• 대한원격탐사학회지
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• 제35권6_4호
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• pp.1417-1424
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• 2019

최근 전지구적으로 재난재해가 빈번하게 발생하고 있으며, 재난재해는 규모가 크게 나타나고, 접근하기 어려운 특징이 있어 위성영상을 활용한 재난재해 연구는 꾸준히 진행되어 왔다. 2018년 라오스 세피안-세남노이 댐 붕괴 역시 인명 및 경제적으로 많은 피해를 발생시켰다. 본 연구에서는 세피안-세남노이 댐 붕괴로 인해 변화된 수계를 탐지하고, 이를 통해 향후 침수가 예상되는 지역을 도출해보고자 하였다. 이를 위하여, 정량적으로 수계변화를 탐지하고자 댐 붕괴 전후의 KOMPSAT-5 amplitude영상 각각으로부터 수계를 추출하여 비교해본 결과, 댐 붕괴 후 10배 이상으로 수계면적이 증가하였음을 확인하였다. 또한, 새롭게 생성된 수계는 고도가 낮은 지역으로 두껍게 생성되었음을 확인할 수 있었다. 이러한 결과는 향후, 기존 운영되는 댐의 이상징후 및 이슈 발생에 대한 사전 대응을 체계화하는 데 활용이 가능할 것이라고 생각된다.

• 대한수의학회지
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• 제40권1호
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• pp.42-48
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• 2000

Akabane disease is transmitted through mosquitoes in cattle, sheep and goats. It shows congenital abnormalities including encephalomyetitis, hydranencephaly, neurogenic arthrogryposis, and deformed neonatal calves. Akabane viruses, 93FMX and K-9 strain, were isolated from fetal matrix of aborted cow and blood of healthy cow, respectively. S gene sequences of 93FMX and K-9 showed 100% homology with that of OBE-1 strain isolated in Japan. Based upon our sequencing data, we synthesized specific primers for PCR diagnosis. Using these primers, we were able to amplify the S gene of Akabane virus not only from the culture fluid of Vero cells but also from the brain tissue of suckling mouse inoculated with, Akabane virus. These PCR products were confirmed by Southern blot hybridization. Not only the sensitivity of PCR test was high enough to detect the viruses of $10^{1.0}TCID_{50}/ml$, but also the time for diagnosis was significantly shorter than that of the virus isolation by tissue culture method. This method was also effective for the detection of Akabane virus in the cerebrum of fetus. RT-PCR method may be used for a useful diagnostic test of the clinical cases of Akabane disease.

• 대한두경부종양학회지
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• 제13권2호
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• pp.241-246
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• 1997

It has become evident in recent years that parathyroid adenoma and well differentiated thyroid cancer occur together more than would be expected by chance alone. However, the association between them is not well understood. We have experienced 4 cases of coexistent parathyroid adenoma and well-differentiated thyroid cancer during the past 16 years. None of them had a familial incidence or a history of radiation exposure. Three cases showed symptomatic hypercalcemia(including renal stones, bone pain, joint pain) and in two of them(patient 1 and patient 2), thyroid abnormalities were detected preoperatively by neck ultrasonography or neck CT for evaluation of parathyroid lesions. However, in patient 3, a parathyoid humor was identified and removed incidentally during the course of thyroidectomy. In 3 cases, surgeries for thyroid carcinoma and parathyroid adenoma were performed during the same exploration of the neck, but in patient 4, thyroidectomy preceded parathyroidectomy; The interval between thyroidectomy and subsequent parathyroidectomy was 11 yeras. The thyroid tumors in 3 cases were papillary carcinoma, the sizes of which ranged from 1.0 cm to 1.5 cm in greatest diameter. The remaining case(patient 4) was minimal invasive follicular carcinoma. Total or near-total thyroidectomy with various types of cervical lymphnode dissection and bilateral neck exploration for the parathyroid lesion was performed in 3 cases with papillary carcinoma. Ipsilateral lobectomy and contralateral partial thyroidectomy with consequent unilateral neck exploration for the parathyroid tumor was performed in the case of follicular cancer. In our experience, parathyroid adenoma and well-differentiated thyroid carcinomas can be coexistent and we felt that the attention to the hypercalcemic patients would be needed for detection of this rare condition.

