Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Differential Protein and Gene Expression after Adenovirus-Mediated p16 Gene Transfer in Human Non-Small Cell Lung Cancer Cells

  • Park, Mi-Sun (KFDA, National Institute of Toxicological Research, Genetic Toxicology Div.) ;
  • Kang , Ho-Il (KFDA, National Institute of Toxicological Research, Genetic Toxicology Div) ;
  • Jee, Seung-Wan (KFDA, National Institute of Toxicological Research, Genetic Toxicology Div) ;
  • Lim, Si-Nae (KFDA, National Institute of Toxicological Research, Genetic Toxicology Div) ;
  • Pyo, Jae-Hee (KFDA, National Institute of Toxicological Research, Genetic Toxicology Div) ;
  • Eom , Mi-Ok (KFDA, National Institute of Toxicological Research, Genetic Toxicology Div) ;
  • Ryeom , Tai-Kyung (KFDA, National Institute of Toxicological Research, Genetic Toxicology Div) ;
  • Kim, Ok-Hee (KFDA, National Institute of Toxicological Research, Genetic Toxicology Div.)
  • Published : 2002.10.01
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Abstract

For the safety evaluation of adenovirus-mediated gene therapy. we have investigated gene and protein expression after transduction of adenoviral vector (Ad5CMV-p16) which contains tumor suppressor gene. p161NK4$\alpha$ in human non-small cell lung cancer (A549) cells. We compared the differential gene expression level in the A549 cells treated with Ad5CMV (null type) and Ad5CMV-p16 virus. respectively. by using cDNA membrane chip and oligonucleotide chip. (omitted)

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