• Korean Journal of Acupuncture
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• v.22 no.3
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• pp.83-104
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• 2005

Objectives : DaeBangPungTang(DBPT) is one of the prescriptions used for the treatment of knee arthritis in oriental medicine. The present study aimed to examine the analgesic effect of DBPT on a rat model of carrageenan-induced arthritis, and the relations between DBPT-induced analgesia and endogenous nitric oxide(NO) and inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and c-Fos protein expression in the spinal cord. Methods : Carrageenan-induced arthritis rat model was used to test the effect of DBPT as a chronic pain model. After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least tile next 4 days. The reduced stepping force of the limb was presumably due to a painful knee, since oral infection of indomethacin produced temporary improvement of weight bearing. DBPT dissolved in normal saline was minted several acupoints. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 12 hours. Results : DBPT produced significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 9 hours. The magnitude of this improvement was equivalent to that obtained after an oral injection of 3mg/kg of indomethacin and this improvement of stepping force was interpreted as an analgesic effect. DBPT produced the improvement of stepping force of the affected hindlimb in a dose-dependent manner. Both NO production and iNOS, COX-2 protein expression increased by arthritis were suppressed by DBPT. DBPT on combination with electroacupuncture (EA) produced more powerful and longer lasting improvement of stepping force of the hindlimb affected by the arthritis than either DBPT or EA did. Conclusion : The present study suggest that DBPT produces a potent analgesic effect on the chronic hee arthritis pain model in the rat and that DBPT-induced analgesia modulate endogenous NO through the suppression of iNOS/COX-2 protein expression.

• Journal of Acupuncture Research
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• v.25 no.3
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• pp.95-106
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• 2008

Objectives : This study is to evaluate Effect of Hong Hua Za acupuncture anti-inflammatory on rheumatoid arthritis that caused by Lipopolysaccharide in mouse. Methods : Hong Hua Za(Carthami Tinctorii Fructus) acupuncture(HA) was prepared and tested for therapeutic potential of rheumatoid arthritis, by measuring the inhibition of inducible nitric oxide synthase (iNOS) expression, nitric oxide(NO) production in vitro experiment, by measuring Tumpr Necrosis Factor-$\alpha$(TNF-$\alpha$) & Nuclear Factor kappa B(NF-$\kappa$B) p65 activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Results : HA showed therapeutic effects on Lipopolysaccharide(LPS)-induced rheumatoid arthritis. HA inhibited iNOS mRNA and NO in RAW264.7cell of LPS-induced rheumatoid arthritis in a dose dependent manner. HA also showed significant inhibition of TNF-$\alpha$ & NF-$\kappa$B p65, activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Conclusions : These results suggest that HA has an therapeutic effects on LPS induced-rheumatoid arthritis by inhibiting TNF-$\alpha$ activation.

• The Journal of Korean Academic Society of Nursing Education
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• v.11 no.1
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• pp.30-38
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• 2005

Purpose: The purpose of this study was to testify effects of Balance Taping Therapy on the pain and range of motion of the knee joint in the female elderly with degenerative knee arthritis. Method: The research design was one group pretest-posttest design. The data were collected from November 15 to December 25, 2004. The subjects were 23 female elderly with degenerative knee arthritis who were registered at one public health center in Busan. Balance Taping Therapy was conducted twice a week for 5 weeks. The data were analyzed such as the number, percentage, paired t-test, Kolmogorov-Smirnov test using SPSS 10.0 WIN Program. Result: The pain in the female elderly with degenerative knee arthritis significantly decreased from 8.82 to 6.04 after Balance Taping Therapy(t=16.781, p=0.001). The knee flexion joint range of motion in the female elderly with degenerative knee arthritis significantly increased from 119.73 to 123.13 after Balance Taping Therapy (t=-6.003, p=0.001). The knee extention joint range of motion statistically significantly increased from 112.74 to 117.83 after Balance Taping Therapy(t=-8.940, p=0.001). Conclusion: Balance Taping Therapy proved an effective nursing intervention in decreasing pain and increasing the range of motion of the knee joint in the female elderly with degenerative knee arthritis.

• Journal of Acupuncture Research
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• v.19 no.3
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• pp.14-25
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• 2002

Objective : The purpose of this study was to investigate the effects of Aurothiomalate acupuncture containing Sodium Aurothiomalate on Type II collagen-induced arthritic DBA/1 mice. Methods : The mice were divided into three groups, one control group and two test groups. The control group was injected with saline on Choksamni(ST36) and the two test groups were injected either with Aurothiomalate acupuncture into Choksamni(AT1 group), or with Aurothiomalate acupuncture into Hwando(G30, AT2 group). We measured the incidence of arthritis, the mean index of arthritis, the number of arthritic limbs for the clinical examination and evaluation. We also examined the changes in the level of TNF-$\alpha$ and IL-$1{\beta}$. Results : 1. The incidence of arthritis in mice of the AT1 and AT2 groups were significantly lower than that of the control group. 2. The mean indices of arthritis in mice of the AT1 and AT2 groups were significantly lower than that of the control group. 3. The mean number of arthritic limbs in mice of the AT1 and AT2 groups were significantly lower than that of the control group. 4. The levels of TNF-$\alpha$ of the mice in the AT1 and AT2 groups were significantly different from that of the control group. 5. The levels of IL-$1{\beta}$ of the mice in the AT1 and AT2 groups were not significantly different from that of the control group. Conclusion : These results indicate that the treatment with Aurothiomalate acupuncture could improve the clinical status of Arthritis by suppressing immune responses in the mice of Type II collagen-induced arthritic.

