• Molecules and Cells
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• v.38 no.11
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• pp.1013-1021
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• 2015

Most of the axons in the vertebrate nervous system are surrounded by a lipid-rich membrane called myelin, which promotes rapid conduction of nerve impulses and protects the axon from being damaged. Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS characterized by infiltration of immune cells and progressive damage to myelin and axons. One potential way to treat MS is to enhance the endogenous remyelination process, but at present there are no available treatments to promote remyelination in patients with demyelinating diseases. Sulfasalazine is an anti-inflammatory and immune-modulating drug that is used in rheumatology and inflammatory bowel disease. Its anti-inflammatory and immunomodulatory properties prompted us to test the ability of sulfasalazine to promote remyelination. In this study, we found that sulfasalazine promotes remyelination in the CNS of a transgenic zebrafish model of NTR/MTZ-induced demyelination. We also found that sulfasalazine treatment reduced the number of macrophages/microglia in the CNS of demyelinated zebrafish larvae, suggesting that the acceleration of remyelination is mediated by the immunomodulatory function of sulfasalazine. Our data suggest that temporal modulation of the immune response by sulfasalazine can be used to overcome MS by enhancing myelin repair and remyelination in the CNS.

• Journal of the Earthquake Engineering Society of Korea
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• v.22 no.1
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• pp.1-14
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• 2018

In this study, we develop and propose damping correction factors for the Korean standard design spectra. The newly proposed Korean standard design spectra has been given only for 5% damping ratio. But in practice, engineers need design spectra for damping values other than 5%. To obtain design spectra for various damping values from the standard spectra, damping correction factors are derived. These factors modify the shape of design spectra in accordance with the damping ratio. Response spectra for various damping values are calculated from the earthquake records that had been used to calculate standard design spectra. They consist of 55 records from 18 earthquakes occurred in overseas intraplate regions and Korea. The regressed spectra for the damping values ranging from 0.5% to 50 % are compared with standard spectra at three regions acceleration, velocity and displacement sensitive regions. The regression analysis of these data rendered formula for damping correction factors. Finally, a single formula for damping correction factors is recommended that is valid for both horizontal and vertical design spectra and that is applicable to the entire range of periods. One thing to note that recommended damping correction factors is valid for the design spectrum of the rock grounds because the design spectra was developed based on the earthquake records of the rock ground.

• Physical Therapy Korea
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• v.13 no.4
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• pp.79-86
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• 2006

The purpose of the current experiment was to describe interlimb coordination when swing limb conditions are being manipulated by constraining step length or by adding a 5 or 10 pound weight to the swing limb distally. Subjects were asked to begin walking with the right limb to land on the primary target (normal step length) that is 10 cm in diameter. However, if, during movement, the light was illuminated, then the subject had to step on one of the secondary targets (long and short step length). These three step length conditions were repeated while wearing a 5 pound ankle weight and then when wearing a 10 pound ankle weight. Ground reaction force (GRF) data indicated that there were changes in the forces and slopes of the swing and stance Fx GRFs. Long stepping subjects had to increase the propulsive force required to increase step length. Consequently, swing and stance toe-off greatly increased in the long step length condition. Short step length subjects had to adequately adjust step length, which decreased the speed of gait initiation. Loading the swing limb decreased the force and slope of the swing limb. Swing and stance toe-off was longest for the long step length condition, but there was a small difference of temporal events between no weight and weight condition. It appears that subjects modulated GRFs and temporal events differently to achieve the peak acceleration force of the swing and stance limb in response to different tasks. The findings from the current study provide preliminary data, which can be used to further investigate how we modulate forces during voluntary movement from a quiet stance. This information may be important if we are to use this or a similar task to evaluate gait patterns of the elderly and patient populations.

• Journal of the Earthquake Engineering Society of Korea
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• v.11 no.6
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• pp.23-32
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• 2007

This study developed an analytical model for predicting nonlinear behavior of PT flat plate frames having slab-column connections with and without slab bottom reinforcement passing through the column. The developed model can predict the failure sequence until punching failure occurs. For verifying the analytical model, the test results of PT flat plate slab-column connections were compared with the results of the analysis. Moreover, the results of static pushover test and shaking table test of 2 story PT flat plate frame were compared with analysis results. For evaluating seismic performance of PT flat plate frame, this study conducted nonlinear response history analysis of the 2 story PT flat plate frame with and without slab bottom reinforcement passing through the column under 1940 El Centro ground motion scaled to have pseudo spectral acceleration of 0.3, 0.5, and 0.7g at the fundamental period of the frame. This study observed that as ground motion is more intense, seismic demands for the frame having the connections without slab bottom reinforcement passing through the column are larger than those without slab bottom reinforcement.

