• Advances in concrete construction
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• v.8 no.4
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• pp.269-276
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• 2019

The cracking and spalling caused by fracture of concrete lining have adverse impacts on serviceability and durability of the tunnel, and the subsequent maintenance work for damaged structure needs to be specific to the damaging causes. In this paper, a particular case study of an operational tunnel structure is presented for the serious cracking and spalling behaviours of concrete lining, focusing on the multi-factors inducing lining failure. An integrated field investigation is implemented to characterize the spatial distribution of damages and detailed site situations. According to results of nondestructive inspection, insufficient lining thickness and cavity behind lining are the coupled-inducement of lining failure bahaviors. To further understanding of the lining structure performance influenced by these multiple construction deficiencies, a reliable numerical simulation based on extended finite element method (XFEM) is performed by using the finite element software. The numerical model with 112 m longitudinal calculation, 100 m vertical calculation and 43 m vertical depth, and the concrete lining with 1450 solid elements are set enrichment shape function for the aim of simulating cracking behavior. The numerical simulation responses are essentially in accordance with the actual lining damaging forms, especially including a complete evolutionary process of lining spalling. This work demonstrates that the serious lining damaging behaviors are directly caused by a combination of insufficient thickness lining and cavity around the surrounding rocks. Ultimately, specific maintenance work is design based on the construction deficiencies, and that is confirmed as an efficient, time-saving and safe maintenance method in the operational railway tunnel.

• Advances in concrete construction
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• v.8 no.4
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• pp.335-349
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• 2019

To investigate the axial compressive performance of the recycled aggregate concrete (RAC) filled glass fiber reinforced polymer (GFRP) tube and profile steel composite columns, static loading tests were carried out on 18 specimens under axial loads in this study, including 7 RAC filled GFRP tube columns and 11 RAC filled GFRP tube-profile steel composite columns. The design parameters include recycled coarse aggregate (RCA) replacement percentage, profile steel ratio, slenderness ratio and RAC strength. The failure process, failure modes, axial stress-strain curves, strain development and axial bearing capacity of all specimens were mainly analyzed in detail. The experimental results show that the GFRP tube had strong restraint ability to RAC material and the profile steel could improve the axial compressive performance of the columns. The failure modes of the columns can be summarized as follow: the profile steel in the composite columns yielded first, then the internal RAC material was crushed, and finally the fiberglass of the external GFRP tube was seriously torn, resulting in the final failure of columns. The axial bearing capacity of the columns decreased with the increase of RCA replacement percentage and the maximum decreasing amplitude was 11.10%. In addition, the slenderness ratio had an adverse effect on the axial bearing capacity of the columns. However, the strength of the RAC material could effectively improve the axial bearing capacity of the columns, but their deformability decreased. In addition, the increasing profile steel ratio contributed to the axial compressive capacity of the composite columns. Based on the above analysis, a formula for calculating the bearing capacity of composite columns under axial compression load is proposed, and the adverse effects of slenderness ratio and RCA replacement percentage are considered.

• Advances in concrete construction
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• v.8 no.4
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• pp.285-294
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• 2019

In the present paper, the fiber theory has been employed to model the reinforced concrete (RC) deep beams (DBs) considering the reinforcing steel bar-concrete interaction. To simulate numerically the behavior of materials, the uniaxial materials' constitutive laws have been employed for reinforcements and concrete and the bond stress-slip between the reinforcing steel bars and surrounding concrete are taken into account. Because of the high sensitivity of DBs to shear deformations, the Timoshenko beam theory has been applied. The shear stress-strain (S-SS) relationship has been defined by the modified compression field theory (MCFT) model. By modeling about 300 RC panels and employing a produced numerical database, a study has been carried out to show the sensitivity of the MCFT model. This is performed based on the multiple linear regression (MLR) models. The results of this research also illustrate how different parameters such as characteristic compressive strength of concrete, yield strength of reinforcements and the percentages of reinforcements in different directions get involved in the shear behavior of RC panels without applying complex theories. Based on the results obtained from the analysis of the MCFT S-SS model, a relatively simplified numerical S-SS model has been proposed. Application of the proposed S-SS model in modeling and analyzing the considered samples indicates that there is a good agreement between the simulated and the experimental test results. The comparison between the proposed S-SS model and the MCFT model indicates that in addition to the advantage of better accuracy, the main advantage of the proposed method is simplicity in application.

