• Health Policy and Management
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• v.13 no.2
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• pp.67-84
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• 2003

Immunization has been one of the most effective measures preventing from infectious diseases. However, children routine vaccination rate of Korea was 68.2% and it was not higher than expected. Korean government revised the School Health Law for every primary school children to submit the vaccination certificate record from 2005. It is quite important national Infectious disease prevention policy to keep the immunizations rate high and monitor the immunizations rate continuously. To do this, National Institute of Health introduced the National Immunization Registry(NIR) Program at 2000. Objective : The aims of this study was to evaluate the Immunization Registry program which has been implementing since 2000 at the Public Health Centers(PHC). Methods : The mail survey was done from November 2001 to January 2002. 169 (69%) Public Health Centers among 244 PHC were responded. Results : The respondents of PHC sud the Immunization Registry(IR) program had reduced the workload (18.5%). 69.2% said they inputted the immunization data into the IR program after the shots were given. 86.5% said they hadn´t checked or retrieved the children lists who had missed the scheduled immunization. Only 17.2% said the speed of internet for the R program was good. It showed that 20% of respondents hadn´t written down documents, records on immunization any more. Even there were a lot of negative results, the respondents of PHC thought that the IR program was effective. They especially agreed that the IR program could make the job accurate (81.5%), convenient (71.3%), and reduced the chances of making mistakes (71.3%), increase the service quality (78.5%). And they were well adapting the job process of the IR (79.63%). Bivariate analysis showed that the software program was the important determinants of IR success. The only Bit Computer software program has been evaluated to be less satisfactory than the Integrated (Posdata operating system + Bit software) program. Other variables, such as age, duration of present job, and location of PHC (metropolitan, small city, rural area) were not significantly related. Conclusion : It seemed that the success of NIR might depend on the software program. Because Integrated program, which has been developed from 1994, include not only the general operating and management program for PHC but also IR program. It was natural to prefer Integrated program to Bit software program. So we can suggest that it is essential for the NIR to be successful that not only the immunization software program but also hardware equipments and public health information system should be further improved.

• Korean Journal of Biological Psychiatry
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• v.3 no.2
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• pp.216-221
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• 1996

The quantitative EEGs of obsessive-compulsive disorder patients were analyzed using spectral analysis and compared to age and sex-matched controls. The subjects were 19 patients(men=15, women=4) suffering from obsessive-compulsive disorder(DSM-III-R). Absolute power, relative power and interhemispheric asymmetry of EEG were used to compare obsessive-compulsive disorder patients with controls. In order to fit the EEG data to a normal distribution, a log transformation of power values of every bandwidth in each deviation was calculated prior statistical analysis. The Wilcoxon rank test was performed to compare obsessive-compulsive group to the control group. In obsessive-compulsive disorder, abnormalities of quantitative EEGs are prominent in fronto-central. These results ore compatible with other brain imaging studies of obsessive-compulsive disorder and suggested that fronto-central area plays an important role in the pathophysiology of obsessive-compulsive disorder.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1426-1436
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• 2004

There have been several reports on the relationship between G protein β3 subunit gene (GNB3), angiotensin converting enzyme gene (ACE), β3-adrenergic receptor gene (ADRB3), and β2-adrenergic receptor gene (ADRB2) genotype and obesity or obesity related disease. The objective of this study was to examine the relationship between the combinations of these four genes' polymorphism and probability of obesity related disease in Korean female subjects. The experimental group was consisted of 85 obese Korean female subjects (body mass index, BMI≥27㎏/㎡). To determine the polymorphism, genomic DNA was isolated, and PCR was performed. Serological examinations (fasting plasma glucose, FPG; aspartate aminotranferase, AST; alanine aminotransferase, ALT; total cholesterol, TC; triglyceride, TG; high density lipoprotein-cholesterol, HDL; low density lipoprotein-choles terol, LDL) were carried by an autoanalyzer and serological methods. BMI, waist circumference (WC), hip circumference and waist hip ratio (WHR) were measured. Consequencely in the analysis with grouping of general genotyping and variant allele carrier/non-carrier, the result was not significantly different within all gene combinations and polymorphic pairings except higher waist circumference in Arg16Arg group of ADRB2 codon16 (P=0.024). And there was no significantly contrast result about age, height, weight, AST and ALT that are index feature of liver and gall bladder disease in polymorphic pairings of gene combinations. However, the statistical analysis of waist-hip ratio and waist circumference that could be recognized as the physical type of obesity showed T-Arg16 pairing carrier in GNB3-ADRB2 codon16 combination had increased WHR and WC significantly (P=0.046 and P=0.015 respectively). Futhermore, the levels of total cholesterol (TC) and low density lipoprotein choresteral (LDL) were significantly lower in C-I pairing of GNB3-ACE combination (P=0.032 and P=0.005). These results suggest that the T-Arg16 pairing carrier in GNB3-ADRB2 codon16 gene might have increased waist circumference and C-I pairing carrier in GNB3-ACE combination have lower possibility of contraction of cardiovascular disease related cholesterol and LDL despite of obese state.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.4
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• pp.417-424
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• 2014