• Journal of the Ergonomics Society of Korea
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• v.30 no.1
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• pp.237-250
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• 2011

The train transportation has a lot of advantages-energy efficiency is high, it is eco-friendly, safety is better than normal roads and it is possible for people to arrive on time. In these days, the valuation of ride comfort, which is only limited to road transportation, is newly recognized in order to having competitiveness from other transportation. Especially, in the development of the Korean high-speed railroad business, the ride comfort enhancement of train is very important problem to be solved. Currently, there are international standards of ride comfort such as UIC13, ISO2631. In Korea case, although it has own standard like KS R9216, it mainly depends on the physical parameter such as vibration and noise. So recently, in the valuation of ride comfort, the movements of living parameter technique introduction are increasing on the base of Japan and many developed countries of Europe techniques. Presently, the method of train ride comfort is mainly based of vibration, that is, mechanical parameter adding selection of variable acceleration and noise. This paper would like to show biological parameter; heart rate and blood pressure variation. This method is more direct, based on human body response, than mechanical parameter method. In this experiment, the variability of heart rate and blood pressure of passengers according to tilting angle change of Train, the Korean tilting train, we are supposed to know that the extent of tilting on the simulation has influence on variability of heart rate and blood pressure, which are living parameter of heart's blood.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.28 no.4
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• pp.202-211
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• 2016

This study aims to analyze seismic responses of suction foundations for offshore wind turbine. For this purpose, dynamic centrifuge model tests were carried out. The skirt length of the suction foundation is a critical element for bearing mechanism against environmental loads. Thus, dynamic centrifuge model tests were performed and analyzed for three suction foundation models with the ratios of skirt length to suction foundation diameter of 0.5, 0.75, and 1 installed in dense sand. As results, the acceleration amplification at the suction foundation, residual settlement, and residual tilting angle were compared.

• Journal of the Earthquake Engineering Society of Korea
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• v.19 no.1
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• pp.21-28
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• 2015

The nuclear accident due to the recent earthquake in Japan has triggered awareness of the importance of safety with regard to nuclear power plants (NPPs). An earthquake is one of the most important parameters which governs the safety of NPPs among external events. Application of a base isolation system for NPPs can reduce the risk for earthquakes. At present, a soil-structure interaction (SSI) analysis is essential in the seismic design of NPPs in consideration of the ground structure interaction. In the seismic analysis of the base-isolated NPP, it is restrictive to consider the nonlinear properties of seismic isolation devices due to the linear analysis of the SSI analysis programs, such as SASSI. Thus, in this study, SSI analyses are performed using an iterative approach considering the material nonlinearity of the isolators. By performing the SSI analysis using an iterative approach, the nonlinear properties of isolators can be considered. The difference between the SSI analysis results without iteration and SSI with iteration using SASSI is noticeable. The results of the SSI analysis using an effective linear (non-iterative) approach underestimate the spectral acceleration because the effective linear model cannot consider the nonlinear properties of isolators. The results of the SSI analysis show that the horizontal response of the base-isolated NPP is significantly reduced.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.5
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• pp.351-358
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• 2013

In the electric power supplying industry, outdoor sealing end (pothead) is used and sometimes it is necessary to check the seismic qualification analysis or test which is intended to demonstrate that the equipment have adequate integrity to withstand stress of the specified seismic event and still performs their function. And since the pothead is mounted on the supporting jig, the avoidance of resonance between the pothead and jig is required. In order to design jig, three types of optimization are performed to get the minimum weight while satisfying the natural frequency constraint using ANSYS. Optimal array, position and thickness of truss members of the jig are obtained through topology, shape and sizing optimization process, respectively. And seismic analysis of the pothead on the jig for given RRS acceleration computes the displacement and stress of the pothead which shows the safety of the pothead. The obtained natural frequency, mass, and member thickness of the jig are compared with those of the reference jig which was used for seismic experimental test. The numerical results of the jig in the research is more optimized than the jig used in the experimental test.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.11a
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• pp.261-261
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• 2007

Wearable and ubiquitous micro systems will be greatly growing and their related devices should be self-powered in order to avoid the replacement of finite power sources, for example, by scavenging energy from the environment. With ever reducing power requirements of both analog and digital circuits, power scavenging approaches are becoming increasingly realistic. One approach is to drive an electromechanical converter from ambient motion or vibration. Vibration-driven generators based on electromagnetic, electrostatic and piezoelectric technologies have been demonstrated. Among various generator types proposed so far, piezoelectric generator possesses considerable potential in micro system. To overcome low mechanical-to- electric energy conversion, the piezoelectric device should activate in resonance mode in response to external vibration. Normally, the external vibration excretes at low frequency ranging 0.1 to 200 Hz, whereas the resonant frequencies of the devices are fixed as constant. Therefore, keeping their resonant mode in varying external vibration can be one of important points in enhancing the conversion efficiency. We investigated the possibility of use of multi-bender type piezoelectric devices. To match the external vibration frequency with the device resonant frequency, the various devices with different resonant frequency were chosen. Under an external vibration acceleration of 0.1G at 120 Hz, the device exhibited a peak-to-peak voltage of 2.8 V and a power of 0.5 mw in resonance mode.

• Journal of Korean Society of Transportation
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• v.27 no.5
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• pp.63-74
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• 2009

One of the effective countermeasures for preventing traffic accidents is to provide traffic safety warning information to drivers. Provision of warning information would lead to safer driving to avoid accident occurrence. This study investigated the effects of in-vehicle warning information on driver's behavior. A variety of warning information contents using text, sound, and pictograms were prepared for the field experiments. Individual vehicle speed and acceleration data, which represent quantitative drivers' behavior in response to in-vehicle warning information, were collected using differential global positioning systems (DGPS). Statistical analyses including ANOVA and Tukey's pairwise comparison were conducted. It is expected that the results could be invaluable for designing more effective warning information.