• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.9 no.2
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• pp.69-79
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• 2014

Objectives : The purpose of this review is to investigate the trends of Traditional Korean Medicine treatments on degenerative knee arthritis. Methods : We investigated the studies on traditional Traditional Korean Medicine (TKM) treatments for degenerative knee arthritis via searching 5 Korean web databases. Results : 31 research papers were found to be analyzed according to their published year, the titles of journals, published institution, the types of study, the number of cases, the types of treatments. 31 papers were published since 1992. The studies on TKM treatments about degenerative knee arthritis were mainly published in The journal of korean acupuncture & moxibustion medicine. 13 Randomized Controlled Trials, 10 Case series, 4 Reviews, 3 Non RCTs, and 1 Case Report had been under research. In 22 cases of the studies, one method was used to treat the symptoms. Whereas in 5 cases of the studies, various TKM treatments were used to treat the symptoms. Visual analogue score(VAS) and patient's subjective complaints were used as primary assessments. Conclusion : In this study, we analyzed the trends of TKM treatments on degenerative knee arthritis. Reviewing the domestic trends of studies on Traditional Korean Medicine treatments on degenerative knee arthritis and examining the strong and weak points of those treatments are essential for the further studies.

• Journal of Acupuncture Research
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• v.19 no.2
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• pp.177-188
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• 2002

Objective : The purpose of this study is to investigate the immunohistological effect of Buthus martensi Karsch Herbal-acupuncture in treating the arthritis, performed several experimental items : those are paw edema, $IL-1{\beta}$, IL-6, IL-8, $TNF-{\alpha}$ and $PGE_2$. Methods : All the male Sprague Dawley rats used in this study were bred and maintaned in our pathogen-free rat colony and were 8 weeks of age at the start of to experiment. The experimental model of arthritis was induced by injection of $50{\mu}g/{\mu}{\ell}$ adjuvant(mineral oil mixed Mycobacterium butyricum). Buthus martensi Karsch Herbal-acupuncture was injected into ST36(足三里) of rats daily for 21 days. Immunohistological analysis was carried out to assess paw edema, $IL-1{\beta}$, IL-6, IL-8, $TNF-{\alpha}$ and $PGE_2$ expression in synovial membrane and sera Buthus martensi Karsch Herbal-acupuncture injected. Results : Buthus martensi Karsch Herbal-acupuncture group showed a decrease with statistical significance, in paw edema, $IL-1{\beta}$, IL-6, IL-8, $TNF-{\alpha}$ and $PGE_2$ in synovial membrane and sera compared with control group. Conclusion : Buthus martensi Karsch Herbal-acupuncture stimulation inhibited the development of immunity to adjuvant induced arthritis in rats. Thus, Buthus martensi Karsch Herbal-acupuncture may have preventive effects on autoimmune inflammatory joint diseases as arthritis. The effect of Buthus martensi Karsch Herbal-acupuncture on the immune function and the disease activity in patients with arthritis warrants further investigation.

• The Korea Journal of Herbology
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• v.30 no.3
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• pp.25-34
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• 2015

Objectives : This study was performed to investigate the efficacy and safety of the Mulberry Extract Complex in a placebo-controlled randomized clinical trial and animal study on degenerative arthritis. Methods : Animal study: Mulberry Extract Complex is composed of extracts of mulberry (Morus alba L.) fruit, mulberry leaves and black beans (Glycine max (L.) Merr.). To evaluate the serum level of interleukin-2, interferon-$\gamma$, and prostaglandin E2, an animal model of degenerative arthritis induced by monosodium iodoacetate was employed. Clinical study: The efficacy index (VAS, K-WOMAC) was compared among patients with symptoms of degenerative arthritis before and after Mulberry Extract Complex ingestion as well as the one in groups. Evaluations of the improvement by the subjects and by doctor assessment were also performed. Results : Animal study: Mulberry Extract Complex reduced the serum level of interferon-$\gamma$ and prostaglandin E2 in an animal model with degenerative arthritis. Clinical study: The VAS change showed statistical significance in the experimental groups after 4 weeks (PP set) and 8 weeks (ITT set) of ingestion. When the K-WOMAC was analyzed using a modified ITT set to determine the effectiveness, statistically significant results were obtained in the fields of pain & symptom within the Mulberry Extract Complex group as well as between the Mulberry Extract Complex and placebo groups after 8 weeks of ingestion. Results from the improvement evaluation by subjects and the assessment of improvement by doctors showed statistical significance in the experimental groups (PP set) after 8 weeks. Conclusions : Mulberry Extract Complex could be useful for the improvement of various symptoms of degenerative arthritis based on its anti-inflammatory activity and its reduction of VAS and K-WOMAC pain scores.

