• Journal of Acupuncture Research
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• 제20권4호
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• pp.237-244
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• 2003

Objective : Hemophilia, a genetically determined disorder, is characterized by abnormality of the coagulation mechanism due to functional deficiency of a specific factor, namely VIII or IX. In this study, the effect of Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was evaluated. Methods : We treated him with acupuncture by stimulating Dong-Si acupuncture point(Yuk Wan) and assessed the effect by using manual dynamic evaluation of MRC(Medical Research Council) and Modified Barthel Index. Results : After treatment, the bleeding tendency was grossly reduced and bleeding lesion was absorbed gradually. And manual dynamic evaluation of the upper extremity increased from 4 grade to 5 grade. Conclusions : This result suggest that Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was effective. And futher studies are required to concretely prove the effectiveness of Dong-Si acupuncture therapy for treating hemorrhagic diseases.

• Journal of Acupuncture Research
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• 제37권4호
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• pp.281-284
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• 2020

Filum terminale lipoma is an inherited lumbosacral abnormality that can cause tethered cord syndrome. This report describes an unusual case of lumbago and sciatica, pain suspected to be caused by a filum terminale lipoma where a herniated intervertebral disc had occurred. The patient was hospitalized for 43 days and received integrative Korean medicine treatment, including acupuncture, pharmacopuncture, Chuna therapy, cupping therapy, physiotherapy and herbal medicine. Treatment effectiveness was assessed using the numerical rating scale, Oswestry Disability Index, European Quality of Life 5-Dimensions, and patient symptoms. After inpatient treatment, the pain the patient suffered was significantly reduced, and the evaluation indices scores reflected this. Integrative Korean remedies may be an effective option for lower back pain and lower extremity symptoms which are caused by filum terminale lipoma where a herniated intervertebral disc has occurred. Additional clinical research is required to support this observation.

• Computers and Concrete
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• 제20권5호
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• pp.563-572
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• 2017

Ordinary reinforced concrete (RC) and prestressed concrete bridges are two popular and typical types of short- and medium-span bridges that accounts for the vast majority of all existing bridges. The cost of maintaining, repairing or replacing degraded existing RC bridges is immense. Detecting the abnormality of RC bridges at an early stage and taking the protective measures in advance are effective ways to improve maintenance practices and reduce the maintenance cost. This study proposes a systematic method from influence line (IL) identification to damage detection with applications to RC bridges. An IL identification method which integrates the cubic B-spline function with Tikhonov regularization is first proposed based on the vehicle information and the corresponding moving vehicle induced bridge response time history. Subsequently, IL change is defined as a damage index for bridge damage detection, and information fusion technique that synthesizes ILs of multiple locations/sensors is used to improve the efficiency and accuracy of damage localization. Finally, the feasibility of the proposed systematic method is verified through experimental tests on a three-span continuous RC beam. The comparison suggests that the identified ILs can well match with the baseline ILs, and it demonstrates that the proposed IL identification method has a high accuracy and a great potential in engineering applications. Results in this case indicate that deflection ILs are superior than strain ILs for damage detection of RC beams, and the performance of damage localization can be significantly improved with the information fusion of multiple ILs.

• Archives of Reconstructive Microsurgery
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• 제18권2호
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• pp.67-74
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• 2009

Purpose: The etiology and treatment strategy of the anterior interosseous nerve (AIN) syndrome are still controversial. Seven patients with the AIN syndrome who were treated by surgical exploration and neurolysis were reviewed at a mean of 35.9 months follow up period. Materials & Methods: There were six men and one woman. The mean age was 37.3 years, ranging from 26 to 59. No patient was related to trauma and associated neurological lesion. Surgical exploration was performed at 7.7 months after onset of paralysis. Results: All except one patients experienced pain around the elbow region before the onset of the palsy. On 7 patients, only the flexor pollicis longus was paralysed in 1, only the index flexor digitorum profundus in 2, and none had paralysis of the middle. The most common compression structures were fibrous bands within flexor digitorum sublimis arcade. However there was no demonstrable abnormality in three. Recovery was complete in all cases within 12 months after surgery. Conclusion: We recommended surgical exploration and neurolysis in patients who have shown no improvement after 6 months of conservative treatment. And careful preoperative examination is essential to avoid misdiagnosis and inappropriate surgery, especially in incomplete AIN syndrome.

