• Title/Summary/Keyword: Acetaldehyde

Search Result 550, Processing Time 0.034 seconds

Characteristics of Alcohol Metabolism of Hahyangju in Rats (하향주의 랫드에 대한 알코올 대사 특성)

  • Jung, Hee-Kyoung;Park, Chi-Duck;Hwang, Mi-Hyun;Park, Seung-Chun;Kim, Dae-Ik;Hong, Joo-Heon
    • Food Science and Preservation
    • /
    • v.15 no.1
    • /
    • pp.155-160
    • /
    • 2008
  • This study was conducted to examine the volatile flavor compounds of Hahyangju, a traditional Korean liquor, and to evaluate the effect of the beverage on alcohol metabolism in rats. By GC/MS analysis, 17 volatile flavor compounds including iso-butyl alcohol and iso-amyl alcohol were detected in Hahyangju. The concentrations of acetaldehyde and ethylacetate in Hahyangju were decreased by filtration. Alcohol (0.035 mg/dL) and acetaldehyde (0.29 mg/dL) levels in the blood of rats given Hahyangju (HT animals) were lower than in rats given 17% (v/v) alcohol (AT rats). Also, alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities in HT rats were $24.63{\pm}1.8{\mu}$moles/mg protein and $9.8{\pm}1.3{\mu}$moles/mg protein, respectively, and were higher than in AT animals. The increases in ADH and ALDH activity in HT animals resulted in decreases in alcohol and acetaldehyde concentrations in blood, compared to the levels seen in rats given 17% (v/v) alcohol. These results suggest that Hahyangju may increase alcohol metabolizing activity, and consumption of Hahyangju may result in less of a hangover than follows ingestion of beverages (such as wine) containing about 17% (v/v) alcohol.

Effects of Glucose Degradation Products on Human Peritoneal Mesothelial Cells (포도당분해산물이 사람 복막중피세포 활성화에 미치는 영향)

  • Song, Jae-Sook;Lee, Kyung-Lim;Ha, Hunjoo
    • Microbiology and Biotechnology Letters
    • /
    • v.33 no.4
    • /
    • pp.308-314
    • /
    • 2005
  • Both high glucose and glucose degradation products (GDP) have been implicated in alterations of peritoneal membrane structure and function during long-term peritoneal dialysis (PD). The present study examined the role of GDP including methylglyoxal (MGO), acetaldehyde, and 3,4-dideoxyglucosone (3,4-DGE) in HPMC activation with respect to membrane hyperpermeability or fibrosis. The role of reactive oxygen species (ROS) and activation of protein kinase C (PKC) in GDP-induced HPMC activation were also examined. Using M199 culture medium as control, growth arrested and synchronized HPMC were continuously stimulated by MGO, acetaldehyde, and 3,4-DGE for 48 hours. Vascular endothelial growth factor (VEGF) was quantified as a marker of peritoneal membrane hyperpermeability and fibronectin and heat shock protein 47 (hsp47) as markers of fibrosis. Involvement of ROS and PKC was examined by the inhibitory effect of N-acetylcystein (NAC) or calphostin C, respectively. MGO significantly increased VEGF (1.9-fold), fibronectin (1.5-fold), and hsp47 (1.3-fold) secretion compared with control M199. NAC and calphostin C effectively inhibited MGO-induced VEGF upregulation. Acetaldehyde stimulated and 3,4-DGE inhibited VEGF secretion. Fibronectin secretion and hsp47 expression in HPMC were not affected by acetaldehyde or 3,4-DGE In conclusion, MGO upregulated VEGF and fibronectin secretion and hsp47 expression in HPMC, and PKC as well as ROS mediate MGO-induced VEGF secretion by HPMC. This implies that PKC activation and ROS generation by GDP may constitute important signals for activation of HPMC leading to progressive membrane hyperpermeability and accumulation of extracellular matrix and eventual peritoneal fibrosis.

Analysis of Formaldehyde and Acetaldehyde in Alcoholic Beverage (유통 주류의 포름알데히드 및 아세트알데히드 함량분석)

  • Park, Young-Seok;Lee, Yun-Jeung;Lee, Ki-Teak
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.35 no.10
    • /
    • pp.1412-1419
    • /
    • 2006
  • Concentrations of formaldehyde and acetaldehy de were respectively analysed in forty-five alcoholic beverages obtained from the market. After derivatization with PFBHA, GC-ECD and GC-MSD were employed for analysis. The peak area of aldehyde oximes (derivatives with PFBHA) increased with the increasing ethanol content (5%, 10%, 15%, 20% and 40%). When three-point calibration corves for the selected ethanol concentration (5, 13, 21 and 40%, v/v) were studied, suitable linearity against ethanol concentration was observed only under 5, 13, and 21% (ethanol, v/v). After analysis, maximum content of formaldehyde (average of 0.272 ppm) and acetaldehyde (average of 15.262 ppm) among the observed 45 alcoholic beverages was found from whisk (2 species) while minimum content of formaldehyde (average of 0.009 ppm) and acetaldehyde (average of 0.805 ppm) was found from diluted soju (4 species).

