• Korean Journal of Radiology
• /
• v.21 no.6
• /
• pp.647-659
• /
• 2020

Objective: The occurrence of intramyocardial hemorrhage (IMH) and microvascular obstruction (MVO) in myocardial infarction (MI), known as severe ischemia/reperfusion injury (IRI), has been associated with adverse remodeling. APT102, a soluble human recombinant ecto-nucleoside triphosphate diphosphohydrolase-1, can hydrolyze extracellular nucleotides to attenuate their prothrombotic and proinflammatory effects. The purpose of this study was to temporally evaluate the therapeutic effect of APT102 on IRI in rats and to elucidate the evolution of IRI in the acute stage using cardiovascular magnetic resonance imaging (CMRI). Materials and Methods: Fifty-four rats with MI, induced by ligation of the origin of the left anterior descending coronary artery for 60 minutes, were randomly divided into the APT102 (n = 27) or control (n = 27) group. Intravenous infusion of APT102 (0.3 mg/kg) or placebo was administered 15 minutes before reperfusion, and then 24 hours, 48 hours, 72 hours, and on day 4 after reperfusion. CMRI was performed at 24 hours, 48 hours, 72 hours, and on day 5 post-reperfusion using a 7T system and the hearts were collected for histopathological examination. Cardiac function was quantified using cine imaging and IMH/edema using T2 mapping, and infarct/MVO using late gadolinium enhancement. Results: The extent of infarction (p < 0.001), edema (p < 0.001), IMH (p = 0.013), and MVO (p = 0.049) was less severe in the APT102 group than in the control group. IMH size at 48 hours was significantly greater than that at 24 hours, 72 hours, and 5 days after reperfusion (all p < 0.001). The left ventricular ejection fraction (LVEF) was significantly greater in the APT102 group than in the control group (p = 0.006). There was a negative correlation between LVEF and IMH (r = -0.294, p = 0.010) and a positive correlation between IMH and MVO (r = 0.392, p < 0.001). Conclusion: APT102 can significantly alleviate damage to the ischemic myocardium and microvasculature. IMH size peaked at 48 hours post reperfusion and IMH is a downstream consequence of MVO. IMH may be a potential therapeutic target to prevent adverse remodeling in MI.

• TTA Journal
• /
• s.55
• /
• pp.94-102
• /
• 1998

아시아$\cdot$태평양 지역에서의 전기통신 분야에 대한 표준화의 인식 제고와 표준화를 통한 국제경쟁력 강화를 위해, 최근 동 지역에서는 지역 표준화기구 설립 문제등을 포함한 표준화활동 강화가 주요 이슈로 제기되고 있다. 이에 본 고에서는 제21차 APT Management Committee(관리이사회) 회의결과를 바탕으로 그 동안 논의되어 왔던 지역 표준화기구 설립에 대한 주요 사항을 분석하였으며, 아울러 국내의 향후 대응방향도 간략히 살펴보았다.

• Journal of Korean Neurosurgical Society
• /
• v.48 no.6
• /
• pp.485-489
• /
• 2010

Objective : To introduce the frequency and segment analysis of in-stent stenosis for intracranial stent assisted endovascular treatment on complex aneurysms. Methods : A retrospective study was performed in 158 patients who had intracranial complex aneurysms and were treated by endovascular stent application with or without coil embolization. Of these, 102 patients were evaluated with catheter based angiography after 6, 12, and 18 months. Aneurysm location, using stent, time to stenosis, stenosis rate and narrowing segment were analyzed. Results : Among follow-up cerebral angiography done in 102 patients, 8 patients (7.8%) were shown an in-stent stenosis. Two patients have unruptured aneurysm and six patients have ruptured one. Number of Neuroform stents were 7 cases (7.5%) and Enterprise stent in 1 case (11.1%). Six patients demonstrated in-stent stenosis at 6 months after stent application and remaining two patients were shown at 12 months, 18 months, respectively. Conclusion : In-stent stenosis can be confronted after intracranial stent deployment. In our study, no patient showed symptomatic stenosis and there were no patients who required to further treatment except continuing antiplatets medication. In-stent stenosis has been known to be very few when they are placed into the non-pathologic parent artery during the complex aneurysm treatment, but the authors found that it was apt to happen on follow up angiography. Although the related symptom was not seen in our cases, the luminal narrowing at the stented area may result the untoward hemodynamic event in the specific condition.

• Proceedings of the Korea Database Society Conference
• /
• 1999.06a
• /
• pp.95-102
• /
• 1999

The web-based group collaborative systems are emerging as enterprise-wide information systems. Since data in group collaborative systems are apt to be shared among multiple concurrent users and modified simutaneously by them, the web-based group collaborative systems must support synchronous collaboration in order to provide users with synchronized and consistent views of shared data. This Paper proposes an active web server which can facilitate synchronous collaboration in web-based group collaborative systems. To accomplish such a goal, the active web server manages dependency relationships between shared data and web browsers referencing them and actively propagates changing details of the shared data to all web browsers referencing them. And, this paper examines usefullness and effectiveness of the active web server to apply it to the ball-bearing design example of concurrent engineering design systems. The prototype system of the active web server is developed on a commercial Object-oriented Database Management System (ODBMS) called OBJECTSTORE using the C＋＋ programming language.

