• 대한한의학방제학회지
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• 제17권1호
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• pp.99-111
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• 2009

Rheumatoid arthritis is characterized by focal loss of cartilage due to an up-regulation of inflammatory pathways, which produce pro-inflammatory mediators, such as interleukin-1(IL-1), tumour necrosis factor alpha($TNF-\alpha$), prostaglantin, and nitric oxide(NO). We investigated the anti-arthritic effects of water extracts from Pellodendri cortex and Atractylodis rhizoma in vitro and in vivo. Each extract suppressed the production of inflammatory mediators(NO, $IL-1\beta$, $TNF-\alpha$, and prostaglandin $E_2$) and the expression of inducible NO synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated macrophages in a dose-dependent manner. These suppressive effects were synergistically increased by their combination. The same results were also observed in the rat osteoblast sarcoma cell line ROS17/2.8 stimulated with $IL-1\beta$, $IFN-\gamma,$ and $TNF-\alpha$. Moreover, the combination of these water extracts significantly suppressed collagen-induced mouse arthritis. These results suggest that the combination of water-extractable components of Pellodendri cortex and Atractylodis rhizoma may be useful for therapeutic drugs against rheumatoid arthritis, probably by suppressing the production of inflammatory mediators.

• Biomolecules & Therapeutics
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• 제15권4호
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• pp.235-239
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• 2007

In order to evaluate the improvement effects of head of Panax ginseng on chronic arthritis, we have investigated the activity of butanol fraction (BuOH fraction) in vitro and in vivo system. BuOH fraction showed significant inhibition on the elastase activity. Anti-arthritic activity of BuOH fraction was also examined on type II collagen-induced arthritis in DBA/1J mice. Mice were immunized with injection of type II collagen emulsified in Freund's complete adjuvant, followed by a booster injection 21 days later. BuOH fraction(BHPG) was administered at an oral dose of 500mg/kg for 2 weeks from the 1st day boost. The hind paw edema was significantly decreased in the group of treatment with BuOH fraction compared to control. In collagen-induced DBA/1J mice, BuOH fraction did not affected the collagen antibody titer but significantly inhibited the tumor necrosis factoralpha(TNF-${\alpha}$) activity. These results were confirmed with histological evaluation of joint tissues. This study may raise the possibility that the usage of BuOH fraction of head of Panax ginseng as alternative medicine for the relief and prevention of rheumatoid arthritis symptoms.

• 기본간호학회지
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• 제8권2호
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• pp.189-198
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• 2001

The purpose of this study was done to identify the relationship between the level of pain and depression in patients with rheumatoid arthritis. The subjects for this study were 222 patients registered in H University Hospital Rheumatoid Arthritis Center, and the period of data collection was from July 20, 2000 to August 30, 2000. The research instruments used in this study were the Graphic Rating Scale of Pain and the CES-D for depression. The cronbach's ${\alpha}$ of the CBS-D scale was .89. Data analysis, was done by the SPSSWIN 10.0 program using descriptive statistics. The results are as follows. 1) The total pain score ranged from 0 to 147 with a mean score for pain in patients with rheumatoid arthritis of 72.64. 2) The total depression score ranged from 20 to 72 with a mean score of 39.86. 3) There was a significant difference in pain according to sex(F=5.26, p<.05) and education level (F = 3.59, p<.05). 4) There was a significant difference in depression scores according to sex (F=7 76, p<.05) and education level (F=3.02, p<.05). 5) The level of pain had a significant correlation with the level of education level(r=-.174, p<.01). The level of depression was significant correlation with the level of pain (r=.237. p<.01).

• 한국치위생학회지
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• 제16권6호
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• pp.1105-1114
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• 2016

Objectives: The purpose of this study was to examine the scaling experience and related factors of people diagnosed with rheumatoid arthritis. Methods: The subjects were 30,680 people diagnosed with rheumatoid arthritis from the 2014 community health survey who were $${\geq_-}19$$ years old. Data were analyzed by chi-square test and multiple logistic regression analysis. Results: Those having regular scaling included well educated people, drinkers, more than three times tooth brushing practice, and regular dental checkup. The respondents were in the higher quartile of income And the respondents who were in the higher quartile of income were less likely to have scaling experience (p<0.05). Conclusions: The scaling experience was closely related with the age, educational level, residential area, income, drinking, tooth brushing practice, and regular dental checkup. It is necessary to investigate the influencing factors of rheumatoid arthritis and periodontal diseases in the further studies.

• 대한한방내과학회지
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• 제27권4호
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• pp.975-983
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• 2006

Degenerative arthritis is characterized by progressive degenerative change, particularly change occurring to the joint due to the burden of body weight. Arthritis means inflammation occurring to the joint: it causes pain and limits exercise involving movement of the joint. Edema is not a disease but a condition which is accompanied by progression of a certain disease. Degenerative arthritis patients also have various diseases and mostly brings edema. Even though the cause is known to be abrasion of the joints, there are many cases in which walking difficulties are caused by pressure and pain due to edema. We found patients with walking difficulties caused by pain and increase of pressure in the joints walk better after treatment of both the pain and edema.

