• Title/Summary/Keyword: AIMS (Abnormal Involuntary Movement Scale)

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Correlations of Abnormal Involuntary Movements with Blood Glucose, Lipid Levels in Chronic Schizophrenics (만성정신분열병 환자들에서 비정상적 불수의 운동과 혈당, 지질과의 상관관계)

  • Kim, Hyeong-Seob;Kim, Eung-Jo;Lee, Joo-Ho;Ji, Seong-Hak
    • Korean Journal of Biological Psychiatry
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    • v.11 no.2
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    • pp.117-126
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    • 2004
  • Objects:It has been reported that the incidence of tardive dyskinesia(TD), the remarkable abnormal involuntary movement, was higher in the schizophrenics with high blood sugar levels and that TD had been improved by small amount of insulin-injection for 90 days. And also it was generally known that the blood lipids were higher in the schizophrenics with tardive dyskinesia. Thus, we tried to replicate the correlations of abnormal involuntary movements with blood sugar levels and blood lipids in chronic schizophrenics treated with antipsychotics. Methods:Thirty-eight male schizophrenic inpatients who were stable in clinical state with medications, were included. The patients who had been already diagnosed as diabetes mellitus(DM), organic brain disorder, substance- related disorder, physical illness were excluded and also we excluded female patients to remove the hormonal effect on TD. Eleven patients who ranked higher(above five) in the Abnormal Involuntary Movement Scale(AIMS) were assigned into 2 groups, a dibenese group and a placebo group. Diabinese or placebos were administrated for 3 weeks with antipsychotics and AIMS was rechecked. Results:There were no correlations between the total AIMS scores and blood sugar and lipids levels in all subjects. The means of total and subscale scores(objective, face, and extremity) of AIMS did not reveal statistical significances between diabinese and placebo groups. However(total, jaw, face, upper arm, and objective feeling), were statistically higher in the diabinese group than those in the placebo group. And correlations of total cholesterol(TC) with fast blood sugar(FBS), weight with body mass index(BMI) and waist, total glycerol (TG) with BMI were statistically significant. Conclusion:In this study, there were statistical significances in the changes in ratings of AIMS scores between the diabinese group and the placebo group. Application of oral hypoglycemic agent might be a way of improving abnormal involuntary movements in schizophrenics with abnormal involuntary movements or TD. Althogugh it was not certain that there were correlations of abnormal involuntary movement with blood sugar and lipids, correlations of TC/TG with AIMS, of FBS with AIMS cautiously suggest that the regular check of $HbA_1C$, waist, and weight are recommended for schizophrenics.

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A Clinical Report of Patient with Mandibula Tremor Caused by Spiritual Trauma (심리적인 충격으로 인해 발병한 하악진전(下顎振顫) 환자 치험 1례)

  • Seo, Young-Min;Lee, Ji-Won;Cha, Hye-Jin;Seo, Deok-Won;Park, Se-Jin;Lee, Chang-Hee
    • Journal of Oriental Neuropsychiatry
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    • v.20 no.3
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    • pp.237-247
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    • 2009
  • Objectives : Tremor is increasing recently especially among senior citizens. In this case, the patient who had mandibular tremor caused by trauma, was not improved by western medicine. We tried to apply Oriental medical treatment. Methods : We treated the patient with acupuncture therapy and herbal medication and measured the frequency of the tremor, Jaw expression of Abnormal Involuntary Movement Scale(AIMS) and Visual analog scale. Results: After treatment symptom of mandibular tremor was decreased significantly and other symptoms such as insomnia disappeared. Conclusions : During the admission days symptoms are decreased in contentment. This result suggests that Oriental medical treatment has good effect on tremor.