• Journal of muscle and joint health
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• v.8 no.2
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• pp.302-322
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• 2001

This study was carried out in order to examine the health status of arthritis patients living in K city of southern part of Korea. The data were collected with AIMS2 instrument from 56 subjects who were asked to complete the questionnaire by the trained surveyor. The AIMS2 has been approved useful instrument for assessing the outcome of various treatments and programs in rheumatic diseases. The component variables of the AIMS2 are Mobility, Walking and Bending, Hand and finger function, Arm function, Self-care tasks, Household tasks, Social activity, Support from family and friends, Arthritis pain, Work, Mood, Level of tension, The total number of items of AIMS 2 are 78. The results are as follows: The average age of the subjects was 58 years old and no gender difference. The mean scores of the 12 sub-concepts of AIMS2 are 15.0 of mobility, 12.16 of walking and of bending, 9.32 of hand and finger function, 9.03 of arm function, 13.53 of self-care tasks, 10.19 of household tasks, 15.09 of social activity, 19.58 support from family and friends, 13.82 of arthritis pain, work, 14.85 of level of tension, 15.12 of mood. The Cronbach Cronbach $\alpha$. is 0.72-91 for RA patients and 0.74-96 for OA patients. This results showed that the health status of Arthritis patients at home in K-city was almost not so serious, but the level of tension and mood were quite higher than the average score. Considering the results of this particular subjects, an appropriate rehabilitation program should be developed and implemented.

• The Journal of Korean Academic Society of Nursing Education
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• v.7 no.2
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• pp.245-253
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• 2001

The aim of this study is to describe degree of fatigue and factors related to fatigue in patients with rheumatoid arthritis. The subjects of the study consist of one hundred fifty-eight outpatients with rheumatoid arthritis at three university hospitals in Taegu between July 10 and August 30, 1999. The instrument used in this study was the Multidimensional Assessment of Fatigue developed by Belza et al.(1995) and revised by Jung, Bok Hee. Kim, Myung Ae(1998). Analysis of data was done by using the descriptive statistics, t-test, ANOVA and Duncan with SPSS program. The major findings can be summarized as follows: 1. Degree of fatigue in patient with Rheumatoid Arthritis was shown the average 22.91 out of the total scores 40. Four subscales of fatigue scores are common fatigue degree 6.37, fatigue timing at the last week 5.92, distress due to fatigue 5.40 and degree of daily activity fatigue 5.22. Among the realms of daily activity fatigue, outdoor activity(6.00), sexual life(5.84), doing the household(5.66), shopping(5.61), other exercise except stroll(5.54) were shown the high degree of fatigue and cooking(4.97), a stroll(4.48), recreation(4.35) showed the low degree of fatigue. 2. There were no significant differences on the total degree of fatigue according to demographic variables. But there were some significant differences on the subscale fatigue scores according to demographic variables. Degree of daily activity fatigue according to sex was shown significant difference (t=-2.358, p=.020), and according to education level was shown significant difference(F=3.938, p=.005) and common fatigue degree according to age was shown significant difference(F=2.853, p=.026). Conclusively fatigue is one of difficult problems for patients with rheumatoid arthritis. Therefore it is necessary to develop some nursing intervention for reducing fatigue of rheumatoid arthritis patients.

