Browse > Article

The Value of I-Scan Image-Enhanced Endoscopy in the Diagnosis of Vocal Cord Leukoplakia  

Lee, Young Chan (Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University)
Eun, Young-Gyu (Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University)
Park, Il-Seok (Department of Otorhinolaryngology-Head and Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine)
Publication Information
Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics / v.29, no.2, 2018 , pp. 98-102 More about this Journal
Abstract
Background and Objectives : Detection of vascular abnormalities in vocal cord (VC) leukoplakia is important for the diagnosis of neoplastic change of the mucosa. The aim of this study was to investigate the value of i-scan in the differential diagnosis of VC leukoplakia based on visualization of abnormal vascular features. Material and Methods : Fifty-two patients with leukoplakia were enrolled in the study. Images of their larynx obtained using conventional white light endoscopy and an i-scan-enhanced endoscopy (Pentax DEFINA EPK-3000 Video Processors, with Pentax VNLJ10) were reviewed. The microvascular features of the lesions and vascular changes were analyzed and the results were compared with the histopathologic diagnosis. Results : Among the 52 leukoplakia patients, 7 (13.5%) patients had squamous hyperplasia, 10 (19.3%) mild dysplasia, 2 (3.8%) moderate dysplasia, 14 (26.9%) severe dysplasia, 4 (7.7%) carcinoma in situ, and 15 (28.8%) invasive squamous cell carcinoma on histopathologic examination. Using i-scan-enhanced endoscopy, abnormal vascular change with neoplastic neoangiogenesis was detected in most cases of malignant VC lesion [severe dysplasia : 9/14 (64.3%), carcinoma in situ: 2/4 (50.0%), and invasive squamous cell carcinoma : 11/15 (73.4%)]. Conclusion : i-scan-enhanced endoscopy is a useful optical technique for the diagnosis of VC leukoplakia. Our results suggest that i-scan may be a promising diagnostic tool in the early detection of laryngeal cancer.
Keywords
Leukoplakia; Vocal cord; Carcinoma; Endoscopy;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Frangez I, Gale N, Luzar B. The interpretation of leukoplakia in laryngeal pathology. Acta Oto-Laryngologica 1997;117(sup527):142-4.   DOI
2 Isenberg JS, Crozier DL, Dailey SH. Institutional and comprehensive review of laryngeal leukoplakia. Annals of Otology, Rhinology & Laryngology 2008;117(1):74-9.   DOI
3 Arens C, Piazza C, Andrea M, Dikkers FG, Gi RETP, Voigt-Zimmermann S, et al. Proposal for a descriptive guideline of vascular changes in lesions of the vocal folds by the committee on endoscopic laryngeal imaging of the European Laryngological Society. European Archives of Oto-Rhino-Laryngology 2016;273(5):1207-14.   DOI
4 Ni X, He S, Xu Z, Gao L, Lu N, Yuan Z, et al. Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging. The Journal of Laryngology & Otology 2011;125(3):288-96.   DOI
5 Kodashima S, Fujishiro M. Novel image-enhanced endoscopy with i-scan technology. World Journal of Gastroenterology: WJG 2010;16(9):1043-9.   DOI
6 Iacucci M, Poon T, Gui XS, Ghosh S. High definition i-SCAN endoscopy with water immersion technique accurately reflects histological severity of celiac disease. Endoscopy International Open 2016;4(5):E540.   DOI
7 Graham DG, Banks MR. Advances in upper gastrointestinal endoscopy. F1000Research 2015;4.
8 Barnes L, Eveson JW, Reichart P, Sidransky D. Pathology and genetics of head and neck tumours: IARC;2005.
9 Korean Society of Thyroid-Head and Neck Surgery Guideline Task Force, Ahn SH, Hong HJ, Kwon SY, Kwon KH, Roh JL, et al. Guidelines for the surgical management of laryngeal cancer: Korean Society of Thyroid-Head and Neck Surgery. Clin Exp Otorhinolaryngol 2017;10(1):1-43.   DOI
10 Stevens SM, Johnson EA, Pfau PR, Dailey SH. Visual evaluation of the larynx and hypopharynx during esophagogastroduodenoscopy: a safety and feasibility study. Surgical endoscopy 2015;29(5):1209-15.   DOI
11 Kuznetsov K, Lambert R, Rey J-F. Narrow-band imaging: potential and limitations. Endoscopy 2006;38(01):76-81.   DOI
12 Yao K, Anagnostopoulos G, Ragunath K. Magnifying endoscopy for diagnosing and delineating early gastric cancer. Endoscopy 2009;41(05):462-7.   DOI
13 Huang F, Yu J, Zhang F, He C, Li S, Shao J. The usefulness of narrow-band imaging for the diagnosis and treatment of vocal fold leukoplakia. Acta Oto-Laryngologica 2017;137(9):1002-6.   DOI
14 Hoffman A, Sar F, Goetz M, Tresch A, Mudter J, Biesterfeld S, et al. High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a prospective randomized controlled trial. Endoscopy 2010;42(10):827-33.   DOI
15 van der Heijden EH, Hoefsloot W, van Hees HW, Schuurbiers OC. High definition bronchoscopy: a randomized exploratory study of diagnostic value compared to standard white light bronchoscopy and autofluorescence bronchoscopy. Respiratory Research 2015;16(1):33.   DOI