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The Clinical Observations of 2 Case of Senile Oro-facial Dyskinesia (노인성 구강-안면 이상운동증 환자 2례에 대한 증례보고)

  • Na, Gun-Ho;Shin, Jung-Chul;Wei, Tung-Shuen;Lyu, Chung-Yeol;Cho, Myung-Rae;Chae, Wu-Suk;Yoon, Yeo-Choong;Lee, Dong-Hyun
    • Journal of Acupuncture Research
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    • v.22 no.5
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    • pp.183-193
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    • 2005
  • Objectives : The purpose of this case is to report the improvement after the acupuncture therapy and herbal medicine about two patients with senile oro-facial dyskinesia. Methods : We treated the patient with acupuncture therapy and herbal medicine by evaluating facial, lips, jaw and tongue expression of AIMS(Abnormal Involuntary Movement Scale) and clinical symptom progress. Results : We have recently experienced two cases of senile oro-facial dyskinesia. Two patients were improved significantly through the acupuncture therapy and herbal medicine, so we report it for the better treatment. Conclusion : Oro-facial dyskinesia is stereotyped movements, consisting of smacking and pursing of the lips, lateral deviation and protrusion of the tongue, and occasionally lateral deviation and protrusion of the jaw. Spontaneous oro-facial dyskinesias occur in the elderly and had been said to result from edentulousness. Oriental medical treatment for oro-facial dyskinesia resulted in satisfactory results by diminishing the symptoms progressively during the admission periods. More research of oro-facial dyskinesia is needed.

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A Case Report of 2 Patients with Psychologic Tremor Using Korean Medical Treatments with MCVT (Melonis Calyx Vomiting Therapy) (과체(瓜蔕) 토법(吐法)을 이용한 심인성 진전 환자 치험 2례)

  • Lim, Gyo Min;Song, Guneui;Park, Se Jin;Jo, Seung Wan;Lee, Ju Hyeon
    • Journal of Oriental Neuropsychiatry
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    • v.30 no.2
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    • pp.107-118
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    • 2019
  • Objectives: The objective of this study is to report the effectiveness of Korean medicine therapy on Psychologic tremor patients with MCVT. Methods: Korean medicine therapy including MCVT, herb, acupuncture, and psychotherapy are applied to psychologic tremor patients. Vas and AIMS are used as assessment tools to evaluate the effects of therapy. MCVT is a traditional Korean medicine technique usually for chronic diseases. Similarly, autogenic training by J.H.Schultz and Giungoroen-therapy was conducted as psychotherapy. Results: In case 1, the patient lost all symptoms from vas10 to vas0, while in case 2, symptoms of the patient decreased from vas10 to vas3. Additionally, there was a significant decrease in the AIMS measurement score for both patients. Psychotherapy helped to reduce depression and anxiety. Conclusions: Psychologic tremor can be treated using Korean traditional medicine such as MCVT, Sosiho-tang and psychotherapy.

A Case of Combined Korean-Western Medicine Treatment on Chorea Hyperglycemia Basal Ganglia Syndrome Induced by Nonketotic Diabetes Mellitus (비케톤성 당뇨병으로 유발된 고혈당성 무도증의 한·양방 복합치료 증례보고)

  • Cha, Jiyun;Heo, Jong-won;Yoo, Ho-ryong;Kim, Yoon-sik;Seol, In-chan;Jo, Hyun-kyung
    • The Journal of Korean Medicine
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    • v.37 no.3
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    • pp.131-138
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    • 2016
  • Objectives: Chorea Hyperglycemia Basal Ganglia Syndrome(C-H-BG) is a syndrome with chorea-ballismus induced by hyperglycemia. This case study reports the clinical effect of Korean medicine treatment on C-H-BG. Methods: A 73-year-old male patient with left side chorea-ballismus visited Daejeon Korean Medicine Hospital. He had no diabetes mellitus(DM) history but the laboratory test result suggested nonketotic DM. We diagnosed him as C-H-BG and treated with herbal medicine, acupuncture and hyperglycemic medication. To evaluate chorea-ballismus, we checked Abnormal Involuntary Movement Scale(AIMS) score everyday. Results: After 14 days of treatment, the chorea-ballismus improved and AIMS score decreased from 38 to 4. Gait disturbance caused by the symptom disappeared. Conclusions: We suggest that Korean medicine treatment can improve the symptom of C-G-BG.

