• Korean Journal of Clinical Pharmacy
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• v.29 no.2
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• pp.125-132
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• 2019

Objective: To examine the perceptions and attitudes toward spontaneous adverse drug reaction (ADR) reporting system among community pharmacists and identify factors that influence reporting, by implementing a survey. Methods: A structured questionnaire was developed and distributed online. Request for the survey was posted on the website of pharmacy's billing program, and the survey was conducted for 8 days. We collected the participants' response on their work environment, experience of ADR reporting, and their perception and attitude on the reporting system. Multivariate logistic regression was used to evaluate factors influencing ADR reporting. Results: A total of 382 pharmacists participated in the survey. Significant contributing factors for reporting level were age (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.84-0.96), knowledge of reporting method (OR, 53.56; 95% CI, 9.10-315.41), installation of reporting program (OR, 31.92; 95% CI, 4.16-244.75), and encouragement from the Korean pharmaceutical association (OR, 4.13; 95% CI, 1.11-15.35). Regarding the attitude toward spontaneous ADR reporting system, 'lack of time for reporting' (OR, 0.29; 95% CI, 0.15-0.53) and 'complexity of reporting procedure' (OR, 0.51; 95% CI, 0.31-0.84), were associated with a low likelihood of reporting. Conclusion: Our results indicated that the knowledge of ADR reporting method, installation of the reporting program, and encouragement from the Korean Pharmaceutical Association contribute to active reporting. It is necessary to simplify the reporting method, make the ADR reporting program user-friendly, and provide educational interventions to increase participation in spontaneous reporting by the community pharmacists.

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.2
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• pp.50-63
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• 2018

Objective : The purpose of this study is to examine the effects of parent - child interaction therapy on parenting skills and children's problem behaviors by meta - analysis and to provide a basis for intervention methods. Methods : This study was conducted from January 2007 to March 2018 and the study was conducted using the parent-child interaction program for children with disabilities. PubMed and CINAHL, EBSCOhost, Science Direct were used to search for studies, and reference searching was also conducted as a secondary search option. A total of 7 studies was selected to meet the selection criteria, and the final 7 studies were assessed by using the Jadad scale. Statistical tests were performed using the R-meta-analysis program. Results : The effect size of parenting skill was large and the size of the effect of parenting stress was moderate. The children's problem behaviors also showed moderate effect sizes and all p-values were statistically significant (p < .0001). Conclusion : This study examined the effects of parent-child interaction therapy on parenting skills, parenting stress, and children's problem behaviors. Future research is needed to establish the basis for intervention for family involvement in pediatric occupational therapy.

• Journal of Climate Change Research
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• v.3 no.1
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• pp.51-69
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• 2012

This work aims to propose a vulnerability assessment methodology of ecosystem at present time, and an to suggest an adaptation strategy of ecosystem in the future for local government, in the fields of plant, animal and conservation area, which would occurred due to climate change. Vulnerability assessment in ecosystem includes first, tree growth and distribution part, mainly for conifers, secondly, insect part for pest and bee, and thirdly conservation area management part, especially at the national parks. To evaluate the degree of vulnerability of each substitute variables, such as exposure of climatic element, sensitivity, and adaptation ability, are respectively selected. Vulnerabilities of conifer growth and distribution, pest and bee, and national park management seem to be strongly influenced by the exposure of climatic element than other factors, such as sensitivity and adaptation ability. With time regional gaps of ecosystem vulnerability are expected to be greater in both conifers growth and distribution, and national park management, but reduced in pest and bee in 2100 in comparison with present time.

• Journal of Climate Change Research
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• v.5 no.1
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• pp.21-36
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• 2014

Forest ecosystem provides variety goods and services for human being. Unlike goods, forest ecosystem services could not be easily priced by market mechanism. This uncertainty has been caused to conflict in decision-making related forest ecosystem services. Quantification of forest ecosystem services is required to understand the importance of ecosystem services and their contribution to decision-making. As a growing concern of climate change, it is necessary to quantify and calculate carbon storage and sequestration in forest. In this study, for quantifying carbon storage and sequestration, we compared scale, output, input data availability of the models and analyzed the applicability of the models to Korea. The results of this study show that most models are applicable for quantifying carbon storage and sequestration. However, relatively few models are applicable for other regulating services (air quality regulation, flood mitigation, erosion control, water quality, etc.) of forest. This study would be helpful for quantifying regulating services of forest ecosystem research.

