• 한국임상수의학회지
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• 제35권1호
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• pp.26-29
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• 2018

A 6-month-old, female poodle presented with a three-month history of persistent regurgitation immediately after eating. On physical examination, the patient was emaciated and dehydrated. Thoracic radiography showed ventral displacement of the trachea and increased radiopacity in the mediastinum, cranial to the heart base. A severely dilated esophagus was identified cranial to the heart on esophagram. Computed tomography (CT) revealed the esophagus was filled with gas, fluid and a little of contrast and dilated from caudo-cervical to cranio-thoracic part. The esophageal diameter was markedly decreased at the heart base. In addition, the trachea was displaced to the left-ventral side of the right aortic trunk and an aberrant left subclavian artery originating from the aorta was identified. There was no evidence of abdominal vascular anomaly. Based on diagnostic imaging, persistent right aortic arch (PRAA) with an aberrant left subclavian artery was diagnosed. The patient did not undergo surgery and died at 15 days after diagnosis. This report describes imaging diagnosis, including CT and radiography in a weaned dog with regurgitation due to esophageal obstruction by PRAA. When PRAA is suspected and conventional radiography or contrast study is insufficient for diagnosis, CT may be helpful for diagnosing PRAA.

• Journal of Chest Surgery
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• 제43권4호
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• pp.458-461
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• 2010

53세 된 여자 환자가 우측 대동맥 궁, Kommerell 게실 및 비정상 좌측 쇄골하동맥 등의 병변으로 내원하였으며 증상은 없었다. 6 mm ringed Gore-Tex 인조혈관을 이용하여 비정상 좌측 쇄골하동맥과 좌측 총경동맥을 연결하여 우회하고, 대동맥 궁의 Kommerell 게실을 막고자 stent graft를 삽입하는 hybrid 수술을 시행 하였다. 수술 직후 시행한 혈관 조영술과 수술 후 첫날 시행한 전산화 단층 촬영상 성공적인 대동맥류 차단 및 좌측 쇄골하동맥의 우회소견을 보여주었다. 수술 및 시술에 동반된 합병증은 없었다.

• Molecules and Cells
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• 제44권11호
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• pp.805-829
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• 2021

CCCTC-binding factor (CTCF) critically contributes to 3D chromatin organization by determining topologically associated domain (TAD) borders. Although CTCF primarily binds at TAD borders, there also exist putative CTCF-binding sites within TADs, which are spread throughout the genome by retrotransposition. However, the detailed mechanism responsible for masking the putative CTCF-binding sites remains largely elusive. Here, we show that the ATP-dependent chromatin remodeler, chromodomain helicase DNA-binding 4 (CHD4), regulates chromatin accessibility to conceal aberrant CTCF-binding sites embedded in H3K9me3-enriched heterochromatic B2 short interspersed nuclear elements (SINEs) in mouse embryonic stem cells (mESCs). Upon CHD4 depletion, these aberrant CTCF-binding sites become accessible and aberrant CTCF recruitment occurs within TADs, resulting in disorganization of local TADs. RNA-binding intrinsically disordered domains (IDRs) of CHD4 are required to prevent this aberrant CTCF binding, and CHD4 is critical for the repression of B2 SINE transcripts. These results collectively reveal that a CHD4-mediated mechanism ensures appropriate CTCF binding and associated TAD organization in mESCs.

• Journal of Chest Surgery
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• 제6권2호
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• pp.159-164
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• 1973

Bronchopulmonary sequestration is a congenital malformation characterized by a cystic portion of the lung that derives its arterial blood supply through anomalous aberrant vessel directly of the systemic circulation. An aberrant systemic vessel supplying the lung was reported by Huber in 1777. Although this lesion is uncommon disorder, there are several reports on operative death caused by exanguinating hemorrhage from the aberrant arteries to the bronchopulmonary sequestration to that it has received a great deal of attention. Two type of bronchopulmonary sequestration have been identified: Intralobar pulmonary sequestration is usually contained within the visceral pleura of a pulmonary lobe and its venous drainage to the pulmonary venous system. Extrapulmonary sequestration is usually within the pleural sheath its own and its vasculature drains into the azygos or hemiazygos system. we presented one case of intralobar pulmonary sequestration which led to motor paralysis, chylothorax and hemorrhage that are consequent on postoperative complication.

