• 제목/요약/키워드: ARB

검색결과 79건 처리시간 0.027초

소지역모형 추정기법을 활용한 전·월세 추정 (A case study of small area estimation about charter and monthly rent price index)

  • 이승수;박원란;정성석
    • Journal of the Korean Data and Information Science Society
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    • 제28권2호
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    • pp.327-337
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    • 2017
  • 조사를 통한 자료생성은 시간과 경제적인 제약이 많고, 조사 방법 및 특성에 따라 자료의 질이 결정되며, 수집된 조사정보를 통계정보로 활용하기까지 오랜 시간이 소요된다. 이와 같은 어려움을 줄이고자 조사 표본설계 단위 보다 작은 지역 또는 다른 영역에 대한 자료를 기존에 조사된 자료 및 행정자료를 이용하여 추정하는 소지역추정 통계방법 활용 연구는 꾸준히 진행되고 있다. 따라서 본 논문에서는 소지역추정기법을 이용하여 인간이 기본적인 삶을 영위하는데 반드시 필요한 필수재이며, 동시에 우리나라에서 투자재로서의 특징을 나타내는 주택과 관련하여, 요즈음 새로운 주거형태를 차지하는 전세와 월세 지수에 모형기반 소지역추정기법을 적용하고자 한다. 적용된 소지역추정 모형은 회귀모형 추정법, 계층적 베이지안 추정법, 시-공간적 추정법이며, 분석결과 전세와 월세에서 시-공간적 추정모형이 가장 효율적인 것으로 나타났다.

멀티도어코트하우스제도: 기원, 확장과 사례분석 (The Multi-door Courthouse: Origin, Extension, and Case Studies)

  • 정용균
    • 한국중재학회지:중재연구
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    • 제28권2호
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    • pp.3-43
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    • 2018
  • The emergence of a multi-door courthouse is related with a couple of reasons as follows: First, a multi-door courthouse was originally initiated by the United States government that increasingly became impatient with the pace and cost of protracted litigation clogging the courts. Second, dockets of courts are overcrowded with legal suits, making it difficult for judges to handle those legal suits in time and causing delays in responding to citizens' complaints. Third, litigation is not suitable for the disputant that has an ongoing relationship with the other party. In this case, even if winning is achieved in the short run, it may not be all that was hoped for in the long run. Fourth, international organizations such as the World Bank, UNDP, and Asia Development Bank urge to provide an increased access to women, residents, and the poor in local communities. The generic model of a multi-door courthouse consists of three stages: The first stage includes a center offering intake services, along with an array of dispute resolution services under one roof. At the second stage, the screening unit at the center would diagnose citizen disputes, then refer the disputants to the appropriate door for handling the case. At the third stage, the multi-door courthouse provides diverse kinds of dispute resolution programs such as mediation, arbitration, mediation-arbitration (med-arb), litigation, and early neutral evaluation. This study suggests the extended model of multi-door courthouse comprised of five layers: intake process, diagnosis and door-selection process, neutral-selection process, implementation process of dispute resolution, and process of training and education. One of the major characteristics of extended multi-door courthouse model is the detailed specification of individual department corresponding to each process within a multi-door courthouse. The intake department takes care of the intake process. The screening department plays the role of screening disputes, diagnosing the nature of disputes, and determining a suitable door to handle disputes. The human resources department manages experts through the construction and management of the data base of mediators, arbitrators, and judges. The administration bureau manages the implementation of each process of dispute resolution. The education and training department builds long-term planning to procure neutrals and experts dealing with various kinds of disputes within a multi-door courthouse. For this purpose, it is necessary to establish networks among courts, law schools, and associations of scholars in order to facilitate the supply of manpower in ADR neutrals, as well as judges in the long run. This study also provides six case studies of multi-door courthouses across continents in order to grasp the worldwide picture and wide spread phenomena of multi-door courthouse. For this purpose, the United States and Latin American countries including Argentina and Brazil, Middle Eastern countries, and Southeast Asian countries (such as Malaysia and Myanmar), Australia, and Nigeria were chosen. It was found that three kinds of patterns are discernible during the evolution of a multi-door courthouse model. First, the federal courts of the United States, land and environment court in Australia, and Lagos multi-door courthouse in Nigeria may maintain the prototype of a multi-door courthouse model. Second, the judicial systems in Latin American countries tend to show heterogenous patterns in terms of the adaptation of a multi-door courthouse model to their own environments. Some court systems of Latin American countries including those of Argentina and Brazil resemble the generic model of a multi-door courthouse, while other countries show their distinctive pattern of judicial system and ADR systems. Third, it was found that legal pluralism is prevalent in Middle Eastern countries and Southeast Asian countries. For example, Middle Eastern countries such as Saudi Arabia have developed various kinds of dispute resolution methods, such as sulh (mediation), tahkim (arbitration), and med-arb for many centuries, since they have been situated at the state of tribe or clan instead of nation. Accordingly, they have no unified code within the territory. In case of Southeast Asian countries such as Myanmar and Malaysia, they have preserved a strong tradition of customary laws such as Dhammthat in Burma, and Shriah and the Islamic law in Malaysia for a long time. On the other hand, they incorporated a common law system into a secular judicial system in Myanmar and Malaysia during the colonial period. Finally, this article proposes a couple of factors to strengthen or weaken a multi-door courthouse model. The first factor to strengthen a multi-door courthouse model is the maintenance of flexibility and core value of alternative dispute resolution. We also find that fund raising is important to build and maintain the multi-door courthouse model, reflecting the fact that there has been a competition surrounding the allocation of funds within the judicial system.

