• Title/Summary/Keyword: AE events

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Characteristics of Tuberculosis Detected during Chemotherapy for a Solid Tumor (고형암에 대한 항암화학요법 치료 중 병발한 결핵의 특성)

  • Kim, Deog Kyeom;Lee, Sei Won;Kang, Young Ae;Yoon, Young Soon;Yoo, Chul-Gyoo;Kim, Young Whan;Han, Sung Koo;Shim, Young-Soo;Yim, Jae-Joon
    • Tuberculosis and Respiratory Diseases
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    • v.58 no.3
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    • pp.285-290
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    • 2005
  • Background : Some malignancies including lymphoma, head and neck cancer, and lung cancer are believed to be associated with the reactivation of tuberculosis (TB) because cyclic anti-cancer chemotherapy can induce the leukopenia or immunological deterioration. This report describes the clinical characteristics and treatment response of TB that developed during cyclic anti-cancer chemotherapy in patients with a solid tumor. Materials and Methods : From January 1 2000 to July 31 2004, patients with TB diagnosed microbiologically, pathologically, or clinically during anti-cancer chemotherapy in a tertiary hospital were enrolled, and their medical records were reviewed. Patients with the known risk factors for the reactivation of TB were excluded. Results : Twenty-two patients were enrolled and their mean age was 56.5 years (range 21-78). The male to female ratio was 3.4:1 and pulmonary TB was the main variant (20 patients, 90.9%). Gastric cancer (10 patients, 45.4%) and lymphoma (4 patients, 18.2%) were the leading underlying malignancies. The other malignancies included lung cancer, head and neck cancer, breast cancer, cervix cancer, and ovary cancer. Fifteen patients (68.2%) had a healed scar on a simple chest radiograph suggesting a previous TB infection. Among these patients, new TB lesions involved the same lobe or the ipsilateral pleura in 13 patients (87.6%). An isoniazid and rifampicin based regimen were started in all the subjects except for one patient with a hepatic dysfunction. The mean duration of medication was $9.9{\pm}2.4$ months and no adverse events resulting in a regimen change were observed. With the exception of 5 patients who died of the progression of the underlying malignancy, 70.6% (12/17) completed the anti-TB treatment. Conclusion : The clinical characteristics and response to anti-TB treatment for TB that developed during anticancer chemotherapy for a solid tumor were not different from those of patients who developed TB in the general population.

Spatial Distributions and Monthly Variations of Water Quality in Coastal Seawater of Tongyeong, Korea (통영 주변 해역 수질의 공간분포 및 월 변화 특성)

  • Lee, Young-Sik;Lim, Weol-Ae;Jung, Chang-Su;Park, Jong-Soo
    • Journal of the Korean Society for Marine Environment & Energy
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    • v.14 no.3
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    • pp.154-162
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    • 2011
  • Seawater quality was investigated each month at 30 stations near Tongyeong, South Korea, to provide data for the effective use of coastal fisheries and the reduction of economic damage to marine products. Water temperature was lowest in January and highest at the end of August. Neither extremely low water temperature below $4^{\circ}C$ nor fish damage caused by low water temperature was observed. Salinity ranged from 24.04 to 34.39 psu in the surface layer and from 29.92 to 34.39 psu in the bottom layer. The minimum salinity, attributable to rainfall events, was observed in July; salinity increased to high of about 34 psu in November. Low dissolved oxygen (DO), below 4 mg/L, was observed at Wenmun and Buksin Bays during May to October. Concentrations of $NO_2$-N, $NO_3$-N, and $PO_4$-P were low from March to September and high from October to February. Transparency was 6 m on average and was high in Wenmun Bay. Chemical oxygen demand (COD) and chlorophyll a (Chl. a) were high during summer, when the water temperature was high. With cluster analysis based on environment factors related to water quality, the study area could be divided into three main sea areas: Buksin Bay, coastal seawater, and offshore seawater. Buksin Bay was characterized by low salinity, high DO and Chl. a, and high transparency in the surface layer and by low DO and high $NH_4$-N in the bottom layer. Offshore seawater had high salinity and $NO_3$-N and low Chl. a concentration. In summer season that oyster need lots of phytoplankton, $NO_3$-N and Chl. a concentrations at this study area were low compare to Gwangy-ang and Gamak Bays. In winter, a sea squirt swallow much more than other season, the Chl. a concentrations were also low than Gwangyang and Gamak Bays.

