• Food Science of Animal Resources
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• v.41 no.2
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• pp.335-342
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• 2021

Vitamin B12 deficiency may lead to serious health issues in both infants and adults. A simple analytical method involving sample pretreatment with enzyme, followed by cyanide addition under acidic conditions; separation on an immunoaffinity column; and high-performance liquid chromatography (HPLC) was developed for the rapid detection and quantitation of vitamin B12 in powdered milk. Detection limit and powdered milk recovery were determined by quantitative analysis. The limits of detection and quantitation were 2.71 and 8.21 ㎍/L, respectively. Relative standard deviations of the intra-day and inter-day precisions varied in the ranges of 0.98%-5.31% and 2.16%-3.90%, respectively. Recovery of the analysis varied in the range of 83.41%-106.57%, suggesting that the values were acceptable. Additionally, vitamin B12 content and recovery in SRM 1849a were 54.10 ㎍/kg and 112.24%, respectively. Our results suggested that the analytical method, including the sample pretreatment step, was valid. This analytical method can be implemented in many laboratory-scale experiments that seek to save time and labor. Therefore, this study shows that immunoaffinity-HPLC/ultraviolet is an acceptable technique for constructing a reliable database on vitamin B12 in powdered milk containing starch as well as protein and/or fat in high amounts.

• Earthquakes and Structures
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• v.23 no.1
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• pp.87-100
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• 2022

Limiting the displacement of seismic isolators causes a pounding phenomenon under severe earthquakes. Therefore, the ASCE 7-16 has provided minimum criteria for the design of the isolated building. In this research the seismic response of isolated buildings by Triple Friction Pendulum Isolator (TFPI) under the impact, expected, and unexpected mass eccentricity was evaluated. Also, the effect of different design parameters on the seismic behavior of structural and nonstructural elements was found. For this, a special steel moment frame structure with a surrounding moat wall was designed according to the criteria, by considering different response modification coefficients (RI), and 20% mass eccentricity in one direction. Then, different values of these parameters and the damping of the base isolation were evaluated. The results show that the structural elements have acceptable behavior after impact, but the nonstructural components are placed in a moderate damage range after impact and the used improved methods could not ameliorate the level of damage. The reduction in the RI and the enhancement of the isolator's damping are beneficial up to a certain point for improving the seismic response after impact. The moat wall reduces torque and maximum absolute acceleration (MAA) due to unexpected enhancement of mass eccentricity. However, drifts of some stories increase. Also, the difference between the response of story drift by expected and unexpected mass eccentricity is less. This indicates that the minimum requirement displacement according to ASCE 7-16 criteria lead to acceptable results under the unexpected enhancement of mass eccentricity.

• ETRI Journal
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• v.46 no.2
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• pp.227-237
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• 2024

This study proposes a novel, conditionally applied neural network technique to reduce the overall peak-to-average power ratio (PAPR) of an orthogonal frequency division multiplexing (OFDM) system while maintaining an acceptable bit error rate (BER) level. The main purpose of the proposed scheme is to adjust only those subcarriers whose peaks exceed a given threshold. In this respect, the developed C-ANN algorithm suppresses only the peaks of the targeted subcarriers by slightly shifting the locations of their corresponding frequency samples without affecting their phase orientations. In turn, this achieves a reasonable system performance by sustaining a tolerable BER. For practical reasons and to cover a wide range of application scenarios, the threshold for the subcarrier peaks was chosen to be proportional to the saturation level of the nonlinear power amplifier used to pass the generated OFDM blocks. Consequently, the optimal values of the factor controlling the peak threshold were obtained that satisfy both reasonable PAPR reduction and acceptable BER levels. Furthermore, the proposed system does not require a recovery process at the receiver, thus making the computational process less complex. The simulation results show that the proposed system model performed satisfactorily, attaining both low PAPR and BER for specific application settings using comparatively fewer computations.

• Journal of applied mathematics & informatics
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• v.42 no.2
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• pp.257-281
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• 2024

In real life, a decision-maker can assign multiple values for pairwise comparison with a certain confidence level. Studies incorporating multi-choice parameters in multi-criteria decision-making methods are lacking in the literature. So, In this work, an extension of the Best-Worst Method (BWM) with multi-choice pairwise comparisons and multi-choice confidence parameters has been proposed. This work incorporates an extension to the original BWM with multi-choice uncertainty and confidence level. The BWM presumes the Decision-Maker to be fully confident about preference criteria vectors best to others & others to worst. In the proposed work, we consider uncertainty by giving decision-makers freedom to have multiple choices for preference comparison and having a corresponding confidence degree for each choice. This adds one more parameter corresponding to the degree of confidence of each choice to the already existing MCDM, i.e. multi-choice BWM and yields acceptable results similar to other studies. Also, the consistency ratio remained low within the acceptable range. Two real-life case studies are presented to validate our study on proposed models.