The purpose of this study was to analyze the psychobiological traits of each Sasang typology based on the Sasang Digestive function Inventory (SDFI) which measures the Sasang type-specific pathophysiological digestive symptom. The SDFI, Temperament and Character Inventory (TCI) and NEO-Personality Inventory (NEOPI) were measured with 199 College students. The correlation coefficient was measured with Pearson correlation among SDFI, TCI, and NEOPI. The influence of TCI, sex and age on SDFI and its subscales were analyzed with regression analysis. We also compared the psychobiological features between high and low SDFI score groups to elucidate its psychobiological profiles. There was significant correlation between SDFI and TCI Harm-Avoidance (r=-0.192, p<0.001). The SDFI subscales were showed to have significant correlations with subscales of NEOPI and TCI. The regression model with TCI can explain 8-16% of type-specific pathophysiological digestive symptoms. The low SDFI score group ($39{\pm}9.3$) has significantly (p=0.007) higher than the high SDFI group ($33.6{\pm}12.2$) in TCI Harm-Avoidance which is considered important for the gastrointestinal dysfunction and So-Eum type differentiation. We found that the TCI may explain the mechanism underneath the Sasang type-specific pathophysiological symptom. It was suggested that the TCI Reward-Dependence would be useful for the study on Tae-Eum Sasang type, and its clinical meanings were discussed in the pathophysiological perspectives.

• Pediatric Infection and Vaccine
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• v.8 no.2
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• pp.160-167
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• 2001

Purpose : To assess the immunogenicity, safety, and tolerability of hepatitis A vaccine ($VAQTA^{TM}$) in healthy children and adolescents. Methods : Eligible subjects aged 2 to 17 years received 25 U/0.5 mL of $VAQTA^{TM}$ intramuscularly at 0 and 24 week schedule. Bleeds were obtained prior to vaccination and 4 weeks after the second dose to ascertain serostatus. To detect antibody to HAV after vaccination with an inactivated HA vaccine, a modification of the $Abbott^{(R)}$ HAVAB kit was used. Sample with titers ${\geq}10$ mIU/mL were considered seroconverted. Adverse experiences were monitored. Results : 102 subjects(54 male, 48 female) were enrolled. The mean age was $6.8{\pm}3.5$ years. Two subjects were seropositive, two were lost of follow up. 88 subjects were available for a per protocol analysis and 90 for all subjects with serology after the second dose, and ten withdral. All subjects(95% CI, 94.8~100) seroconverted. Geometric mean titers was 7,991.1(95% CI, 6,481.1~9,852.7) with very little difference in per protocol analysis and all subjects analysis. Adverse experiences to $VAQTA^{TM}$ were generally mild and transient. Conclusion : The pediatric two-dose regimen of $VAQTA^{TM}$ was found to be highly immunogenic, generally well tolerated and resulted in 100% seroconversion. Regarding Korea is in transition from a high to low risk region resulting in a paradox increase of clinical disease and disease burden, routine vaccination should be considered in order to control hepatitis A effectively.

• Journal of Preventive Medicine and Public Health
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• v.26 no.4 s.44
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• pp.587-598
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• 1993

