• Proceedings of the PSK Conference
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• 2003.10b
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• pp.250.1-250.1
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• 2003

Background Aldosterone has an important role in the pathophysiology of heart failure. Aldosterone promotes the retention of sodium, the loss of magnesium and potassium, sympathetic activation, parasympathetic inhibition, myocardial and vascular fibrosis, baroreceptor dysfunction, and vascular damage and impairs arterial compliance. Objectives We investigated the effects of additional spironolactone to angiotensin-converting enzyme inhibitor (ACEI) / angiotensin-II receptor blocker (ARB) in patients with heart failure. (omitted)

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.43 no.9 s.351
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• pp.53-58
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• 2006

A Vertex Shader is designed to show more 3D graphics expressions, and to increase flexibility of the fixed function T&L (Transform and Lighting) engine. Design of this Shader is based on Vertex Shader 1.1 of DirectX 8.1 and OpenGL ARB. The Vertex Shader consists of four floating point ALUs for vectors operation. The previous 32bits floating point data type is replaced to 24bits floating point data type in order to design the Vertex Shader that consume low-power and occupy small area. A Xilinx Virtex2 300M gate module is used to verify behaviour of the core. The result of Synopsys synthesis shows that the proposed Vertex Shader performs 115MHz speed at the TSMC 0.13um process and it can operate as the rate of 12.5M Polygons/sec. It shows the complexity of 110,000 gates in the same process.

• Journal of Arbitration Studies
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• v.21 no.3
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• pp.55-87
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• 2011

This paper is to illustrate a variety of court-annexed ADR programs and vindicate its implications of court-annexed ADR in United States. It has been almost three decades since Frank Sender articulated his vision of the multi-door courthouse. The court-annexed ADR originated from the concept of multi-door court house. Professor Sander argued that the court must transform from the court that provides litigation, only one type of dispute resolution, to the multi-door courthouse which provides a variety of dispute resolution methods including a number of ADR programs. The types of court-annexed ADR on which this paper focus are court-annexed mediation, court-annexed arbitration, mini trial, early neutral evaluation(ENE), summary jury trial, rent-a-judge, and med-arb in United States. The findings of this paper is as follows. First, the ADR movement is the irreversible and dominant phenomenon in the US court. The motivation of incorporating ADR into court is to reduce the cost of court to handle the civil disputes and to eliminate the delay of litigation process in the court. At the same time, a couple of studies of ADR revealed that the ADR program satisfied users of ADR. Second, the landscape of ADR has not been fixed. In 1970's, the court-annexed arbitration has been popular. In 1980's, the diverse kinds of ADR programs were introduced into the federal court as well as state courts, such as mini trial, early neutral evaluation(ENE), summary jury trial, and court-annexed mediation. But in 2000s, the court-annexed mediation has been the dominant type of ADR in United States. Third, the each type of ADR program has its own place for the dispute resolution. Since Korean society enters into the stage in which diverse kind of disputes occur in the areas of environment, construction, medicare, etc, it is desirable to take into consideration of the introduction of ADR to dispute resolution in Korea.

• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.751-754
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• 2005

In this paper, we designed a vertex shader for mobile devices. Proposed Vertex shader is compatible with the OpenGL ARB & DirectX 8.0 Vertex Shader 1.1 and is organized of modified IEEE-754 24 bits float point SIMD architecture. All float point arithmetic unit process 1 cycle operation with 100Mhz frequency more. We made a vertex shader demo system with Xilinx-Virtex II and get synthesis result that confirm 11M gates size at TSMC 0.13um @ 115MHz.

