• IMMUNE NETWORK
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• v.21 no.3
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• pp.22.1-22.17
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• 2021

Chitinase-3-like-1 (CHI3L1) is known to induce inflammation in the progression of allergic diseases. Previous our studies revealed that 2-({3-[2-(1-cyclohexen-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanamide (K284-6111; K284), the CHI3L1 inhibiting compound, has the anti-inflammatory effect on neuroinflammation. In this study, we investigated that K284 treatment could inhibit the development of atopic dermatitis (AD). To identify the effect of K284, we used phthalic anhydride (5% PA)-induced AD animal model and in vitro reconstructed human skin model. We analyzed the expression of AD-related cytokine mediators and NF-κB signaling by Western blotting, ELISA and quantitative real-time PCR. Histological analysis showed that K284 treatment suppressed PA-induced epidermal thickening and infiltration of mast cells. K284 treatment also reduced PA-induced release of inflammatory cytokines. In addition, K284 treatment inhibited the expression of NF-κB activity in PA-treated skin tissues and TNF-α and IFN-γ-treated HaCaT cells. Protein-association network analysis indicated that CHI3L1 is associated with lactoferrin (LTF). LTF was elevated in PA-treated skin tissues and TNF-α and IFN-γ-induced HaCaT cells. However, this expression was reduced by K284 treatment. Knockdown of LTF decreased the expression of inflammatory cytokines in TNF-α and IFN-γ-induced HaCaT cells. Moreover, anti-LTF antibody treatment alleviated AD development in PA-induced AD model. Our data demonstrate that CHI3L1 targeting K284 reduces AD-like skin inflammation and K284 could be a promising therapeutic agent for AD by inhibition of LTF expression.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.11B
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• pp.1031-1037
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• 2003

A new scheduling scheme, which uses channel quality information of each flow in Bluetooth system of ad-hoc network for effective bandwidth assignment, has been proposed in this paper. By an effective bandwidth assignment, QoS (Quality of Service) could have been ensured in case of asymmetric data traffic, mixed data transmission, and congested data transmission in a specific channel. The scheduling algorithm determines channel weights using partial channel information of flows. Case studies conducted by NS-2 (Network Simulator 2) and Bluehoc simulator has been presented to show the effectiveness of the proposed scheduling scheme.

• Proceedings of the Korea Information Processing Society Conference
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• 2001.10b
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• pp.1395-1398
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• 2001

본 논문에서는 설치가 용이하고, 이동이 자유로우며 능동적으로 연결을 맺을 수 있는 무선 환경 특성에 대해 알아보고, 특히 무선 Ad-hoc환경에서의 TCP 버전별 특성을 분석해 보았다. 또한 지연과 오류 확률이 높은 무선환경에서 여러 가지 버전의 TCP가 동시에 사용되는 경우에 각 TCP 버전의 트래픽 특성을 모의 실험하였다. 이 실험을 위해 가장 많이 사용되어지고 있는 네트워크 시뮬레이터2(NS2)를 이용하였다.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.327.2-327.2
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• 2002

Inflammatory as well as oxidative tissue damage has been associated with pathophysiology of Alzheimer's disease (AD), and nonsteroidal anti-inflammatory drugs have been shown to retard the progress of AD. In this study, we have investigated the molecular mechanisms underlying oxidative and inflammatory cell death induced by beta-amyloid (Abeta), a neurotoxic peptide associated with senile plaques formed in the brains of patients with AD, in cultured PC12 cells. (omitted)

• The KIPS Transactions:PartC
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• v.8C no.4
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• pp.459-468
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• 2001

실제적인 이동 Ad Hoc 망에서는 단말의 비대칭성이나 무선환경 특성으로 인해 단방향 링크가 존재할 수 있다. 그러나 현재 Zone 라우팅 프로토콜이외의 기존의 이동 Ad Hoc 라우팅 프로토콜은 양방향 링크들만을 지원하도록 구현되어 있다. 따라서 본 논문에서는 가장 대표적인 라우팅 프로토콜인 DSR(Dynamic Source Routing) 프로토콜이 단방향 링크를 포함하는 이동 Ad Hoc 망에서 구동될 수 있도록 동적 소스 라우팅을 이용한 새로운 단방향 라우팅 프로토콜을 제안한다. 단방향 링크 상에서 효율적으로 구동하기 위해서 제안한 단방향 라우팅 프로토콜은 새로운 경로발견 및 경로유지 방법을 사용하였다. 성능평가를 위해서 미국 버클리 대학의 NS-2 시뮬레이터 프로그램에 제안한 내용을 코드로 삽입시켰으며, 성능평가 파라미터를 얻기 위해 카네기멜론 대학에서 제공한 이동 패턴파일과 연결 패턴파일을 조합하여 사용하였다. 성능평가 항목으로 데이터수신율 및 평균경로 설정시간을 고려하였으며, 제안된 3가지 경로설정 방식들에 대해 비교·평가하였다.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.113-113
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• 2010

