• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2005년도 춘계학술발표회
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• pp.333-334
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• 2005

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2012년도 춘계학술논문요약집
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• pp.35-36
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• 2012

• 대한의생명과학회지
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• 제11권4호
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• pp.441-446
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• 2005

The molecular mechanism of ischemia/reperfusion injury remains unclear. Reactive oxygen species (ROS) are implicated in cell death caused by ischemia/reperfusion in vivo or hypoxia in vitro. Poly (ADP-ribose) polymerase (PARP) activation has been reported to be involved in hydrogen peroxide-induced cell death in renal epithelial cells. This study was therefore undertaken to evaluate the role of P ARP activation in chemical hypoxia in opossum kidney (OK) cells. Chemical hypoxia was induced by incubating cells with antimycin A, an inhibitor of mitochondrial electron transport. Exposure of OK cells to chemical hypoxia resulted in a time-dependent cell death. In OK cells subjected to chemical hypoxia, the generation of ROS was increased, and this increase was prevented by the $H_2O_2$ scavenger catalase. Chemical hypoxia increased P ARP activity and chemical hypoxia-induced cell death was prevented by the inhibitor of PARP activation 3-aminobenzamide. Catalase prevented OK cell death induced by chemical hypoxia. $H_2O_2$ caused PARP activation and $H_2O_2-induced$ cell death was prevented by 3-aminobenzamide. Taken together, these results indicate that chemical hypoxia-induced cell injury is mediated by PARP activation through H202 generation in renal epithelial cells.

• 한국항행학회논문지
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• 제20권1호
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• pp.1-7
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• 2016

국토교통부는 2014년부터 한국형 위성보강항법시스템 (SBAS; satellite based augmentation system)인 KASS (Korea augmentation satellite system) 개발 구축 사업을 진행 중이다. KASS는 실제 운영 중 문제가 발생할 경우 인명 및 재산피해와 연결될 수 있어 시스템 개발을 위한 안전성 평가가 매우 중요하다. 안전성 평가의 핵심은 위해 식별과 심각도 판정에 따른 개발보증레벨 (DAL; design assurance level) 할당이다. 본 연구에서는 항공시스템의 안전성 평가 방법론을 제시하는 국제표준인 SAE (society of automotive engineers) ARP4761 (aerospace recommended practice)을 기반으로 KASS 및 그 하위시스템에 대해 개발보증레벨 할당을 수행한다. 이것은 전체 시스템 안전성 평가의 첫 단계이므로 향후 KASS 개발 구축 사업의 안전성 평가에 활용될 수 있다.

• 한국철도학회논문집
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• 제11권1호
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• pp.101-106
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• 2008

최근 아키텍처 프레임워크가 정보관리 시스템 개발에 사용되고 있다. 본 논문은 미국방 아키텍처 프레임워크를 사용하여 철도 안전성 평가에 대한 운용 아키텍처 개발 방법론에 대해 기술한다. 철도 시스템과 같이 안전에 민감한 시스템의 경우는 안전성 평가 업무를 효과적이고, 효율적으로 수행하기 위해 정보관리 시스템의 필요성이 증대되고 있다. 운용 아키텍처를 기반으로 안전성 평가에 대한 정보관리 시스템의 요구사항을 생성하는 것은 필수적이다. 철도시스템에 적용 가능한 안전성 평가 운용 아키텍처를 개발하기 위해 ARP4761이 참고 되었다. 우선, 상용 시스템엔지니어링 도구인 CORE를 활용한 운용 아키텍처 개발 프로세스를 수행하기 위해 스키마 및 템플릿 개발하였다. 운용 아키텍처는 유연한 정보 관리 시스템 구축을 가능하게 할 뿐만 아니라 업무 프로세스의 문제도 해결하는데 도움을 준다.

• 중소기업융합학회논문지
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• 제6권2호
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• pp.31-36
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• 2016

Sniffing은 공격자가 암호화 되지 않은 패킷들을 수집하여 순서대로 재조합 하고난 후 공격 대상의 개인정보, 계좌정보 등 중요 정보를 유출하기 위한 수동적 형태의 공격이다. Sniffing 공격으로 인해 패킷들이 유출되는 것을 방지하기 위해 기존의 방법들을 살펴보고, 효율적인 방어대책을 제시하였다. Sniffing공격은 공격 대상의 근거리 네트워크를 Promiscuous Mode을 이용해 조작한 후 필터링을 해제하고 패킷을 훔치는 방식으로 작동한다. 공격의 형태로 Switch Jamming, Port mirroring, ARP Redirect, ICMP Redirect 공격 등이 있다. 제안하는 공격 대응 방법으로는 SSL을 통한 패킷의 암호화, 스위칭 환경의 네트워크 구성 관리, DNS를 이용하는 방법과 decoy방법을 이용하면 안전한 통신이 가능할 것으로 기대하며, 더 효율적이며 안전한 ICT 연구에 기여한다. 향후 프로토타입 프로토콜을 통하여 효율성을 증명하는 것은 향후 연구로 진행할 예정이다.