• 대한한방부인과학회지
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• 제23권3호
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• pp.156-172
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• 2010

Purpose: In Oriental medicine, menstruation is a significant index of women's health. Especially high school girls often have various menstrual problems. We think that students who have menstrual problem have some symptoms in relation to an etiological cause. So we had carried out this study to investigate association of DSOM scores and an abnormality of menstruation in oriental medicine. Methods: First we have 2137 high school girls answer to menstrual questionnaire that we made and DSOM, next investigated the pathogenic factor of DSOM which effect dysmenorrhea and menorrhagia using regression model. Logistic regression analysis indicate as follows. Results: 1. In comparison with dysmenorrhea, Qi depression(氣滯), blood stasis(血瘀), dampness (濕), phlegm(痰) is associated positively and liver(肝) negatively. The sensitivity is 64.3%, and the specificity is 75.1%. 2. In comparison with menorrhagia, Blood deficiency(血虛), Qi depression(氣滯), blood stasis(血瘀) is associated positively and liver(肝) negatively. The sensitivity is 53.9%, and the specificity is 76.1%. Conclusion: In this study, that has been carried out to organize the diagnosis of dysmenorrhea and menorrhagia in Oriental medicine, we can see that the disease factors of them were correlated with our Medical theory.

• Animal Bioscience
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• 제35권11호
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• pp.1666-1674
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• 2022

Objective: Letrozole, a potent aromatase inhibitor, is known to have the potential to modify male reproductive function by altering sex hormone levels. This study aimed to evaluate the semen and testicular characteristics and hormonal profile of aged Mrakhoz bucks (Capra hircus) treated with letrozole. Methods: Twelve Markhoz male goats, aged between 4.5 to 5.5 years with an average body weight (BW) of 61.05±4.97 kg were used for the study. Animals were randomly divided into two equal groups and subcutaneously received either 0.25 mg/kg BW of letrozole or a control every week for 2 months. The semen collections were performed every 10 days, and blood samples and testicular biometric records were collected at 20 days intervals. Results: Letrozole causes increased testosterone and follicle-stimulating hormone levels, testosterone to estradiol ratio, semen index and reaction time during the period from 20th to 60th days (p<0.05). Furthermore, letrozole-treated bucks had higher semen volume, sperm concentration, and total sperm per ejaculate from 30th to 60th days (p<0.05). However, no differences occurred between the groups in scrotal circumference, relative testicular volume, semen pH, abnormality, acrosome integrity, and membrane integrity of sperm during the study (p>0.05). The serum luteinizing hormone levels, sperm viability, motility, and progressive motility increased, and estradiol levels decreased after 40th to 60th days of letrozole treatment (p<0.05). Conclusion: Letrozole application to aged Markhoz bucks provokes reproductive hormonal axis which, in turn, induces enhancement of semen production and quality.

• 셀메드
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• 제12권1호
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• pp.3.1-3.7
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• 2022

Background & Objectives: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine abnormality in women of reproductive age affecting from 4% - 21% of the reproductive women and is characterized by chronic anovulation and hyperandrogenism. The aim of the study was to evaluate the effect of majoon idraare haiz in menstrual regulation and morphological changes in ovaries in poly cystic ovarian syndrome. Methods: A Pilot study was carried out in the department of Ilmul qabalat wa amraze niswan, National institute of unani medicine, hospital, Bengaluru. Fifteen Patients of PCOS aged 18-35 diagnosed using Rotterdam criteria were included in the study. Patients with insulin sensitizing treatment within 3 months, hormonal treatment and those with h/o diabetes mellitus, hypertension, pregnant and lactating women were excluded.Majoon idraare haiz was administered orally at a dose of 10 g with 20 ml arqbed mushk once daily from fifth day of cycle for 21 days for three consecutive cycles. Primary outcome measure was menstrual regularity while changes in USG pelvis(normal ovarian morphology) was considered as secondary outcome measure. In addition, duration of flow and changes in basal metabolic index (BMI), modified Ferriman Gallwey (mFG) score, acanthosis nigricanswere observed. Data were analyzed using, ANOVA, paired student 't' test, fisher exact test. Results: Changes in duration of cycle, duration and amount of flow was achieved in 93.3% patients with p<0.0001 and 46.6% patients showed normal findings on pelvic ultrasonography with p=0.006. In addition, significant changes were also observed in BMI, hirsutism and acanthosis nigricans with p value of 0.0001, p=0.003 and p=0.009 respectively Conclusion: Majoonidraare haiz can be used as an effective alternative in management of PCOS patients. It has significant effect on menstrual regulation and changes in polycystic ovarian morphology to normal.

