• Proceedings of the Korea Information Processing Society Conference
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• 2006.05a
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• pp.1139-1142
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• 2006

Mobile Ad-hoc 네트워크(MANET)에서 각 노드들은 한정된 배터리에 의존하여 통신한다. 이와 같은 제한사항을 극복하기 위해 링크의 안정성을 유지하거나 파워 소모를 고려한 프로토콜에 대한 연구들이 활발히 이루어져 왔다. 하지만 링크의 안정성 또는 파워 소모의 어느 한 측면만을 고려함으로써 링크의 안정성은 높일 수 있으나 파워 소모가 효율적이지 못했다. 반면에 전체 파워소모는 줄일 수 있었으나 파워소모의 균형을 이루지 못함으로써 네트워크 수명을 오래 지속시킬 수 없는 문제점이 발생 했다. 본 논문에서는 배터리 잔량에 대한 threshold를 적용함과 동시에 신호세기를 고려하여 각 노드들의 균형된 파워소모와 네트워크 전체의 파워 소모를 최소화함으로써 네트워크 수명을 오래 지속시키기 위한 프로토콜인 PRTRS(Power Aware Routing Protocol based on Both Threshold by Residual Battery Capacity and Signal Strength in Mobile Ad-hoc Network)를 제안한다. PRTRS는 AODV(Ad-hoc On-demand Distance Vector Routing)를 기반으로 하였다. NS-2 네트워크 시뮬레이션 결과 PRTRS는 특정 노드로 집중되는 트래픽을 분산시켜 파워소모의 균형을 이루고 네트워크 전체의 파워소모를 최소화함으로써 네트워크 수명이 연장됨을 확인하였다.

• Journal of Korean Biological Nursing Science
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• v.16 no.3
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• pp.219-225
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• 2014

Purpose: This study was aimed to evaluate the effect of blending oils on atopic dermatitis (AD) model of NC/Nga mice. Methods: Adult NC/Nga mice were assigned to 1 of 3 groups: control group (C, n=8), experimental group [AD-induced group, blending oil-treated group (E=8, 8)]. Mice in the E group were given a treatment of blending oils such as Lavender, Rosemary and Lemon Balm (LRL) for 2 sessions (every day) for 6 days. Results: The AD-induced mice with LRL blending oils treatment showed a significant decrease in epidermal thickness, number of mast cells and degranulation, expression of TNF-${\alpha}$ and scoring of sensual assessment. Conclusion: LRL blending oils may be a putative resource for the cure of or treatment of AD by the diminution of AD-pathological factors such as the epidermal thickness, the number of mast cells and degranulation as well as the expression of TNF-${\alpha}$.

• Journal of Communications and Networks
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• v.11 no.1
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• pp.47-56
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• 2009

We investigate the connectivity of fading wireless ad-hoc networks with a pair of novel connectivity metrics. Our first metric looks at the problem of connectivity relying on the outage capacity of MIMO channels. Our second metric relies on a probabilistic treatment of the symbol error rates for such channels. We relate both capacity and symbol error rates to the characteristics of the underlying communication system such as antenna configuration, modulation, coding, and signal strength measured in terms of signal-to-interference-noise-ratio. For each metric of connectivity, we also provide a simplified treatment in the case of ergodic fading channels. In each case, we assume a pair of nodes are connected if their bi-directional measure of connectivity is better than a given threshold. Our analysis relies on the central limit theorem to approximate the distribution of the combined undesired signal affecting each link of an ad-hoc network as Gaussian. Supported by our simulation results, our analysis shows that (1) a measure of connectivity purely based on signal strength is not capable of accurately capturing the connectivity phenomenon, and (2) employing multiple antenna mobile nodes improves the connectivity of fading ad-hoc networks.