당뇨를 동반한 심부전 환자에 대한 beta-blocker의 유효성 평가 (Retrospective Evaluation for Efficacy and Tolerance of beta-blocker in Heart Failure Patients with Concomitant Diabetes)

  • 장선미;강민희;임성실;이준섭;이명구
    • 한국임상약학회지
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    • 제16권2호
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    • pp.113-122
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    • 2006
  • Purpose: A retrospective study was performed to assess the efficacy and tolerance of ${\beta}-blocker$ administration in patients with heart failure and diabetes. Method: Records of 164 patients who were treated for the heart failure condition more than a year were studied retrospectively. Patients were divided into 4 groups based on their diabetes(DM) status and the administration of ${\beta}-blockers$ ($DM+{\beta}-blocker$ group: 14, DM w/o ${\beta}-blocker$: 19, No DM + ${\beta}-blocker$: 62, No DM + no ${\beta}-blocker$: 69). All patients had been receiving conventional therapy such as digoxin, ACE-I, ARB, diuretics, nitrates, aspirin, anticoagulants or lipid-lowering agents. The primary endpoints (death and hospital admission) were recorded during 1 year period and hemodynamic factors (HR, LVEF, SBP, DBP) were obtained from all patient groups before and after 12 months of ${\beta}-blocker$ treatment. To evaluate toxicity of ${\beta}-blocker$, SCr, BUN, AST, ALT and Alkaline phosphatase were obtained. Result: There were less death and hospital admission in DM + ${\beta}-blocker$ group than in DM without ${\beta}-blocker$ group (p=0.014). Relative risk of hospital admission for $DM+{\beta}-blocker$ group over no DM group was 1.17. Long term ${\beta}-blocker$ administration was associated with an improvement of heart rate in patients with DM (P< 0.02) with no significant improvement of LVEF, SBP, DBP. in DM patient. In patient without DM, ${\beta}-blocker$ was associated with improvement in LVEF, HR and DBP (P<0.01, P<0.03), but not in SBP. The incidence of toxicity was similar between the four group with no significant difference. Conculsion: Treatment of heart failure patients with ${\beta}-blocker$ appears to be beneficial in terms of hospital admission event and several hemodynamic factors. The toxicities of ${\beta}-blocker$ treatment were not significant and the treatment is generally well-tolerated in most of the heart failure patients.