• 한국발생생물학회지:발생과생식
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• 제23권3호
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• pp.285-295
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• 2019

Junction-mediating and regulatory protein (JMY) is a regulator of both transcription and actin filament assembly. The actin-regulatory activity of JMY is based on a cluster of three actin-binding Wiskott-Aldrich syndrome protein homology 2 (WH2) domains that nucleate actin filaments directly and promote nucleation of the Arp2/3 complex. In addition to these activities, we examined the activity of JMY generation in early embryo of mice carrying mutations in the JMY gene by CRISPR/Cas9 mediated genome engineering. We demonstrated that JMY protein shuttled expression between the cytoplasm and the nucleus. Knockout of exon 2, CA (central domain and Arp2/3-binding acidic domain) and NLS-2 (nuclear localization signal domain) on the JMY gene by CRISPR/Cas9 system was effective and markedly impeded embryonic development. Additionally, it impaired transcription and zygotic genome activation (ZGA)-related genes. These results suggest that JMY acts as a transcription factor, which is essential for the early embryonic development in mice.

• Journal of Korean Dental Science
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• 제14권1호
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• pp.1-11
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• 2021

Purpose: The alveolar ridge preservation (ARP) is widely conducted for implant placement. However, experimental results using deproteinized porcine bone mineral (DPBM) have been scarce. This retrospective study evaluated factors affecting the primary stability of implants in an area where ARP was performed using DPBM. Materials and Methods: Thirty-eight patients were divided into two groups based on the primary stability, with torque value of 30 Ncm as borderline. To determine the factors that affect the primary stability of implants, we collected data from patients' medical records including age, sex, reentry time, socket location, remaining bone wall at the time of extraction, and type of collagen membrane, as well as from radiographs and histomorphometric analysis. Result: The results showed statistically significant difference for the remaining extraction socket wall (P=0.014), residual graft (P=0.029), and fibrovascular tissue (P=0.02) between the two groups. There was an insignificant tendency toward the time of reentry surgery (P=0.052) and location (P=0.077). All implants placed in sites using DPBM functioned well up to 3 years. Conclusion: Within the limitations of the present study, extraction socket wall, residual graft, and fibrovascular tissue can affect the primary stability at the time of implant placement on grafted sites using DPBM and collagen membranes. In addition, reentry time and locations can be considered. In future studies, comparative experiments in quantified models will be required to supporting the findings.

• 한국표면공학회지
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• 제56권1호
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• pp.84-93
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• 2023

The spent nuclear fuel is burned during the planned cycle in the plant and then generates elements such as actinide series, fission products, and plutonium with a long half-life. An 'interim storage' step is needed to manage the high radioactivity and heat emitted by nuclides until permanent-disposal. In the case of Korea, there is no space to dispose of high-level radioactive waste after use, so there is a need for a period of time using interim storage. Therefore, the intensity of neutrons and gamma-ray must be determined to ensure the integrity of spent nuclear fuel during interim storage. In particular, the most important thing in spent nuclear fuel is burnup evaluation, estimation of the source term of neutrons and gamma-ray is regarded as a reference measurement of the burnup evaluation. In this study, an analysis of spent nuclear fuel was conducted by setting up a virtual fuel burnup case based on CE16×16 fuel to check the total amount and spectrum of neutron, gamma radiation produced. The correlation between BU (burnup), IE (enrichment), and CT (cooling time) will be identified through spent nuclear fuel burnup calculation. In addition, the composition of nuclide inventory, actinide and fission products can be identified.

• Journal of Periodontal and Implant Science
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• 제47권6호
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• pp.372-380
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• 2017

Purpose: The aim of this prospective pilot study was to compare alveolar ridge preservation (ARP) procedures with open-healing approach using a single-layer and a double-layer coverage with collagen membranes using radiographic and clinical analyses. Methods: Eleven molars from 9 healthy patients requiring extraction of the maxillary or mandibular posterior teeth were included and allocated into 2 groups. After tooth extraction, deproteinized bovine bone mineral mixed with 10% collagen was grafted into the socket and covered either with a double-layer of resorbable non-cross-linked collagen membranes (DL group, n=6) or with a single-layer (SL group, n=5). Primary closure was not obtained. Cone-beam computed tomography images were taken immediately after the ARP procedure and after a healing period of 4 months before implant placement. Radiographic measurements were made of the width and height changes of the alveolar ridge. Results: All sites healed without any complications, and dental implants were placed at all operated sites with acceptable initial stability. The measurements showed that the reductions in width at the level 1 mm apical from the alveolar crest (including the bone graft) were $-1.7{\pm}0.5mm$ in the SL group and $-1.8{\pm}0.4mm$ in the DL group, and the horizontal changes in the other areas were also similar in the DL and SL groups. The reductions in height were also comparable between groups. Conclusions: Within the limitations of this study, single-layer and double-layer coverage with collagen membranes after ARP failed to show substantial differences in the preservation of horizontal or vertical dimensions or in clinical healing. Thus, both approaches seem to be suitable for open-healing ridge preservation procedures.