• 대한의생명과학회지
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• 제24권4호
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• pp.305-310
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• 2018

Microglia are emerging as critical regulators of innate immune responses in AD and other neurodegenerative disorders, highlighting the importance of understanding their molecular and cellular mechanisms. We attempted to determine the role of crosstalk signaling between $IFN-{\gamma}$ and $TGF-{\beta}$ in $A{\beta}$ clearance by microglia cells. We used in vitro and in vivo mouse models that recapitulated acute and chronic aspects of microglial responses to $A{\beta}$ peptides. We showed that crosstalk signaling between $TGF-{\beta}$ and Smad2 was an important mediator of neuro-inflammation. These findings suggest that microglial $TGF-{\beta}$ activity enhances the pathological progression to AD. As $TGF-{\beta}$ displays broad regulatory effects on beneficial microglial functions, the activation of inflammatory crosstalk signaling between $TGF-{\beta}$ and Smad2 may be a promising strategy to restore microglial functions, halt the progression of $A{\beta}$-driven pathology, and prevent AD development.

• Journal of Multimedia Information System
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• 제6권2호
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• pp.87-90
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• 2019

Machine learning techniques have been applied in almost all the domains of human life to aid and enhance the problem solving capabilities of the system. The field of medical science has improved to a greater extent with the advent and application of these techniques. Efficient expert systems using various soft computing techniques like artificial neural network, Fuzzy Logic, Genetic algorithm, Hybrid system, etc. are being developed to equip medical practitioner with better and effective diagnosing capabilities. In this paper, a comparative study to evaluate the predictive performance of subtractive clustering based ANFIS hybrid system (SCANFIS) with Fuzzy C-Means (FCM) based ANFIS system (FCMANFIS) for Alzheimer disease (AD) has been taken. To evaluate the performance of these two systems, three parameters i.e. root mean square error (RMSE), prediction accuracy and precision are implemented. Experimental results demonstrated that the FCMANFIS model produce better results when compared to SCANFIS model in predictive analysis of Alzheimer disease (AD).

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.291.2-291.2
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• 2002

For the safety evaluation of adenovirus-mediated gene therapy. we have investigated gene and protein expression after transduction of adenoviral vector (Ad5CMV-p16) which contains tumor suppressor gene. p161NK4$\alpha$ in human non-small cell lung cancer (A549) cells. We compared the differential gene expression level in the A549 cells treated with Ad5CMV (null type) and Ad5CMV-p16 virus. respectively. by using cDNA membrane chip and oligonucleotide chip. (omitted)

• East Asian Economic Review
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• 제26권2호
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• pp.95-117
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• 2022

This paper empirically examines what factors affected the termination of anti-dumping measures in Korea during the 2006-2019 period. Employing a meticulous literature review, the paper investigates the WTO's and Korea's rules on the termination of anti-dumping measures and sets up the related variables in the Cox proportional hazards model. The empirical results show that the GDP growth rate, employment, and trade competitiveness in domestic industries had positive effects on the hazard of the termination of AD measures, while free trade agreements had negative effects. By industry, the hazard of the termination of AD measures was less prominent in the steel industry, while it was more prominent in the machinery industry. These results imply that AD measures in Korea had the properties of a proper trade remedy policy and, at the same time, a protectionism tool to sustain its domestic industries, depending on industrial characteristics and other trade policies.

• 한국산업정보학회논문지
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• 제14권2호
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• pp.81-85
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• 2009

VANET 환경에서는 차량이 고속으로 이동하므로 차량간 긴급 데이터 전송이 일방향으로 이루어지는 것이 바람직하며 위험 정보를 후방의 차량들에게 전송 시 목적지가 정해지지 않은 브로드캐스트로 전송하는 것이 요구된다. 제안한 인증 프로토콜은 디지털 서명 방식을 사용하여 경로상의 노드를 인증하며 이는 위장 공격이나 매시지 위조 공격을 막을 수 있다. 또한, 제안한 프로토콜은 경로의 중간노드를 인식하기 위하여 노드 리스트를 사용하며 이 노드 리스트, 시간 및 난수는 재사용 공격을 막을 수 있다

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5089-5093
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• 2013

Objective: This study aimed to investigate the effects of BCRP expression on tumor recurrence, metastasis and treatment tolerability. Methods: A VX2 rabbit liver tumor model was established. Division was randomly into 4 groups: namely saline control group; A group, given hydration lipiodol; B group, Ad-p53; and C group, Ad-p53+hydration lipiodol. After the intervention, samples were collected to detect the BCRP, MMP-2, VEGF and PCNA. Results: The expression of BCRP, MMP-2, PCNA and VEGF in tumors in Group A had no significant difference when compared with the control group, while in B and C group, the values were significantly lower (P<0.05). BCRP positive expression in metastatic lesions significantly increased (P<0.05), and was correlated with MMP-2 ($X^2=6.172$, P=0.0131). Conclusions: BCRP may play an important role in mediating liver cancer multidrug resistance to chemotherapy, and may be correlated with tumor recurrence and metastasis, which leads to weakened treatment effect. Ad-P53 can down-regulate the expression of related genes, playing a role in multidrug resistance reversal and increased sensitivity in liver cancer treatment.

