• Korean Journal of Computational Design and Engineering
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• v.8 no.1
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• pp.55-63
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• 2003

ADE i,1 a software tool for the design and implementation of multi-agent systems. ADE allows a designer to draw a multi-agent system graphically, specify the necessary properties, and deploy their applications. ADE offers a set of intuitive, easy to use interfaces that enable a designer to completely specify the agents and agent interactions in a multi-agent system. In this environment, JATLite/sup ［1］/ is improved significantly. Furthermore, ADE provides a unique set of features for a multi-agent system design tool. An agent description method based on Design roadmap/sup ［2］/ theory, a hierarchy of agents, and a fully featured Java-based Graphical User Interface are combined in ADE. This distinct combination of features mates ADE stand out among the existing multi-agent system design tools. This paper presents the research related to the application of the ADE, along with descriptions of its design and implementation.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1944-1946
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• 2008

본 논문에서는 통신해양기상위성의 추력기 구동장치에 대하여 기술하였다. 위성에서는 위성체 전력공급을 위한 태양전지판, 위성의 자세제어를 위한 모멘텀 휠과 추진계, 온도제어 등을 담당하는 다양한 추력기 (actuator)가 존재한다. 위성의 안정적인 동작을 위해 각각의 추력기를 제어하기 위한 전기 및 기계 접속 요구사항을 수용하는 인터페이스 기능을 담당하는 추력기 구동장치 (Acutator Drive Electronics, ADE)가 필요하다. 통신해양기상위성의 추력기 구동장치는 안정적인 동작을 위해서 1개의 ADE5 구조체 안에 ADE5 A와 ADE5 B가 중복되어서 구현되었다. ADE5는 ADE5 A와 B가 수동적 중복구조를 갖지만, 추력기와 ADE5 A, B가 상호연결되어 있어서 위성의 상태에 따라서 2개의 ADE5 A, B가 혼합적으로 사용될 수 있다.

• The Korean journal of internal medicine
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• v.38 no.5
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• pp.704-713
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• 2023

Background/Aims: Antimicrobial de-escalation (ADE) remains a challenging strategy in the treatment of pneumonia. We investigated the outcomes of ADE as measured by mortality and duration of the use of antibiotics in patients with culture-negative pneumonia. Methods: We performed a systematic review and meta-analysis in accordance with PRISMA guidelines. The primary outcome was inpatient mortality. Results: We examined six studies comprising 11,933 subjects, of whom 1,152 received ADE. Overall, the ADE strategy was associated with a statistically lower risk of in-hospital mortality compared with non-ADE (risk ratio [RR] = 0.60, 95% confidence interval [CI] = 0.38 to 0.93). Although substantial heterogeneity was found among the included studies (I² = 66%), a meta-regression analysis could not reveal plausible sources of heterogeneity. And ADE was associated with a shorter duration of total and initial antibiotic therapies and total length of hospital stay compared with non-ADE. Conclusions: Our findings suggest that ADE seems to be significantly associated with better clinical outcomes compared with non-ADE. Caution is demanded when interpreting data of this study because of substantial between-study heterogeneity.

• Biomedical Science Letters
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• v.27 no.2
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• pp.59-68
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• 2021

Multidrug-resistant strain of Acinetobacter baumannii (MDRAB) is an emerging pathogen in health care facilities, preventing MDRAB is a public health concern. We conducted this experiment on a clinical isolate of A. baumannii with two main goals: the role of the efflux pump system in the stress provision of carbapenem and the response to the transcription level of the efflux pump gene. A total of 34 strains of A. baumannii was isolated from the Yangsan Hospital of Pusan National University. First, when we compared and observed the expression of the efflux pump gene and antibacterial resistance to carbapenem, a strong correlation was observed between carbapenem resistance and overexpression of adeB (P=0.0056). Second, a correlation between the efflux pump and concentration gradient and tolerance to carbapenem stress at the AdeABC efflux pump genes transcription level was confirmed. Our results revealed that the expression of the AdeABC efflux pump is an important resistance determinant in obtaining antibiotic resistance of the carbapenem group in A. baumannii.

• The Journal of Korean Medicine
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• v.42 no.4
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• pp.197-207
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• 2021

Objectives: The purpose of this study was to confirm effect of reducing inflammation of Coptis chinensis extract-ceramide complex through the endocannabinoid system (ECS) control in atopic dermatitis. Methods: 8-week-old ICR mice were divided into normal group (Ctrl), lipid barrier elimination group (ADE), palmitoylethanolamide treated group after lipid barrier elimination (PEAT), and Coptis chinensis extract-ceramide complex applied group after lipid barrier elimination (CRA). After inducing atopic dermatitis, cannabinoid receptor (CB) 1, CB2, CD68, p-I𝜅B, iNOS, substance P and serotonin were observed to confirm the regulation of the ECS, macrophage activity and mast cell activity. Results: CB1 and CB2 showed higher positive reactions in the CRA than in the ADE and PEAT. CD68, p-I𝜅B and iNOS showed higher positive reaction in the ADE, PEAT and CRA than in the Ctrl, but the increase in the positive reaction was lower in the CEA compared to the ADE and PEAT. Substance P and serotonin showed higher positive reaction in the ADE, PEAT and CRA than in the Ctrl, but the increase in the positive reaction was lower in the CEA compared to the ADE and PEAT. Conclusions: The effects of Coptis chinensis extract -ceramide complex were confirmed on the regulation of the ECS, macrophage activity and mast cell activity.

