• The Journal of the Korea institute of electronic communication sciences
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• v.4 no.4
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• pp.247-252
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• 2009

This paper presents an Integer-N phase-locked loop (PLL) frequency synthesizer using a novel prescaler based on a charge pump and clock triggering circuit. A quadrature VCO has been designed for the 900MHz UHF RFID application. In this circuit, a voltage-controlled oscillator(VCO), a novel Prescaler, phase frequency detector(PFD), charge pump(CP), and analog lock detector(ALD) have been integrated with 0.35-${\mu}m$CMOS process. The integer divider has been developed with a verilog-HDL module, and the PLL mixed mode simulation has been performed with Spectre-Verilog co-simulator. The sweep range of VCO is designed from 828 to 960 MHz and the VCO generates four phase quadrature signals. The simulation results show that the phase noise of VCO is -102dBc/Hz at 100 KHz offset frequency, and the maximum lock-in time is about 4us with 32MHz step change (from 896 to 928 MHz).

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.4
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• pp.490-500
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• 2017

This study was performed to evaluate repeated dose oral toxicity upon administration of the test substance 1,2-benzisothiazolin-3-one for 90 days and to determine NOAEL (no observed adverse effect level) and target organs in Sprague-Dawley rats. Single, 2-week repeated, and 13-week repeated oral dose toxicity studies were conducted in Sprague-Dawley rats. The dose levels of groups were 1,250, 2,500, and 5,000 mg/kg/d. All dose groups were compared with the vehicle control group. The animals were observed for clinical signs and weekly body weight. Urinalysis, hematology, and serum biochemistry analyses were conducted. Subsequently, animals were sacrificed and subjected to histopathological examination. For the result, NOAEL of ethanol extract from unripe fruit of bitter melon had an optimal dose of 5,000 mg/kg/d and acceptable daily intake up to 3,000 mg/man. There was no target organ detected. Therefore, bitter melon, which contains a variety of bioactive substances, could be widely used as a health functional food ingredient.