• Dementia and Neurocognitive Disorders
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• v.16 no.3
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• pp.72-77
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• 2017

Background and Purpose Although sleep disturbances are common and considered a major burden for patients with Alzheimer's disease (AD), the fundamental mechanisms underlying the development and maintenance of sleep disturbance in AD patients have yet to be elucidated. The aim of this study was to examine the correlation between regional cerebral blood flow (rCBF) and sleep disturbance in AD patients using technetium-99m hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT). Methods A total of 140 AD patients were included in this cross-sectional study. Seventy patients were assigned to the AD with sleep loss (SL) group and the rest were assigned to the AD without SL group. SL was measured using the sleep subscale of the Neuropsychiatric Inventory. A whole-brain voxel-wise analysis of brain SPECT data was conducted to compare the rCBF between the two groups. Results The two groups did not differ in demographic characteristics, severity of dementia, general cognitive function, and neuropsychiatric symptoms, with the exception of sleep disturbances. The SPECT imaging analysis displayed decreased perfusion in the bilateral inferior frontal gyrus, bilateral temporal pole, and right precentral gyrus in the AD patients with SL group compared with the AD patients without SL group. It also revealed increased perfusion in the right precuneus, right occipital pole, and left middle occipital gyrus in the AD with SL group compared with the AD without SL group. Conclusions The AD patients who experienced sleep disturbance had notably decreased perfusion in the frontal and temporal lobes and increased rCBF in the parietal and occipital regions. The findings of this study suggest that functional alterations in these brain areas may be the underlying neural correlates of sleep disturbance in AD patients.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.1
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• pp.87-94
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• 2009

The intrusion detection system is one of the active fields of research in wireless networks. Intrusion detection in wireless mobile Ad hoc network is challenging because the network topologies are dynamic, lack centralization and are vulnerable to attacks. Detection of malicious nodes in an open ad-hoc network in which participating nodes do not have previous security association has to face number of challenges which is described in this paper. This paper is about determining the malicious nodes under critical conditions in the mobile ad-hoc network and deals with security and vulnerabilities issues which results in the better performance and detection of the intrusion.

• Convergence Security Journal
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• v.12 no.4
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• pp.49-55
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• 2012

In this paper, we consider the limit of the previous works for ad-hoc network, then propose a dynamic routing scheme which employs a 2-tier hierarchical structure. We adopt the advantages of proactive and reactive routing scheme for efficient network management. We define this method as NSDR(New Secure Dynamic Routing) scheme. We also propose a trustworthy authentication and key management for the proposed ad-hoc network. We currently study the possibility that ad-hoc networks can provide a service such as key management and authentication for the next generation mobile network.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.6
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• pp.1177-1186
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• 2003

The multimedia ad hoc wireless network is quite an attractive issue since it offers a flexible solution to enable delivery of multimedia services to mobile end users without fixed backbone networks. However, with the unique design challenges of ad hoc wireless networks, it is a non-trivial issue to provide bounded delay guarantee, with fair share of resources. In this paper, we implemented the delay guaranteed fair queueing (DGFQ) scheme distributively. Through the results of performance evaluation, we can conclude that DGFQ also performs well to control bounded delay in multimedia ad hoc wireless networks.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.7B
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• pp.463-471
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• 2007

Because of MANET's dynamic characteristic, the hidden node problem can happen. Thus it must use with distributed channel access. In Ad hoc networks, carrier sense multiple access with collision avoidance(CSMA/CA) is one of the most widely used medium access control(MAC) schemes for asynchronous data traffics. However, CSMA/CA could not guarantee the quality of multimedia traffics. CSMA is a contention based protocol. Therefor once a node gets a channel, it can momopolze. Thus the fairness problem with channel starvation will happen. We will propose a new MAC protocol to guarantee QoS for multimedia data in ad hoc networks.

• Molecules and Cells
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• v.40 no.9
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• pp.613-620
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• 2017

The most common form of senile dementia is Alzheimer's disease (AD), which is characterized by the extracellular deposition of amyloid ${\beta}-peptide$ ($A{\beta}$) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson's disease, and Pick's disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than $A{\beta}$ plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD. A growing amount of evidence suggests that soluble $A{\beta}$ oligomers in concert with hyperphosphorylated tau (pTau) serve as the major pathogenic drivers of neurodegeneration in AD. Increased $A{\beta}$ oligomers trigger neuronal dysfunction and network alternations in learning and memory circuitry prior to clinical onset of AD, leading to cognitive decline. Furthermore, accumulated damage to mitochondria in the course of aging, which is the best-known nongenetic risk factor for AD, may collaborate with soluble $A{\beta}$ and pTau to induce synapse loss and cognitive impairment in AD. In this review, I summarize and discuss the current knowledge of the molecular and cellular biology of AD and also the mechanisms that underlie $A{\beta}-mediated$ neurodegeneration.

• The Journal of the Korea Contents Association
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• v.11 no.1
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• pp.65-71
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• 2011

In this paper, the RFID / USN-based ad-hoc network structure is presented for efficient operation of a container terminal yard. Communication between fixed or mobile devices in the container terminal yard is accomplished through the ad-hoc node, to collect the status information of a container in real time. Any outside shipper of the container as well as central server allows to share the status information of a container through ad-hoc communication. In addition, to predict the maximum wireless transmission range of nodes by RFID tag position in the yard, LAODV (Location based AODV) routing protocol is proposed. The validity is proved by performance evaluation via computer simulation.

• Journal of the Korea Computer Industry Society
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• v.2 no.9
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• pp.1219-1224
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• 2001

There can exist unidirectional links due to asymmetric property of mobile terminals or current wireless environments on practical mobile ad hoc networks. However, at present, the existing mobile ad hoc routing protocols are implemented to support only bidirectional links. Thus, in this paper, we extend the existing dynamic source routing protocol in order to implement a new routing protocol, which is fit to mobile ad hoc networks containing unidirectional links. For performance evaluation, we use combinations of mobility scenario files and connection pattern files from Carnegimelon Univ. We consider received data rate and average route discovery time as evaluation items, which are compared and evaluated for three suggested route discovery methods.

• The Journal of the Korea Contents Association
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• v.13 no.11
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• pp.866-876
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• 2013

For the purpose of creating or maintaining a favorable customers' attitude tourism service firms use an advertising as a communication tool by changing ad-execution formats. Affective or informational ad-executions are normally applied for the service industry. In this study ad-attitude, products attitude, and purchase intention are tested whether the variables would be influenced by the ad-execution formats. As the result the study found that Ad-attitude influenced on product attitude but not on purchase intentions in the affective ad-execution format, whereas the Ad-attitude influenced both on product attitude and purchase intentions.

• Journal of Korea Multimedia Society
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• v.8 no.8
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• pp.1108-1118
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• 2005

A mobile Ad Hoc network is a dynamic mobile wireless network that can be formed without the need for any pre-existing wired or wireless infrastructure. A mobile ad hoc node has limited battery capacity. Hence, Ad Hoc routing protocol ought to be energy conservative. Previous energy aware routing has limit in fairness among nodes and network wide power consumption. In this research, we propose a new routing protocol called Clustering Based Energy-Aware Routing(CBEAR) which can improve the problems. Simulation results show that the routing protocol improves fairness and network wide power consumption as well as life time of nodes.