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Immunohistochemistry of CK7, CK19, CK20, SMA and Ki-67 Expression in Adenoid Cystic Carcinoma of the Head and Neck  

Moon, Young-Eun (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chungbuk National University)
Jeong, Woo-Jin (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chungbuk National University)
Lee, Dong-Wook (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chungbuk National University)
Song, Hyung-Geun (Department of Pathology, College of Medicine, Chungbuk National University)
Publication Information
Korean Journal of Head & Neck Oncology / v.25, no.2, 2009 , pp. 123-127 More about this Journal
Abstract
Objectives : The aim of this study was to investigate immunohistochemical expression of CK7, CK19, CK20, SMA and Ki-67 in Adenoid cystic carcinoma(ACC) of the Head and Neck. Material and Methods : Sixteen patients who were treated in Chungbuk National University Hospital from 1992 to 2004, were included in this study. Ten ACCs, 3 MECs, 1 Salivary duct carcinoma, 1 Adenocarcinoma(NOS), and 1 cacinoma ex pleomorphic adenoma were analyzed immunohistochemically for CK7, CK19, CK20, SMA, and Ki-67. Results : CK7 was expressed in 100% of the adenoid cystic carcinoma and 75% of the other tumors. CK19 was expressed in 75% of the adenoid cystic carcinoma and 100% of the other tumors. CK20 was not expressed in all tumors. SMA was expressed in 88.9% of the adenoid cystic carcinoma and not expressed in the other tumors. Ki-67 was expressed in low level in the adenoid cystic carcinoma. Conclusion : The Ki-67 index could explain the natural course of tumor. Immunohistochemistry of CK7, CK19, CK20, SMA and Ki-67 expression in Adenoid cystic carcinoma may provide useful information to diagnosis.
Keywords
Adenoid cystic carcinoma; Immunohistochemical staining; Head and neck;
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