유비쿼터스 시대를 맞이하여 현재의 전자제품은 초고주파 환경에서의 소형화된 마이크로파 소자를 요구하고 있다. 마이크로파 대역에서 세라믹 소재는 대부분의 폴리머 소재에 비해 낮은 유전손실 값을 보이고 있어 향후 확대되는 고주파화에 적합한 소재로 평가되고 있다. 하지만 세라믹 재료는 깨지기 쉬운 특성을 가지고 있어 공정 및 취급이 어려우며 높은 소결온도를 가지고 있어 융점이 낮은 재료와의 집적화에 있어서 난점을 가지고 있다. 이를 위해 본 연구실에서는 실온에서 세라믹을 비롯한 금속 및 폴리머 재료의 치밀한 코팅막의 성막 및 이종 접합이 가능한 Aerosol Deposition (AD 법)에 주목하였고 마이크로파 소자 제작 공정으로서 AD 법의 응용 가능성을 연구하였다. 마이크로파 소자의 기판으로서는 AD 법을 이용하여 유전손실이 낮고 플렉서블한 $Al_2O_3$-PTFE 혼합 기판을 제작하고 적용하였다. 금속 선로 패터닝 제작 공정으로는 도금법이 대표적이지만 고비용 및 복잡한 공정 절차, 폐화학용액으로 인한 환경문제 등의 단점을 지니고 있어 이를 대체하는 금속 선로 패터닝 공정이 절실히 요구되고 있다. 이를 위해 본 연구에서는 AD 법을 이용하여 금속 필름을 제작하고 대체 공정으로서의 가능성을 확인하였다. 하지만 AD 법을 이용한 세라믹 필름 제작에 관한 연구는 크게 활성화되어 있는 반면에 금속 필름의 제작, 특성 측정 및 개선에 관한 연구는 그에 비해 미비한 수준이다. 이를 위해 이번 연구에서는 AD 법을 이용하여 금속 필름을 성막 시에 영향을 미치는 요인을 고찰하였으며 또한 마이크로파 소자의 도체 손실에 크게 관계되는 금속 필름의 비저항 특성의 측정 및 개선에 관한 연구를 수행하였다. 이를 위해 본 연구에서는 정전장 시뮬레이션을 활용하여 AD 법으로 성막된 금속 필름의 정밀한 비저항 측정에 관한 연구방법을 마련하고 후열처리를 통한 비저항 특성을 개선시키는 연구를 진행하였다.

• Journal of Convergence Korean Medicine
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• v.2 no.1
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• pp.13-22
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• 2021

Objectives: Atopic dermatitis (AD) is an easily recurrent inflammatory skin disease. Since AD has complex pathology, people have been investigating it on different aspects with various experimental models. One of them is in vivo model which has spontaneously developed AD-like skin lesions by various inducers. Methods: In this study, two kinds of mouse species were applied in the experiment; BALB/c and C57BL/6 mice. We compared features among the animal species making AD mouse model with protein allergen, ovalbumin. AD-like skin lesions were induced by ovalbumin on two kinds of scheme and were evaluated with the histological results and size of spleen which is a critical immunological organ. Also, we measured the level of immunoglobulin E in serum. In addition, we investigated the results of ovalbumin induced-AD-like skin lesions along with obesity. Results and Conclusion: We evaluated weight of organs and thickness of epidermis. These results suggest the possibility of the appropriate in vivo experimental model for AD or the comorbidity with obesity.

• Journal of Yeungnam Medical Science
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• v.12 no.1
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• pp.32-47
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• 1995

Glutathione(GSH) has a very important role in detoxification of cells and is closely related to antitumor drug-resistance of cancer cells. In order to evaluate the importance of glutathione metabolism in the drug-resistant cancer cells, the concentration of celluar GSH and activities of ${\gamma}$-glutamylcysteine synthetase(GCS), ${\gamma}$-glutamyl transpeptidase (GGT) and glutathione S-transferases(GST) in the adriamycin, vincristine, or cisplatin resistant L1210 (L1210AdR, L1210VcR, or L1210Cis) sublines were measured. Expression and amplification of GCS, GGT, and GST-${\pi}$ genes were also observed in the parent Ll210 and the drug-resistant Ll210 sublines. The concentration of GSH was increased 5.34 fold in L1210Cis, 2.83 fold in L1210VcR, and 1.78 fold in L1210AdR, compared to L1210. The activities of GCS and GGT were increased in drug-resistant L1210 sublines. The GST activity was increased in L1210VcR and L1210Cis but decreased in L1210AdR compared to Ll210. Expression of GCS, GGT, and GST-${\pi}$ genes were increased in the resistant L1210 sublines compare to the parent L1210 in northern blot analyses. Overexpression of GCS, GGT, and GST-${\pi}$ were observed in the resistant sublines, and the increases of the concentration of glutathione and the activities of GCS and GGT in the resistant sublines may be involved in a part of the drug-resistance in the resistant sublines.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.2
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• pp.371-388
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• 2014

Cognitive Radio (CR) has been recently proposed as a promising technology to remedy the problems of spectrum scarcity and spectrum underutilization by enabling unlicensed users to opportunistically utilize temporally unused licensed spectrums in a cautious manner. In Cognitive Radio Ad Hoc Networks (CRAHNs), data routing is one of the most challenging tasks since the channel availability and node mobility are unpredictable. Moreover, the network performance is severely degraded due to large numbers of path failures. In this paper, we propose the Fault-Tolerant Cognitive Ad-hoc Routing Protocol (FTCARP) to provide fast and efficient route recovery in presence of path failures during data delivery in CRAHNs. The protocol exploits the joint path and spectrum diversity to offer reliable communication and efficient spectrum usage over the networks. In the proposed protocol, a backup path is utilized in case a failure occurs over a primary transmission route. Different cause of a path failure will be handled by different route recovery mechanism. The protocol performance is compared with that of the Dual Diversity Cognitive Ad-hoc Routing Protocol (D2CARP). The simulation results obviously prove that FTCARP outperforms D2CARP in terms of throughput, packet loss, end-to-end delay and jitter in the high path-failure rate CRAHNs.