• BMB Reports
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• 제45권7호
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• pp.402-407
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• 2012

Nardostachys jatamansi (NJ) belonging to the Valerianaceae family has been used as a remedy for gastrointestinal inflammatory diseases for decades. However, the potential for NJ to ameliorate alcoholic chronic pancreatitis (ACP) is unknown. The aim of this study was to examine the inhibitory effects of NJ on ACP. C57black/6 mice received ethanol injections intraperitoneally for 3 weeks against a background of cerulein-induced acute pancreatitis. During ACP, NJ was ad libitum administrated orally with water. After 3 weeks of treatment, the pancreas was harvested for histological examination. NJ treatment increased the pancreatic acinar cell survival (confirmed by amylase level testing) and reduced collagen deposition and pancreatic stellate cell (PSC) activation. In addition, NJ treatment reduced the activation but not death of PSC. In conclusion, our results suggest that NJ attenuated ACP through the inhibition of PSC activation.

• 방사성폐기물학회지
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• 제2권3호
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• pp.155-164
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• 2004

사용후핵연료의 효율적인 관리를 위하여 원자력연구소에서 개발중인 사용후핵연료 차세대관리 종합공정(ACP)은 공정타당성연구 단계를 마치고 이의 실증을 위한 $\alpha$-${\gamma}$ type핫셀 건설 단계에 이르렀다. 핫셀의 설계에 앞서 사용후핵 연료를 취급하게 되는 과정에서 발생할 수 있는 방사능에 대한 환경영향평가를 정상운전 시와 사고발생 시로 나누어 수행하였다. 평가에 필요한 자료들은 공정의 개념설계 보고서와 최근 연구소부지 기상 테이터 및 부지특성 자료를 바탕으로 하였으며 기존의 유사한 시설에 대한 평가방법을 참조하였다. 각 핵종별 발생량과 방출량을 계산하여 피폭선량을 계산하였으며 평가결과 원자력법관련 규제기준과 핫셀이 위치하게 되는 IMEF 건물의 안전성분석 기준보다 매우 안전한 결과를 얻어 시설 운영에 대한 안전성을 확보하였다.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2005년도 Proceedings of The 6th korea-china joint workshop on nuclear waste management
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• pp.60-75
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• 2005

The remote operation of the Advanced Spent Fuel Conditioning Process (ACP) is analyzed by using the 3D graphic simulation tools. The ACP equipment operates in intense radiation fields as well as in a high temperature. Thus, the equipment should be designed in consideration of the remote handling and maintenance. As well as suitable remote handling and maintenance method needs to be provided. To provide such remote operation technology, we developed the graphic simulator which provides the capability of verifying the remote operability of the ACP without fabrication of the process equipment. In other words, by applying virtual reality to the remote maintenance operation, a remote operation task can be simulated in a computer, not in a real environment. In this way the graphic simulator can substantially reduce the design cost of the remote operation process and the equipment. Also it can provide new operation concept that is more reliable, easier to implement, and easier to understand.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2003년도 가을 학술논문집
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• pp.411-420
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• 2003

원자력발전소 운전과 함께 국내 원전에서 계속 발생, 저장하고 있는 사용후핵연료를 안전하고도 효율적으로 관리하기 위하여 차세대관리 종합공정을 개발하고 있으며, 이를 실증하기 위한 시설을 설계 중에 있다. 이 실증시설은 조사재시험시설에 마련된 예비 핫셀을 차세대관리 종합공정의 특성을 고려하여 개조하여 사용할 예정이다. 이 연구에서는 실증시설에 대한 기존 시설 및 부대시설의 개조방안 등 기본 건축구조 설계에 대한 기준과 설계내용을 제시하였으며, 건축구조물의 안전성을 입증하기 위한 해석을 수행하고 그 결과를 제시하였다. 본 연구결과는 차세대관리 종합공정 실증시선의 상세설계를 위한 자료로 사용될 것이며, 시설의 인허가를 위한 자료로 활용될 것이다.