• Clinical and Experimental Reproductive Medicine
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• 제38권3호
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• pp.126-134
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• 2011

Preimplantation genetic diagnosis (PGD) is gradually widely used in prevention of gene diseases and chromosomal abnormalities. Much improvement has been achieved in biopsy technique and molecular diagnosis. Blastocyst biopsy can increase diagnostic accuracy and reduce allele dropout. It is cost-effective and currently plays an important role. Whole genome amplification permits subsequent individual detection of multiple gene loci and screening all 23 pairs of chromosomes. For PGD of chromosomal translocation, fluorescence $in-situ$ hybridization (FISH) is traditionally used, but with technical difficulty. Array comparative genomic hybridization (CGH) can detect translocation and 23 pairs of chromosomes that may replace FISH. Single nucleotide polymorphisms array with haplotyping can further distinguish between normal chromosomes and balanced translocation. PGD may shorten time to conceive and reduce miscarriage for patients with chromosomal translocation. PGD has a potential value for mitochondrial diseases. Preimplantation genetic haplotyping has been applied for unknown mutation sites of single gene disease. Preimplantation genetic screening (PGS) using limited FISH probes in the cleavage-stage embryo did not increase live birth rates for patients with advanced maternal age, unexplained recurrent abortions, and repeated implantation failure. Polar body and blastocyst biopsy may circumvent the problem of mosaicism. PGS using blastocyst biopsy and array CGH is encouraging and merit further studies. Cryopreservation of biopsied blastocysts instead of fresh transfer permits sufficient time for transportation and genetic analysis. Cryopreservation of embryos may avoid ovarian hyperstimulation syndrome and possible suboptimal endometrium.

• 한국컴퓨터정보학회논문지
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• 제26권10호
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• pp.139-145
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• 2021

본 논문에서는 소의 사료 취식량(Feed Intake), 반추(Rumination), 발정기(In Heat) 모니터링 기술을 이용하여, RFI(Residual Feed Intake) 모니터링 및 신진대상 이상을 예측하는 웨어러블 디바이스 및 PC용 웹과 스마트폰 어플리케이션을 이용한 모니터링 시스템을 설계하고 구현하였다. 본 시스템의 개발로 농장주는 경제적 효율성의 증가가 기대된다. 사료 섭취량을 분석하면, 소의 체중에 근거한 추천 사료량과 소가 섭취하는 사료량과의 차이를 확인할 수 있으며, Metabolic disorder(신진대사 이상)에 대한 조기 발견이 가능할 것으로 예상된다. 본 논문의 결과물을 사용하는 농장주는 가장 효율적인 성과를 나타내는 소를 구별할 수 있으며, 소의 표피(목)에 부착하는 웨어러블 장치로부터 입력되는 6축 모션 센서 신호와 웨어러블 장치에 부착된 마이크를 통해 입력되는 소의 목넘김 소리를 통해서 소의 반추와 사료섭취량을 측정할 수 있다. 향후에는 심박, 호흡 등의 추가적인 생체신호를 측정할 수 있도록 개선 작업을 진행할 예정이다.

• Journal of Genetic Medicine
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• 제15권2호
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• pp.64-71
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• 2018

Purpose: Overgrowth syndromes are conditions that involve generalized or localized areas of excess growth. In this study, the clinical, molecular, and genetic characteristics of Korean patients with overgrowth syndrome were analyzed. Materials and Methods: We recruited 13 patients who presented with overgrowth syndrome. All patients fulfilled inclusion criteria of overgrowth syndrome. Analysis of the clinical and molecular investigations of patients with overgrowth syndrome was performed retrospectively. Results: Among the 13 patients with overgrowth syndrome, 9 patients (69.2%) were found to have molecular and genetic causes. Among the seven patients with Sotos syndrome (SS), two had a 5q35microdeletion that was confirmed by fluorescent in situ hybridization. In two patients with SS, intragenic mutations including a novel mutation, c.5993T>A (p.M1998L), were found by Sanger sequencing. One patient had one copy deletion of NDS1 gene which was confirmed by multiplex ligation-dependent probe amplification. Among five patients with Beckwith-Wiedemann syndrome, three had aberrant imprinting control regions; 2 hypermethylation of the differentially methylated region of H19, 1 hypomethylation of the differentially methylated region of Kv. In one patient displaying overlapping clinical features of SS, a de novo heterozygous deletion in the chromosomal region 7q22.1-22.3 was found by single nucleotide polymorphism-based microarray. Conclusion: Considering high detection rate of molecular and genetic abnormalities in this study, rigorous investigations of overgrowth syndrome may be an important tool for the early diagnosis and genetic counseling. A detailed molecular analysis of the rearranged regions may supply the clues for the identification of genes involved in growth regulation.