• IMMUNE NETWORK
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• v.7 no.4
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• pp.179-185
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• 2007

Background: Adenovirus (Ad) vectors have been widely used for many gene therapy applications because of their high transduction ability and broad tropism. However, their utility for cancer gene therapy is limited by their poor transduction into cancer cells lacking the primary receptor, coxsackievirus and adenovirus receptor (CAR). Methods: To achieve CAR-independent gene transfer via Ad, we pretreated Ad with 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) and analyzed their transduction efficiency into cancer cells in vitro and in vivo comparing with the virus alone. Results: Treatment of DOTAP significantly increased adenoviral gene transfer in tumor cells in vitro. Moreover, DOTAP at an optimum dose $(10{\mu}g/ml)$ enhanced IL-12 transgene expression by fivefold in tumor, and twofold in serum after intratumoral injection of adenovirus expressing IL-12N220L (Ad/IL-12N220L). In addition, cotreatment of DOTAP decreased tumor growth rate in the Ad/IL-12N220L-transduced tumor model, finally leading to enhanced survival rate. Conclusion: Our results strongly suggest that DOTAP could be of great utility for improving adenovirus-mediated cancer gene therapy.

• Biomedical Science Letters
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• v.26 no.3
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• pp.192-200
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• 2020

Natural products have received revived interest via traditional remedies or alternative medicine used for the treatment of various diseases. Zanthoxylum piperitum (ZP) has been utilized in traditional medicine for various medicinal purposes. The present study was conducted to evaluate whether ZP modulates allergic inflammation both in vivo and in vitro. We examined the pharmacological effects of ZP on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) symptoms in mice. Additionally, in order to clarify the anti-inflammatory mechanisms of ZP, we elucidate the effect of ZP on the expression levels of inflammatory cytokines and nuclear factor-κB (NF-κB) in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). The results demonstrated that ZP attenuated AD clinical symptoms such as erythema, edema and dryness as well as histamine and IgE serum levels in DNCB-induced AD model mice. Additionally, ZP suppressed the expression of inflammatory cytokines and activation of NF-κB in AD-like skin lesions and stimulated HMC-1. These results provide experimental evidence that ZP may be useful candidate for treating allergic inflammation including AD.

• Molecular & Cellular Toxicology
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• v.5 no.2
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• pp.108-112
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• 2009

Alzheimer's disease(AD) is a neurodegenerative disorder characterized pathologically by senile plaques, neurofibrillary tangles, and synapse loss. Especially, extracellular beta-amyloid (Abeta) deposition is a major pathological hallmark of Alzheimer's disease (AD). In AD senile plaques, high level of iron and car-bonylated Abeta were detected. Iron has a Lewis acid property which can increase the electrophilicity of carbonyls, which may react catalytically with nucleophiles, such as amines. Hence, this study investigated whether or not iron could promote the carbonylation of amine with malondialdehyde (MDA) in the physiological condition. As the basic study, we examined that iron might promote the conjugation reaction between propylamine, monoamine molecule and MDA in the physiological condition. As the concentration of iron increased, the fluorescence intensity produced from the conjugation reaction increased in a dose-dependent manner. Instead of propylamine, we applied the same reaction condition to Abeta 1-40 peptide, one of major components founded in AD senile plaques for the conjugation reaction. As the result, the fluorescence intensity produced from the conjugation reaction between Abeta 1-40 peptide and MDA showed the similar trend to that of the reaction used with propylamine. This study suggests that iron can accelerate the conjugation reaction of MDA to Abeta 1-40 peptide and play an another important role in deterioration of AD brain.