• Archives of Pharmacal Research
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• 제25권4호
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• pp.463-468
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• 2002

We have previously reported on the identification of the endogenous transmethylation inhibitor oligosaccharide-linked acyl carrier protein (O-ACP), In this study, the role of the transmethylation reaction on cell cycle progression was evaluated using various transmethylase inhibitors, including O-ACP. O-ACP significantly inhibited the growth of various cancer cell lines, including NIH3T3, ras-transformed NIH3T3, MDA-MB-231, HT-1376, and AGS. In addition, exposure of ras-transformed NIH3T3 to O-ACP caused cell cycle arrest at the $G_0/G_1$ phase, which led to a decrease in cells at the S phase, as determined by flow cytometry. In contrast, transmethylase inhibitors did not affect the expression of $p21^{WAF1/Cip1}$, a well known inhibitor of cyclin dependent kinase, indicating that the cell cycle arrest by transmethylase inhibitors might be mediated by a $p21^{WAF1/Cip1}$-independent mechanism. Therefore, O-ACP, a novel transmethylase inhibitor, could be a useful tool for elucidating the novel role of methylation in cell proliferation and cell cycle progression.

• Geomechanics and Engineering
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• 제33권1호
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• pp.65-75
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• 2023

Recycled concrete aggregate (RCA) is widely used as a construction material in road construction, concrete structures, embankments, etc. However, it has been reported that calcite (CaCO₃) precipitation from RCA can be a cause of clogging when used in drainage applications. An accelerated calcite precipitation (ACP) procedure has been devised to evaluate the long-term geochemical performance of RCA in subsurface drainage systems. While the ACP procedure was useful for the French Drain application, there remained opportunities for improvement. In this study, key factors that control the formation of calcite precipitation were quantitatively evaluated, and the results were used to improve the current prototype ACP method. A laboratory parametric study was carried out by investigating the effects of reaction temperature and time on the formation of calcite precipitation of RCA, with determining an optimum reaction temperature and time which maximizes calcite precipitation. The improved ACP procedure was then applied to RCA samples that were graded for Type I Underdrain application, to compare the calcite precipitation. Two key findings are (1) that calcite precipitation can be maximized with the optimum heating temperature (75℃) and time (17 hours), and (2) the potential for calcite precipitation from RCA is not as significant as for limestone. With the improved ACP procedure, the total amount of calcite precipitation from RCAs within the life cycle of a drain system can be determined when RCAs from different sources are used as pipe backfill materials in a drain system.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.217.2-217.2
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• 2003

In the type II system. there are two elongation enzymes in E. coli, FabB is well-known to its ability to elongate cis-3-decenoly-ACP (C10:1) in unsaturated fatty acid synthesis, whereas FabF is important for the thermal regulation of fatty acid composition by its ability to elongate palmitoleic acid to vaccenic acid. based on their genetic mutation anaylsis. Radiochemical enzyme assay was performed using myristoyl-ACP as a substrate, which is known for general substrate of FabB and FabF. (omitted)

• International Journal of Oral Biology
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• 제37권3호
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• pp.109-114
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• 2012

In the gingival tissues of patients with periodontitis, inflammatory responses are mediated by a wide variety of genes. In this study, we screened for differentially expressed genes (DEGs) in periodontitis compared with normal tissue using an annealing control primer (ACP) system. By ACP RT-PCR analysis, we obtained about 160 amplicons, 8 of which were found to be differentially expressed. DEGs in patients with periodontitis were thus successfully and reliably identified by the ACP-based RT PCR technique. The DEGs identified in the screen may also enhance our understanding of the pathogenesis of periodontitis.

• 호남수학학술지
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• 제34권1호
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• pp.85-92
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• 2012

Our purpose of this paper is to introduce and study some properties related to approximations by points. More precisely, we introduce strongly AP, strongly AFP, strongly ACP, and strongly WAP properties which are stronger than AP, AFP, ACP, and WAP respectively. Also they are weaker than strongly Fr$\acute{e}$chet property. And we study general properties and topological operations on such spaces and give some examples.

• 대한수학회지
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• 제44권2호
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• pp.261-273
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• 2007

In this paper, we introduce some new properties of a topological space which are respectively generalizations of $Fr\'{e}chet$-Urysohn property. We show that countably AP property is a sufficient condition for a space being countable tightness, sequential, weakly first countable and symmetrizable, to be ACP, $Fr\'{e}chet-Urysohn$, first countable and semimetrizable, respectively. We also prove that countable compactness is a sufficient condition for a countably AP space to be countably $Fr\'{e}chet-Urysohn$. We then show that a countably compact space satisfying one of the properties mentioned here is sequentially compact. And we show that a countably compact and countably AP space is maximal countably compact if and only if it is $Fr\'{e}chet-Urysohn$. We finally obtain a sufficient condition for the ACP closure operator $[{\cdot}]_{ACP}$ to be a Kuratowski topological closure operator and related results.