• Journal of Korean Neurosurgical Society
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• 제29권11호
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• pp.1476-1483
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• 2000

Objectives : The incidence of acute hydrocephalus(AHC) after aneurysmal subarachnoid hemorrhage reported as 13-31%. The AHC resolves spontaneously in some cases(simple AHC), but about 30% of the AHC progresses to shunt-dependent hydrocephalus(SDHC). The aim of this study was to understand clinical predisposing factors causing SDHC with performing differential clinical analyses between 2 subgroups, the simple AHC and the progresed SDHC. Methods : The 250 surgically treated patients with aneurysmal SAH over last two years were evaluated. Forty four patients(17.6%) of them showed the AHC. Of theses 37 cases were retrospectively analyzed, excluding 7 patients who died within 2 weeks after hemorrhage attack. Of the 37 AHC cases, 21 patient(56.8%) were complicated with the simple AHC, and 16 cases(43.2%) were progressed SDHC. Results : The older age(p<0.05), poor clinical grade(p＝0.03), larger amount of SAH in perimesencephalic cistern on CT scan(p＝0.005) were significantly related to the SDHC. No significant difference was noted in aneurysm location, multiplicity, rebleeding, hypertension and Fisher grade between 2 subgroups. Conclusion : Of the total 37 AHC, the simple AHC was 56.8% and the progressed SDHC 43.2%. The older age, poor clinical grade, large amount of SAH in perimesencephalic cistern were significant predisposing factors causing the SDHC. The large amount of SAH in perimesencephalic cistern is the single most important predisposing factor developing the progressed SDHC.

• Parasites, Hosts and Diseases
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• 제48권1호
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• pp.71-73
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• 2010

This cross sectional study was conducted in the city of Taiz, Yemen, during the period from August 2006 to August 2007 in order to investigate the seroprevalence and incidence of toxoplasmosis among apparently healthy children (AHC) and visually and/or hearing disabled children (DC). The seroprevalence was 16.0% among AHC compared to 32.5% among DC. The effect of gender was clear as the seroprevalence rate was significantly higher among females (18.3 and 43.8% for AHC and DC, respectively) than males (13.8 and 25% for AHC and DC, respectively). The seroprevalence was proportionally increased with the age, and the highest rates (20.9 and 53.0%) were reported among the oldest age group (> 10-14 years) for AHC and DC groups, respectively. The incidence rate was also higher (4.2%) in DC group compared to AHC group (2.4%) during 1 year period. These data indicate that the seroprevalence and incidence of toxoplasmosis are significantly higher in DC group than those of AHC group. We need to check further relationship between toxoplasmosis and visual and/or hearing disability.

• Journal of Preventive Medicine and Public Health
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• 제37권4호
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• pp.312-320
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• 2004

Objectives : An outbreak of acute hemorrhagic conjunctivitis (AHC) caused by coxsackie A24 (CA24) virus occurred in South Korea in 2002. CA24 was isolated for the first time from patients with AHC. Therefore, this study was conducted to understand the transmission routes and prevent another AHC outbreaks. Methods : The authors conducted a questionnaire survey among 1,730 students from 2 middle schools and 1 technical high school in Gyeongju city. For statistical analysis the chi-square test was used, and chi-square for trend method showing a level of significance less than p<0.05 was proven to be significant. Variables which were proven to be significant in univariate analysis were analysed by multiple logistic regression. Results : The attack rate was 57.1%. The student groups with rubbing one s own eyes, computer usage, and sharing cellular phone had a significantly higher AHC attack rate (p<0.05). According to the multiple logistic regression, the odds ratios for male, high school, computer use, sharing cellular phone, and rubbing one s own eyes were significant (p<0.05). Conclusion : The most significant feature of this outbreak was that many students rubbed their own eyes following contact with AHC patients in a deliberate attempt to avoid going to school. Other transmission methods were computer usage and sharing cellular phone. In the future, health and school authorities must plan new strategies for the prevention of AHC.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2010년도 추계학술대회 논문집
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• pp.945-946
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• 2010

