• Title/Summary/Keyword: Abnormal change

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The Ripple Effects of Climate X-Events

  • Sang-Keun Cho;Ji-Min Lee;Sang-Hyuk Park
    • International Journal of Advanced Culture Technology
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    • v.11 no.3
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    • pp.83-88
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    • 2023
  • The increasing global average temperature and the emergence of various abnormal climate phenomena are already being experienced in reality. The problems arising from climate change are expanding and becoming catastrophic, despite the efforts of various organizations to prevent them. In order to avoid climate issues from becoming black elephants, we conducted interviews with emergency planning officer from various institutions to identify potential X-events caused by climate change. The results of analyzing the anticipated X-events by these emergency planning officer revealed a chain of ripple effects associated with their occurrence. This implies that once an X-event happens, its influence is broader and more significant. Through this study, we aim to share the understanding of the ripple effects of climate X-events with many people, raising awareness of the severity of climate issues. We hope that this will serve as a starting point for more institutions, individuals, and nations to make efforts in resolving climate problems, turning X-events into opportunities rather than crises.

The Clinical study of Su-Gi therapy's Effects on Bell's palsy by observing of DITI (DITI로 관찰한 Bell's palsy에 미치는 수기요법의 영향에 관한 임상적 연구)

  • Hong, Seung Cheol;Ahn, Hun Mo;Lee, Jae Heung;Ha, Jeong-A
    • Journal of Korean Medical Ki-Gong Academy
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    • v.15 no.1
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    • pp.44-60
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    • 2015
  • Objective : The purpose of this study is to investigate the effect of Su-Gi therapy for Bell's palsy by using DITI. Methods : We investigated 16 patients with Bell's palsy who had visited in the H Korean medicine hospital in Gyeonggi Province from December 27th, 2010 to April 8th, 2015. The Su-Gi therapy was done by 1 times daily. We evaluated the change of them by using Digital Infrared Thermographic Imaging and Yanagihara's unweighted grading system. Results : There aren't meaningful differences in values for the meridian points in pretest and posttest which were observed by DITI of abnormal side and normal side. There are meaningful differences in values, for abnormal side and normal side of the meridian points in pretest and posttest of DITI. It was of significance that pretest Y and average ΔT of each the meridian points in the type of hyperthermia but not in the type of hypothermia. In the Correlation analysis of values of pretest and posttest, chaotic aspects of body heat distribution in the pretest change as a relatively consistent aspects in the posttest. It wasn't of significance that Correlation Analysis of Ups and downs in temperature of TE17 and Recovery speed observed by ΔY. In simple regression analysis of posttest's Y-system values against absolute ΔT by subtracting ΔTE17 from ΔST6, we didn't predict in the pretest, but could predict significantly in the posttest(Regression coefficient : -2.11) In the regression analysis result of the meridian points' ||pretest ΔT|-|posttest ΔT||, 陽白(GB14) and 頰車(ST6) are of significance (Total R-Square=0.447). But we couldn't obtain final regression analysis model. Conclusions: These results suggest that Su-Gi therapy may be effective for Bell's palsy.

Association between Minimal Change Esophagitis and Gastric Dysmotility: A Single-Center Electrogastrography and Endoscopy Study in Children

  • Lim, Kyung In;Shim, Sung Bo;Tchah, Hann;Ryoo, Eell
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.21 no.1
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    • pp.20-27
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    • 2018
  • Purpose: Minimal change esophagitis (MCE) is a reflux disease without mucosal breaks, known to be partially associated with abnormal gastric motor function. Electrogastrography (EGG) is commonly applied to assess gastric motor function in a noninvasive fashion. We aimed to determine the relationship between MCE and gastric myoelectrical activity (GME) recorded on EGG in children. Methods: We retrospectively assessed the records of 157 children without underlying disease who underwent both EGG and upper gastrointestinal endoscopy at Gachon University Gil Medical Center between January 2010 and June 2015. The children were stratified according to the appearance of the esophagus (normal vs. MCE). Between-group differences in EGG parameters and their correlation with each MCE finding were statistically analyzed. Results: Only the power ratio, one of the EGG parameters analyzed, differed significantly between the two groups (MCE, $1.68{\pm}3.37$ vs. normal, $0.76{\pm}1.06$; p<0.05), whereas the other parameters, such as dominant frequency, dominant power, and the ratio of abnormal rhythm, showed no differences. Among children with MCE, significant correlations were noted between erythema and power ratio (p<0.05), friability and postprandial dominant frequency (p<0.05), and edema and/or accentuation of mucosal folds and pre-prandial frequency (p<0.05). Helicobacter pylori infection correlated with postprandial arrhythmia (MCE, $33.59{\pm}15.52$ vs. normal, $28.10{\pm}17.23$; p<0.05). EGG parameters did not differ between children with normal esophagus and those with biopsy-proven chronic esophagitis. Conclusion: In children with MCE, gastric dysmotility may affect the development of MCE, manifesting as EGG abnormalities. H. pylori infection may also affect GME. However, larger prospective investigations are needed to confirm these findings.