• Laboraroty Animal Research
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• v.33 no.2
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• pp.57-67
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• 2017

The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines and animal models. To evaluate the hepatotoxicity and nephrotoxicity of A. cochinchinensis toward the livers and kidneys of ICR mice, alterations in related markers including body weight, organ weight, urine composition, liver pathology and kidney pathology were analyzed in male and female ICR mice after oral administration of 150, 300 and 600 mg/kg body weight/day saponin-enriched extract of A. cochinchinensis (SEAC) for 14 days. The saponin, total flavonoid and total phenol levels were found to be 57.2, 88.5 and 102.1 mg/g in SEAC, respectively, and the scavenging activity of SEAC gradually increased in a dose-dependent manner. Moreover, body and organ weight, clinical phenotypes, urine parameters and mice mortality did not differ between the vehicle and SEAC treated group. Furthermore, no significant alterations were measured in alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), blood urea nitrogen (BUN) and the serum creatinine (Cr) in the SEAC treated group relative to the vehicle treated group. Moreover, the specific pathological features induced by most toxic compounds were not observed upon liver and kidney histological analysis. Overall, the results of the present study suggest that SEAC does not induce any specific toxicity in the livers and kidneys of male and female ICR mice at doses of 600 mg/kg body weight/day.

• Journal of Applied Biological Chemistry
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• v.61 no.4
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• pp.423-428
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• 2018

Anaerobic growth-inhibiting and acaricidal activities of 2'-hydroxy-5'-methoxyacetophenone derived from Cyanachum paniculatum oil and its derivatives against five intestinal bacteria (Bifidobacterium bifidum, B. longum, Clostridium pefringens, Escherichia coli and Lactobacillus casei) and Haemaphysalis longicornis were examined. In the packet test against the larvae of H. longicornis, none of the C. paniculatum oil exhibited acaricidal activity, while the C. paniculatum oil showed only antimicrobial activity against five intestinal bacteria in the disc diffusion method. Based on the inhibition zones and MIC values, 2',4'-dimethoxyacetophenone, 2',5'-dimethoxyacetophenone, 2'-hydroxy-4'-methoxyacetophenone, 2'-hydroxy-5'-methoxyacetophenone, 2'-methoxyacetophenone, and 4'-methoxyacetophenone, containing a methyl group on the acetophenone skeleton, possessed growthinhibiting activities against C. perfringens and E. coli. However, acetophenone, 2'-hydroxyacetophenone, 4'-hydroxyacetophenone, 2',4'-hydroxyacetophenone and 2',5'-hydroxyacetophenone, which contained a hydroxyl group on the acetophenone skeleton, had no growth-inhibiting activity against intestinal bacteria. These results indicated that 2'-hydroxy-5'-methoxyacetophenone and its derivatives could potentially be developed as natural antimicrobial agents to specific control of C. perfringens and E. coli.

• Journal of Bone Metabolism
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• v.25 no.4
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• pp.195-211
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• 2018

Background: To develop guidelines and recommendations to prevent and treat glucocorticoid (GC)-induced osteoporosis (GIOP) in Korea. Methods: The Korean Society for Bone and Mineral Research and the Korean College of Rheumatology have developed this guideline based on Guidance for the Development of Clinical Practice Guidelines ver. 1.0 established by the National Evidence-Based Healthcare Collaborating Agency. This guideline was developed by adapting previously published guidelines, and a systematic review and quality assessment were performed. Results: This guideline applies to adults aged ${\geq}19years$ who are using or plan to use GCs. It does not include children and adolescents. An initial assessment of fracture risk should be performed within 6 months of initial GC use. Fracture risk should be estimated using the fracture-risk assessment tool (FRAX) after adjustments for GC dose, history of osteoporotic fractures, and bone mineral density (BMD) results. All patients administered with prednisolone or an equivalent medication at a dose ${\geq}2.5mg/day$ for ${\geq}3months$ are recommended to use adequate calcium and vitamin D during treatment. Patients showing a moderate-to-high fracture risk should be treated with additional medication for osteoporosis. All patients continuing GC therapy should undergo annual BMD testing, vertebral X-ray, and fracture risk assessment using FRAX. When treatment failure is suspected, switching to another drug should be considered. Conclusions: This guideline is intended to guide clinicians in the prevention and treatment of GIOP.