• Journal of IKEEE
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• v.28 no.3
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• pp.382-389
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• 2024

In this paper, a design of dynamic braking resistor for stationary mode of azimuth driving equipment (ADE) for multi-function radar (MFR) is presented. The ADE carries out missions which is the rotation mode for all directions and the stationary mode for tracing a subject with standstill. The ADE has to transfer the operation mode in demand time from rotation mode to stationary mode for precise target tracing. During the transition with deceleration, it may cause the fault of input power device due to back-electromotive force (back-EMF) of PMSM with generator mode. To protect the power device, a design of dynamic braking resistor is essential for consuming back-EMF. This paper presents the development of dynamic braking resistor for consuming back-EMF of ADE with deceleration mode. The validity and effect of the design is verified using simulation results.

• Journal of Korean Society for Atmospheric Environment
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• v.25 no.1
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• pp.26-37
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• 2009

Recently rapid environmental changes due to desertification and industrialization in China make a threat to Korea, especially during Asian Dust Event (ADE). This study was aimed to compare symptoms and behaviors related to ADE between Korea and China. We conducted questionnaires on self-reported symptoms and behaviors before and during ADE. Korean and Chinese subjects were grouped into children, adults, and elderly by nation (n=791). Statistical analyses were performed by $X^2$-test, Fisher's exact test, t-test and chow's test for comparing differences between Korean and Chinese. We estimated the odds ratio for perceived symptoms during ADE by preventive behavior, using Generalized Estimation Equation (GEE). The study indicated that there were significant differences between symptoms in Korea and those in China such as cold, cough, and sore throat, especially in elderly. Preventive behaviors such as avoiding outdoor activity and wearing sunglasses were more often performed in China than Korea. However wearing mask was more often performed in Korea than China. After adjusting for age, sex, educational level, and smoking status, the odds ratio (OR) of dry cough symptom in Korea was significantly decreased by closing the windows and wearing a mask during ADE. In China, the OR of dry cough symptom was decreased by wearing a mask and avoiding outdoor activity. We found that China which had higher performance of preventive behavior showed lower prevalence of symptoms during ADE than Korea. Also preventive behaviors could affects prevalence of symptoms during ADE. This results suggest that preventive behavior. could reduce symptoms during ADE and there are needed for. more attentions to reduce a threat of ADE.

• Horticultural Science & Technology
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• v.31 no.6
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• pp.813-820
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• 2013

Monoterpenoids were recently found as main biologically active compounds which is responsible for various physiological effect in goat's beard (Aruncus dioicus). Ethyl acetate extract of A. dioicus (ADE) was treated to B16F10 melanoma cells for the examination of whitening activity. MTT assay was performed to evaluate cell toxicity and the result showed that slight cell toxicity (> 10%) by over $500{\mu}g{\cdot}mL^{-1}$. Thus, 0, 5, 10, or $50{\mu}g{\cdot}mL^{-1}$ ADE was used for further experiments. We found that tyrosinase activity was decreased according to ADE concentration, and the total melanin content was also dramatically reduced. Especially with $50{\mu}g{\cdot}mL^{-1}$ ADE treatment tyrosinase activity was reduced to 35.6%, and 58.8% of melanin content was lowered. In addition, whitening related proteins including tyrosinase, tyrosinase related protein 1 (TRP1), TRP2, microphthalmia associated transcription factor (MITF) and cAMP and protein kinase A (PKA) were reduced by ADE treatment. It caused decreased phosphorylation of cAMP response binding protein (CREB) but increased phosphorylation of extracellular signal related kinase (ERK). Therefore, in this paper we would like to suggest the potent usage of A. dioicus natively grown in Ulleungdo, Korea as materials of functional cosmetics by confirming whitening activity related with melanin content.

• Journal of Korea Water Resources Association
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• v.37 no.11
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• pp.889-896
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• 2004

The fractal advection-diffusion equation (ADE) is a generalization of the classical AdE in which the second-order derivative is replaced with a fractal order derivative. While the fractal ADE have been analyzed with a stochastic process In the Fourier and Laplace space so far, in this study a fractal ADE for describing solute transport in rivers is derived with a finite difference scheme in the real space. This derivation with a finite difference scheme gives the hint how the fractal derivative order and fractal diffusion coefficient can be estimated physically In contrast to the classical ADE, the fractal ADE is expected to be able to provide solutions that resemble the highly skewed and heavy-tailed time-concentration distribution curves of contaminant plumes observed in rivers.

• Journal of Microbiology and Biotechnology
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• v.26 no.12
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• pp.2043-2050
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• 2016

Exploring novel antibiotics is necessary for multidrug-resistant pathogenic bacteria. Because the probiotics in soybean food have antimicrobial activities, we investigated their effects on multidrug-resistant Acinetobacter baumannii. Nineteen multidrug-resistant A. baumannii strains were clinically isolated as an experimental group and 11 multidrug-sensitive strains as controls. The growth rates of all bacteria were determined by using the analysis for xCELLigence Real-Time Cell. The combination of antibiotics showed synergistic effects on the strains in the control group but no effect on the strains in the experimental group. Efflux pump gene adeS was absent in all the strains from the control group, whereas it exists in all the strains from the experimental group. Furthermore, all the strains lost multidrug resistance when an adeS inhibitor was used. One strain of probiotics isolated from soybean food showed high antimicrobial activity for multidrug-resistant A. baumannii. The isolated strain belongs to Bacillus subtilis according to 16S RNA analysis. Furthermore, E. coli showed multidrug resistance when it was transformed with the adeS gene from A. baumannii whereas the resistant bacteria could be inhibited completely by isolated Bacillus subtilis. Thus, probiotics from soybean food provide potential antibiotics against multidrug-resistant pathogenic bacteria.