• Korean Journal of Acupuncture
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• v.24 no.4
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• pp.111-129
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• 2007

Objectives & Methods : The purpose of this study is to observe the effects of Coicis Semen Herbal-acupuncture solution (CS-HAS) at the Joksamni (ST36) on the collagen-induced arthritis in the DBA/1J mouse. The author performed several experiments to analyze the effects of CS-HAS on arthritis; change of the weight; the spleen size and adhesion rate; serum cytokine levels; serum antibody levels; changes of immunocyte counts; the histological changes of joint. Results : In the Coicis Semen Herbal-acupuncture (CS-HA), arthritis index, the incidence of arthritis, and the degree of joint edema were decreased. In CS-HA, there was no weight loss. The size of the spleen, adhesion rate, and the edema and transformation of joint were lowered. In CS-HA, the levels of IL-1${\beta}$, IL-6, TNF-${\alpha}$, IFN-${\gamma}$, IgG, IgM, and anti-collagen II in serum and the levels of IFN-${\gamma}$, IL-4, IL-10 in spleen were significantly decreased. In CS-HA, the expression ratios of $CD45^+$ to $CD3e^+$ and $CD8^+$ to $CD4^+$ were decreased. Also, the overall $CD4^+/CD8^+$ cell ratio was lowered in spleen. Ratios of the $CD4^+/CD25^+$, $CD45^+/CD69^+$ cells were decreased in lymph nodes. In addition, ratios of the $CD3^+/CD69^+$, $CD11b^+/Gr-1^+$ cells were also decreased in synovium. In the histological study, the cartilage destruction and synovial cell proliferation, and collagen fiber destruction were decreased with CS-HA treated group. Conclusions : From the results mentioned above, it is suggested that CS-HA at the ST36 has several significant effects on the collagen-induced arthritis.

• Journal of Acupuncture Research
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• v.24 no.6
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• pp.75-88
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• 2007

Objectives : We investigated the effects of Hominis placenta Herbal acupuncture on rheumatoid arthritis. Methods : We investigated the Type II collagen-induced arthritis test, vascular permeability test, phenyl benzoquinone-induced writhing test, hot plate test, carbon clearance test, determination of prostaglandin $E_2$ content and cyclooxygenase-2 activity test. Results : Hominis placenta Herbal acupuncture suppressed Type II collagen-induced arthritis in DBA/1J mice and vascular permeability with 10.2% inhibition in ICR mice. We see the phenyl benzoquinone-induced writhing test and the hot plate test in the analgesic activity test. In the phenyl benzoquinone-induced writhing test, Hominis placenta Herbal acupuncture showed that it increased its analgesic effect more than the control(test?) by 85.5%. In the hot plate test, it was also shown that the analgesic effect increased more than the control(test) by 32.1%. In the carbon clearance test, the immuno-stimulatory effect showed more than the control(test) by 8.0%. The formation of prostaglandin $E_2$ was also reduced more than the control(test) by 10.1%. Finally, cyclooxygenase-2 activity was inhibitedwith 36.3%. Conclusions : Hominis placenta Herbal acupuncture may be useful for the treatment of rheumatoid arthritis after injection.

• Journal of Acupuncture Research
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• v.23 no.6
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• pp.103-115
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• 2006

Objectives : Rheumatoid arthritis(RA) is a systemic & a chronic inflammatory autoimmune disease . A chronic , locally destructive inflammmatory reaction in human is examplified by the synovitis present in some connective tissue disorder. The presence of a number of cytokines, $TNF-{\alpha}$, iNOS & expression of nitric oxide, NF-kB p65 activation implies an important role of cellular immune response in RA inflammatory reaction. This study was designed to evaluate on the effects of the Homnis Placenta herbal acupuncture on EX-LE201 & ST 35 reducing expression of LPS-induced arthritis model in mice. Materials and Methods : Homnis Placenta herbal acupuncture was inserted into 10 rats induced rheumatoid arthritis. The acupunctures were injected into the EX-LE201 and ST35 points. Such indexes were measured the inhibition of inducible nitric oxide synthase(iNOS) expression, nitric oxide(NO) production in vitro experiment and Tumor Necrosis $Factor-{\alpha}(TNF-{\alpha})$ & Nuclear Factor kappa $B(NF-{\kappa}B)$ p65 activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice in vivo experiment. Results : 1.Homnis Placenta Herbal acupuncture inhibited iNOS mRNA and NO in RAW 264.7 cell of LPS-induced rheumatoid arthritis in a dose dependent manner. 2.Homnis Placenta Herbal acupuncture also showed significant inhibition of $TNF-{\alpha}$ & $NF-{\kappa}B$ p65, activation, synovial hyperplasia, angiogenesis and fibrosis in synovial membrane of knee joint of mice. Conclusion : These results suggest that Homnis Placenta Herbal acupuncture has an therapeutic effects on LPS induced-rheumatoid arthritis by inhibiting $TNF-{\alpha}$ activation.