• The Journal of Korean Physical Therapy
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• 제19권1호
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• pp.45-55
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• 2007

Purpose: This study was conducted to investigate the effects of kinesiotaping on the muscle activities in patients with degenerative arthritis. To evaluate the effects of taping therapy, we calculated activation of vastus medialis and vastus lateralis. Methods: 40 female patients with degenerative arthritis of knee joint were participated in this study. Muscle activation were assessed by using a surface EMG. This procedure was performed with and without taping. Results: The activation of vastus lateralis was significantly increased in comparison between pre and post test. And vastus medialis was significantly increased in comparison between pre and post test. Conclusion: We thought that kinesio taping have effectiveness on the muscle activation of vastus lateralis and vastus medialis in patients with degenerative arthritis.

• 동의생리병리학회지
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• 제28권6호
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• pp.643-649
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• 2014

This study was designed to report treatment for Behcet's disease with arthritis We treated 2 Behcet's disease patients with arthritis. A 46-year-old female patient was treated with Cheongsimyeonja-tang. Another case, 44-year-old female patient was diagnosed as Sjogren's disease at first and diagnosed as The Behcet's diseases about 1 year later, treated with Cheonglijagam-tang. The progress was evaluated with the visual analogue scale for joint pain and hot flush, and length of sleeping time. There was improvement in the symptoms of visual analogue scale for joint pain and hot flush, also length of sleeping time. Cheongsimyeonja-tang, Cheonglijagam-tang can be considered as a treatment for patient diagnosed as Behcet's disease suffering from arthritis, especially.

• 한국동물위생학회지
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• 제40권3호
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• pp.161-168
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• 2017

Caprine arthritis encephalitis (CAE) virus is a causative agent of caprine arthritis-encephalitis. In our previous study we reported a prevalence of CAE. In this study, we described the further detailed pathological features of CAE and examined the detection of virus by in situ hybridization (ISH). Histopathologically, interstitial pneumonia and bronchopneumonia in lung, focal inflammation in mammary glands, perivascular cuffing in brain, arthritis, and focal necrosis, mild steatosis, inflammatory cell infiltration of liver were noted. CAEV proviral-DNA was identified by nested polymerase chain reaction (PCR) in blood cells, brain, synovial fluid, and lymph node. Confirmation by nested PCR involved amplification of a 296 bp ($1^{st}$ PCR) and 185 bp ($2^{nd}$ PCR) fragments corresponding to a conserved region on the gag gene of CAEV. Positive ISH signals were detected in the brain and liver. In conclusion, significant histopathological findings included parenchymal infection in various organs, including the lung, liver, brain, joint, and mammary gland were noted in the CAEV infected dairy goat. ISH can help confirm the diagnosis of CAE in formalin-fixed samples.

• 대한한의학방제학회지
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• 제18권2호
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• pp.183-199
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• 2010

Rheumatoid arthritis is characterized by the focal loss of cartilage due to an up-regulation of inflammatory pathways, which produce inflammatory mediators, such as interleukin-1beta(IL-$1{\beta}$), IL-6, tumour necrosis factor alpha(TNF-$\alpha$), prostaglandin, and nitric oxide(NO). We investigated the anti-arthritic effects of water extract from FLOS LONICERAE(FLWE) in vitro and in vivo. Extract inhibited the production of inflammatory mediators(NO, IL-$1{\beta}$, TNF-$\alpha$, and prostaglandin $E_2$) and the expression of inducible NO synthase(iNOS) and cyclooxygenase-2(COX-2) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in a dose-dependent manner. FLWE also inhibited TNF-$\alpha$, IL-$1{\beta}$, IL-6, and $PGE_2$ production as well as COX activity in collagen-induced mouse arthritis. Moreover, FLWE significantly suppressed collagen-induced mouse arthritis. These results suggest that FLOS LONICERAE may be useful for therapy against inflammatory immune diseases and rheumatoid arthritis, probably by suppressing the production of inflammatory mediators.

• 지역사회간호학회지
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• 제20권1호
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• pp.87-95
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• 2009

Purpose: The purpose of this study was to examine the effects of aquatic exercise on pain, fatigue, physical fitness, disability in ADL, and psychological variables in women with arthritis. Methods: With a quasi-experimental design, 46 women who has arthritis were assigned into an experimental group (n=23), or a control group (n=23). Data were analyzed with SPSS/WIN using descriptive statistics, t-test and ANCOVA. Results: The mean age of the subjects was 60.9 years in the experimental group and 59.8 years in the control group. The pretest scores of the outcome variables were similar between the two groups except fatigue and waist flexibility. After controlling fatigue and waist flexibility, the experimental group showed more improvement than the control group in Rt shoulder flexibility score (F=4.36, p=.04), sit-up score (F=32.34, p=.00), and muscle strength score (F=30.78, p=.00). The score of disability in ADL decreased in the experimental group (F=5.49, p=.02). The depression score decreased in the experimental group (F=12.01, p=.00), and self-efficacy was improved more than the other variables(F=8.88, p=.00). Conclusion: Aquatic exercise is likely to be an effective nursing intervention to improve physical fitness, to reduce pain, fatigue, and disability in ADL, and to enhance psychological functions in women with arthritis.