• Archives of design research
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• v.13 no.1
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• pp.29-38
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• 2000

Many computer system; (or program;) have been desigoc>d without taking their users needs into accOlmt To provide a practical and comprehensive introduction to the design and development of user interfaces, desigrer (or developer) is suggested to analyze and evaluate requirements from the view point of users and to design more effective program;. The su~ect of this thesis is to analyze and criticize tre details of Wonder-land, that is a demo multimedia ill-ROM title, in respect to User Interface Design and Development. By applying the coocepts, teclmiques and ideas to a real life study and analyzing and criticizing it from the view point of users, desigrer lets the program revised and developed by users. For User Interface Design and Development purposes this tresis analyzes and criticize the characteristics of the program already made, the current user interface design, mental models and users learning about the program. As a result it is founded that the program requires to be analyzing and criticizing continuously from a cognitive point of view to design and develop it successfully.

• Journal of Plant Biotechnology
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• v.4 no.1
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• pp.7-15
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• 2002

Eight cDNAs corresponding to fruit-specific genes were isolated from ripened melon through differential screening. Sequence comparison indicated that six of these cDNAs encoded proteins were previously characterized into aminocyclopropane-1-carboxylate (ACC) oxidase, abscisic acid, stress and ripening inducible (ASR) gene, RINC-H2 zinc finger protein, pyruvate decarboxylase, or polyubiquitin. RFS2 and RFS5 were the same clone encoding polyubiquitin. The other cDNAs showed no significant homology with known protein sequences. The ASR homologue (Asr1) gene was further characterized on the cDNA and genomic structure. The deduced amino acid sequence had similar characteristics to other plant ASR. The Asr1 genomic DNA consisted of 2 exons and 1 intron, which is similar to the structure of other plants ASR genes. The promoter region of the Asr1 gene contained several putative functional cis-elements such as an abscisic acid responsive element (ABRE), an ethylene responsive element (ERE), a C-box or DPBf-1 and 2, Myb binding sites, a low temperature responsive element (LTRE) and a metal responsive element (MRE). The findings imply that these elements may play important roles in the response to plant hormones and environmental stresses in the process of fruit development. The results of this study suggest that the expressions of fruit specific and ripening-related cDNAs are closely associated with the stress response.

• Korean Journal of Head & Neck Oncology
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• v.25 no.2
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• pp.123-127
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• 2009

Objectives : The aim of this study was to investigate immunohistochemical expression of CK7, CK19, CK20, SMA and Ki-67 in Adenoid cystic carcinoma(ACC) of the Head and Neck. Material and Methods : Sixteen patients who were treated in Chungbuk National University Hospital from 1992 to 2004, were included in this study. Ten ACCs, 3 MECs, 1 Salivary duct carcinoma, 1 Adenocarcinoma(NOS), and 1 cacinoma ex pleomorphic adenoma were analyzed immunohistochemically for CK7, CK19, CK20, SMA, and Ki-67. Results : CK7 was expressed in 100% of the adenoid cystic carcinoma and 75% of the other tumors. CK19 was expressed in 75% of the adenoid cystic carcinoma and 100% of the other tumors. CK20 was not expressed in all tumors. SMA was expressed in 88.9% of the adenoid cystic carcinoma and not expressed in the other tumors. Ki-67 was expressed in low level in the adenoid cystic carcinoma. Conclusion : The Ki-67 index could explain the natural course of tumor. Immunohistochemistry of CK7, CK19, CK20, SMA and Ki-67 expression in Adenoid cystic carcinoma may provide useful information to diagnosis.

• Toxicological Research
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• v.30 no.1
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• pp.19-25
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• 2014

Licochalcone (LC), a major phenolic retrochalcone from licorice, has anti-inflammatory activity. This study investigated the effects of licochalcone A (LCA) and licochalcone E (LCE) on Liver X receptor-${\alpha}$ ($LXR{\alpha}$)-mediated lipogenic gene expression and the molecular mechanisms underlying those effects. LCA and LCE antagonized the ability of $LXR{\alpha}$ agonists (T0901317 or GW3965) to increase sterol regulatory element binding protein-1c (SREBP-1c) expression and thereby inhibited target gene expression (e.g., FAS and ACC) in HepG2 cells. Moreover, treatment with LCA and LCE impaired $LXR{\alpha}/RXR{\alpha}$-induced CYP7A1-LXRE-luciferase (CYP7A1) transactivation. The AMPK-Sirt1 signaling pathway is an important regulator of energy metabolism and, therefore, a potential therapeutic target for metabolic diseases, including hepatic steatosis. We found here that LCE increased AMPK phosphorylation and Sirt1 expression. We conclude that LC inhibits SREBP-1c-mediated hepatic lipogenesis via activation of the AMPK/Sirt1 signaling pathway.

