• Journal of Microbiology and Biotechnology
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• v.21 no.1
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• pp.28-36
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• 2011

Diblock copolymers composed of poly(${\varepsilon}$-caprolactone) (PCL) and poly(N,N-dimethylamino-2-ethyl methacrylate) (PDMAEMA), or methoxy polyethylene glycol(PEG), were synthesized via a combination of ring-opening polymerization and atom-transfer radical polymerization in order to prepare polymeric nanoparticles as an antifungal drug carrier. Amphotericin B (AmB), a natural antibiotic, was incorporated into the polymeric nanoparticles. The physical properties of AmB-incorporated polymeric nanoparticles with PCL-b-PDMAEMA and PCL-b-PEG were studied in relation to morphology and particle size. In the aggregation state study, AmB-incorporated PCL-b- PDMAEMA nanoparticles exhibited a monomeric state pattern of free AmB, whereas AmB-incorporated PCL-b- PEG nanoparticles displayed an aggregated pattern. In in vitro hemolysis tests with human red blood cells, AmBincorporated PCL-b-PDMAEMA nanoparticles were seen to be 10 times less cytotoxic than free AmB (5 ${\mu}g$/ml). In addition, an improved antifungal activity of AmBincorporated polymeric nanoparticles was observed through antifungal activity tests using Candida albicans, whereas polymeric nanoparticles themselves were seen not to affect activity. Finally, in vitro AmB release studies were conducted, proving the potential of AmB-incorporated PCL-b-PDMAEMA nanoparticles as a new formulation candidate for AmB.

• Journal of Acupuncture Research
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• v.29 no.5
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• pp.187-195
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• 2012

Objectives : Amyotrophic lateral sclerosis(ALS) is a progressive and incurable disease that causes degeneration of the motor neurons of the brain stem and spinal cord. The purpose of this study was to report the effectiveness of Sa-am acupuncture treatment on ALS patient. Methods : Following the stabilization period, a ALS patient respiratory figures(Et $C_{O2}$, Sp $_{O2}$, RR, pulse) were measured by using capnography & pulse oximetry for 30 minutes before acupuncture treatment. Acupuncture treatment such as lung tonification($SP_3(+){\cdot}LU_9(+){\cdot}HT_8(-){\cdot}LU_{10}(-)$), heart tonification($HT_9(+){\cdot}LR_1(+){\cdot}SI_8(-){\cdot}KI_{10}(-)$), liver tonification ($KI_{10}(+){\cdot}LR_8(+){\cdot}LU_8(-){\cdot}LR_4(-)$) were conducted for 5 days. Each Sa-am acupuncture treatment conducted at AM 7 : 00, AM 11 : 00, PM 4 : 30 of the day. During acupuncture treatment, the patient respiratory figures were measured equally for 30 minutes. The patient was treated by using Dong-bang acupuncture needles($0.30{\times}4.0$) and also stimulated using infra red. Results : The value of Et $C_{O2}$ has decreased more after Sa-am acupuncture lung tonification treatment than others. The value of pulse has decreased more after Sa-am acupuncture heart tonification treatment than others. The value of raspiration rate has decreased more after Sa-am acupuncture liver tonification treatment than others. And the value of Sp $O_2$ has increased more after Sa-am acupuncture liver tonification treatment than others. Conclusions : Although this study was subject to a few limitations, but it shows that Sa-am acupuncture treatment for ALS patients has a meaningful effect. This study needs to be developed further using a larger sample size to obtain more valuable and meaningful data.

• Fashion & Textile Research Journal
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• v.7 no.3
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• pp.321-326
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• 2005