Lysophosphatidylcholine Increases $Ca^{2+}$ Current via Activation of Protein Kinase C in Rabbit Portal Vein Smooth Muscle Cells

  • Jung, Seung-Soo;Lee, Young-Ho;Han, Sung-Sik;Kim, Young-Whan;Nam, Taik-Sang;Ahn, Duck-Sun
    • The Korean Journal of Physiology and Pharmacology
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    • v.12 no.1
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    • pp.31-35
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    • 2008
  • Lysophosphatidylcholine (LPC), a metabolite of membrane phospholipids by phospholipase $A_2$, has been considered responsible for the development of abnormal vascular reactivity during atherosclerosis. $Ca^{2+}$ influx was shown to be augmented in atherosclerotic artery which might be responsible for abnormal vascular reactivity. However, the mechanism underlying $Ca^{2+}$ influx change in atherosclerotic artery remains undetermined. The purpose of the present study was to examine the effects of LPC on L-type $Ca^{2+}$ current $(I_{Ca(L)})$ activity and to elucidate the mechanism of LPC-induced change of $I_{Ca(L)}$ in rabbit portal vein smooth muscle cells using whole cell patch clamp. Extracellular application of LPC increased $I_{Ca(L)}$ through whole test potentials, and this effect was readily reversed by washout. Steady state voltage dependency of activation or inactivation properties of $I_{Ca(L)}$ was not significantly changed by LPC. Staurosporine (100 nM) or chelerythrine $(3{\mu}M)$, which is a potent inhibitor of PKC, significantly decreased basal $I_{Ca(L)}$, and LPC-induced increase of $I_{Ca(L)}$ was significantly suppressed in the presence of PKC inhibitors. On the other hand, application of PMA, an activator of PKC, increased basal $I_{Ca(L)}$ significantly, and LPC-induced enhancement of $I_{Ca(L)}$ was abolished by pretreatment of the cells with PMA. These findings suggest that LPC increased $I_{Ca(L)}$ in vascular smooth muscle cells by a pathway that involves PKC, and that LPC-induced increase of $I_{Ca(L)}$ might be, at least in part, responsible for increased $Ca^{2+}$ influx in atherosclerotic artery.

The Value of I-Scan Image-Enhanced Endoscopy in the Diagnosis of Vocal Cord Leukoplakia

  • Lee, Young Chan;Eun, Young-Gyu;Park, Il-Seok
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.29 no.2
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    • pp.98-102
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    • 2018
  • Background and Objectives : Detection of vascular abnormalities in vocal cord (VC) leukoplakia is important for the diagnosis of neoplastic change of the mucosa. The aim of this study was to investigate the value of i-scan in the differential diagnosis of VC leukoplakia based on visualization of abnormal vascular features. Material and Methods : Fifty-two patients with leukoplakia were enrolled in the study. Images of their larynx obtained using conventional white light endoscopy and an i-scan-enhanced endoscopy (Pentax DEFINA EPK-3000 Video Processors, with Pentax VNLJ10) were reviewed. The microvascular features of the lesions and vascular changes were analyzed and the results were compared with the histopathologic diagnosis. Results : Among the 52 leukoplakia patients, 7 (13.5%) patients had squamous hyperplasia, 10 (19.3%) mild dysplasia, 2 (3.8%) moderate dysplasia, 14 (26.9%) severe dysplasia, 4 (7.7%) carcinoma in situ, and 15 (28.8%) invasive squamous cell carcinoma on histopathologic examination. Using i-scan-enhanced endoscopy, abnormal vascular change with neoplastic neoangiogenesis was detected in most cases of malignant VC lesion [severe dysplasia : 9/14 (64.3%), carcinoma in situ: 2/4 (50.0%), and invasive squamous cell carcinoma : 11/15 (73.4%)]. Conclusion : i-scan-enhanced endoscopy is a useful optical technique for the diagnosis of VC leukoplakia. Our results suggest that i-scan may be a promising diagnostic tool in the early detection of laryngeal cancer.