• Proceedings of the Korea Inteligent Information System Society Conference
• /
• 1999.03a
• /
• pp.95-102
• /
• 1999

The web-based group collaborative systems are emerging as enterprise-wide information systems. Since data in group collaborative systems are apt to be shared among multiple concurrent users and modified simutaneously by them, the web-based group collaborative systems must support synchronous collaboration in order to provide users with synchronized and consistent views of shared data. This paper proposes an active web server which can facilitate synchronous collaboration in web-based group collaborative systems. To accomplish such a goal, the active web server manages dependency relationships between shared data and web browsers referencing them and actively propagates changing details of the shared data to all web browsers referencing them. And, this paper examines usefullness and effectiveness of the active web server to apply it to the ball-bearing design example of concurrent engineering design systems. The prototype system of the active web server is developed on a commercial Object-oriented Database Management System (ODBMS) called OBJECTSTORE using the C++ programming language.

• Journal of the Korean Institute of Landscape Architecture International Edition
• /
• no.1
• /
• pp.102-110
• /
• 2001

A townscape has both aspects of seeing and living. However, the main streams of townscape making have been mostly focused on the former perspective so far. Such trends are apt to lack the realities of urban living. In this view, a prerequisite to complement the existing formalistic view with this realistic one is needed in order to accomplish the holistic characteristics of a townscape. Many city governments of Korea are currently trying to improve the quality of living quarters by providing diverse kinds of open spaces such as vest-pocket parks, pedestrian-friendly streets, and supporting the residents participatory village making. In this context, this paper will review the possibilities of the realistic approaches in townscape making by examining some current cases being tried in Korea cities. In conclusion some main issues to be solved in future can be listed as the conflict between general citizen′s view and the residents′ view", the conflict between social aspects and aesthetical aspects" and the conflict between the tradition and the vernacular reality in design".

• Journal of Power System Engineering
• /
• v.18 no.5
• /
• pp.80-87
• /
• 2014

The pipelines are apt to erosion or corrosion because of the high-speed flow of water and steam with high temperatures or high pressures. This study was carried out a finite element analysis (FEA) and an experimental for the fracture behavior of T-joint pipes with local wall thinning under internal pressure. Local wall thinning was machined on the pipes in order to simulate erosion and corrosion of the metal. The configurations of the eroded area included an eroded ratio of d/t=0.80~0.963 and an eroded length of l=25 mm, 50 mm, and 102 mm. Three-dimensional elastic-plastic analyses were also carried out using FEA, which accurately simulates failure behaviors. In regards to the relationship between pressure and eroded, the criterion that indicates what can be used safely under operating pressure and design pressure were obtained from FEA. The FEA results were in relatively good agreement with that of the experiment.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 1999.11a
• /
• pp.102-144
• /
• 1999

The major problems of food crop cultivation in Korea are low yield of most crops except rice. inefficient cultivation techniques for aged farmers. and low international competibility. Therefore, development of cultivation techniques of food crops should aim the yield. quality improvement, labor reduction and production cost. The primary issue for increasing the yield of soybean, barely and wheat is to reduce the yield gap between the farmer's yield and recommended ones of experiment station. More advanced cultivation techniques needs to be developed. and/or the conventional breeding methods to be reconsidered. The newly developed labor-saving mechanized technique needs to reduce labor hours , and the cost of agricultural implements and machineries. In other words the labor-saving mechanized technique should be developed based on the improvement of total farming system as well as systemic fundamental innovation of cultural methods. The efficiency of solar energy use in food production of Korea in 1997 is as low as $0.52{\%}$ so there is much room to increase yield. It is recommendable that the concept of food Production should be changed to energy Producing efficiency Per unit area basis from volume and weight of food materials. Moreover, introduction of resonable cropping system is needed to increase yield of main crops, farmer's income, solar energy use efficiency, and decrease of land service expenditure. Current cropping system emphasized on economic crops. especially in vegetables , is not desirable for resonable use of arable land. stability of agricultural management and staple food crop self-sufficiency ratio. It is desirable to increase food crops . that are energy of carbohydrate and protein rich and land dependent crops. in cropping system. And the agronomist should develop the cultural methods to replace food crops for food self-sufficiency and stable farming management instead of economic crops in current cropping system. Low-input and environmentally-sound crop cultivation techniques, especially nitrogen-reducing culture technique which is directly related to food crop quality, also needs to be developed urgently. The extended cultivation of corn in upland and barely and wheat in lowland as a feed stuffs is recommended to prevent further decrease of food self-sufficiency ratio, which is mainly caused by the high reliance on imported feed grain. It is also considered that the calculation and presentation methods of standard agricultural income needs to be improved. The current calculation method uses unit land area of 10a regardless of crop kinds , characteristics of agricultural management and cultivation scale. So, it is apt to lead misunderstanding of farm income value. Therefore. it should show an income of average farmers for certain number of years. Research and developing system for food producing is not desirable because they are conducted currently individual crop and mono-culture basis. But actual agricultural income is usually earned by cropping system including upland and lowland. For example. the barley and wheat is usually cultivated in double cropping system. The cooperation among research institutes such as university agribusiness. government and farmers is indispensible. The public information and education on importance and consumption habit of food crops is necessary in Korean society to increase food self-sufficiency through nationwide cooperation.