The purpose of this study was to investigate the effect of body fat on energy metabolic response and subjective sensations under the hot environment. Fifteen female university students volunteered as subjects. We organized subjects into three groups: low body fat group(group L : less than 20% of body fat), medium body fat group(group M : 20%~30% of body fat) and high body fat group(group H: more than 30% of body fat). The experiment was conducted with $32^{\circ}C$, 60%RH. The subjects repeated 'Exercise' and 'Rest' period. The results of this study are as follows ; The oxygen uptake value of AM is higher than PM. The value of group H is the highest in three fat groups. But it showed group L is the highest in oxygen uptake per weight. %body fat is the lower, oxygen uptake is the higher. In Calorie, group L has higher value in AM in than in PM. In M group and group H, a value of PM is higher than AM. In group H, difference of AM and PM is the highest. From a view point of three groups, a value of group H is the highest. This support that calorie increases as oxygen uptake increase. The heart rate values of group L and group H are the higher in AM than in PM. This support that heart rate was relation to oxygen uptake. In all three groups, the value of blood pressure is higher in AM than in PM. Subjective sensations of temperature sensation, thermal comfort, and wetness sensation are higher in Am than in Pm. This explains that subject sensations are similar to experimental data, such as oxygen uptake, heart rate, blood pressure. In oxygen uptake, heart rate and blood pressure, general tend to showed higher AM than PM. This showed that heart rate, oxygen uptake increase in AM, as blood pressure increase, too. From a view point of %body fat, group H is higher than the others in oxygen uptake, heart rate and blood pressure.

• Archives of Plastic Surgery
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• v.40 no.1
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• pp.11-18
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• 2013

Background To minimize the inflammatory reaction and improve healing, a new modified dermal substitute composed of an atelocollagen, chondroitin-6-sulfate, and amniotic membrane (AM) was applied to full-thickness skin defects in a pig. Atelocollagen was extracted from bovine skin, and two modified dermal substitutes were generated according to the cross-linking type. Methods The AM-collagen dermal substitutes were characterized and compared with currently used dermal substitutes in a pig skin defect model. There were five experimental groups: dehydrothermal (DHT) cross-linking atelocollagen with the AM on the top (AM-DHT), DHT and chemical cross-linking atelocollagen with the AM on the top (AM-DHT/chemical), Terudermis, Integra, and AlloDerm. After $3{\times}3cm$ full-thickness skin defects on the back of a pig were created, each dermal substitutes dermal substitutes was randomly grafted on the defects. Two weeks after grafting, autologous partial-thickness skin was over-grafted on the neodermis. The take rate of the dermal substitutes, skin, and histological sections were all assessed at 1, 2, and 4 weeks postoperatively. Results More rapid healing and a higher take rate were evident in the AM-DHT and Terudermis groups. Histological examination revealed fewer inflammatory cells and more fibroblast hyperplasia in these two groups. Four weeks after surgery, the amount of newly formed collagen was significantly more appropriate in the AM-DHT group. Conclusions These observations provide supporting evidence that a newly developed amniotic-collagen dermal substitute may inhibit inflammatory reactions and promote wound healing.

• Nuclear Engineering and Technology
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• v.53 no.8
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• pp.2454-2463
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• 2021

The objective of this research is to the use of americium (AmO₂) as a burnable absorber effectively instead of conventional gadolinium (Gd₂O₃) for VVER-1200 reactor by analyzing its impacts on reactivity, power peaking factor (PPF), safety factor, and quality of the spent fuel. The assembly is burned to 60 GWd/t by using SRAC-2006 code and JENDL-4.0 data library for finding the optimum amount and effective way of using AmO₂ as a burnable absorber. From these studies, it is found that AmO₂ can decrease the excess reactivity like Gd₂O₃ without changing the criticality life span and enrichment of ²³⁵U. A homogeneous mixture of the 0.20% AmO₂+ 4.95% enriched UO₂ fuel rod (model MF-4) decreases the PPF than the reference assembly. The use of AmO₂+UO₂ in the integral burnable absorber (IBA) rod or the outer layer could also decrease the PPF up to 10 GWd/t but increases rapidly after 30 GWd/t, which could be a safety threat. The fuel temperature coefficient and void coefficient of the model MF-4 are the same as the reference assembly. In addition, 22% of initially loaded Am are burning effectively and contributing to the power production.

• Journal of Acupuncture Research
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• v.29 no.2
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• pp.107-113
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• 2012

Objectives : The purpose of this study was to evaluate the effects of $Sa-am$ acupuncture treatment on an interstitial cystitis patient. Methods : A 51 year-old woman who diagnosed as interstitial cystitis, was enrolled in this study. The clinical data was analyzed on a patient with interstitial cystitis due to $Shinheo$(腎虛). The patient had visited Korean medicine department of Yangsan public health care center, and was treated with a $Sa-am$ acupuncture($Sinjeongkyeok$) for 4 weeks. Results : After 4 weeks of $Sa-am$ acupunture treatment($Sinjeongkyeok$), improvement was seen in the subsection of the international prostate symptom score and the part of qualiveen questionnaire score. Conclusions : This clinical case indicates that acupuncture treatment is significantly effective in treatment of a interstitial cystitis.

