• Korean Journal of Acupuncture
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• v.27 no.3
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• pp.67-78
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• 2010

Objectives : The aim of the study is to draw a consensus in acupuncture point locations (APLs) which are frequently used in experimental animal studies. Well-documented APL is needed not only for human but also for rodents because stimulation of precise point is very important factor in acupuncture. Methods : We organized a committee with experts to reach a consensus on the APLs in rat. The subject points were limited to 22 points used in the papers published at international peer-review journals. To describe point locations, we adopted the syntax of sentence used in the WHO standard acupuncture point locations. Results : Locations of 22 acupuncture points such as ST36, LI4, PC6, and SP6 were described in English with photographic illustrations. Interestingly, we found that ST36 had been inserted into 2 different locations in rodent. Under consideration of practical use, the location of ST36 point was described in 2 different ways. Conclusion : We hope that newly developed APLs would be a good indicator of acupuncture experiments in rats and mice.

• Bulletin of the Korean Space Science Society
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• 2010.04a
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• pp.40.3-40.3
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• 2010

The most frequently suggested source for Pi2 pulsations in the inner magnetosphere (L < 4) is standing fast-mode waves trapped in the plasmasphere (i.e., plasmaspheric resonances). They have been considered as the source of low-latitude Pi2 pulsations. The plasmaspheric resonance model suggests that compressional fast-mode waves can be detected at all local times inside the plasmasphere provided reflection of the wave energy is efficient. Until now, however, there are no reports about compressional Pi2s observed in the dayside inner magnetosphere. That is, there is longitudinal limit of inner magnetosphere. In February 2008, THEMIS probes were near dawn and/or dusk sides, which are the transition regions between the nightside and dayside, in the inner magnetosphere (L = 2-4) when low-altitude Pi2s were identified at Bohyun (L = 1.35) station in Korea. Using the THEMIS electric field data, we examined if Pi2s are excited by longitudinally localized disturbances. We found that compressional Pi2s having high coherence with a low-latitude Pi2 pulsation occur on dawnside. However, any compressional pulsations in the Pi2 frequency band were not detected on duskside. This indicates that compressional Pi2s disappear near the duskside. Our observations are discussed with spatial plasmaspheric structure and possible Pi2 mechanisms.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.286-286
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• 2022

The properties of starch play an important role in determining the palatability of rice. In addition, the gelatinization temperature (GT) of rice starch is an important factor in determining the quality of rice because it is related to the cooking time and texture of rice. For the development of high-quality rice, it is important to understand the genetic basis of palatability-related traits, and QTL analysis is an effective method to explain the genetic basis of variation in complex traits. QTL mapping related to alkali digestion value (ADV) of brown and milled rice was performed using the 120 Cheongcheong/Nagdong double haploid (CNDH) line. As a result, 12 QTLs related to ADV were detected, and 20 candidate genes were selected from the RM588-RM1163 region of chromosome 6 through screening by gene function analysis. The comparison of the relative expression level of candidate genes showed that OsSS1q6 is highly expressed in CNDH lines with high ADV in both brown rice and milled rice. In addition, OsSS1q6 has high homology with starch synthase 1 protein, and interact with various starch biosynthesis-related proteins, such as GBSSII, SBE, and APL. Therefore, we suggest that OsSS1q6 identified through QTL mapping could be one of the various genes involved in the GT of rice by regulating starch biosynthesis. This study can be used as basic data for breeding high-quality rice and provides a new genetic resource that can increase the palatability of rice.

• Journal of Korean Society of Water and Wastewater
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• v.37 no.6
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• pp.335-345
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• 2023

In Korea, as part of the Green New Deal project toward a carbon-neutral society, it is necessary to build a climate-resilient urban environment to green the city, space, and living infrastructure. To this end, SWMM-ING was improved and the model was modified to analyze the carbon reduction effect. In addition, I plan to select target watersheds where urbanization is rapidly progressing and evaluate runoff, non-point pollution, and carbon reduction effects to conduct cost estimation and optimal design review for domestic rainwater circulation green infrastructure. In this study, green infrastructure facilities were selected using SWMM-ING. Various scenarios were presented considering the surface area and annual cost of each green infrastructure facility, and The results show that the scenario derived through the APL2 method was selected as the optimal scenario. In this optimal scenario, a total facility area of 190,517.5 m² was applied to 7 out of 30 subwatersheds to achieve the target reduction. The target reduction amount was calculated a 23.50 % reduction in runoff and a 26.99 % reduction in pollutant load. Additionally, the annual carbon absorption was analyzed and found to be 385,521 kg/year. I aim to achieve additional carbon reduction effects by achieving the goal of reducing runoff and non-point pollution sources and analyzing annual carbon absorption. Moreover, considering the scale-up of these interventions across the basin, it is believed that an objective assessment of economic viability can be conducted.