• Korean Journal of Radiology
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• v.19 no.6
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• pp.1119-1129
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• 2018

Objective: To compare the image quality of low-tube-voltage and low-iodine-concentration-contrast-medium (LVLC) computed tomography urography (CTU) with iterative reconstruction (IR) with that of conventional CTU. Materials and Methods: This prospective, multi-institutional, randomized controlled trial was performed at 16 hospitals using CT scanners from various vendors. Patients were randomly assigned to the following groups: 1) the LVLC-CTU (80 kVp and 240 mgI/mL) with IR group and 2) the conventional CTU (120 kVp and 350 mgI/mL) with filtered-back projection group. The overall diagnostic acceptability, sharpness, and noise were assessed. Additionally, the mean attenuation, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and figure of merit (FOM) in the urinary tract were evaluated. Results: The study included 299 patients (LVLC-CTU group: 150 patients; conventional CTU group: 149 patients). The LVLC-CTU group had a significantly lower effective radiation dose ($5.73{\pm}4.04$ vs. $8.43{\pm}4.38mSv$) compared to the conventional CTU group. LVLC-CTU showed at least standard diagnostic acceptability (score ${\geq}3$), but it was non-inferior when compared to conventional CTU. The mean attenuation value, mean SNR, CNR, and FOM in all pre-defined segments of the urinary tract were significantly higher in the LVLC-CTU group than in the conventional CTU group. Conclusion: The diagnostic acceptability and quantitative image quality of LVLC-CTU with IR are not inferior to those of conventional CTU. Additionally, LVLC-CTU with IR is beneficial because both radiation exposure and total iodine load are reduced.

• Journal of Korea Technology Innovation Society
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• v.22 no.1
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• pp.119-157
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• 2019

It is important for the people in the 3D printing industry to determine which factors influence the decision-making that determine the adoption of 3D printers and the role of the factors. Through this, we intend to find ways to contribute to the development of 3D printing industry in Korea by increasing utilization of 3D printer used in domestic companies and increasing investment in related industries. 3D printers are making rapid progress according to the development of technology, the public interest, and the activation of investment. Foreign countries have made remarkable progress in equipment, materials, software, and industrial applications, but they are lower than expected in Korea. It is necessary to introduce a smooth 3D printer in order to revitalize the 3D printer industry and enlarge the base, but it is insufficient for actual introduction and field application. The independent variables that represent economic, technological, and environmental characteristics were selected through a literature survey, and a model for accepting integrated technology for convergence of societies in the 3D printing industry was proposed. This study confirms that economic factors such as output unit price, government support, and environmental factors such as 3D contents should be developed organically for the introduction of 3D printing technology and equipment. This require systematic and effective support from the government, and it is necessary to improve the economic support, related laws, and systems that can be directly experienced by the user as a user. As the domestic 3D printing industry develops with economic, technological and time investment, 3D printing industry should be the key engine of the 4th industrial revolution.

• Korean Journal of Clinical Pharmacy
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• v.29 no.3
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• pp.166-172
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• 2019

Background: Hypercalcemia is an important metabolic emergency condition in cancer patients. Bisphosphonate is the treatment of choice for hypercalcemia, whereas calcitonin and hydration with furosemide are recommended for acute supportive therapy. However, data regarding real-world treatment patterns and outcomes of pharmacological treatments are limited. Therefore, we aimed to investigate the treatment patterns and clinical outcomes of hypercalcemia treatment in solid tumor patients. Methods: Electronic medical records of 123 adults with solid cancers and albumin-corrected calcium levels >10.5 mg/dL or ionized calcium levels >1.35 mmol/L were reviewed. We retrospectively analyzed the pharmacological treatment and recovery rate according to the severity of hypercalcemia. Results: A total of 177 cases were identified, of which 49 were not treated and 30 were treated with hydration only. In moderate-to-severe cases, 86.5% received pharmacological treatment. Thirty-four cases (19.2%) were treated with bisphosphonate alone and 58 cases (32.8%) were treated with bisphosphonate and calcitonin. In mild hypercalcemia cases, the recovery rate was higher for those receiving hydration only or pharmacological treatment (79.7%) than for those receiving no treatment (61.4%, p = 0.041). Most moderate-to-severe cases were treated with medication and of those treated, 56.3% recovered. The recovery rate was lower in those treated with bisphosphonate alone (38.2%) than in those who underwent calcitonin combination treatment (73.7%, p = 0.001). Conclusions: Bisphosphonate combined with calcitonin was found to be more effective than bisphosphonate alone for the treatment of moderate-to-severe hypercalcemia. Considering the current shortage of calcitonin, further efforts are required to ensure its stable supply.