The influence of sea surface temperature for vertical extreme wind shear change and its relation to the atmospheric stability at coastal area

  • Geonhwa Ryu;Young-Gon Kim;Dongjin Kim;Sang-Man Kim;Min Je Kim;Wonbae Jeon;Chae-Joo Moon
    • Wind and Structures
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    • v.36 no.3
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    • pp.201-213
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    • 2023
  • In this study, the effect of sea surface temperature (SST) on the distribution of vertical wind speed in the atmospheric boundary layer of coastal areas was analyzed. In general, coastal areas are known to be more susceptible to various meteorological factors than inland areas due to interannual changes in sea surface temperature. Therefore, the purpose of this study is to analyze the relationship between sea surface temperature (ERA5) and wind resource data based on the meteorological mast of Høvsøre, the test bed area of the onshore wind farm in the coastal area of Denmark. In addition, the possibility of coastal disasters caused by abnormal vertical wind shear due to changes in sea surface temperature was also analyzed. According to the analysis of the correlation between the wind resource data at met mast and the sea surface temperature by ERA5, the wind speed from the sea and the vertical wind shear are stronger than from the inland, and are vulnerable to seasonal sea surface temperature fluctuations. In particular, the abnormal vertical wind shear, in which only the lower wind speed was strengthened and appeared in the form of a nose, mainly appeared in winter when the atmosphere was near-neutral or stable, and all occurred when the wind blows from the sea. This phenomenon usually occurred when there was a sudden change in sea surface temperature within a short period of time.

Firm's Market Value Trends after Information Security Management System(ISMS) Certification acquisition (정보보호 관리체계 인증 취득 후 기업가치의 변화에 관한 연구)

  • Jo, Jung-Gi;Choi, Sang-Hyun
    • Journal of the Korea Convergence Society
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    • v.7 no.6
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    • pp.237-247
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    • 2016
  • This study analyzed quantitative effects of ISMS certification. To measure the company value change the stock data was used and the methodology of event study was also applied. Event study methodology is a method of analyzing the effects of information or public announcement about certain events on the stock market through abnormal return of stock price. First, ISMS certification was acquired followed by the measurement of abnormal excess return of company. Based on the increase or decrease of abnormal excess return, the group was classified. There are 3 types of groups("Increase", "Reduce", "Maintain"). Next, the cluster analysis was performed for each group. Cluster analysis or clustering is the task of grouping a set of objects in such a way that objects in the same group (called a cluster) are more similar (in some sense or another) to each other than to those in other groups(clusters). The purpose of this study is to have a quantitative measurement of performance of ISMS certification. So, the result of this study will be promoted a company's ISMS certification acquisition. And it would further be beneficial to your company's information security activities.

Rank Correlation Coefficient of Energy Data for Identification of Abnormal Sensors in Buildings (에너지 데이터의 순위상관계수 기반 건물 내 오작동 기기 탐지)

  • Kim, Naeon;Jeong, Sihyun;Jang, Boyeon;Kim, Chong-Kwon
    • Journal of KIISE
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    • v.44 no.4
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    • pp.417-422
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    • 2017
  • Anomaly detection is the identification of data that do not conform to a normal pattern or behavior model in a dataset. It can be utilized for detecting errors among data generated by devices or user behavior change in a social network data set. In this study, we proposed a new approach using rank correlation coefficient to efficiently detect abnormal data in devices of a building. With the increased push for energy conservation, many energy efficiency solutions have been proposed over the years. HVAC (Heating, Ventilating and Air Conditioning) system monitors and manages thousands of sensors such as thermostats, air conditioners, and lighting in large buildings. Currently, operators use the building's HVAC system for controlling efficient energy consumption. By using the proposed approach, it is possible to observe changes of ranking relationship between the devices in HVAC system and identify abnormal behavior in social network.