• Journal of Ginseng Research
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• 제44권3호
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• pp.453-460
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• 2020

Background: BIOGF1K, a fraction of Panax ginseng, has desirable antimelanogenic, anti-inflammatory, and antiphotoaging properties that could be useful for treating skin conditions. Because its potential positive effects on allergic reactions in skin have not yet been described in detail, this study's main objective was to determine its efficacy in the treatment of atopic dermatitis (AD). Methods: High-performance liquid chromatography was used to verify the compounds in BIOGF1K, and we used the (3-4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide method to determine its cytotoxicity in RBL-2H3 and HMC-1 cell lines. RBL-2H3 cells were induced using both anti-DNP-IgE/DNP-BSA and calcium ionophore (A2187) treatments, whereas HMC-1 cells were induced using A2187 alone. To measure mast cell degranulation, we performed histamine (enzyme-linked immunosorbent assay) and β-hexosaminidase assays. To quantify interleukin (IL)-4, IL-5, and IL-13 levels in RBL-2H3 cells, we performed quantitative polymerase chain reaction (PCR); to quantify expression levels of IL-4 and IL-13 in HMC-1 cells, we used semiquantitative reverse transcription polymerase chain reaction (RT-PCR). Finally, we detected the total and phosphorylated forms of extracellular signal-regulated kinase, p-38, and c-Jun N-terminal kinase proteins by immunoblotting. Results: BIOGF1K decreased the AD response by reducing both histamine and β-hexosaminidase release as well as reducing the secretion levels of IL-4, IL-5, and IL-13 in RBL-2H3 cells and IL-4 and IL-13 in HMC-1 cells. In addition, BIOGF1K decreased MAPK pathway activation in RBL-2H3 and HMC-1 cells. Conclusions: BIOGF1K attenuated the AD response, hence supporting its use as a promising and natural approach for treating AD.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제3권5호
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• pp.155-162
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• 2014

본 논문에서는 MANET 환경에서 2-level 트리기반 클러스터링 라우팅 알고리즘을 제안한다. 이를 통해 네트워크에 속해 있는 무선 노드들의 생존시간을 증가시키고 네트워크 데이터 전송률을 향상시키는 것이 주요 목표이다. 무선 네트워크의 기본 특성인, 무선 자원과 배터리 상의 제약으로 인해 클러스터 형성과 유지 및 관리기법은 네트워크의 안정성을 향상시키기 위해서는 필수적이다. 그러나 애드 혹 네트워크 환경의 클러스터링 기법에서 클러스터 헤드는 호스트의 기능을 수행함과 동시에 라우팅 기능을 담당하는 라우터의 역할까지 수행한다. 따라서 클러스터 헤드의 에너지 고갈이나 부재는 클러스터를 붕괴시키고, 전체 네트워크의 통신을 어렵게 하며, 나아가서는 네트워크의 수명을 단축시킨다. 결국 클러스터 헤드의 효율적인 관리는 전반적인 네트워크의 성능을 결정짓는 핵심이라고 볼 수 있다. 때문에 본 제안 기법은 클러스터 헤드와 이웃 노드들의 유지 및 효율적인 관리를 통해 전체적인 네트워크의 생존시간과 Throughput을 향상시키고자 하였다. 또한 시뮬레이션을 통해 MANET 환경에서 기존 LS2RP기법에 비해 Qos측면에서 평균 17%의 성능 향상이 이루어짐을 알 수 있었다.

• 한국통신학회논문지
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• 제32권4B호
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• pp.200-207
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• 2007

최근에 인터넷에서는 많은 Peer-to-Peer (P2P) 시스템이 등장하여 자료 공유가 활발히 이루어지고 있다. P2P 시스템은 자가 형성, 자가 치료, 분산처리와 같은 특징을 지니고 있어, 그러한 특징을 공유하는 애드혹 환경에서도 적절한 응용 프로그램으로 인식되고 있다. 본 논문은 가장 널리 사용되는 P2P 시스템중의 하나인 Gnutella를 애드혹 망에서 보다 효율적으로 동작할 수 있도록 개선하여 시스템 수명 연장, 오버헤드 감소, 향상된 성능을 제공하는 것을 목적으로 한다. 이를 위해 계층적 피어를 사용하는 Gnutella 방식에 계량값을 이용한 울트라피어 선택방안, 능동적 울트라피어 정보제공 방안 등을 도입하였다. 모의실험 결과, 본 논문에서 제안한 방안은 Gnutella 보다 망을 더욱 효율적으로 사용함으로써 검색 성공률을 높이고, 응답시간을 줄였으며, 오버헤드 측면에서도 훨씬 좋은 결과를 보였다. 또한 애드혹 망 및 P2P 시스템의 지속시간에 영향을 미칠 수 있는 노드들의 잔여 에너지양을 높일 수 있었다.

• 대한불안의학회지
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• 제20권1호
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• pp.8-16
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• 2024

Objective : The purpose of this study is to compare the signal obtained from the frontal 2-electrodes EEG with that obtained from the temporal, central, and parietal 2 electrodes. Methods : EEGs were recorded in a total of 67 patients with major depressive disorder (MDD), 104 patients with schizophrenia (SCZ), and 29 patients with Alzheimer's disease (AD). For each disease group, there were healthy controls (HC) that were paired accordingly (HC1=69, HC2=104, HC3=27). The following measurements were compared across electrodes: band power, alpha peak frequency (APF), APF power, alpha asymmetry (AA), and Kolmogorov complexity (KC). Results : Statistically significant differences were found in band power measured from frontal electrodes compared to electrodes placed in other locations. Specifically, the power of theta waves was measured higher in the temporal electorodes, alpha 1 and alpha 2 waves in the parietal, beta 1 and beta 2 in the central, and gamma waves in the temporal electrodes. Both SCZ and AD patients showed increased theta power in all electrodes. In SCZ patients, APF decreased in the central and temporal electrodes, but the APF power analysis showed no difference between the patients and controls. Additionally, AD patients exhibited increased AA in the central EEG, while SCZ patients showed decreased KC in the parietal and temporal electrodes. Conclusion : Depending on the electrode location, sensitive EEG frequencies differed. Compared with signals from other electrodes, frontal EEG in MDD patients revealed generally constant signal values, though the temporo-parieto-central electrodes appeared to be more reliable in SCZ and AD patients.