• Journal of Oral Medicine and Pain
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• 제44권3호
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• pp.103-111
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• 2019

Purpose: Patients with taste complaints presenting with various abnormal perceptions and alterations in gustatory function are often encountered in dental clinics. Since taste perception is thought to be influenced by numerous factors including neurological and psychological factors, the gustatory profiles of patients complaining of taste abnormalities should be very different. However, the gustatory profiles based on the clinical subtypes of taste complaints have not been fully studied. This study aimed to better understand the gustatory profiles depending on the clinical subtypes of taste complaints. Methods: Clinical data from 169 patients with complaints of altered taste were retrospectively collected to analyse their clinical and gustatory profiles. These complaints were subdivided into hypergeusia, hypogeusia, and dysgeusia for each taste quality according to the clinical types of these complaints. The gustatory profiles were then established by analysing the detection and recognition thresholds for each taste quality depending on the clinical subtypes of taste complaints. Results: Clinical analysis revealed that patients with taste complaints had widely diverse clinical profiles. There were significant differences between males and females with taste complaints in the prevalence rates of symptoms like dry mouth, tongue coating, and burning sensation. While hypogeusia (76.3%) was the most frequent type of taste complaint, it was revealed that the taste thresholds were not always consistent with the patient's description of gustatory symptoms. Conclusions: Patients with taste complaints exhibited diverse clinical profiles with sex differences. Considering the diversity of the taste complaints, the quantitative gustatory testing methods can be valuable to differentially evaluate the presence and intensity of altered taste in patients with these complaints.

• BLOOD RESEARCH
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• 제53권4호
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• pp.281-287
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• 2018

Background Bone marrow involvement (BMI) affects the lymphoma stage, survival, and treatment. Bone marrow biopsy (BMB) and fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) are useful techniques to detect BMI. Both have advantages and disadvantages. We aimed to identify factors that could be used to predict BMI with positive and negative results on PET/CT compare them with BMB in newly diagnosed patients with lymphoma. Methods We included 22 non-Hodgkin and 16 Hodgkin lymphoma patients in this single center study. All patients had PET/CT examination and BMB before treatment. BMI in BMB was reported as negative or positive. Bone marrow was classified into 3 types by FDG uptake on PT/CT; diffuse involvement, focal involvement, and normal bone marrow. Results PET/CT and BMB results were concordant (7 positive, 15 negative) in 22 patients (57%). We evaluated concordant and discordant patient characteristics and risk-stratified patients for BMI. Our findings suggest that patients with diffuse FDG uptake on PET/CT, especially patients with advanced age and low platelet and white blood cell counts, are likely to have BMI and could potentially forego BMB. Patients with negative PET/CT findings and no significant laboratory abnormalities are very unlikely to have BMI. Conclusion Our results suggest that BMI should not be decided solely based PET/CT or BMB findings. It is reasonable to use both diagnostic assays along with clinical and laboratory findings. PET/CT result, clinical and laboratory findings could be useful for predicting BMI in patient for whom BMB is contraindicated.

• 인터넷정보학회논문지
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• 제22권3호
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• pp.17-26
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• 2021

최근 COVID-19가 확산하고 외출 자제 권고와 같은 방역지침에 따라 집에서 생활하는 시간이 늘고 있다. 이에 따라 집에서 생활하는 1인 가구가 증가하고 있지만 1인 가구는 다인 가구보다 집 안에서 위급한 상황이 발생할 때 외부에 알리기 어렵다. 본 연구는 집안에서 발생하는 다양한 상황을 라이다, 영상, 음성 센서로 수집하고 센서에 따른 데이터를 각각의 알고리즘을 통해 분석하였다. 이를 이용해 위급상황 등의 비정상 패턴을 분석하여 사람의 이상징후를 탐지하는 연구를 진행했다. 각 센서에 따른 사람의 이상징후를 탐지하는 인공지능 알고리즘을 연구하였으며 센서에 따른 이상징후 탐지 정확도를 측정했다. 또한, 본 연구는 다양한 상황에 대한 센서의 탐지 가능 여부를 실험하여 센서 간의 장단점을 보완한 융합 방식을 제안한다.

• 한국전산구조공학회논문집
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• 제34권4호
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• pp.183-189
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• 2021

구조물에 장기적으로 발생하는 노후화를 정량적으로 파악하기 위해 상시진동 데이터를 활용한 일반화된 모니터링 시스템에 관한 연구가 세계적으로 활발히 수행중이다. 본 연구에서는 구조물에서 장기적으로 취득되는 동특성을 앙상블 학습에 활용하여 구조물의 이상을 감지하기 위한 보급형 엣지 컴퓨팅 시스템을 구축하였다. 시스템의 하드웨어는 라즈베리파이와 보급형 가속도계, 기울기센서, GPS RTK 모듈, 로라 모듈로 구성됐다. 실험실 규모의 구조물 모형 진동실험을 통해 동특성을 활용한 앙상블 학습의 구조물 이상감지를 검증하였으며, 실험을 기반으로 한 실시간 동특성 추출 분산처리 알고리즘을 라즈베리파이에 탑재하였다. 구축된 시스템을 하우징하고 포항시 행정복지센터에 설치하여 데이터를 취득함으로써 개발된 시스템의 현장 적용성을 검증하였다.