• International Journal of Quality Innovation
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• v.10 no.1
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• pp.115-126
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• 2009

Video transmission effectiveness in the Ad Hoc network is becoming important recently, if different routing protocols are applied. Some researchers conclude that the reactive protocols are better for file transfer protocol (FTP) and constant bit rate (CBR) or hypertext transfer protocol (HTTP) transmission in an Ad Hoc wireless network but the performance report of video transmission is not much. This study adopts Qualnet (Network Simulator) as a simulation tool for environmental designing and performance testing, and employs an experimental design with eight groups. Our experiment shows that: (1) The performance of AODV (reactive) protocol is better than DSDV, ZRP and DSR when the transmission load has only one video stream; (2) Proactive (DSDV) and Hybrid protocols (ZRP) are better for a smaller Ad Hoc network when it transmits a video stream with some applications (VoIP, FTP and CBR). We conclude that packet loss rate is sensitive to the quality of video transmission and it has negative relationship with Peak Signal-to-Noise Ratio (PSNR) value. In addition, our experiment also shows that PSNR is a simple Metric for the performance evaluation of video transmission.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.16 no.3
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• pp.96-115
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• 2003

Introduction and Objectives : Administrating the Sopungchengyoungtanggami-bang (SCG) extract on to the atopic dermatitis(AD) is to study change of external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide and this study is done through forcing injury to rat's back skin which are lipid protect formation in stratum corneum. Materials and Methods : The AD which caused intentionally using the external application on the rat's back skin was used the SCG. The change of leukocytes in vasculature has been identified through optima 5.2 and student t-test and the results were made into dermal formation graph. Results : After dispensing SCG extract into the AD, the dermal injury was decreased. Especially, recover of lipid protection formation which include lipid and ceramide in stratum corneum is suppressing acute inflammation that some factors are PKC, TNF-${\alpha}$, IL-12B which controled the secretion of relating inflammatory cytokine, also went onto decrease of angiogenesis, and the decrease of degranulated mast cell. In addition, the decrease of epithelial injury also caused the growth of cell to decrease in stratum basale and cytoclasis. In the vasculature, the leukocytes were also decreased and it could relate to decrease AD Conclusions : Thus, SCG has effect on AD suppressing the dermal injury through recovering of lipid protection formation in stratum corneum.

• Journal of Communications and Networks
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• v.13 no.1
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• pp.43-49
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• 2011

In this paper, a new medium access control (MAC) protocol entitled three-phase multiple access with continual contention resolution (TPMA-CCR) is proposed for wireless multi-hop ad hoc networks. This work is motivated by the previously known three-phase multiple access (TPMA) scheme of Hou and Tsai [2] which is the suitable MAC protocol for clustering multi-hop ad hoc networks owing to its beneficial attributes such as easy collision detectible, anonymous acknowledgment (ACK), and simple signaling format for the broadcast-natured networks. The new TPMA-CCR is designed to let all contending nodes participate in contentions for a medium access more aggressively than the original TPMA and with continual resolving procedures as well. Through the systematical performance analysis of the suggested protocol, it is also shown that the maximum throughput of the new protocol is not only superior to the original TPMA, but also improves on the conventional slotted carrier sense multiple access (CSMA) under certain circumstances. Thus, in terms of performance, TPMA-CCR can provide an attractive alternative to other contention-based MAC protocols for multi-hop ad hoc networks.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.16 no.1
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• pp.112-129
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• 2003

Introduction and Objectives : Applying the saingheylyunbooemgami(SY) extract on to the atopic dermatitis(AD) is to study change of external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide and this study is done through forcing injury to rat's back skin which are lipid protect formation in stratum corneum. Materials and Methods : The AD which caused intentionally using the external application on the rat's back skin was used the SY. The change of leukocytes in vasculature has been identified through optima 5.2 and student t-test and the results were made into dermal foramtion graph. Results : After dispensing SY extract into the AD, the dermal injury was decreased, Especially, recover of lipid protection formation which include lipid and ceramide in stratum corneum is suppressing acute inflammation that some factors are PKC, TNF-${\alpha}$, lL-12B which controled the secretion of relating inflammatory cytokine, also went onto decrease of angiogenesis, and the decrese of degranulated mast cell. In addition, the decrease of epithelial injury also caused the growth of cell to decrease in stratum basale and cytoclasis. In the vasculature. the leukocytes were also decreased and it could relate to decrease AD. Conclusions : Thus. SY has effect on AD suppressing the dermal injury through recovering of lipid protection formation in stratum corneum.