• Proceedings of the Materials Research Society of Korea Conference
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• 2003.03a
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• pp.26-26
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• 2003

본 연구에서는 누적압연접합공정(ARB)을 통하여 5052 알루미늄 합금의 결정립을 약 0.2$\mu\textrm{m}$ 크기로 미세화 하였다. 누적압연에 의한 변형량 증가에 따른 미세 조직 변화와 결정립 간의 상대적인 방위각 차이를 TEM을 이용하여 관찰하였다. 누적 변형량을 함수로 상온 인장특성을 분석하였고, 초미세립 소재를 후속 열처리한 후 미세 조직 변화를 관찰하여 제조된 초미세립 소재의 열적 안정성을 평가하였다. 상온 대기 중에서 pin-on-disk 형태의 마멸시험기를 사용하여 초미세립 소재의 미끄럼 마멸시험을 변형량과 하중을 변수로 행하였다. 강소성 변형에 의해 제조된 5052 알루미늄 합금 소재의 마멸저항성은 강소성 변형 전과 비교하여 소재의 경도가 크게 증가하였음에도 불구하고 오히려 감소하였다. 마멸시험 후 마멸면의 SEM, 마멸단면의 OM 관찰과 마멸면 직하의 깊이에 따른 경도측정을 통하여 초미세립 소재의 마멸기구를 분석하였고 마멸표면의 변형 층을 관찰하였다. 또한 마멸면 직하 조직의 TEM 관찰을 통해서 마멸시험 중의 미세 조직 변화를 연구하였다.

• Journal of Industrial Technology
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• v.22 no.B
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• pp.45-50
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• 2002

Airbag systems have improved the occupant safety in reducing the injuries of driver and passenger during collisions. They have occasionally caused fatalities; especially to small occupant and children. Recent airbag related fatalities of children have raised serious concerns on how to evaluate the safety of children in various crash environments. This paper present the development of the 3-year-old human model. Child human model is composed of skin, skeleton and joints. The positions of joint and mass properties of body segments are calculated from ARB(Ariticulated Rigid Body) program GEBOD. To verify the developed human model, ROM simulation and OOP simulations are conducted.

• Journal of Advanced Marine Engineering and Technology
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• v.36 no.7
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• pp.902-909
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• 2012

This study is aimed to develop a new type of micro cross-flow hydro turbine which has very simple structure and relatively high efficiency. Micro eco cross-flow hydro turbine (ECFT) is proposed to apply in the ranges of very low and middle specific speeds in order to extend the operational range of the turbine. In order to not only obtain a basic data for a new design method of ECFT but also improve the turbine efficiency, experiments and CFD analysis on the performance and internal flow characteristics of the turbine model are conducted. According to the present study results, anti-recirculation block (ARB) and relatively wide turbine width with high flow rate improve the turbine efficiency.

• Kidney Research and Clinical Practice
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• v.34 no.1
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• pp.53-56
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• 2015

MYH9-related disorder is an autosomal dominant disease caused by a mutation in the MYH9 gene, which encodes nonmuscle myosin heavy chain IIA (NMMHC-IIA). This disease is characterized by giant platelets, thrombocytopenia, granulocyte inclusion bodies, proteinuria, and high-pitch sensorineural deafness. Nephropathy has been observed in 30% of patients with MYH9-related disorder. The characteristic features are early onset proteinuria and rapidly progressing renal disorder. However, the prognosis of MYH9 nephropathy remains unclear. Herein, we describe a 36-year-old woman who presented with proteinuria and was diagnosed with MYH9 nephropathy via renal biopsy and gene analysis. Her proteinuria improved after administration of an angiotensin II receptor blocker, but was aggravated after changing to a calcium channel blocker.

