• Proceedings of the Korean Information Science Society Conference
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• 2005.07a
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• pp.286-288
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• 2005

최근 기지국(Base Station)의 도움 없이 이동 단말기 간의 다중 무선 홉을 사용하여 송,수신자 간의 데이터 전송을 가능하게 하는 Ad-hoc 통신망에 관한 연구가 활발히 진행되고 있다. 유선망과 달리 Ad-hoc 통신망은 무선 전송 매체를 사용하기 때문에 신호의 페이딩(Fading), 간섭(Interference), 잡음(Noise) 등에 의해 높은 BER(Bit Error Rate)이 발생하는 특징을 가지고 있다. 하지만, 현재 인터넷 상에서 광범위하게 사용되고 있는 전송 규약인 TCP(Transmission Control Protocol)는 유선망의 신뢰적인 전송 매체를 고려하여 개발된 프로토콜이기 때문에 TCP를 수정 없이 Ad-hoc 통신망에 적용할 경우 전송 성능이 저하되는 문제를 가지고 있다. 전송 성능이 저하되는 문제는 기존 TCP가 에러 발생의 원인을 혼잡에 의한 것으로 인식하고 불필요한 혼잡 제어를 하기 때문이다. 본 논문에서는 송신자가 에러 발생 원인을 구별하고, 그에 따라 전송률을 조절함으로써 Ad-hoc 망에서의 TCP성능 향상을 위한 방법을 제시하였다. 또한 ns-2 시뮬레이터를 이용한 실험을 통해 TCP의 성능이 제안된 알고리즘에 의해 향상되었음을 확인하였다

• Journal of Korea Multimedia Society
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• v.13 no.2
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• pp.258-264
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• 2010

In the Ad-hoc networks, the limitation on the availability of power for operation is a significant bottleneck, given the requirements of portability, weight, and size of mobile devices. Hence, the use of routing metrics that consider the capabilities of the power sources of the network nodes contributes to the efficient utilization of energy. This paper presents a QoS routing protocol that minimize the power consumed by a packet in traversing from source node to the destination node. Results obtained of simulation show that, with our approach we can reduce the power consumption of nodes and increases the life time of the network.

• Journal of Korean Academy of Nursing
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• v.31 no.2
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• pp.279-291
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• 2001

Rapid progress in modern medical technology has made it possible to sustain life and/or delay death using 'heroic' treatments. The availability of life-sustaining treatment brings several issues in end-of-life care such as 'dying with dignity' and an radical increase in health care costs. The use of Advance Directives(AD) have been widely heralded by health care providers, gerontologists, and advocacy groups as means of protecting patients' right to accept or refuse life-sustaining treatment in end-of-life care. The use of AD can not only improve patients' autonomy and quality of life but also bring efficiency in distributing health care resources. The proportion of older persons in Korean population has been increasing. Those 65 years of age or over were about 7 percent of the population. Death and dying is not limited to older persons, but it is more prevalent among them. In conjunction with an aging population and the increasing prevalence of death, the issues of death and dying will become crucial in near future in terms of 'dying with dignity', 'autonomy', and 'self-control'. This paper attempts to explode and establish the concept of advance directives (AD) based on literature review. Data sources are computer searches with the MEDLINE database. Due to the lack of prior study on AD for a Korean cases, studies abroad are reviewed. This paper suggests the need for future study on the possibility of the use of AD in Korea.

• Journal of the Korea Society of Computer and Information
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• v.12 no.2 s.46
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• pp.189-196
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• 2007

In this paper, we proposed a mobile ad hoc routing protocol based on AODV(Ad hoc On demand Distance Vector) with QoS(Quality of Service) support and evaluated the performance through simulation. The waste of communication resources is reduced by establishing the shortest route suitable to QoS support, considering in advance the usable communication resources at each node. For performance evaluation, we analyzed the average data reception rate, considering the node mobility and the number of best effort/QoS data flows. We found that in the mobile Ad Hoc networks the QoS service for some specific data flows increased the average data reception rate for the QoS data flows.