Characteristics of a Metal-loaded SnO2/WO3 Thick Film Gas Sensor for Detecting Acetaldehyde Gas

  • Jun, Jae-Mok;Park, Young-Ho;Lee, Chang-Seop
    • Bulletin of the Korean Chemical Society
    • /
    • v.32 no.6
    • /
    • pp.1865-1872
    • /
    • 2011
  • This study investigates the sensitivity of a gas sensor to volatile organic compounds (VOCs) at various operating temperatures and catalysts. Nano-sized powdered $WO_3$ prepared by sol-gel and chemical precipitation methods was mixed with various metal oxides. Next, transition metals (Pt, Ru, Pd, and In) were doped on the surface of the mixture. Metal-$WO_3$ thick films were prepared using the screen-printing method. The physical and chemical properties of the films were studied by SEM/EDS, XRD, and BET techniques. The measured sensitivity to VOCs is defined as the ratio ($R_a/R_g$) of resistance ($R_{air}$) of $WO_3$ film in the air to resistance ($R_{gas}$) of $WO_3$ film in a VOCs test gas. The sensitivity and selectivity of the films were tested with various VOCs such as acetaldehyde, formaldehyde, methyl alcohol, and BTEX. The thick $WO_3$ film containing 1 wt % of Ru and 5 wt % of $SnO_2$ showed the best sensitivity and selectivity to acetaldehyde gas at an operating temperature of 300 $^{\circ}C$.

Effects of Dried Persimmon Snacks on Alcohol Metabolism in Men

  • Kim, Suk-Gi;Lee, Young-Chul;Park, Hye-Seon
    • Preventive Nutrition and Food Science
    • /
    • v.6 no.1
    • /
    • pp.62-65
    • /
    • 2001
  • Persimmon has been known to help alcohol intoxication in Korea for a long time and is prepared as a processed food. The effect of dried persimmon snacks on alcohol metabolism was determined in vivo. Eight Korean men (25~27 years old) were administered 3.5 mL/kg of alcohol (22.5%, w/v) with or without a dried persimmon snack (2g/kg). The levels of alcohol in the blood and of acetaldehyde in the blood and the urine were determined by alcoholmeter and assay using alcohol dehydrogenase and HPLC, respectively. All subjects showed decreased levels of alcohol in blood, and six subjects showed a decrease of alcohol in urine after consumption of ethanol with dried persimmon snacks. Concentration of acetaldehyde in the blood an urine decreased significantly in three and five of the eight subjects, respectively. Reduction was more significant for alcohol than for alcohol than for acetaldehyde with administration of ethanol and dried persimmon snacks. This in vivo result suggests that dried persimmon snacks are effective in decreasing th concentration of alcohol after alcohol intake.

  • PDF

Growth and Acid Production by Leuconostoc mesenteroides in Milk Added with Cereal and Analysis of Several Volatile Flavor Compounds (곡류를 첨가한 우유에서 Leuconostoc mesenteroides의 생육과 산생성 및 몇가지 휘발성 향기성분의 분석)

  • 고영태;김경희
    • Korean journal of food and cookery science
    • /
    • v.11 no.3
    • /
    • pp.316-322
    • /
    • 1995
  • A curd yogurt was prepared from milk added with skim milk powder or four kinds of cereal. Addition of cereals markedly stimulated acid production by Leuc. mesenteroides. The acidity significantly increased during fermentation by Leuc. mesenteroides for 30 hours while pH significantly decreased during fermentation. The number of viable cells markedly increased until the first 12 or 18 hours of fermentation by Leuc. mesenteroides. Acetaldehyde, acetone, ethanol, diacetyl, butanol and acetoin in curd yogurt were detected by gas chromatographic analysis. Among these compounds, acetaldehyde, ethanol, diacetyl and acetoin were produced during fermentation by Leuc. mesenteroides.

  • PDF

Identification of the Endogenous IAA Analogues in Pea(Pisum sativum L.) Shoots (백색(白色) 완두(豌豆) 유묘(幼苗)에서 IAA 유도체의 확인(確認))

  • Kim, Jeong-Bong;Park, Ro-Dong;Suh, Yong-Taik;Park, Chang-Kyu
    • Applied Biological Chemistry
    • /
    • v.32 no.2
    • /
    • pp.162-169
    • /
    • 1989
  • Tryptophan, indole-3-acetaldehyde, indole-3-acetic acid(IAA), and indole-3-aldehyde were identified as endogenous IAA analogues in etiolated pea(Pisum sativum L. var. 'Sparkle') shoots, which suggests a metabolic sequence(s) of tryptophan${\rightarrow}$(?)${\rightarrow}$indole-3-acetaldehyde${\rightarrow}$IAA${\rightarrow}$indole-3-aldehyde occurring in pea plants. IAA-rhamnose and IAA-glucose were tentatively confirmed as IAA conjugates.