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혈액투석 환자의 빈혈관리에서 Erythropoietin 반응에 영향을 미치는 인자 (Determinants of Erythropoietin Hyporesponsiveness in Management of Anemia in Hemodialysis Patients)

  • 신승희;지은희;이영숙;오정미
    • 한국임상약학회지
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    • 제21권2호
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    • pp.122-130
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    • 2011
  • Objective: Although recombinant human erythropoietin (rhEPO) has revolutionized the treatment of anemia in chronic kidney disease (CKD) receiving hemodialysis (HD) with no need of blood transfusion, some patients have a blunted or appear to be resistant to rhEPO. There is a controversy in the causes of rhEPO resistance in maintenance HD patients with anemia. This study is to examine current anemia treatment outcomes and the factors influencing the rhEPO responsiveness in HD patient with CKD. Methods: The clinical parameters or factors relating to erythrompoietin treatment outcomes and erythropoietin responsiveness were collected from the HD patients in two large dialysis centers for three months. The collected paramenters included serum iron, total iron biding capacity (TIBC), transferrin saturation rate, ferritin, albumin, intact PTH, C-reactive protein (CRP), nPCR and medications such as an angiotensin converting enzyme inhbitor, an angiotension II receptor blocker and an HMG-CoA reductase inhibitor (HMG-CoA RI). The data were analyzed to examine the degree of acheiveing the anemia treatment goal and factors relating to ERI. Results: Among total 111 patients, 42 (42.3%) and 47 (37.8%) patients achieved the target Hct and Hb based on the Health Insurance Review and Assessment Services (HIRA) reimbursement criteria. In the higher ERI group (upper quartile), the patients had higher CRP levels (0.5 mg/dl) (p=0.0096), and lower TIBC score (<$240{\mu}g/dl$) (p=0.0027), and less patients were taking HMG-CoA RI (p=0.0019). Male patients (p=0.0204), patients with high TIBC score ($R^2$=0.084, p=0.0021) and patients taking HMG-CoA RI (p=0.0052) required to administer less dose of rhEPO meaning higher erythropoietin responsiveness. Conclusion: Less than 50% of CKD patients were achieving the goals of anemia by erythropoietin administration in large hospitals in Korea even though the goals were lower than those of NKF-K/DOQI practice guideline. The factors influencing ERI were sex, TIBC and HMG-CoA RI administration status, and neither an ACEI nor an ARB did not influence ERI.

LC50 Determination of tert-Butyl Acetate using a Nose Only Inhalation Exposure in Rats

  • Yang, Young-Su;Lee, Jin-Soo;Kwon, Soon-Jin;Seo, Heung-Sik;Choi, Seong-Jin;Yu, Hee-Jin;Song, Jeong-Ah;Lee, Kyu-Hong;Lee, Byoung-Seok;Heo, Jeong-Doo;Cho, Kyu-Hyuk;Song, Chang-Woo
    • Toxicological Research
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    • 제26권4호
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    • pp.293-300
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    • 2010
  • tert-Butyl acetate (TBAc) is an organic solvent, which is commonly used in architectural coatings and industrial solvents. It has recently been exempted from the definition of a volatile organic compound (VOC) by the Air Resources Board (ARB). Since the use of TBAc as a substitute for other VOCs has increased, thus its potential risk in humans has also increased. However, its inhalation toxicity data in the literature are very limited. Hence, inhalation exposure to TBAc was carried out to investigate its toxic effects in this study. Adult male rats were exposed to TBAc for 4 h for 1 day by using a nose-only inhalation exposure chamber (low dose, $2370\;mg/m^3$ (500 ppm); high dose, $9482\;mg/m^3$ (2000 ppm)). Shamtreated control rats were exposed to clean air in the inhalation chamber for the same period. The animals were killed at 2, 7, and 15 days after exposure. At each time point, body weight measurement, bronchoalveolar lavage fluid (BALF) analysis, histopathological examination, and biochemical assay were performed. No treatment-related abnormal effects were observed in any group according to time course. Based on those findings, the median lethal concentration ($LC_{50}$) of TBAc was over $9482\;mg/m^3$ in this study. According to the MSDS, the 4 h $LC_{50}$ for TBAc for rats is over $2230\;mg/m^3$. We suggested that this value is changed and these findings may be applied in the risk assessment of TBAc which could be beneficial in a sub-acute study.