• Journal of Korean Orthopaedic Sports Medicine
• /
• v.1 no.1
• /
• pp.102-107
• /
• 2002

Purpose: The aim of this retrospective study were to report the short-term results of inferior capsular shift procedure using splitting subscapularis and capsule for the patients who had shoulder instability and were apt to recur after arthroscopic stabilization procedure. Materials & Methods : Fifteen cases of instability of the shoulder were included with an average follow-up of 2 years (range: 1$\~$3 years). There were 13 men and 2 women with an average age of 27years. Multidirectional instability was found in 4 cases, voluntary instability in 3 cases, bony Bankarte lesion in 2 cases and 6 cases were contact sportmen. Thirteen shoulders underwent the inferior capsular shifts and Bankart repairs and 2 shoulders without Bankart lesion underwent the inferior capsular shift only. Average 19 mm of shift (range: 10$\~$25 mm) was done. Results : Fourteen patients showed good and excellent results with one subluxation and one positive apprehension test. Postoperative ranges of motions did not change in forward elevation, external rotation at side and external rotation at 90$^{\circ}$ abduction (p>0.05). Conclusion : Inferior capsular shift procedure using splitting subscapularis and capsule can be helpful in shoulder instability patients who were high-risk group of recurrence with arthroscopic procedure.

• Journal of Korean Academy of Nursing
• /
• v.8 no.2
• /
• pp.89-102
• /
• 1978

Owing to the development of modern science, prolonging man's life, the sudden increase of population and betterment of the standard of living has increased health needs. In order to fulfill these health needs, more active plans for developing health should be made. Health education is one of the methods at hand that can improve the health behavior of the community and the individual through the contact of individuals with their groups. Proper understanding of the characteristics of the sampled group and participation of individuals within the community for the development of their health plan are needed for efficient health education. This study was attempted for the purpose of presenting some data helpful for pre-paring the fundamentals of a health education plan that can improve personal health maintenance practice of a community through efficient health education by investigating the relationship between the response of subjects to personal health maintenance practice and selected decisive factors in personal health maintenance practice. The subjects for this study were a systematic sample of 120 housewives selected from 600 housewives from B Zone Apt. Younhi-3-Dong in Seoul. Data was collected for 4 days from May 16th to May 19th, 1578 through personal interviews with questionnaires by well trained interviewers. Percentage, t-test and stepwise multiple regression analysis by use of EDPS were employed for statistical analysis. Results of this study can be summarized : 1. General characteristics of subjects Subjects over 20 and below 40 years of age formed 62.5% of the toed and the rest were subjects of 40 years and upward. 76.7% of the subjects have less than 4 children. 51.3% of the subjects had completed at least the senior high school course. 2. The response of subjects to personal health maintenance practice. Ratios of personal health maintenance practice to the maximum score for each category are as follows; 84.1% in the category of population and family planning, which was the highest ratio; 82.4% in the prevention of accidents; 68.0% in control of communicable disease; 67.8% in personal health care and habits of daily life, 64.3% in mental health and 52.5% in control of parasites, which was the lowest. 3. The response of subjects to selected decisive factors. in personal health maintenance practice. The arithmetic mean of the score for each decisive factor was as follows: the mutual relation between family members marked 18.33, which is under 73,3% of the maximum score; the degree of interest in health marked 34.48, 70.0% of the maximum score: the degree of utilization and demand for health care facilities marked 25.79 or 64.5% of the maximum score and health maintenance of the family marked 11.58, 43.6% of the maximum score. 4. The relationship between personal health maintenance practice and general characteristics of subjects. 1) There was a significant difference in the numbers of children. (t = 1.83, d.f. =117, p< 0.1) 2) There was a significant difference in the contact rates with mass-media, (t = 5.02, d.f. = 118, p< 0,05) 5. The multiple correlation between personal health maintenance practice and their selected decisive factors. 1) The factor“the degree of interest in health”could account for personal health maintenance practice in 43.6% of the sample. (R = 0.6602, R²= 0,4359, F = 91.1678, p< 0.001) 2) When the factor,“health maintenance of family”is added to this, it accounts for 51.2% of personal health maintenance practice. (R = 0.7158, R²= 0.5124, F = 61.4653, p< 0.001) 3) When the factor,“mutual relations between family members”is also included, it accounts for 53.7% of personal health maintenance practice. (R = 0.7324, R²= 0.5365, F = 44.7509, p< 0.001) 4) When the factor, “the degree of utilization and demand for health care facilities”is included, it accounts for 55.1% of personal health maintenance practice. (R = 0.7421, R²= 0.5507, F = 35.2430, p< 0.001).