Hydrofluoric acid is one of the strongest irritating, corrosive and poisonous inorganic chemicals. Hydrofluoric acid burns are occurring with ever-increasing frequency due to the wide use of this acid in industries. Hydrofluoric acid burns are characterized by severe progressive tissue destruction and excruciating pain due to the unique properties of the freely dissolvable fluoride ion. The authors reviewed medical records of 32 cases (36 spells) of hydrofluoric acid burns which occurred in a hydrofluoric acid manufacturing factory from Sep. 1, 1990 to June 30, 1993. The results are as follows; 1. Eleven measurements of air concentrations of hydrofluoric acid by detection tube method from 1990 to 1992 were all below TLV (Department of Labor, R.O. K). 2. There were 19 cases (22 spells) of hydrofluoric acid burns which occurred during the study period among regular employees. The overall incidence density of hydrofluoric acid was 17.8 cases (20.6 spells) per 100 person-year. Incidence density was 19.0 cases (22.0 spells) per 100 person-year among male workers and there were no female cases. Incidence density was 32.9 cases (38.3 spells) per 100 person-year among production workers and 1.9 cases (1.9 spells) per 100 person-years among management workers with the difference being statistically significant (P<0.01). 3. Of 32 cases (36 spells) of hydrofluoric acid burns among workers who were regularly employed or temporarily employed, 26 spells (81.2%) were between age 20 to 39. In 15 spells(41.7%) burns occurred between 12:00 and 17:59 with 16 spells(44.3%) having arrived at hospital within 2 hours after the accident. 4. Of 36 spells, the main cause of hydrofluoric acid burns were by splashes (8 spells, 22.2 %). The most frequent site of burns were fingers and pain was the most frequent symptom. Thirty spells (83.3%) of the hydrofluoric acid burns were treated with local injection of antidote (calcium gluconate). Complete recovery without scarring were observed in most of the cases (34 out of 36 cases, 94.4%). The study results suggest that to prevent hydrofluoric acid burns, environmental control and the wearing of hydrofluoric acid resistant protective clothes and gloves are important. It is also stressed that establishment of an emergency management and a transfer system for hydrofluoric acid burn victims is necessary.

• Korean Journal of Medicinal Crop Science
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• v.11 no.3
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• pp.216-223
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• 2003

This experiment was carried out to investigation the growth differentiation between direct sowing and transplanting on P. ginseng cultivated on field and underwood. The results were as follows: In direct sowing treatment, emergence rate of P. ginseng cultivated on field and under conifer forest was above 80%, but it was only 40% at cultivated under broad-leaved forest. And survival rate was directly diminished about 10% every year. In transplanting treatment, survival rate was also diminished every year, it was slighter than that of direct sowing treatment. The growth amount of P. ginseng cultivated underwood was poor, compared to field culture, but there was no significant between conifer forest and broad-leaved forest. In transplanting treatment of 1 to 6 year-root seedling, survival rate of P. ginseng cultivated underwood was equal or slightly good compared to that of cultivated on field. Among seedling age, survival rate of elder seedling was lower than that of younger seedling. In P. ginseng cultivated underwood, the annual growth increment of 1 and 2 year-root seedling increased slowly and continually, whereas, that of 3 to 6 year-root seedling stopped or decreased slightly.

• Child Health Nursing Research
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• v.3 no.1
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• pp.71-82
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• 1997

The purpose of the survey was to Identify the degree and the relationship of sexual knowledge, sexual attitude. This information will provide useful data for a more systematic, desirable, and practical sex education. The data was collected from 187 first grade schoolchildren(95 boys and 92 girls) of two Junior high school in Chun-nam area. The data was gathered by questionnaire from Oct. 1 to 15, 1996. The questionnaire was modified by authors using the questionnaire developed by You-Jeong, Han (1996). Data was analyzed by using the statistical computer package, SAS to manipulate the data along with percentages, means, standard deviation, t-test, χ²-test, GLM, and Pearson correlation coeffiency. The results in this study were summarized as follows: 1. Sex related knowledges.-The mean score of sex related knowledges showed significant differences between boys and girls (boys : 22.3, girls .21.0, p<0.025), and in the area of pregnancy & delivary(boys : 9.4, girls : 7.9, P<0.000) showed significant difference between boys and girls, but in the area of physical differeces of the other sex(boys : 12.9, girls ; 13.1, p<0.551) showed no significant difference between boys and girls. 2. Sex related attitudes.-The mean score of sex related altitudes showed significant difference between boys and girls (boys : 56.7, girls : 60.5, p<0.002) and in the area of psychological difference the other sex(boys 28.9, girls : 32.5, p

• Research in Community and Public Health Nursing
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• v.11 no.1
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• pp.209-221
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• 2000