• Journal of Chest Surgery
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• 제18권3호
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• pp.482-486
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• 1985

Pulmonary sequestration is an uncommon congenital malformation characterized by the presence of non-functioning lung tissues which receives its blood supply from an anomalous systemic artery instead of a pulmonary arterial branch. We present a case of intralobar pulmonary sequestration experienced lately. The patient was 7 years old girl with the complaints of chronic productive cough and right lower chest pain. Serial chest films showed a large cyst with or without a air-fluid level on the right lower lung field. Aortography revealed an aberrant artery originating from thoracic aorta just above the diaphragm and that drained into the right inferior pulmonary vein. During operation, a large abscess cavity measuring 6.5x5x5 cm in dimension at the right lower lobe was noted. And the two aberrant arteries, measuring 3 mm in diameter, arising from thoracic aorta 5 cm above the diaphragm was noted. After division and ligation of the aberrant arteries, right lower lobectomy was performed and the patient`s postoperative course was uneventful.

• Journal of Chest Surgery
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• 제23권2호
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• pp.357-361
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• 1990

The pulmonary sequestration is rare congenital pulmonary disease with nonfunctioning lung tissue supplied by aberrant arteries arising from systemic arteries-thoracic aorta, subclavian artery, innominate artery, internal mammary artery, etc. In our country, only 23 cases were reported previously and the majority was intralobar pulmonary sequestration except 2 cases. The patient was 17 year-old man and admitted due to intermittent cough, productive sputum and fever for 8 years. On simple chest P \ulcornerA view, multiple cysts with air-fluid levels were located at left lower lobe area. Aortogram revealed two aberrant arteries arising from thoracic aorta just above the diaphragm. On the operative field, the arteries were 0.7 and 0.3 cm in diameter. Left lower lobectomy was done with ligation of aberrant arteries. The patient was recovered and discharged uneventfully.

• Journal of Korean Neurosurgical Society
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• 제48권4호
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• pp.367-370
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• 2010

We present a case of posterior atlantoaxial screw-rod fixation in a patient with an aberrant vertebral artery (VA) course combined with bilateral high-riding VA. An aberrant VA which courses below the posterior arch of the atlas (C1) that does not pass through the C1 transverse foramen and without an osseous anomaly is rare. However, it is important to consider an abnormal course of the VA both preoperatively and intraoperatively in order to avoid critical vascular injuries in procedures which require exposure or control of the VA, such as the far-lateral approach and spinal operations.

• BMB Reports
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• 제42권8호
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• pp.467-474
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• 2009

The modification of proteins by reversible phosphorylation is a key mechanism in the regulation of various physiological functions. Abnormal protein kinase or phosphatase activity can cause disease by altering the phosphorylation of critical proteins in normal cellular and disease processes. Alzheimer' disease (AD), typically occurring in the elderly, is an irreversible, progressive brain disorder characterized by memory loss and cognitive decline. Accumulating evidence suggests that protein kinase and phosphatase activity are altered in the brain tissue of AD patients. Tau is a highly recognized phosphoprotein that undergoes hyperphosphorylation to form neurofibrillary tangles, a neuropathlogical hallmark with amyloid plaques in AD brains. This study is a brief overview of the altered protein phosphorylation pathways found in AD. Understanding the molecular mechanisms by which the activities of protein kinases and phosphatases are altered as well as the phosphorylation events in AD can potentially reveal novel insights into the role aberrant phosphorylation plays in the pathogenesis of AD, providing support for protein phosphorylation as a potential treatment strategy for AD.

• Journal of Chest Surgery
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• 제18권4호
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• pp.780-784
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• 1985

A sequestrated Mass of ectopic non functioning pulmonary Tissue artery is an uncommon but clinically recognizable Entity. Pulmonary sequestrated, in general usage, designates an intralobar process intralobar pulmonary sequestration is a rare congenital malformation characterized by a cystic portion of the lung that derive its arterial blood supply through aberrant vessel directly of systemic circulation. As aberrant systemic vessel supplying the lung was reported by Hurber in 1777. We experienced a case of Intralobar pulmonary sequestration Pre-Operatively, confirm by Aortogram. The operative finding show that large Abscess cavity measuring 7x8 Well circumscribed, child fist sized Mass, and 4cm-length aberrant vessel arising from Descending aorta Just above the Diaphragm. The Anomalous systemic artery was ligatures & resection, and associated with left lower lobectomy was done. Post-Operative course was uneventful, and 7 days later discharged.

• Journal of Chest Surgery
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• 제27권11호
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• pp.961-964
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• 1994

The pulmonary sequestration is an uncommon congenital anomaly characterized by the presence of nonfunctioning lung tissue supplied by aberrant artery from the aorta or its branches and usually has no communication with the normal bronchial tree. The patient was 35 year old female and had no specific complaints. The lung mass was found incidentally and was continned to be intralobar pulmonary sequestration by aotography whitch showed aberrant blood supply from thoracic aorta at the T. vertebra level. The right lower lobectomy was done.