• Journal of Multimedia Information System
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• v.8 no.4
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• pp.233-242
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• 2021

Various anatomical MRI imaging biomarkers for Alzheimer's Disease (AD) identification have been recognized so far. Cortical and subcortical volume, hippocampal, amygdala volume, and genetics patterns have been utilized successfully to diagnose AD patients from healthy. These fundamental sMRI bio-measures have been utilized frequently and independently. The entire possibility of anatomical MRI imaging measures for AD diagnosis might thus still to analyze fully. Thus, in this paper, we merge different structural MRI imaging biomarkers to intensify diagnostic classification and analysis of Alzheimer's. For 54 clinically pronounce Alzheimer's patients, 58 cognitively healthy controls, and 99 Mild Cognitive Impairment (MCI); we calculated 1. Cortical and subcortical features, 2. The hippocampal subfield, amygdala nuclei volume using Freesurfer (6.0.0) and 3. Genetics (APoE ε4) biomarkers were obtained from the ADNI database. These three measures were first applied separately and then combined to predict the AD. After feature combination, we utilize the sequential feature selection [SFS (wrapper)] method to select the top-ranked features vectors and feed them into the Multi-Kernel SVM for classification. This diagnostic classification algorithm yields 94.33% of accuracy, 95.40% of sensitivity, 96.50% of specificity with 94.30% of AUC for AD/HC; for AD/MCI propose method obtained 85.58% of accuracy, 95.73% of sensitivity, and 87.30% of specificity along with 91.48% of AUC. Similarly, for HC/MCI, we obtained 89.77% of accuracy, 96.15% of sensitivity, and 87.35% of specificity with 92.55% of AUC. We also presented the performance comparison of the proposed method with KNN classifiers.

• Dementia and Neurocognitive Disorders
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• v.17 no.4
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• pp.131-136
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• 2018

Alzheimer's disease (AD) related genes have been elucidated by advanced genetic techniques. Familial autosomal dominant AD genes founded by linkage analyses are APP, PSEN1, PSEN2, ABCA7, and SORL1. Genome-wide association studies have found risk genes such as ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-HLA-DRB1, INPP5D, MEF2C, MS4A6A/MS4A4E, NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1. ABCA7, SORL1, TREM2, and APOE are proved to have high odds ratio (>2) in risk of AD using next generation sequencing studies. Thanks to the promising genetic techniques such as CRISPR-CAS9 and single-cell RNA sequencing opened a new era in genetics. CRISPR-CAS9 can directly link genetic knowledge to future treatment. Single-cell RNA sequencing are providing useful information on cell biology and pathogenesis of diverse diseases.

• The KIPS Transactions:PartC
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• v.9C no.6
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• pp.935-944
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• 2002

It is the Mobile Ad Hoc Networks that constituted with serveral mobile node that can communicate with other mobile nodes. Until now, there were no routing protocols considering such as Multimediadata, VOD (Video On Demand), which is required of lots of bandwidth in Mobile Ad Hoc Network, io we are in the need of QoS (Quality of Service)routing protocol to transmit the data packets faster and more accurate. Also, there are an unidirectional links due to asymmetric property of mobile terminals or current wireless environments on practical mobile ad hoc networks. However, at present, the existing mobile ad hoc routing protocols are implemented to support only bidirectional links. In this paper, we propose the Advanced Routing routing protocol in order to implement a new routing protocol, which is fit to mobile ad hoc networks containing unidirectional links and to support QoS service. For the performance evaluation, we use NS-2 simulator of U.C. Berkeley. We could get not only increased received data rate and decreased average route discovery time, but also network load decreases with compared Best effort service.

• Journal of Nutrition and Health
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• v.38 no.6
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• pp.419-431
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• 2005