• 한국해양학회지
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• v.28 no.1
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• pp.35-46
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• 1993

To delineate water properties and current patterns in the spawning area of walleye pollock, hydrographic cast and current meter data collected in Strait, Gulf of alaska, were analysed, three water masses are identified in Shelikof Strait. A small amount of cold and dilute water ($<{\;}3^{\circ}C{\;}and{\;}<{\;}31.5\textperthousand$) originates from the lower Cook Inlet and flows southwestward close to the Alaska Peninsula coast. One branch of alaska coastal Current which enters the strait from the northeast comprises the main body of the upper and middle layers of the strait, and flows toward the southwest. Estimation of geostrophic baroclinic currents reveals that comparatively fast flow exists in the surface over the deepest portion of the strait, and most water exits through the southwestern entrance between Semidi and chirikof Is. On the other hand, a relatively slow-moving warm and saline ($>{\;}5^{circ}C{\;}and{\;}>{\;}32\textperthousand$) of the southwestern entrance flows northeasterly, and occupies the bottom layer in Shelikof Strait.

• Journal of Chest Surgery
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• v.44 no.2
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• pp.108-114
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• 2011

Background: Homograft cardiac valves and valved-conduits have been available in our institute since 1992. We sought to determine the long-term outcome after right ventricular outflow tract (RVOT) reconstruction using homografts, and risk factors for reoperation were analyzed. Materials and Methods: We retrospectively reviewed 112 patients who had undergone repair using 116 homografts between 1992 and 2008. Median age and body weight at operation were 31.2 months and 12.2 kg, respectively. The diagnoses were pulmonary atresia or stenosis with ventricular septal defect (n=93), congenital aortic valve diseases (n=15), and truncus arteriosus (N=8). Mean follow-up duration was $79.2{\pm}14.8$ months. Results: There were 10 early and 4 late deaths. Overall survival rate was 89.6%, 88.7%, 86.1% at postoperative 1 year, 5 years and 10 years, respectively. Body weight at operation, cardiopulmonary bypass (CPB) time and aortic cross-clamping (ACC) time were identified as risk factors for death. Forty-three reoperations were performed in thirty-nine patients. Freedom from reoperation was 97.0%, 77.8%, 35.0% at postoperative 1 year, 5 years and 10 years respectively. Small-sized graft was identified as a risk factor for reoperation. Conclusion: Although long-term survival after RVOT reconstruction with homografts was excellent, freedom from reoperation was unsatisfactory, especially in patients who had small grafts upon initial repair. Thus, alternative surgical strategies not using small grafts may need to be considered in this subset.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.29 no.6
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• pp.365-373
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• 2003

Tamoxifen is an selective estrogen receptor antagonist widely used in the management of patients with breast cancer for more than 30 years. It was thought to act primarily through occupying the estrogen receptor sites in ER positive breast cancer cells and directly on cancer cell proper. These inhibitory effects, which have been shown to be independent of the ER, highlight new mechanism of therapeutic action of tamoxifen. The purposes of this study were to identify ER in oral carcinoma cell lines and to evaluate ER independent cytotoxic effect of tamoxifen. KB(SCC), HSC-3(SCC) and A253(ACC) cell line were used and capacity of cell proliferation, apoptosis, in vitro invasion and gelatin zymography were tested. ER expression of each cell line were detected by RT-PCR and immunocytochemistry. Dose dependent inhibition of cell proliferation and inhibition of gelatinolytic activity were observed in all oral carcinoma cell lines and significant difference of apoptotic index were observed in A253 and KB. Tamoxifen inhibited in vitro invasion in all experimental groups. ER expression was detected in KB and A253. These data suggest that tamoxifen may play a role in management of oral carcinoma by independent cytotoxic effect and more advanced research must processed confirming ER-dependent cytotoxicity.