• Journal of muscle and joint health
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• v.11 no.1
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• pp.50-60
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• 2004

Purpose: The purpose of this study was to examine the relationships among the health promoting behavior, pain, self-esteem, family support, self-efficacy in patients with chronic arthritis. Method: The data for this study were collected from February 19, 2003 to April 7, 2003. The subjects were 150 chronic arthritis patients who visited University Hospital in D City. The research instruments used in this study were HPLP II, Visual analogue scale, Self-esteem scale, Family support scale, Self-efficacy scale. In data analysis, SPSS PC ver 10.0 program was utilized and data were analyzed using descriptive statistics and t-test, ANOVA, Multiple Stepwise Regression and Pearson's correlation coefficient. Result: The average score of the pain, self-esteem, family support, self-efficacy, health promoting behavior was 5.38, 3.37, 4.29, 70.30, 2.68, respectively and the variable with the highest degree of it's subscale was interpersonal support(3.08), whereas the one with the lowest degree was exercise(1.66). There was a positive correlation(r=.327, p=.000) between the self-esteem and health promoting behavior. There was a positive correlation(r=.540, p=.000) between the family support and the self-efficacy and health promoting behavior. Family support, self-efficacy and marital status were significant factors to explain a variance of health promoting behavior in patients with chronic arthritis(51.6%). health promoting behavior. There was a positive correlation(r=.477, p= .000) between Conclusion: The health promoting behavior were positively correlated with self-esteem, family support and self-efficacy. These findings help to understand relationships among self-esteem, family support and self-efficacy in chronic arthritis patients. In addition, family support, self-efficacy and marital status were the mainly influencing factors of health promoting behavior. Among these variables family support was the most significant factor to predict a health promoting behavior. According to the results of this study, family support must be considered as a main factor in the nursing strategy for health promoting behavior of chronic arthritis patients.

• Journal of muscle and joint health
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• v.11 no.1
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• pp.31-41
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• 2004

Purpose: The purpose of this study was to test the effects of self-help program offered to patients with arthritis. Method: A quasi-experimental study design with nonequivalent groups was employed for the study. The subjects in the experimental group were 19 residents of K City who visited K Health Center with chief complaints of osteoarthritis and who agreed to participate in the self-help program from January through April 2003. The subjects in the control group were 18 patients with arthritis, selected among patients on the waiting list of self-help program using random sampling method. Data related to pain, ADL, exercise self-efficacy, and knowledge about arthritis were obtained from both groups. SPSS Win 11.5 was used for the data analysis. Results: The results of this study were as follows. 1. The pain score and exercise self-efficacy of the study group were significantly higher than the control group. 2. The ADL score and knowledge about arthritis were not significantly higher than the control group. Conclusion: Based on the study results, self-help program was proved to be effective in alleviating pain, and promoting exercise self-efficacy related to arthritis.

• 대한근관절건강학회:학술대회논문집
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• 2001.04a
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• pp.179-190
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• 2001

The purpose of this study was to explore the effects of GEAP on pain, joint function, activities of daily living(ADL) and fatigue in chronic arthritis patients. The GEAP was held twice a week for 6 weeks for chronic arthritis patients at one university hospital in Seoul, Korea. Thirty four subjects completed the program, who were recruited at four times from September, 1999 to September, 2000. The effect of GEAP were evaluated as follows: Pain severity and number of painful joints ADL, fatigue were measured before and after the GEAP. In order to examine the joint flexibility and strengthening, the followings were measured: the extent of the upward arm reach in both sides(flexibility of shoulder), the ability to touch fingertips of the both hands in back pat and rub(flexibility of arm), the degree of range of motion (ROM) of both ankles in their dorsiflexion(flexibility of ankle) and plantarflexion with standing with toe(strengthening of ankle), and the degree of knee extension, and the grip strength. Paired t-test and Wilcoxon signed rank test were used for data analysis and the significance of the differences in the variables was examined to compare the data obtained before and after the GEAP. After the GEAP, followings were found: 1. Pain severity and number of painful joints was significantly decreased. 2. The flexibility of both shoulders and arms, knee, both ankle were significantly improved. 3. The strengthening of both arms was significantly improved, but the strengthening of ankle was not changed. 4. ADL was significantly increased. 5. Fatigue was significantly decreased. In conclusion, GEAP used in this study was clearly proved to be an effective exercise program to reduce pain and fatigue, to enhance joint function and ADL in people with chronic arthritis. It is suggested that the GEAP should be recommended as one of the useful and appropriate nursing interventions for chronic arthritis patients.