• Journal of Genetic Medicine
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• 제14권1호
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• pp.27-30
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• 2017

Adrenal hypoplasia congenita (AHC) is a rare cause of adrenal insufficiency during neonatal period. Mutations in the gene coding for DAX1 cause X-linked adrenal hypoplasia. Most affected patients are shown to have salt wasting and hyperpigmentation on the skin during the neonatal period and require intensive medical care. In addition, it is usually associated with hypogonadotropic hypogonadism in adolescence. The DAX1 gene is expressed in the adrenal cortex, pituitary gland, hypothalamus, testis, and ovary. We report on a patient with genetically confirmed AHC whose initial clinical presentations were consistent with congenital adrenal hyperplasia. A point mutation in the DAX1 gene identified in this report resulted in a truncated DAX1 protein. Our patient was diagnosed with AHC.

• Journal of Plant Biotechnology
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• 제47권1호
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• pp.66-72
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• 2020

Alstroemeria plants were transformed by using an improved particle-gun-mediated transformation system. Friable embryogenic callus (FEC) induced from the leaves with axil tissues of Alstroemeria plant was used as the target tissue. Also, FEC was transformed with the bar gene was used as a selectable marker. In the case of plasmid pAHC25, 7.5% of the twice-bombarded FEC clumps showed blue foci, whereas the clumps with single bombardment showed only 2.3%. Additionally, a 90° rotation with double bombardment led to a higher frequency (6 times) of luciferase gene expression in PBL9780 than the control treatment. After 8 weeks of bombardment, more than 60 independent transgenic lines were obtained for pAHC25 and nearly 150 independent transgenic lines were obtained for PBL9780, all of which were resistant to PPT and demonstrated either GUS or luciferase activity. Regarding effect of osmotic treatment (0.2 M mannitol) with 7 different periods, the highest transient gene expression was obtained in 8 h before and 16 h after transformation in both pAHC25 and PBL9780. Compared with the control, at least three times more GUS foci and photons were observed in this treatment. With respect to different combinations of mannitol and sorbitol with 8 h before and 16 h after transformation, high numbers of transient and stable transgene expressions were observed in both 0.2 M mannitol and 0.2 M sorbitol used in the osmotic pre-culture. This combination showed the highest transformation efficiency in both pAHC25 (8.5%) and PBL9780 (14.5%). In the control treatment, only 10% of the FEC clumps produced somatic embryos. However, by using 0.2 M mannitol and 0.2 M sorbitol, the frequency of somatic embryos increased to 36.5% (pAHC25) and 22.9% (PBL9780). Of the somatic embryos produced, at least 60% germinated. Approximately 100 somatic embryos from these 210 independent transgenic lines from 2 plasmids developed into shoots, which were then transferred to the greenhouse. PCR analysis confirmed the presence of the bar gene. This is the report on the production of transgenic Alstroemeria plants by using particle bombardment with a high efficiency, thereby providing a new alternative for the transferring of gene of interests in Alstroemeria in the breeding program in the future.

• 한국초지조사료학회지
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• 제25권3호
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• pp.177-184
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• 2005