XSNP: 고성능 SoC 버스를 위한 확장된 SoC 네트워크 프로토콜 (XSNP: An Extended SaC Network Protocol for High Performance SoC Bus Architecture)

  • 이찬호;이상헌;김응섭;이혁재
    • 한국정보과학회논문지:시스템및이론
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    • 제33권8호
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    • pp.554-561
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    • 2006
  • 최근, SoC 설계연구가 활발히 진행되고 있으며, 하나의 시스템에 보다 많은 수의 IP가 포함되고 있다. 많은 IP 간의 효율적인 통신과 재사용율을 높이기 위해 다양한 프로토콜과 버스 구조들이 연구되고 있다. 기존의 공유 버스 구조의 문제점을 해결하기 위해 제안된 SNP(SoC Network Protocol) 와 SNA(SoC Network Architecture)는 각각 peer-to-peer 방식의 프로토콜과 버스 구조이다. 한편 AMBA AHB 는 대규모 SoC 시스템에 다소 부적절한 구조를 가짐에도 불구하고 산업 표준으로 자리매김 해왔다. 따라서 기존의 많은 IP들이 AMBA 인터페이스를 가지고 있으나 SNP 와는 프로토콜과 완벽하게 호환되지 않는 문제점을 가지고 있다. 기존의 IP 들의 인터페이스를 SNP 로 바꾸기 전까지는 새로 제안된 버스 구조에서도 AMBA AHB 와의 호환성을 완전히 배제할 수가 없다. 본 논문에서는 기존의 SNP 가 확장된 XSNP(extended SNP) 스펙과 SNA 기반 시스템에서 이를 지원하는 SNA 컴포넌트를 제안한다. AMBA AHB 와 SNP 사이의 프로토콜 변환을 지원하기 위해서 기존 SNP 의 페이즈를 1 비트 확장하여 새로운 8 개의 페이즈를 추가하였다. 따라서 AMBA 호환 가능한 IP 는 SNP 를 통해 성능 감쇠 없이 AHB-to-XSNP 변환기를 통해 통신할 수 있다. 또한 이러한 확장 방법은 AMBA AHB 뿐 아니라 SNP 와 다른 버스 프로토콜 사이의 신호 변환에도 이용하여 SNP 의 유연성과 성능을 향상시킬 수 있다. 제안된 구조의 검증 / 평가를 위해 다양한 시뮬레이션을 수행하였으며, AMBA AHB 와의 호환성에 있어 문제가 없다는 것을 검증하였다.

UV광 측정용 아조벤젠 코팅된 FBG의 열적 효과 제거 및 파장 의존성에 대한 연구 (The Study of Thermal Effect Suppression and Wavelength Dependence of Azobenzene-coated FBG for UV Sensing Application)

  • 최동석;김현경;안태정
    • 한국광학회지
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    • 제22권2호
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    • pp.67-71
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    • 2011
  • 본 논문에서는 ultraviolet (UV) 광의 세기를 원격으로 측정하기 위한 아조벤젠 (azobenzene) 코팅된 fiber Bragg grating (FBG)를 구현하였다. 아조벤젠 폴리머는 UV 광에 의해서 탄성이 변화하여 FBG의 코어 격자의 주기 변화를 유도하여 중심파장을 이동시킨다. 중심파장의 이동은 UV 광과 UV 이외의 파장대역의 빛에 의해서 복합적으로 발생하는데 중심파장의 이동량은 약 0.18 nm 이다. 측정의 정확성을 향상시키기 위해서 광원의 복사열에 의한 중심파장의 이동을 열차단 필터(thermal filter)를 사용하여 제거한 결과 중심파장의 이동량은 약 0.06 nm로 다소 감소하였지만 분석 결과 열에 의한 이동량이 충분히 제거된 것을 확인하였다. 또한 서로 다른 방법인 열경화법과 UV 경화법으로 각각 제작된 아조벤젠 폴리머를 이용하여 아조벤젠 코팅 FBG를 제작하였고, 각 제조법에 따른 UV센서로서의 적합성을 확인하였다. 몇 개의 밴드패스 필터(band pass filter)를 사용하여 파장에 대한 민감도를 측정한 결과, 단위 UV 세기당 중심파장의 이동량은 370nm 파장 밴드에서 가장 큰 값인 0.029로, 단파장 영역에서 반응성이 우수하다는 사실을 확인 하였다. 아조벤젠 폴리머의 흡수 스펙트럼과 아조벤젠 코팅 FBG의 파장 의존도가 서로 잘 일치하는 것을 확인하였다.

Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver

  • Cho, Kae Won;Cho, Du-Hyong
    • Journal of Yeungnam Medical Science
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    • 제36권1호
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    • pp.26-35
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    • 2019
  • Background: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in addition to common blood pressure-lowering effects. The effects and mechanism of telmisartan on HGP have not been fully elucidated and, therefore, we investigated these phenomena in hyperglycemic HepG2 cells and high-fat diet (HFD)-fed mice. Methods: Glucose production and glucose uptake were measured in HepG2 cells. Expression levels of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase ${\alpha}$ ($G6Pase-{\alpha}$), and phosphorylation levels of insulin receptor substrate-1 (IRS-1) and protein kinase C ${\zeta}$ ($PKC{\zeta}$) were assessed by western blot analysis. Animal studies were performed using HFD-fed mice. Results: Telmisartan dose-dependently increased HGP, and PEPCK expression was minimally increased at a $40{\mu}M$ concentration without a change in $G6Pase-{\alpha}$ expression. In contrast, telmisartan increased phosphorylation of IRS-1 at Ser302 ($p-IRS-1-Ser^{302}$) and decreased $p-IRS-1-Tyr^{632}$ dose-dependently. Telmisartan dose-dependently increased $p-PKC{\zeta}-Thr^{410}$ which is known to reduce insulin action by inducing IRS-1 serine phosphorylation. Ectopic expression of dominant-negative $PKC{\zeta}$ significantly attenuated telmisartan-induced HGP and $p-IRS-1-Ser^{302}$ and -inhibited $p-IRS-1-Tyr^{632}$. Among ARBs, including losartan and fimasartan, only telmisartan changed IRS-1 phosphorylation and pretreatment with GW9662, a specific and irreversible peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) antagonist, did not alter this effect. Finally, in the livers from HFD-fed mice, telmisartan increased $p-IRS-1-Ser^{302}$ and decreased $p-IRS-1-Tyr^{632}$, which was accompanied by an increase in $p-PKC{\zeta}-Thr^{410}$. Conclusion: These results suggest that telmisartan increases HGP by inducing $p-PKC{\zeta}-Thr^{410}$ that increases $p-IRS-1-Ser^{302}$ and decreases $p-IRS-1-Tyr^{632}$ in a $PPAR{\gamma}$-independent manner

Efficacy and safety of losartan in childhood immunoglobulin A nephropathy: a prospective multicenter study

  • Hyesun Hyun;Yo Han Ahn;Eujin Park;Hyun Jin Choi;Kyoung Hee Han;Jung Won Lee;Su Young Kim;Eun Mi Yang;Jin Soon Suh;Jae Il Shin;Min Hyun Cho;Ja Wook Koo;Kee Hyuck Kim;Hye Won Park;Il Soo Ha;Hae Il Cheong;Hee Gyung Kang;Seong Heon Kim
    • Childhood Kidney Diseases
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    • 제27권2호
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    • pp.97-104
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    • 2023
  • Purpose: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (ARBs) are frequently employed to counteract the detrimental effects of proteinuria on glomerular diseases. However, the effects of ARBs remain poorly examined in pediatric patients with immunoglobulin A (IgA) nephropathy. Herein, we evaluated the efficacy and safety of losartan, an ARB, in pediatric IgA nephropathy with proteinuria. Methods: This prospective, single-arm, multicenter study included children with IgA nephropathy exhibiting proteinuria. Changes in proteinuria, blood pressure, and kidney function were prospectively evaluated before and 4 and 24 weeks after losartan administration. The primary endpoint was the difference in proteinuria between baseline and 24 weeks. Results: In total, 29 patients were enrolled and received losartan treatment. The full analysis set included 28 patients who received losartan at least once and had pre- and post-urinary protein to creatinine ratio measurements (n=28). The per-protocol analysis group included 22 patients who completed all scheduled visits without any serious violations during the study period. In both groups, the mean log (urine protein to creatinine ratio) value decreased significantly at 6 months. After 24 weeks, the urinary protein to creatinine ratio decreased by more than 50% in approximately 40% of the patients. The glomerular filtration rate was not significantly altered during the observation period. Conclusions: Losartan decreased proteinuria without decreasing kidney function in patients with IgA nephropathy over 24 weeks. Losartan could be safely employed to reduce proteinuria in this patient population. ClinicalTrials.gov trial registration (NCT0223277)