Drug-Induced Dyskinesia Outpatient Suspected to be Induced by Risperidone Management with Yigan-san with Citri Pericarpium and Pinelliae Rhizoma (modified Yigan-san, Yokukan-san Kachimpihang), Electro-Acupuncture at GB34 (陽陵泉), and Stopping Suspected Medication: A Case Report (Risperidone으로 유발된 것으로 의심된 약물유발성 이상운동증에 대한 의심약물 중단 및 억간산가진피반하와 GB34(陽陵泉) 전침치료를 통한 외래기반 관리 : 증례보고)

  • Roh, Min-yeong;Jang, Seung-won;Kim, Hyun-ho;Han, Yang-hee;Leem, Jungtae
    • The Journal of Internal Korean Medicine
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    • v.40 no.6
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    • pp.1303-1310
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    • 2019
  • Objectives: Drug-induced Parkinsonism has similar symptoms to Parkinson's disease, but each has different causes. Drug-induced Parkinsonism accounts for the largest proportion of secondary Parkinsonism We report a outpatient case of drug-induced Parkinsonism after taking Risperidone, an atypical antipsychotic. Method: With discontinuing of antipsychotic drug, modified Yigan-san extract was administered for 12 weeks, and acupuncture and electroacupuncture procedures were performed 20 times. Results: Abnormal Involuntary Movement Scale (AIMS) score decreased from 23 to 3 during 59 days of treatment period without adverse events and worsening of depression. The Patient was highly satisfied. Conclusion: Modified Yigan-san and electroacupuncture (GB34) can be used as an treatment option in patients with drug-induced Parkinsonism.

Case of Drug-Induced Parkinsonism Treated with Traditional Korean Medicine (약인성 파킨슨증후군 환자의 한방 치험 1례)

  • Kim, Yeon-jin;Yang, Seung-bo;Kim, Jeong-hwa;Lee, Bo-yun;Cho, Seung-yeon;Park, Seong-uk;Park, Jung-mi;Ko, Chang-nam
    • The Journal of Internal Korean Medicine
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    • v.37 no.2
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    • pp.381-388
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    • 2016
  • Objective: This clinical study reports on the effect of Korean medicine on a patient with drug-induced Parkinsonism.Method: We used herbal medicine (Yigan-san), acupuncture, moxibustion, pharmacopuncture, and bee venom acupuncture to treat a patient with drug-induced Parkinsonism during hospitalization for 11 days. We observed the changes of symptoms using the unified Parkinson’s disease rating scale (UPDRS), the abnormal involuntary movement scale (AIMS), and the Beck depression inventory (BDI).Results: After treatment, the patient’s symptoms showed improvement in tremor, gait disturbance, and general condition. The UPDRS, AIMS, and BDI scores were also improved after treatment.Conclusion: This clinical case study suggests that traditional Korean medicine treatment could be effective in the treatment of drug-induced Parkinsonism.

Depression in Schizophrenia Patients with Tardive Dyskinesia (지연성 이상운동이 있는 조현병 환자의 우울증)