Comparison of Methods for Estimating Extreme Significant Wave Height Using Satellite Altimeter and Ieodo Ocean Research Station Data (인공위성 고도계와 이어도 해양과학기지 관측 자료를 활용한 유의파고 극값 추정 기법 비교)

  • Woo, Hye-Jin;Park, Kyung-Ae;Byun, Do-Seung;Jeong, Kwang-Yeong;Lee, Eun-Il
    • Journal of the Korean earth science society
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    • v.42 no.5
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    • pp.524-535
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    • 2021
  • Rapid climate change and oceanic warming have increased the variability of oceanic wave heights over the past several decades. In addition, the extreme wave heights, such as the upper 1% (or 5%) wave heights, have increased more than the heights of the normal waves. This is true for waves both in global oceans as well as in local seas. Satellite altimeters have consistently observed significant wave heights (SWHs) since 1991, and sufficient SWH data have been accumulated to investigate 100-year return period SWH values based on statistical approaches. Satellite altimeter data were used to estimate the extreme SWHs at the Ieodo Ocean Research Station (IORS) for the period from 2005 to 2016. Two representative extreme value analysis (EVA) methods, the Initial Distribution Method (IDM) and Peak over Threshold (PoT) analysis, were applied for SWH measurements from satellite altimeter data and compared with the in situ measurements observed at the IORS. The 100-year return period SWH values estimated by IDM and PoT analysis using IORS measurements were 8.17 and 14.11 m, respectively, and those using satellite altimeter data were 9.21 and 16.49 m, respectively. When compared with the maximum value, the IDM method tended to underestimate the extreme SWH. This result suggests that the extreme SWHs could be reasonably estimated by the PoT method better than by the IDM method. The superiority of the PoT method was supported by the results of the in situ measurements at the IORS, which is affected by typhoons with extreme SWH events. It was also confirmed that the stability of the extreme SWH estimated using the PoT method may decline with a decrease in the quantity of the altimeter data used. Furthermore, this study discusses potential limitations in estimating extreme SWHs using satellite altimeter data, and emphasizes the importance of SWH measurements from the IORS as reference data in the East China Sea to verify satellite altimeter data.

Geological Structures of the Taean Formation in the Gomseom Area, Southwestern Gyeonggi Massif (경기육괴 남서부 곰섬 일대 태안층의 지질구조)

  • Kim, Inho;Kim, Ae-Ji;Woo, Hayoung;Park, Seung-Ik
    • Economic and Environmental Geology
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    • v.52 no.2
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    • pp.159-168
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    • 2019
  • The western Gyeonggi Massif, where records evidence of Phanerozoic subduction/collision tectonics, is an important area to understand the crustal evolutionary history of the Korean Peninsula. This study presents geometric and kinematic characteristics of the geological structures of the Taean Formation in the Gomseom area, southwestern Gyeonggi Massif. We interpreted the geometric relationships between structural elements, and conducted stereographic and down-plunge projections for structural domains. As a result, at least three different deformational events ($D_1$, $D_2$ and $D_3$) are recognized in the study area. In the first deformational event ($D_1$), regional foliations being well defined by the preferred orientation of muscovite and biotite were formed. In the second deformational event ($D_2$), NNE-trending low-angle contractional faults and related crenulation lineations/cleavages were formed. The crenulation lineations shallowly plunge toward SSW~SSE or NNW~NNE. In the third deformational event ($D_3$), SE-plunging folds and NE-trending high-angle faults were formed as 'fault-related fold' and 'fold-accommodation fault', indicating that the $D_3$ folds and faults are genetically linked to each other. This contribution provides important insights into the structural evolution of the Taean Formation along western Gyeonggi Massif, where had evolved as subduction/collisional orogenic belts in the East Asia.

Social Anxiety in Korean Society (한국 사회의 사회적 불안에 관한 연구)

  • Young-Oh Hong;Kwan-Jae Song;Su Ae Park;Hyejin Lee;Jae Chang Lee
    • Korean Journal of Culture and Social Issue
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    • v.12 no.1
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    • pp.129-160
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    • 2006
  • The purposes of this study were to find 1) the realities of social anxiety and perception of various kinds of social problems that exists in Korean society as well as the perception on the events that causes the social anxiety, 2) to see the difference of perceived level of social anxiety through variables of social demography and difference of perception on Korean society. The sample was distributed according to population size distinguishing the nation to 6 regions. The data of 1,375 adult respondents were analysed. The results are as follows. First of all, respondents mentioned that the most immediate problem to be solved in Korean society was financial anxiety, and the most desirable state of society was when the society is financially stabled. Single question was measured about social anxiety of Korean society and scored 6.84 from full marks of 10, showing difference in variables for instance sex, age, and subjective S.E.S. where women, aged under 20, and perceived low class group showed the highest rate of social anxiety. However, there weren't any difference found in social anxiety of the variables like presence of religion, educational background, residence, and monthly average household income. Also, there were differences in level of social anxiety according to the difference of perception of Korean society. Higher the perceived unpredictability, uncontrollability, and unmovability to the upper class, unfairness, and uncertainty, unreliability of the Korean society, higher the social anxiety. And the lower the perceived chance of success of reformation, higher the social anxiety. It was also found that the perceived social anxiety is influenced by social accidents and phenomenon as unemployment, economic depression, and the gap between rich and poor as well as the increase of crime through effluence of personal information. Finally the limitations and implications of this study were discussed.