The prevalence of atopic dermatitis (AD) continues to increase in the industrialized countries related to Western lifestyle and dietary patterns. The purpose of this study was to evaluate the nutritional status, dietary patterns and dietary quality of AD patients. AD patients (n=50) and gender age matched healthy control (HC) were studied in case-control clinical trail. Preference and frequencies of consumption for 98 foods were estimated by questionnaires. Dietary pattern, current nutrients intake, and dietary quality were evaluated by the 3-day food records. As a result, anthropometric measurements from HC and AD patients were not significantly different. AD patients had significantly lower preference for buckwheat, some fishes (shellfish, flatfish, salmon), egg yolk, some vegetables (onion, garlic, Chinese-cabbage, radish, pepper, mushroom), coffee, and snack than those of HC had (p<0.05). AD patients had significantly lower frequency for pea, some fishes (shellfish, herring, flatfish, salmon, codfish), egg, some vegetables (spinach, pumpkin, mushroom), margarine/butter, nuts, coffee and apple juice, fried chicken, coke than those of HC had (p<0.05). The intake of vitamin $B_1$, vitamin $B_2$ (p<0.05) and vitamin E (p<0.001) of AD patients were significantly lower than those of HC. The intake for Ca and Zn of AD patients were remarkably lower than RDA for each nutrient. Moreover, AD patients' index of nutritional quality (INQ) and nutrient adequacy ratio (NAR) of vitamin E, vitamin $B_1$, vitamin $B_2$ were lower than those of HC. AD patients' dietary quality including dietary diversity score (DDS), dietary variety score (DVS), DMGFV (dairy, meat, grain, fruit, vegetable), dietary quality index (DQI) was poor. This results indicate that atopic dermatitis patients had significantly different food preference and food frequency when these were compared with those of healthy people. The dietary diversity, dietary variety and dietary quality of atopic dermatitis patients were very limited.

• Toxicological Research
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• v.34 no.1
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• pp.7-12
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• 2018

Laboratory animal models have been developed to investigate preventive or therapeutic effect of medicinal products, or occurrence or progression mechanism of atopic dermatitis (AD), a pruritic and persistent inflammatory skin disease. The murine model with immunologic phenomena resembling human AD was introduced, which demonstrated skewedness toward predominance of type-2 helper T cell reactivity and pathophysiological changes similar as human AD following 2,4-dinitrochlorobenzene (DNCB) sensitization and challenge. Molecular mechanism on the DNCB-mediated AD was further evaluated. Skin tissues were collected from mice treated with DNCB, and each tissue was equally divided into two sections; one for protein and the other for mRNA analysis. Expression of filaggrin, an important protein for keratinocyte integrity, was evaluated through SDS-PAGE. Level of mRNA expression for cytokines was determined through semi-quantitative reverse transcriptase polymerase chain reaction. Expression of filaggrin protein was significantly enhanced in the mice treated with DNCB compared with the vehicle (acetone : olive oil = 4 : 1 mixture) treatment group or the normal group without any treatment. Level of tumor necrosis factor-alpha and interleukin-18 mRNA expression, cytokines involved in activity of type-1 helper T ($T_H1$) cell, was significantly downregulated in the AD group compared with other control groups. These results suggest that suppression of $T_H1$ cell-mediated immune response could be reflected into the skin tissue of mice treated with DNCB for AD induction, and disturbance of keratinocyte integrity might evoke a compensatory mechanism.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.3
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• pp.371-375
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• 1999

The present study was conducted to evaluate the mottgrass alone and in combination with berseem (Trifolium alexandrinum) at different intake levels to determine the lag time, rate and extent of digestion of DM and NDF of mottgrass. Four ruminally cannulated buffalo calves were used in a $4{\times}4$ Latin Square Design with $2{\times}2$ factorial arrangement of treatments. The two factors were forage intake levels (ad libitum versus restricted) and forage source (mottgrass versus mottgrass plus 25% berseem). Four dietary treatment consisted of 1) ad libitum mottgrass, 2) restricted feeding of mottgrass, 3) ad libitum mottgrass plus berseem with a ratio of 3:1 and 4) restricted mottgrass plus berseem in a ratio of 3:1 Calves fed ad libitum mottgrass supplemented with 25% berseem consumed 25% more DM and 15 % more NDF than those fed mottgrass only. The in situ DM digestibility, the lag time and extent of digestion were not affected by intake level. However, rate of disappearance was greater in restricted fed animals than those fed ad libitum. This increased rate could be due to greater concentration of fibrolytic bacteria in restrict fed animals. The DM digestibility was greater (64.1%) in calves fed mottgrass supplemented with 25% berseem than those fed mottgrass only (57.7%). The reduced mottgrass DM digestion may be due to its higher NDF contents. The NDF digestibility, the lag and extent of NDF digestion were not affected by varying intake levels. However, rate of digestion of NDF was higher in restricted fed animals than those of ad libitum fed animals. The NDF digestibility was greater (58.4%) in calves fed mottgrass supplemented with 25% berseem than those fed mottgrass (48.7%) only.