• The Korean Journal of Nuclear Medicine Technology
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• v.26 no.2
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• pp.43-47
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• 2022

Purpose Radioimmunoassay implement quality control by systematizing the internal quality control system for quality assurance of test results. This study aims to contribute to the quality assurance of radioimmunoassay results and to implement systematic quality control by measuring the average CV of internal quality control and external quality control by plenty of institutions for reference when setting the laboratory's own acceptable range. Materials and Methods We measured the average CV of internal quality control and the bounce rate of more than 10.0% for a total of 42 items from October 2020 to December 2021. According to the CV result, we classified and compared the upper group (5.0% or less), the middle group (5.0~10.0%) and the lower group (10.0% or more). The bounce rate of 10.0% or more was compared by classifying the item of five or more institutions into tumor markers, thyroid hormones and other hormones. The average CV was measured by the overall average and standard deviation of the external quality control results for 28 items from the first quarter to the fourth quarter of 2021. In addition, the average CV was measured by the overall average and standard deviation of the proficiency results between institutions for 13 items in the first half and the second half of 2021. The average CV of internal quality control and external quality control was compared by item so we compared and analyzed the items that implement well to quality control and the items that require attention to quality control. Results As a result of measuring the precision average of internal quality control for 42 items of six institutions, the top group (5.0% or less) are Ferritin, HGH, SHBG, and 25-OH-VitD, while the bottom group (≤10.0%) are cortisol, ATA, AMA, renin, and estradiol. When comparing more than 10.0% bounce rate of CV for tumor markers, CA-125 (6.7%), CA-19-9 (9.8%) implemented well, while SCC-Ag (24.3%), CA-15-3 (26.7%) were among the items that require attention to control. As a result of comparing the bounce rate of more than 10.0% of CV for thyroid hormones examination, free T4 (2.1%), T3 (9.3%) showed excellent performance and AMA (39.6%), ATA (51.6%) required attention to control. When comparing the bounce rate of 10.0% or more of CV for other hormones, IGF-1 (8.8%), FSH (9.1%), prolactin (9.2%) showed excellent performance, however estradiol (37.3%), testosterone (37.7%), cortisol (44.4%) required attention to control. As a result of measuring the average CV of the whole institutions participating at external quality control for 28 items, HGH and SCC-Ag were included in the top group (≤10.0%), however ATA, estradiol, TSI, and thyroglobulin included in bottom group (≥30.0%). Conclusion As a result of evaluating 42 items of six institutions, the average CV was 3.7~12.2% showing a 3.3 times difference between the upper group and the lower group. Cortisol, ATA, AMA, Renin and estradiol tests with high CV will require continuous improvement activities to improve precision. In addition, we measured and compared the overall average CV of the internal quality control, the external quality control and the proficiency between institutions participating of six institutions for 41 items excluding HBs-Ab. As a result, ATA, AMA, Renin and estradiol belong to the same subgroup so we require attention to control and consider setting a higher acceptable range. It is recommended to set and control the acceptable range standard of internal quality control CV in consideration of many things in the laboratory due to the different reagents and instruments, and the results vary depending on the test's proficiency and quality control materials. It is thought that the accuracy and reliability of radioimmunoassay results can be improved if systematic quality control is implemented based on the set acceptable range.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.8 no.2
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• pp.123-133
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• 2010

A statistical evaluation methodology was developed to determine the compliance of candidate waste stream with clearance criteria based upon distribution of radionuclide in a waste stream at a certain confidence level. For the cases where any information on the radionuclide distribution is not available, the relation between arithmetic mean of radioactivity concentration and its acceptable maximum standard deviation was demonstrated by applying widely-known Markov Inequality and One-side Chebyshev Inequality. The relations between arithmetic mean and its acceptable maximum standard deviation were newly derived for normally or lognormally distributed radionuclide in a waste stream, using probability density function, cumulative density function, and other statistical relations. The evaluation methodology was tested for a representative case at 95% of confidence level and 100 Bq/g of clearance level of radioactivity concentration, and then the acceptable range of standard deviation at a given arithmetic mean was quantitatively shown and compared, by varying the type of radionuclide distribution. Furthermore, it was statistically demonstrated that the allowable range of clearance can be expanded, even at the same confidence level, if information on the radionuclide distribution is available.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.1
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• pp.124-130
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• 2007

The purposes of this study were (1) to analyze price sensitivity, (2) to define the range of acceptable prices for each foreign segment, and (3) to provide a price model for Korean traditional restaurants. From October to November, 2006, a total of 781 foreigners responded to individual surveys. Statistical analyses on the survey data were performed using descriptive statistics and Price Sensitivity Measurement (PSM). Major findings from the study are as follows: First, the ranges of the acceptable prices were $98$\sim$$130 for fine dining/gourmet restaurants, $70$\sim$$90 for theme/ambience restaurants, $40$\sim$$60 for popular/family restaurants, and $18$\sim$$30 for convenience/fast food restaurants. Second, the convenience/fast food restaurants showed the highest price sensitivity. Third, a low stress level and wide range of the acceptable price were observed for the fine dining/gourmet restaurants, suggesting that the price sensitivity of the fine dining/gourmet restaurants was quite low. Finally, the price sensitivity indicated by the Japanese was higher than by the other groups. In consequence, the research findings suggest that the managers of the Korean traditional restaurants should strategically plan prices by understanding different customers' price sensitivity within and between customer segments. Through additional research, marketers can compare perceptions of specific brands, the competition, and variations within a product line.