I began the study to identify the issues related to knowledge. attitude and behavior regarding smoking by sixth graders. which will ultimately lead to the development of a smoking prevention program that will not only help deter school-age children from smoking, but also make them aware of the more desirable behaviors and techniques for healthier life. The results are as follows: 1. Smoking Behavior: Of the focus group. 4.15% are current smokers and 18.23% are ever smokers. 2. Correlation between smoking knowledge and ever smoking: Ever smoking sample($11.10{\pm}3.66$) is less knowledge able than the never-smoking sample($12.17{\pm}3.95$), (t=3.23. p=.001). 3. Correlation between smoking attitude and ever smoking: Ever smoking sample($28.12{\pm}8.51$) was less desirable than the never-smoking sample($l2.17{\pm}3.95$). (t=8.24, p=.000). 4. Correlation between smoking Knowledge and smoking attitude: knowledge about smoking and attitude toward smoking are quantitatively correlated in such way that the more knowledgeable the child is about smoking. the more desirable the attitude toward smoking is(r=.17. p=.000). 5. Correlation between socio-anthropological characteristics and ever smoking: family . atmosphere($x^2$=16.49. p=.001), school life ($x^2$=l1.58, p= .003), grades in school( $x^2$=11.89. p=.003), gender($x^2$=8.97. p=.003). friends' gathering place($x^2$=13.19. p=.02), marital status of parents(p* =.03). and family's financial status($x^2$=6.71. p=.035). In addition, Correlation between somking-environmental characteristics and ever smoking: number of friends who smoke($x^2$=76.01. p=.001). information source for smoking($x^2$=48.03. p=.001), whether or not siblings smoke($x^2$=26.07, p=.001), whether or not female relatives smoke ( $x^2$= 15.65. p= .001), whether or not father smokes ($x^2$= 12.10. p= .007), errands to buy cigarettes for someone($x^2$=9.18. p=.010), and whether or not male relatives smoke ($x^2$=8.82. p=.35) 6. Results of the logistic analysis performed to identify the factors correlated to ever smoking show that: one point decrease in attitude score translates to 25.39 times' increase in ever smoking one person decrease in the number of friends who smoke translates to 0.66 times' decrease in ever smoking: the group where the father has quit smoking has 1.40 times more ever smoking than the group where the father does not smoke at all: and likewise, the group where the father currently smokes has 1.40 times more ever smoking than the group where the father has quit smoking. 7. The overall cause-and-effect relationship between the ever smoking and the related factors: attitude toward smoking caused ever smoking by -.43, smoking by friends, by .12, marital status of arents, by .05, school life. by .04, gender, by -.03, and smoking by father, by -.02. Knowledge about smoking (t=-1.67) did not cause significant effects on ever smoking.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.7
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• pp.907-915
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• 2010

Three hundred and seventy-three steers (approximately 7 mo of age and $247{\pm}19.4\;kg$) were utilized to determine the effects of trace mineral (TM) source and growth implants on trace mineral status. Steers were blocked by ranch, post-weaning treatment within ranch, stratified by initial body weight, and randomly assigned to one of 36 pens (9-12 head/pen). Treatment consisted of: I) control (no supplemental Cu, Zn, Mn, and Co), ii) inorganic trace minerals, and iii) organic trace minerals. Six pens of steers per treatment received a growth implant at the beginning of the experiment and were re-implanted during the finishing phase. The remaining steers received no growth implants. Steers were fed a corn silage-based growing diet for 56 d then were gradually switched to a high concentrate finishing diet. Treatments during the finishing phase consisted of: i) control (no supplemental Zn); ii) inorganic Zn (30 mg of Zn/kg DM from $ZnSO_4$); and iii) organic Zn (iso-amounts of organic Zn). By the end of the growing and finishing phases, implanted steers had greater (p<0.01) plasma Cu concentrations than non-implanted steers. During the growing phase, liver Cu concentrations (p<0.01) and plasma Zn concentrations (p<0.02) were greater in steers supplemented with TM compared to control steers. Steers supplemented with inorganic minerals had greater liver Cu concentrations than steers supplemented with organic minerals at the beginning (p<0.01) and end (p = 0.02) of the growing phase. During both the growing (p = 0.02) and finishing phases (p = 0.05), nonimplanted control steers had greater plasma Cu concentrations than non-implanted steers supplemented with TM, whereas, implanted control steers had similar plasma Cu concentrations than implanted steers supplemented with TM. Non-implanted steers that received inorganic TM had lower plasma Cu concentrations (p = 0.03) during the growing phase and ceruloplasmin activity (p<0.04) during the finishing phase than non-implanted steers that received organic TM, whereas, implanted steers supplemented with either organic or inorganic TM had similar plasma Cu concentrations.