  • Cha, Seongjae;Oh, Keun;Kim, Misuk;Park, Seon-Cheol;Kim, Young Hoon
    • Korean Journal of Biological Psychiatry
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    • v.25 no.4
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    • pp.110-117
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    • 2018
  • Objectives This study aimed to investigate the relationship between depressive and anxiety symptoms and tardive dyskinesia (TD) and reveal the association of cognitive function and TD in patients with schizophrenia. Methods We recruited 30 schizophrenia patients with TD and 31 without TD from a national mental hospital in South Korea. To assess depressive and anxiety symptoms, the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI) were conducted. Using the five-factor structure of the BDI-II and BAI, somatic anxiety, cognitive depression, somatic depression, subjective anxiety, and autonomic anxiety were assessed. Computerized neurocognitive function test (CNT) was performed to assess levels of cognitive functions. We compared the clinical characteristics, levels of cognitive functions, and depressive and anxiety symptoms between schizophrenia patients with TD and without TD. Chi-square test, Fisher's exact test, independent t-test and Mann Whitney U test were conducted to compare two groups. Pearson correlation analysis was conducted to evaluate relationships among the abnormal involuntary movement scale (AIMS), BDI-II, BAI, somatic anxiety, cognitive depression, somatic depression, subjective anxiety, and autonomic anxiety. Results The subjects with TD had significantly lower score on the cognitive depression than those without TD (t = -2.087, p = 0.041). There were significant correlations between the AIMS score and the BDI-II score (r = -0.386, p = 0.035) and between the AIMS score and cognitive depression score (r = - 0.385, p = 0.035). Conclusions Our findings suggest the inverse relationship between severities in TD and depression and support the assumption that there is an inverse relationship between the pathophysiology of TD and depression.

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Association between Tardive Dyskinesia and 267C/T Polymorphism of $5-HT_6$ Receptor Gene in Schizophrenia (정신분열병환자에서 만발성 운동장애와 $5-HT_6$ 수용체 유전자 다형성(267C/T)과의 관계)

  • Han, Sang-Woo;Kim, Dong-Hyeon;Jun, Yong-Ho
    • Korean Journal of Biological Psychiatry
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    • v.11 no.1
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    • pp.54-60
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    • 2004
  • Objectives:Tardive dyskinesia(TD) is a serious side effect associated with long-term antipsychotic treatments. Some candidate genetic polymorphisms were reported to be associated with TD and possible involvement of serotonergic receptors in the pathophysiology of TD has been suggested. In the present study, we investigated the association between $5-HT_6$ receptor gene polymorphism and TD with schizophrenia. Methods:To investigate the relationship between $5-HT_6$ receptor gene polymorphism and TD, 60 patients with TD were compared with 60 patients without TD. The 267C/T allele of $5-HT_6$ receptor gene was genotyped by means of polymerase chain reaction method. TD was evaluated using the Abnormal Involuntary Movement Scale(AIMS). Results:The patients with the three 267C/T genotype showed no significant differences in age, gender, and duration of illness. No significant difference in genotype frequencies was observed between schizophrenic patients with and without TD. In addition, there was no difference in allele frequencies. Further analysis with an measure of AIMS scores showed that these scores were not significantly influenced by the $5-HT_6$ receptor gene polymorphism. Conclusion:These results suggest that 267C/T polymorphism of $5-HT_6$ receptor gene is not significantly associated with susceptibility to TD in schizophrenia.

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A Case of Drug-Induced Acute Dyskinesia Treated with Korean Medicine (약인성 급성 이상운동증 환자의 한방 치험 1례)

  • Lee, Sang-hwa;Shin, Hee-yeon;Kim, Jeong-hwa;Kim, Yeon-jin;Cho, Seung-yeon;Park, Jung-mi;Ko, Chang-nam;Park, Seong-uk
    • The Journal of Internal Korean Medicine
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    • v.38 no.5
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    • pp.853-861
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    • 2017
  • Objectives: The objective of this study was to report a clinical case that suggests potential beneficial effects of Korean medicine therapy for the treatment of levosulpiride-induced acute dyskinesia. Methods: A patient having drug-induced acute dyskinesia was given a series of Korean medicine therapy treatments, including administration of the herbal medicine Chengsimyeonja-tang-gamibang, acupuncture, electroacupuncture, pharmacopuncture, and moxibustion over the 17 days of the hospitalization period. During the therapy, the progression of the disease was measured by the Abnormal Involuntary Movement Scale (AIMS). Results: During the therapy, the remission of orofacial dyskinesia and improvement of AIMS scores were observed. Conclusion: Korean medicine therapy has potential benefits for the treatment of drug-induced acute dyskinesia.