• Korean Journal of Clinical Pharmacy
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• v.22 no.4
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• pp.330-339
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• 2012

Background : Hypertension is treated with both lifestyle modification and pharmacotherapy. The Seventh Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7), published in 2003, provides a streamlined management approach to hypertension for the primary care physician. The JNC-7 is the gold standard also in Korea. According to the JNC-7, special therapeutic considerations are recommended for high-risk individuals with compelling indications. The presence of compelling indications in any given patient should be considered when selecting specific pharmacotherapy to treat hypertension. However, in patients with compelling indications, it is unknown that hepatotoxicity is caused by Calcium Channel Blocker (CCB), one of 1st anti-hypertensive drugs. Now, the CCB is the most used 1st anti-hypertensive drug in Korea Therefore, we evaluated the changes in blood liver function parameters (ALT, AST, Total bilirubin, serum albumin) for the study group. Methods : We randomly collected and retrospectively analyzed Electronic Medical Record data (n=28,788) of patients, and who took calcium channel blockers(non-dihydropyridines; diltiazem, verapamil, dihydropyridines; amlodipine, barnidipine, benidipine, clinidipine, efonidipine, felodipine, isradipine, lacidipine, lercanidipine, nicardipine, nifedipine, nimodipine), with having liver function tests (LFTs) from July 1st 2009 to June 30th 2010 at the Seoul National University Hospital in Korea. Control groups are two antihypertensive agents: RAS blockade (ARB; candesartan, irbesartan, losartan, olmesartan, telmisartan, valsartan, ACE-I; cilazapril, enalapril, fosinopril, imidapril, perindopril, ramipril) and, Diuretics (loop; furosemide, torsemide, thiazide; hydrochlorothiazide[HCTZ], indapamide). Patients not having LFT results at these three standard points of time(baseline, during, medication, and after finishing medication) were excluded. The collected data were analyzed by using the SPSS (Version12.0) and Microsoft Excel (Version2007). Results : 711 patients who were treated CCB (297), RAS blockade (232) or Diuretics (182) monotherapy were selected for the study. In selected patients, liver damage degree(changes of each LFTs value) was higher in diuretics group than other groups, followed by RAS blockade and CCB. In diuretics group's was loop-diuretics group was higher than thiazide-diuretics group. In CCB group, Nondihydropyridine-CCB's damage degree was higher than Dihydropyrine-CCB's that. Conclusions : Despite the limitations due to the retrospective study, among patients with abnormal LFTs, the use of CCBs led to a less liver damage than other 1st anti-hypertensive agents. It can be recommended CCBs as one of the initial treatments of hypertension in patients with liver disease.

• Korean Journal of Clinical Pharmacy
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• v.26 no.3
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• pp.213-219
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• 2016

Objective: Although guideline recommends beta blockers (BBs) as first line antianginal agent and calcium channel blockers (CCBs) as alternatives after percutaneous coronary intervention (PCI), the prescription patterns in real practice are not in accordance with the guideline. We aimed to investigate the prescribing patterns of primary antianginal drug and relating factors in patients who underwent PCI. Methods: Patients who have undergone PCI without myocardial infarction (MI) from November 2012 to June 2014 and followed up at least one year in a tertiary teaching hospital were included. Prescribing patterns of primary antianginal drug before, at the time of, and one year after PCI were described. Factors affecting drug selection, and their relationship with incidence of clinical outcomes defined as MI and repeated PCI, unscheduled admission or visit related with heart problem were analyzed with multivariate logistic regression. Results: A total of 506 patients were included and as primary antianginal drugs, BB, CCB, and both were prescribed in 32.2%, 24.5%, and 17.8% of patients, respectively. Also, neither BB nor CCB was prescribed at the time of PCI in 25.5% of patients. Compared with BB, CCBs were more likely prescribed in patients who had hypertension (Odds Ratio, OR 2.18, 95% confidence interval, CI 1.16-4.07), use of same class before PCI (OR 7.18, 3.37-15.2) and concomitant angiotensin receptor blocker (ARB) use (OR, 1.92, 95% CI 1.10-3.33). Incidence of clinical outcomes were not significantly greater in patients who prescribed CCB compared with BB at the time of PCI (aOR 1.32, CI 0.65-2.68). Conclusion: This study demonstrated that half of the patients who underwent PCI were prescribed BB. CCB were favored in patients with hypertension, use of same class before PCI, and concomitant ARB use. Significant difference in clinical outcome was not observed between BB and CCB selection as primary antianginal drug.