• Journal of muscle and joint health
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• v.9 no.2
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• pp.187-202
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• 2002

This study was aim to provide rheumatoid arthritis patients the basic data of development of nursing intervention to help psychosocial adaptation of rheumatoid arthritis patients as exploring the relationship among causal perception, coping pattern, psychosocial adaptation of rheumatoid arthritis. As the results of this study the mean score of causal perception of the subjects was 3.37. The score of the internal-unstable was the highest. which was followed by extra-stable, internal factor, internal-stable, external factor and external-unstable in order among the factor of causal perception. The mean score of coping pattern was 2.64. The type of coping patterns the score of the receptive coping was the highest, which was followed by wishful coping active coping and negative coping in order among the type of coping pattern. The mean score of psychosocial adaptation was 3.28. The subconcept of psychosocial adaptation the score for personal relationship was the highest, which was followed by role function and mental state in order among the psychosocial adaptation. The analysis of the relation among causal perception, coping pattern and psychosocial adaptation showed significant negative correlation between causal perception and psychosocial adaptation(r=-0.3219, P=0.002). The analysis of the relation between the type of coping pattern and psychosocial adaptation showed significant negative correlation between psychosocial adaptation and active coping(r=-0.3210, P=0.002), negative coping(r=-0.2296, P=0.032). Only causal perception(-.36) and period of illness(-.26) effected on the psychosocial adaptation were shown to the negative direction significantly. The psychosocial adaptation was explained the 17% by these two variables. Based on this study results the factor of causal perception and the type of coping pattern of rheumatoid arthritis were shown significant relations between psychosocial adaptation. We suggests that nurses in practice apply to assessing the factor of causal perception of individuals illness and the type of coping patterns when nursing interventions in rheumatoid arthritis patients.

• The Journal of Korean Medicine
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• v.31 no.2
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• pp.19-35
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• 2010

Objectives: This study was carried out to find the effects of Changchuldoin-tanggamibang (hereinafter referred to CDIT) on the inhibition of arthritis induced by collagen on DBA/1J mouse. Methods: The experimental mice were divided into four groups: normal group (Nr), control group (CIA-CT), methotrexate group (CIA-MTX), and Changchuldoin-tanggamibang group (CIA-CDIT). Cytotoxicity, hepatotoxicity, arthritis index, value of immunocytes in draining lymph node and paw joint, and rheumatoid factor (IgG, IgM) in serum were measured in vivo. Results: 1. Cytotoxicity against hFCs was not shown in any concentration. 2. Hepatotoxicity was low in the CDIT-treated group compared with the MTX group. 3. The arthritis index decreased significantly. 4. In total cell counts of DLN and paw joint, the cells in DLN increased significantly while there was a significant decrease in paw joint. 5. In lymph nodes, CD19+, CD3+, CD4+, CD8+, CD3+/CD8+, CD3+/CD69+, CD4+/CD25+, CD3+/CD49b+, and CD4+/CD44+ cells increased significantly, while B220+/CD23+, and CD11c+/MHCII+ cells decreased significantly. 6. In joints, CD3+, CD4+, CD4+/CD25+, and CD11b+/Gr-1+ cells decreased significantly. 7. The level of IgG decreased and the level of IgM significantly decreased compared with the control. 8. Anti-collagen II in serum decreased compared with the control. 9. Around the joint of the CDIT group, infiltration of inflammation, synovial hyperplasia, invasion of cytokine, of cartilage, deposition of collagen and synovial injury decreased compared with the control in histopathologic observation (HE, MT staining). Conclusions: Comparison of the results for this study showed that CDIT had immunomodulatory effects. We expect that CDIT could be used as a effective drug for not only rheumatoid arthritis but also another auto-immune diseases. Therefore, we have to survey continuously, looking for effective substances and mechanisms in the future.