  • PDF

Treatment of Wastewater from Acetaldehyde Plant by Activated Sludge Process (활성슬러지 공정에 의한 Acetaldehyde 제조 공장 폐수의 처리)

  • Suh, Seung-Kyu;Kim, Jung-Ho;Kim, Young-Ho
    • Journal of Environmental Science International
    • /
    • v.6 no.3
    • /
    • pp.259-265
    • /
    • 1997
  • This study was conducted to Investigate the treatment of wastewater from acetaldehyde manufacturing plant by activated sludge process with Micrococcus roseus AW-6, Micrococcus roseus AW-22, Microbacterium lacticum AW-38 and Mlcrobacterium nae- vaniformans AW-41. The $COD_{Mn}$ and $BOD_5$ of the wastewater were 5, 260mg/L and 6, 452mg/L, respectively. pH was 1.85. The main organic component in the wastewater was acetic acrid which was contained 67, 600mg/L. Optimum dilution time for activated sludge process was shown 10 times. The specific substrate removal rate(BL) was 1.95day-1 and the nonbiodegradable matters(Sn) were 23.2mg/L. Saturation constant (Ks) and mainmum specific growth rate(qmax) were 1, 640mg/L and 2.33day-1, respectively. Sludge yield coefficient(Y) and endogenous respiration coefficient(kd) were 0.28mg MLVSS/mgCOD and 0.02day-1, respectively. $COD_{cr}$ removal efficiency was 91% for 1.95day of hydraulic retention time.

  • PDF

Analysis of Waste Water and Isolation of Strains Assimilation Waste Water from Acetaldehyde Plant (아세트 알데히드(특수산업) 공장폐수의 성분과 이용균주의 분리)

  • 정기택;서승교;송형익;박임동;방광웅
    • Korean Journal of Microbiology
    • /
    • v.25 no.4
    • /
    • pp.328-332
    • /
    • 1987
  • As a research for treatment of waste water from acetaldehyde plant by biological method, we investigated general characteristics of the waste water, and isolated and identified some useful bacteria which effectively treated its waste water. Among the total number of 53 strains which were grown in waste water from an acetaldehyde plant, the strains AW-6, AW-22, AW-38 and AW-41 were found to be useful for COD removal of waste water. $COD_{Mn}$ and $BOD_{5}$ of the waste water were 5260 ppm and 6452 ppm, respectively, and pH was 1.85. And the main organic component in waste water was acetic acid which was contained 6.76%. By the taxonomical characteristics, the strains AW-6, AW-22, AW-38 and AW-41 were identified as Micrococcus roseus, Micrococcus luteus, Microbacterium lacticum and Microbacterium laevanifromans or similar strain, respectively.

  • PDF

Purification of Mitochondrial Matrix Aldehyde Dehydrogenase from Pig Brain

  • Kim, Kyu-Tae;Lee, Young-Don
    • BMB Reports
    • /
    • v.28 no.2
    • /
    • pp.177-183
    • /
    • 1995
  • The activity of aldehyde dehydrogenase (ALDH) in the cerebrum, cerebellum, striatum, and medulla oblongata was examined and mitochondrial matrix ALDH was purified prior to immunohistochemical study on the localization of ALDH isozymes in pig brain. Relatively high enzyme activity was found in the striatum and medulla oblongata when using indole-3-acetaldehyde as substrate, and in the striatum when using 3,4-dihydroxyphenylacetaldehyde (DOPAL). The main part of mitochondrial ALDH activities with both acetaldehyde and DOPAL existed in the matrix fraction. The ratio of activity of the matrix to the membrane fraction in the cerebrum was higher than in the cerebellum, suggesting that the distribution pattern of ALDH isozymes was different according to the brain regions. The 276-fold purified mitochondrial matrix ALDH from pig brain was identified to be homologous tetramers with 53 KD subunits. The enzyme showed maximal activity at pH 9.0 and was stable in the temperature range from $25^{\circ}C$ to $37^{\circ}C$. The mitochondrial matrix ALDH activity was considerably inhibited by acetaldehyde in vitro. The $K_m$ values of the enzyme for acetaldehyde and propionaldehyde were 5.8 mM and 4.9 mM, respectively, whereas $K_m$ values for indole-3-acetaldehyde and DOPAL were 44 ${\mu}M$ and 1.6 ${\mu}M$, respectively. The $V_{max}/K_{m}$ ratio was the highest with DOPAL as compared with other substrates. These results suggested that mitochondrial matrix ALDH in the present work might be a low Km isozyme involved in biogenic aldehyde oxidation in pig brain.

  • PDF