• The Korean Journal of Nuclear Medicine Technology
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• v.27 no.1
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• pp.55-61
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• 2023

Purpose In this study, the monthly population distribution was calculated for statistical verification of 10 tests (CA19-9, CA15-3, testosterone, PTH, calcitonin, AFP, CEA, CA72-4, PSA, estradiol) with changed reagents, and the trend of change By comparing and analyzing the results, we want to verify the accuracy of the results and improve the reliability of the test. Materials and Methods From June 2021 to February 2023, for the 10 items in which the reagent was changed, the monthly percentage and standard deviation index before and after the reagent change were compared, respectively. At this time, the reference value was arbitrarily set for the comparison group in consideration of the reference value of the test item, and the groups were subdivided and compared, and the standard deviation index allowed range was -2.0 or more and 2.0 or less. Results For CA19-9, CA15-3, AFP, CEA, and calcitonin 5 test items, the change in monthly ratio in all test sections before and after the reagent change was kept constant. On the other hand, for CA72-4, PSA, testosterone, PTH, and estradiol items, the standard deviation index exceeded the acceptable standard after changing the reagent. CA72-4 test items showed an increasing trend in standard deviation index in the test section exceeding the reference value. In the case of the PSA test item, the maintenance ratio of 0.04 ng/mL was significantly decreased after changing the reagent. The testosterone test item had a standard deviation index of -2.5 in the test section exceeding 10.1 ng/mL after changing the reagent, and the standard deviation index of the PTH test item was out of the acceptable range in all test sections. It was confirmed that the estradiol test item showed an overall increase in the result value. Conclusion Through this study, the continuity and accuracy of the test results could be verified. It is considered that the stability of the test can be secured by analyzing the factors affecting the test result and solving the cause for the test item whose standard deviation index is out of the acceptable standard.

• Food Science and Biotechnology
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• v.15 no.5
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• pp.683-687
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• 2006

The respiration rate of Chinese quince was measured at 0, 5, 10, and $20^{\circ}C$ to determine its tolerable range of storage temperatures. Based on the measured respiration rates, plastic films covering a wide range of gas permeabilities were used for packaging and storing individual Chinese quince at 0 and $10^{\circ}C$. Chinese quince can be categorized as low respiration fruit. Higher respiratory quotients were observed at higher temperature suggesting that the tolerable temperature range for storage is $0-10^{\circ}C$. Packages containing Chinese quince wrapped in highly gas-permeable polyolefin film PD 941 attained, with progressive decreases in volume, 9.5-10.2% $O_2$ and 1.3-1.8% $CO_2$ at $0^{\circ}C$, 8.1% $O_2$ and 2.4% $CO_2$ at $10^{\circ}C$. At these levels, PD 941 could preserve the fruit at acceptable quality levels for 152 and 50 days at 0 and $10^{\circ}C$, respectively. Less gas-permeable packages built up high $CO_2$ concentrations (above 15.8%) and low $O_2$ concentrations (less than 1.8%) causing free volume expansion and eventual dark discoloration of the fruit. The storage life realized by packaging with polyolefin film PD 941 could facilitate the availability of Chinese quinces in winter and spring for medicinal or ornamental purposes in the fresh state.

• Structural Engineering and Mechanics
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• v.58 no.2
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• pp.259-276
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• 2016

Lead-rubber bearings (LRBs) have been used worldwide in seismic design of buildings and bridges owing to their stable mechanical properties and good isolation effect. We have investigated the effectiveness of LRBs in framed underground structures on controlling structural seismic responses. Nonlinear dynamic time history analyses were carried out on the well-documented Daikai Station, which collapsed during the 1995 Hyogoken-Nanbu earthquake. Influences of strength ratio (ratio of yield strength of LRBs to yield strength of central column) and shear modulus of rubber on structural seismic responses were studied. As a displacement-based passive energy dissipation device, LRBs reduce dynamic internal forces of framed underground structures and improve their seismic performance. An optimal range of strength ratios was proposed for the case presented. Within this range, LRBs can dissipate maximum input earthquake energy. The maximum shear and moment of the central column can achieve more than 50% reduction, whereas the maximum shear displacement of LRBs is acceptable.