• 한국생물공학회:학술대회논문집
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• 2001.11a
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• pp.867-870
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• 2001

All-trans-retinoic acid (RA) plays essential roles in the regulation of differentiation and proliferation. It has been proved that RA is effective in the treatments of epithelial and hematologic malignancies. However, in spite of its pronounced effects, the clinical applications of RA are limited due to the retinoid acute resistance. Although RA induces complete remission in a high proportion of the patients of acute promyelocytic leukemia (APL), the cancer was relapsed in many patients after a brief remission in spite of a continued RA treatment. Patients who relapsed from remission that was initially induced by RA had clinically resistant to further RA treatment. That is, specific cytochrome P450 enzymes in the liver were induced by the continuous oral administration of RA, thereby accelerating the metabolism of RA. To overcome this problem, biodegradable microspheres were proposed by us, previously. And, several microsphere formulations for RA delivery have been prepared and studied on their effectiveness. Recently, poly(D,L-lactide) (PDLLA) microsphere formulation was optimized, And, from the animal studies by using a mouse and a rat, it have appeared to be effective on both the inhibition of tumor growth and chemoprevention of a carcinogenesis. In this study, subacute toxicities of the PDLLA microsphere formulation have been investigated as a preclinical test. For the test, the microspheres was injected subcutaneously into the back site of rats, and body weight change, clinical signs, hematological changes, blood biochemistry were evaluated. As a result, severe toxicities such as mortality were observed at the dose of 100mg RA/kg, and toxicities were not observed at the dose of 50mg RA/kg, which is the effective dose against carcinogenesis. Bone fracture, observed at several rats, might be inhibited by treating them with anti-inflammatory drugs.

• Applied Biological Chemistry
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• v.40 no.3
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• pp.189-195
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• 1997

The structural basis of Iysine specificity of Achromobacter protease I (API) was investigated by means of site-directed mutagenesis. The precursor protein in which Glu190, one of the two candidates for determining Iysine specificity, was substituted by glutamine, aspartic acid or leucine was processed autocatalytically to attaln full pretense activity with lysine specificity. The substitution of the other candidate, Asp225, for asparagine or leucine produced no mature active forms of pro-API. The precursor protein of the mutant D225E slowly matured autocatalytically. The lysylendopeptidase activity of the mature D225E was 0.25% of that of native API, and this reduced activity is mainly due to a decrease in the affinity of the enzyme for lysine. These results suggest that Asp225 plays a critical rol in restricted substrate specificity as a lysylendopeptidase. However, D225E exhibited no measurable activity for synthetic ornithine substrate. Since the hydroxyl group of Ser194 in this mutant retained essentially the same reactivity to DFP or PMSF as that in native API, it can be noted that a methylene unit longer side chain of residue 225 is not compensated by a methylene unit shorter side chain at subsite P1 in the bound substrate.

• Resources Recycling
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• v.8 no.4
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• pp.45-56
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• 1999

The purpose of tlus sludy was to preparc raw material powder for Mn-Zn iclrile, h m mined mill scale and fero-Mn, usins a co-spray roasting process The mill scale and ferra-Mn uscd in this raalins process was rcf~nedb y mesn-ns of a slxc~apl rxcss ~nvolvinm~a te~ialsc ontalning imp~u-ltleso r less than 100 pprn In this study an effeclive spray roaster system. wllich produces fme complex oxide powder, collects produccd ~owder.,m d prcvel~tse ~~llssiooifi HCI gas. was also manufactured. By means of spray~ngp urifcd raw malerial solu~lionl nln a manufacued high tcmpervture rumace. &-ferrite powder and a comnpleu o ~ d e powder of Fe,O; and M,x203 were manufactured. The chmcterlstics of the composllion. surface urca, and p'miicle size dismbulion or the produced powder were exmined. ptoduced powdcr was then ~ m e dwi tli ZnO powder. aid olher addilives of defined cornposnion, and Mn-Zn femite cares werc praiuccil by meuns of Sorlning and closely controlled sintering processes. The magpelic p~oprlieso f c olo~ss, initlal permeability. mauin~u~mnn agnehc flux. coz~civcr orcc and residual magnccic flux for the above cores we,= measured, and fmm Il~ase I-csulls the eflicacy of lhe co-spray roasling pncess to pl.ellare raw material powder lor Mn-Zn ferntc was established

• Korean Journal of Food Science and Technology
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• v.40 no.2
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• pp.238-242
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• 2008

In this study, hydrogen sulfide ($H_2S$) production was examined during beer fermentation using two ale and two lager yeast strains. In the lager yeast fermentation, a large amount of $H_2S$ was produced in the early fermentation stages when the yeast were actively fermenting wort, indicating a positive relationship between the level of H2S production and the yeast growth rate during fermentation. The ale yeasts produced much lower levels of H2S than the lager yeasts. In the lager fermentation, a higher fermentation temperature shortened the fermentation period, but much higher levels of $H_2S$ were produced at higher temperatures. American pilsner lager yeast fermenting at $15^{\circ}C$ produced a relatively high level of $H_2S$ at the end of fermentation, which would require a longer aging time to remove this malodorous volatile sulfur compound. Not including the English ale strain, which produced a higher level of H2S at lower temperatures, the ale yeast produced lower levels of $H_2S$ at lower temperatures, suggesting that each strain has an optimum fermentation temperature for H2S production.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.47-55
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• 2019

The army of republic of korea have been continued to transform their logistics support system structure for better efficient logistics support system in preparation for the future environment. Logistics system has supply network structure which is connected by various units and supply network structure received attention as a factor of success of supply network. Many researchers have continuously researched inventory management, transportation or economy factors for supply network, but such a study on the one in military supply network structure analysis is still slower than the study of analysis of other factors until now. In this study, we identify military supply network structure influence factor by application of social network analysis method which is used broadly and analyze co-relationships between supply network structure influence factor and valued APL(average path length) as a criteria of efficiency of military supply network. By this study it has value of military supply network influence factor identification for the better military supply network fabrication.