• Journal of Acupuncture Research
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• v.18 no.5
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• pp.204-212
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• 2001

Objective : Septic arthritis is a disease of when bacterial infection causes inflammatory reactions to occur in the body's joints. Following damage, stiffness, and disformity may occur in the joints. Initially antibiotic treatment is used. Later treatment is the preservation and rehabilitation of the joints. Here we report a case of sequelae of septic arthritis, which is treated and managed by ways of oriental medicine. Methods : We considered that symptoms like fever, arthralgia and ankylosis were similar to Yeol-bi(熱痺) and the patient's constitution was Soyang-in(少陽人). So Yangguksanhwa-tang(凉膈散化湯) was used as medication, and acupuncture, TENS, rehabilitation treatment was carried out. Also Kinesio & Cross(Geok-ja(격자)) taping therapy was done after the contact test. Results : After 4-7 days from the end of antibiotic treatment, the patient regained movement in the joints. After 3 weeks, the patient was able to support his own weight, and one week later joints were restored to nearly normal range. Therefore sequelae of Septic arthritis is thought to be treated earlier when the above treatment is used, compared to western treatment, which mainly consist of antibiotic treatment. Conclusion : This case was managed by herbal medicine, acupuncture, TENS, rehabilitation treatment, and Kinesio & Cross(Geok-ja) taping therapy on sequelae of Septic arthritis. Earlier improvement was gained comparatively to western treatment, which mainly consist of antibiotic treatment.

• Journal of Acupuncture Research
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• v.23 no.2
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• pp.197-205
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• 2006

Objectives : To examine the effects of the collaborative Oriental and Western medicine, we treated a gouty arthritis patient with acute inflammation and liver injury with a combination of Oriental and Western treatments. Methods : Acupuncture, Bangphungtongsung-San(Fangfengtongsheng-san)', 'Kangwhaljetong-Um(Qianghuochutong-yin)', and 'Sosiho-Tang(Xiaochaihu-tang) were offered to an acute gouty arthritis patient with NSAIDs, Corticosteroids and allopurinol. Laboratory data were observed for the duration of hospital days. Results : In spite of Oriental treatments, NSAIDs administration caused liver injury, but continuous Oriental treatments with small amount of Corticosteroids and allopurinol brought recovery of liver function and gouty arthritis. Confusion : Collaborative treatments of Oriental and Western medicine are better than independent Western treatment for gouty arthritis with acute inflammation and liver injury. Further studies will be required to ascertain the collaborative treatment with Oriental and Western medicine for gouty arthritis and other diseases.

• Journal of Ginseng Research
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• v.33 no.2
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• pp.149-154
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• 2009

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and progressive cartilage and bone erosion. Korean red ginseng (KRG) has been shown to have an anti-inflammatory effect by inhibiting the secretion of inflammatory cytokines like $TNF-{\alpha}$, IL-1, -6, and -8, and $IPN-{\gamma}$. In this study, whether KRG extract has an inhibitory effect on the collagen-inducible development of arthritis in DBA/1J mice was investigated. To induce arthritis, type II collagen emulsified in Complete Freund's Adjuvant was intradermally injected into the base of the tails of mice. Three weeks after the initial injection, a booster injection of type II collagen emulsified in Incomplete Freund's Adjuvant was administered. The oral administration of KRG extract for 8${\sim}$10 weeks at the dose of 300 mg/kg (three days a week) inhibited the development of arthritis in the experimental group, compared to the control group which was given saline. While the administration of KRG extract three times a week demonstrated both preventive and inhibitory effects, the administration of KRG extract once a week had little inhibitory effect. In other studies, the regimen of KRG administration has been shown to decrease the plasma level of inflammatory cytokines like IL-8 and TNF-${\alpha}$, but the plasma levels of these cytokines were not decreased in the present study. The results of the present study suggest that KRG has preventive and inhibitory effects on collagen-induced arthritis.