본 연구는 섬유소공급원 7종, alfalfa hay cube (AHC), corn cob (CC), corn silage (CS), cotton seed hull (CSH), peanut hull (PHL), rice straw(RS), sugar cane bagasse(SCB)의 반추위에서의 반추활동, pH, 완충능력과 전소화기관 내 소화율을 알아보고자 실시하였다. 공시 동물은 평균체중 37.1kg인 Corridale종 수 면양 5두 (3두는 반추위 fistula 부착)를 사용하였으며, 실험기간동안 공시동물에게 급여한 사료는 각각의 조사료원 $45\%$와 corn-based 사료 $55\%$의 비율로 하여 1일 2회 (09:00, 21:00) 총 800g(dry matter basis)을 급여하였다. Ruminal pH는 급여 후 4시간까지는 처리구 간에 차이가 없었지만 8시간 후 타 조사료원$(6.24\~6.61)$과 RS(5.78)간에는 차이가 있었다(p<0.05). 반추위 내 완충능력은 SCB구, CC구와 비교하여 CS구에서 사료급여 후 0시간(p<0.05), 2시간(p<0.05)에 유의한 차이를 나타내었고, 사료급여 후 12시간 경과 시 AHC구를 제외한 CC구, CS구, SCB구와 RS구 보다 PHL구(p<0.01)에서 높게 나타났다. DM 소화율은 CS구에서 $78.19\%$로 타처리보다 유의하게 높았으며(p<0.05), DNF 소화율은 CC구, CS구, CSH구와 RS구가 다른 조사료원 급여구보다 높게 나타났다. (p<0.001).

• Asian-Australasian Journal of Animal Sciences
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• 제26권5호
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• pp.654-660
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• 2013

Three Korean native steers ($779{\pm}24$ kg) fitted with duodenal cannulas were used in a $3{\times}3$ Latin square design to investigate the influence of oral administration of soluble proteins, intact casein (IC) and acid hydrolyzed casein (AHC), on gastro-intestinal hormone (GIH) secretion in the blood and pancreatic ${\alpha}$-amylase activity in the duodenum. Oral treatment consisted of a basic diet (control), IC (C+100% protein), or AHC (C+80% amino acid, 20% peptide) for 21 d. Blood and duodenum samples were collected for measurement of serum GI hormones, and pancreatic ${\alpha}$-amylase activity was determined at 900, 1030, 1330, 1630, and 1930 h after feeding on d 21 of treatment. The levels of serum cholecystokinin (CCK) and secretin in the IC treatment group were higher compared to the other treatment groups (p<0.05). In addition to the changes in CCK and secretin levels upon IC treatment, the pancreatic ${\alpha}$-amylase activity in the duodenum was higher in the IC group compared to the control diet group (p<0.05). The response of serum ghrelin to IC and AHC treatment was in accordance with the response of serum secretin. The level of peptide fragments flowing in the duodenum was higher in the IC treatment group than the other treatment groups (p<0.05). In conclusion, this study demonstrated that an increase in duodenal CCK and secretin upon IC oral administration increased pancreatic ${\alpha}$-amylase secretion. In addition, ghrelin may be associated with GI hormone secretion in Korean native steers.

• 산업기술연구
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• 제24권B호
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• pp.65-71
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• 2004

The ultra fine gamma-alumina powder was prepared via ammonium aluminium carbonate hydroxide (AACH). The XRD, SEM, BET, thermal analysis were used to characterize the samples. The effects of various reaction parameters as concentration, of solution, anion on specific area, PH, aging time and thermal decomposition condition on the produced AACH and alumina were discussed.

• 대한유전성대사질환학회지
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• 제13권1호
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• pp.57-61
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• 2013

Glycerol kinase 결핍증(GKD)은 X-linked 열성유전되는 질환으로 생화학적으로 혈중 glycerol이 상승되고 소변으로 glycerol이 분비되는 질환이다. GK 유전자는 X chromosome 단완의 21.3 region에 위치하며, AHC gene과 DMD gene 사이에 직렬로 위치하고 있다. 만약 이부위에 긴 부분의 결손이 발생하면 이들 질환이 동시에 발생하게 되며, 이를 contiguous gene deletion syndrome이라고 부른다. 국내에서는 이 세 질환이 동시에 나타나는 contiguous gene deletion syndrome은 보고된 바 있으나 GK 결핍증만 단독으로 있었던 경우는 보고가 없었다. 저자들은 장염후의 고이화상태에서 저혈당과 의식의 혼탁으로 발현된 단독 GK 결손증을 보고하는 바이다.