• Korean Journal of Radiology
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• 제22권6호
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• pp.890-900
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• 2021

Objective: To identify the association between morphological and functional characteristics of the bicuspid aortic valve (BAV) and bicuspid aortopathy and to identify the determinants of aortic dilatation using transthoracic echocardiography (TTE) and cardiac computed tomography (CCT). Materials and Methods: This study included 312 subjects (mean [SD] age, 52.7 [14.3] years; 227 males [72.8%]) who underwent TTE and CCT. The BAVs were classified by anterior-posterior (BAV-AP) or right-left (BAV-RL) orientation of the cusps and divided according to the presence (raphe+) or absence of a raphe (raphe-) based on the CCT and intraoperative findings. The dimensions of the sinus of Valsalva and the proximal ascending aorta were measured by CCT. We assessed the determinants of aortic root and proximal ascending aortic dilatation (size index > 2.1 cm/m²) by Univariable and multivariable logistic regression analyses. Results: Of the 312 patients, BAV-AP was present in 188 patients (60.3%), and 185 patients (59.3%) were raphe+. Moderate-to-severe aortic stenosis (AS) was the most common hemodynamic abnormality (54.8%). The most common type of aortopathy was the combined dilated root and mid-ascending aortic phenotype (62.5%). On multivariable analysis, age and AS severity were significantly associated with aortic root dilatation (p < 0.05), and age, sex, and AS severity were significantly associated with ascending aortic dilatation (p < 0.05). However, the orientation of the cusps, presence of a raphe, and severity of aortic regurgitation were not associated with aortic root and ascending aortic dilatation. Conclusion: BAV morphological characteristics were not determinants of aortic dilatation. Age, sex, and AS severity were predictors of bicuspid aortopathy. Therefore, age, sex, and AS severity, rather than valve morphology, need to be considered when planning treatment for BAV patients.

• 한국해양환경ㆍ에너지학회지
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• 제16권1호
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• pp.36-41
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• 2013

이 논문에서는 시계열의 파랑자료를 시뮬레이션 하여 파랑계측에서 sampling rate가 파랑자료의 각종 통계적 특성에 미치는 영향을 살펴보았다. 파랑자료의 Sampling rate가 freak wave와 같은 극한파의 통계특성에 미치는 영향을 파악하기 위하여, 이상(AI)지수, 파형의 첨도(kurtosis) 그리고 최대파고 등의 변화를 살펴보았다. Sampling rate가 커지면 각종 파고의 크기가 줄어드는 경향을 보인다. Sampling rate가 커지면 파랑스펙트럼의 0차 모멘트는 큰 변화가 없지만 2차 모멘트는 큰 영향을 받아서, Tz는 과대평가되고 대역폭은 과소평가된다. 따라서 sampling rate변화에 따른 유의파고 크기의 오차는 스펙트럼법에 의한 유의파고 $H_s$가 개별파법에 의한 유의파고 $H_{1/3}$ 보다 작게 나타난다. Sampling rate에 의해서 발생한 오차의 크기는 파랑의 주기가 커지면 줄어드는 경향을 보인다. 파형의 첨도와 AI지수는 sampling rate가 1 Hz 이상인 경우는 큰 오차를 주지 않는다. 일반적으로 freak wave와 같은 극한파가 포함된 파랑을 계측할 때, 1 Hz의 이상의 samping rate로 계측한 해양파의 자료를 사용한다면 sampling rate가 최대파고의 크기의 미치는 오차가 5% 이하가 될 것으로 예상된다.

• 대한치과교정학회지
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• 제27권4호
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• pp.523-538
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• 1997

서울대학교병원 치과 교정과에 내원한 6세 1개월에서 45세 8개월사이(평균 19세 6개월)의 부정교합자 205명(남 67명, 여 138명)을 대상으로 TMD 증상과 기여요인에 관한 설문조사와 Orthopantomogram, 경두개 방사선 사진(transcranial view)의 판독, 교정모형 검사 등을 시행하여 다음과 같은 결론을 얻었다. 1. Helkimo Anamnestic index는 Ai 0 $46.8\%$, Ai I $22.0\%$, Ai II $31.2\%$로 TND의 주관적 증상이 연령에 따라 증가하는 추세(p<0.001)를 보였으며 여성에서 높았다(p<0.05). 2. Orthopantomogram상 하악두의 이상소견은 flattening($4.4\%$)이 가장 많았으며 전체적으로 한가지 이상의 이상소견을 보인 경우는 $8.3\%$였다. 3. 목과 어깨의 동통(p<0.001) 이악물기, 입술을 깨무는 습관(이상 p<0.01). 두통(p<0.05)이 있는 경우 Ai가 높았다. 4. Angle II급에서 Orthopantomogram상 하악두 이상소견의 빈도가 높았고, 상악 대구치의 교모가 있을때 Ai가 높은 경향이 있었다(이상 p<0.05). 그외의 교합 요소는 TMD의 증상과 무관하였다. 5. 하악두 길이(Co'-Inc')와 하악지 길이(Co'-Go')가 짧고 하악두의 비율(Co'-Inc'/Co'-Go')이 낮을때, 그리고 좌우 하악지 길이 (Co'-Go'), 하악두 비율(Co'-Inc'/Co'-Go')이 다를때 Orthopantomogram상 하악두 이상소견이 많았다.