• Journal of Haehwa Medicine
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• v.13 no.2
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• pp.259-265
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• 2004

Objective; This study was designed to investigate the effect of Sa-am acupuncture and Arctii Fructus water extract on Post-herpetic Neuralgia. Method: We have treated them with acupuncture treatment of Sa-am acupuncture and Arctii Fructus water extract and evaluated the effect by Pain Rating Score(P.R.S.) and Visual Analogue Scale(V.A.S.) scale. Result: Before theraphy, the grades of Song's scale were P.R.S. 80 and V.A.S. 100, Kim's sclae's P.R.S. 77 and V.A.S. 100. After theraphy, the grades of song's scale were P.R.S. 5 and V.A.S. 10, Kim's scales's P.R.S. 10 and V.A.S. 10 Conclusion: The treatment of Sa-am-acupuncture and Arctii Fructus water extract on Post-herpetic Neuralgia was effective and will be attempted to the patients with it.

• Journal of The Institute of Information and Telecommunication Facilities Engineering
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• v.2 no.4
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• pp.42-51
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• 2003

In this paper, we are going to analyze on relation of an output spectrum along phase distortion of power amplifier in wireless LAN system, and then considered an ACPR characteristic of power amplifier and consideration of an OFDM method for this. Also, we did implementation for OFDM modulation and transmission section of an IEEE 802.11a standard to have transmission speed of the maximum 54Mbps in order to know an OFDM modulation method and relation of non-linear characteristic of power amplifier. The non-linear characteristic of power amplifier did modeling with AM-to-AM and AM-to-PM, and we analyzed an output spectrum characteristic along phase distortion composed input signal supply for power amplifier. When output spectrum analysis results phase distortion increased, and an AM-to-PM characteristic of power amplifier in 5 degrees, the output spectrum was satisfied with a demand spectrum in P1 dB, but 10-20 degrees were able to confirm what cannot be satisfied with a demand spectrum in phase distortion. Also, an output spectrum of power amplifier by frequency re-growth generated by a non-linear characteristic of power amplifier did not satisfied in P1dE. therefore, a back-off value was requested according to an AM-to-PM distortion degree, and smaller back-off value were able to know what demand became in case of modulation section that used OFDM.

• Korean Journal of Medicinal Crop Science
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• v.21 no.4
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• pp.262-267
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• 2013

The purpose of this study was to research for anti-oxidation and anti-wrinkle effects of Acar mono Sap (AM). To cosmetic effect of AM, safety effect (MTT assay), anti-wrinkle effect (elastase, MMP-1 inhibition assay) and anti-oxidant effect (DPPH assay) were measured. When water extract of AM was used for cell viability, it was over 100% at 6% (6 ml/100 ml in phosphate buffer) concentration. AM showed 45.7% elastase inhibition and 23.7% MMP-1 inhibition at 50% (50 ml/100 ml in phosphate buffer) concentration so that it had good anti-wrinkle characteristic. And AM showed 68.9% antioxidation capacity at 50% concentration by using a DPPH assay. Consequently, AM can be used as natural materials or additives for human skin owing to their beneficial biologic functions, including the anti-wrinkle effect, for cosmetic compositions.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.8
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• pp.1612-1620
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• 2003

This papers describes a nonlinear transfer function modelling of designed GaAs FET power amplifier by measured and simulated values of designed PA amplifier for multi­carrier transmission system, With the results of PA nonlinearity characteristic, we can estimates AM­AM and AM­PM of designed PA. According to the estimated nonlinear characteristics, we can analysis the ACPR of PA for spectral regrowth, the error vector measurement(EVM) of constallation signals and bit error rate of QPSK and 64­QAM. The suggested nonlinear modelling results are used to get an accurate estimate of digital characteristics between PA amplifier and wireless multi­carrier transmission system using OFDM.