Endometrial Curettage in Abnormal Uterine Bleeding and Efficacy of Progestins for Control in Cases of Hyperplasia

  • Mesci-Haftaci, Simender;Ankarali, Handan;Yavuzcan, Ali;Caglar, Mete
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.8
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    • pp.3737-3740
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    • 2014
  • Background: Abnormal uterine bleeding (AUB) is the most important symptom of endometrial hyperplasia and endometrial curettage (EC) is the gold standard diagnostic procedure. We present the results of patients who underwent EC for AUB and the efficacy of progestin administration in those with endometrial hyperplasia. Materials and Methods: A total of 415 female patients who presented to Duzce Public Hospital in 2011-2012 for AUB and who underwent EC were included. We determined the reasons for AUB, and females with hyperplasia were treated with 10 mg/day medroxyprogesterone acetate for 14 days/month or 160 mg/day megestrol acetate continuously for 3 months. We evaluated the efficacy of progestins for periods of three and/or six cycles by repeating EC. A statistical analysis of specific endometrial causes according to age of presentation was conducted using the chi-square test. Results: Among the 415 females (average age, 53.5 years) followed for 6 months, 186 had physiological changes (44.8%), 89 had simple hyperplasia (21.44%), 1 had atypical hyperplasia (0.2%), 6 had (1.44%) complex hyperplasia, 3 had (0.72%) atypical complex hyperplasia, and 5 had adenocarcinoma (1.2%). Regression rates were 72.7-100%, and the optimum results were observed after 6 months of hormonal therapy. Conclusions: The main cause of AUB was physiological change. Progestin therapy resulted in significant regression even in females with atypical hyperplasia.

Clinical Review about Dysphagia associated with Acute Ischemic Stroke (급성 허혈성 뇌졸중에 수반된 연하장애에 관한 임상적 고찰)

  • 한명아;김동웅
    • The Journal of Korean Medicine
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    • v.22 no.3
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    • pp.42-50
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    • 2001
  • Objectives : Dysphagia is common and severe problems of acute stroke determining the prognosis of stroke only second to mental change, and results in secondary fatal complications such as aspiration pneumonia, malnutrition, dehydration, etc. Therefore, we were to investigate the clinical characteristics of dysphagia accompanied by acute ischemic stroke. Methods : We selected subjects through clinical notes retrospectively, whose main problems included dysphagia resulted from acute stroke within 72 hours from onset who were admitted to the Internal Medicine Department of Wonkwang Oriental Medicine Hospital from Jan. 2000 to Apr. 2001. We assessed the severity of dysphagia from admission to discharge using a staging method : stage 0 is normal without dysphagia, stage 1 is nearly normal except for intermittent dysphagia, stage 2 is compensated abnormal swallowing requiring adjusted diets or delayed feeding time, stage 3 is uncompensated abnormal swallowing resulted in weight loss down to 10% of initial and daily aspiration, coughing, and vomiting, stage 4 is uncompensated abnormal swallowing resulting in weight loss beyond 10% and recommended for non-oral feeding, and stage 5 is 100% non-oral feeding by L-tube, or gastrostomy or NPO state. Results : Dysphagia was improved statistically significantly from the mean stage of $3.6{\pm}0.29$ on admission to $1.88{\pm}0.32$ on discharge (P<0.05). On average $7.1{\pm}1.48$ days were required for improving more than one stage level. As patients were older and the stage of dysphagia was worse on admission, severity of dysphagia was more difficult to improve (correlation coefficiency was 0.55 and 0.77 respectively, P<0.05). Aspiration pneumonia was complicated in 13 patients of the total 25 at mean dysphagia stage of $3.36{\pm}0.37$. However, any specific values such as lesion size, lesion site, sex, age, past history and NIH Stroke Scale on admission did not affect it (P>0.05). Conclusion : Clinical course of dysphagia was determined about I week from the onset. Aspiration pneumonia was mainly complicated during oral feeding periods. If there were no improvement of dysphagia over 2-3 weeks, then non-oral feeding such as Levin tube or gastrostomy must be considered.

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