection were performed after small craniotomy. The dura was thick, adhered to the brain cortex, and was accompanied by hyperemic change of the cortex. The pathologic diagnosis was meningovascular syphilis (MS) in HIV infection. After the operation, the patient was treated with aqueous penicillin G. Thereafter, he had no neurological deficit except intermittent headache. At first, this case was suspected to be glioma, but it was eventually diagnosed as MS in HIV coinfection. At this point the case was judged to be worth reporting.

• Bulletin of the Korean Chemical Society
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• 제34권8호
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• pp.2466-2472
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• 2013

Human immunodeficiency virus type-1 (HIV-1) is a causative agent of Acquired immunodeficiency syndrome (AIDS), which has affected a large population of the world. Viral envelope glycoprotein (gp120) is an intrinsic protein for HIV-1 to enter into human host cells. Molecular docking guided molecular dynamics (MD) simulation was performed to explore the interaction mechanism of heterobiaryl derivative with gp120. MD simulation result of inhibitor-gp120 complex demonstrated stability. Our MD simulation results are consistent with most of the previous mutational and modeling studies. Inhibitor has an interaction with the CD4 binding region. Van der Waals interaction between inhibitor and Val255, Thr257, Asn425, Met426 and Trp427 were important. This preliminary MD model could be useful in exploiting heterobiaryl-gp120 interaction in greater detail, and will likely to shed lights for further utilization in the development of more potent inhibitors.

• 디지털융복합연구
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• 제16권4호
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• pp.277-288
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• 2018

본 연구는 중국 남자 대학생들의 에이즈 지식, 자아존중감, 자기통제감, 에이즈에 대한 낙관적 편견, 콘돔 사용의 상관관계를 조사하였다. 중국 두 개 성(省) 도시의 종합대학교의 1학년부터 4학년에 재학 중인 남학생 307명을 편의표집하여 빈도분석과 기술통계량, ANOVA, Pearson 상관관계로 분석하였다. 중국 남자 대학생들의 에이즈 감염에 대한 낙관적 편견이 있는 것으로 나타났으며, 에이즈 지식 점수는 73점이었다. 자아존중감, 자기통제감 점수도 각각 중간값 보다 높게 나타났다. 학년과 연령에 따른 집단 간 분석에서 통계적으로 유의한 차이가 있었다. 본 연구에서 자아존중감, 자기통제감, 에이즈에 대한 낙관적 편견은 정적 상관관계를 보였고, 에이즈 지식, 낙관적 편견, 콘돔 사용의 상관관계는 통계적으로 유의하지 않았다. 차후 중국 문화의 맥락 안에서 콘돔 사용에 영향을 미치는 심리적 변수에 대한 다양한 집단의 반복 연구가 필요하다.

• 간호행정학회지
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• 제15권1호
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• pp.91-105
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• 2009

Purpose: The aim of this study was to analyze the needs of HIV/AIDS care and to develop the job description of HIV/AIDS Counselling nurse in Korea. Methods: The needs assessment was done by focus group interview with HIV/AIDS care recipients who are 16 persons living with HIV/AIDS and four their family members, seven persons from HIV/AIDS high risk group, and five nurses working on HIV/AIDS clinics. Based on the result of needs assessment, job description was developed using the DACUM. Mail survey was done to identify the frequency, importance, and difficulty of duties, tasks, and task elements. Results: The job description was classified under 8 duties, 36 tasks, and 290 task elements. Duties were categorized as needs assessment, health promotion and quality of life, improvement of treatment compliance, symptom care, health education, resource network, administrative activity, and career development. The importance of all duties and tasks showed high score from the survey, but the frequency and the performance level were middle range. Conclusion: It is suggested that the special training program based on the job description needs to be developed. In the political aspects, the introduction of HIV/AIDS nurse specialist certification could be considered.

• 제어로봇시스템학회논문지
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• 제17권8호
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• pp.753-759
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• 2011

The HIV (Human Immunodeficiency Virus) causes AIDS (Acquired Immune Deficiency Syndrome). The process of infection and mutation by HIV can be described by a 3rd order state equation. For this HIV model that includes the dynamics of the mutant virus, we present a parameter estimation scheme using two state variables sporadically measured, out of the three, by employing a genetic algorithm. It is assumed that these non-uniformly sampled measurements are subject to random noises. The effectiveness of the proposed parameter estimation is demonstrated by simulations. In addition, the estimated parameters are used to analyze the equilibrium points of the HIV model, and the results are shown to be consistent with those previously obtained.

• Parasites, Hosts and Diseases
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• 제53권6호
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• pp.705-712
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• 2015

Intestinal parasitic infections are one of the major causes of diarrhea in human immunodeficiency virus (HIV) seropositive individuals. Antiretroviral therapy has markedly reduced the incidence of many opportunistic infections, but parasite-related diarrhea still remains frequent and often underestimated especially in developing countries. The present hospital-based study was conducted to determine the spectrum of intestinal parasitosis in adult HIV/AIDS (acquired immunodeficiency syndrome) patients with or without diarrhea with the levels of $CD4^+$ T-cell counts. A total of 400 individuals were enrolled and were screened for intestinal parasitosis. Of these study population, 200 were HIV seropositives, and the remaining 200 were HIV uninfected individuals with or without diarrhea. Intestinal parasites were identified by using microscopy as well as PCR assay. A total of 130 (32.5%) out of 400 patients were positive for any kinds of intestinal parasites. The cumulative number of parasite positive patients was 152 due to multiple infections. A significant association of Cryptosporidium (P<0.001) was detected among individuals with $CD4^+$ T-cell counts less than $200cells/{\mu}l$.