• 동의생리병리학회지
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• 제28권3호
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• pp.288-295
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• 2014

Bojungchiseub-tang (BJCST) has been used in symptoms and signs of edema, dampness-phlegm, kidney failure, and so on. BJCST is also expected to have strong anti-obesity activities. However, little is known about the mechanisms of its inhibitory effects on adipocyte differentiation and adipogenesis. In the present study, we examined the effects and mechanism of BJCST on transcription factors and adipogenic genes of 3T3-L1 preadipocytes to understand its inhibitory effects on adipocyte differentiation and adipogenesis. Our results showed that BJCST significantly inhibited differentiation and adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner. To elucidate the mechanism of the effects of BJCST on lowering lipid content in 3T3-L1 adipocytes, we examined whether BJCST modulate the expressions of transcription factors to induce adipogenesis and adipogenic genes related to regulate accumulation of lipids. As a result, the expression of steroid regulatory element-binding protein (SREBP)1, cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins ${\alpha}$ ($C/EBP{\alpha}$), $C/EBP{\beta}$, $C/EBP{\delta}$, and peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) genes, which induce the adipose differentiation, liver X receptor $(LXR){\alpha}$ and fatty acid synthase (FAS) genes, which induce lipogenesis and adipose-specific aP2, Adipsin, lipoprotein lipase (LPL), CD36, TGF-${\beta}$, leptin and adiponectin genes, which compose fat formation were decreased. BJCST also reduced the expression of acyl CoA oxidase (ACO) and uncoupling protein (UCP) genes related to lipid oxidation. In conclusion, BJCST could regulate transcript factor related to induction of adipose differentiation and inhibited the accumulation of lipids and expression of adipogenic genes.

• Journal of Nutrition and Health
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• 제6권4호
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• pp.23-36
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• 1973

This study was designed to compare the effect of dietary intakes on different quality protein & levels of caloric consumption supplemented by sugar at the level of 26% of total caloric intakes. 30 males and same number of females of Albino rats, aged 30-40 days were devided into following six groups, 5 rats each. ACO Group: Ad libitum, Casein, no sugar group ACS Group: Ad libitum, Casein, 26% sugar supplemented group RBO Group: 50% restriction,Bean, no sugar group RBS Group: 50% restriction, Bean, 26% sugar supplemented group RAO Group: 50% restriction, Anchovy, no sugar group RAS Group: 50% restriction, Anchovy, 26% sugar supplemented group The rats were kept in individual cage and given 6 different diet for 12 weeks. The result of this study were elucidated as follow. Body weight gained and organ weight showed no significant differences between sugar supplemented group and the others. It was noteworthy that the shrinkage of female sex organ supplemented by sugar in the diet showed lower degree than that of compared groups in this study. In other word, degree of shrinkage due to protein-caloric restriction was decreased by sugar supplementation. Nitrogen Metabolism and total nitrogen retention were not observed any significant differences between sugar supplemented group and the others. Dental caries showed higher incidence for sugar supplemented groups. Hematology and bone growth showed no differences in this study. The similar results on the metabolic effects concerned the above view Points were obtained in the different protein groups such as bean & anchovy as protein sources in the diet. Caloric restriction Produced a lower growth-rate, lower body weight and poorer long bone growth. But composition of bone ash, concentration of nitrogen, calcium and blood glucose, liver fats and liver water content maintenanced at the same levels of standard group.

• 산업경영시스템학회지
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• 제39권2호
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• pp.46-53
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• 2016

In mobile communication systems, location management deals with the location determination of users in a network. One of the strategies used in location management is to partition the network into location areas. Each location area consists of a group of cells. The goal of location management is to partition the network into a number of location areas such that the total paging cost and handoff (or update) cost is a minimum. Finding the optimal number of location areas and the corresponding configuration of the partitioned network is a difficult combinatorial optimization problem. This cell grouping problem is to find a compromise between the location update and paging operations such that the cost of mobile terminal location tracking is a minimum in location area wireless network. In fact, this is shown to be an NP-complete problem in an earlier study. In this paper, artificial bee colony (ABC) is developed and proposed to obtain the best/optimal group of cells for location area planning for location management system. The performance of the artificial bee colony (ABC) is better than or similar to those of other population-based algorithms with the advantage of employing fewer control parameters. The important control parameter of ABC is only 'Limit' which is the number of trials after which a food source is assumed to be abandoned. Simulation results for 16, 36, and 64 cell grouping problems in wireless network show that the performance of our ABC is better than those alternatives such as ant colony optimization (ACO) and particle swarm optimization (PSO).

• 한국환경복원기술학회지
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• 제21권2호
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• pp.27-38
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• 2018

Environmental planning includes resource allocation and spatial planning process for the conservation and management of environment. Because the spatialization of the environmental planning is not specifically addressed in the relevant statutes, it actually depends on the qualitative methodology such as expert judgement. The results of the qualitative methodology have the advantage that the accumulated knowledge and intuition of the experts can be utilized. However, it is difficult to objectively judge whether it is enough to solve the original problem or whether it is the best of the possible scenarios. Therefore, this study proposed a methodology to quantitatively and objectively spatialize various environmental planning. At first, we suggested a quantitative spatial planning model based on an optimization algorithm. Secondly, we applied this model to two kinds of environmental planning and discussed about the model performance to present the applicability. Since the models were developed based on conceptual study site, there was a limitation in showing possibility of practical use. However, we expected that this study can contribute to the fields related to environmental planning by suggesting flexible and novel methodology.

• Animal Systematics, Evolution and Diversity
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• 제11권3호
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• pp.359-377
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• 1995

전국에서 채집된 검정망둑과 민물검정망둑의 지리적 변이를 조사한 결과 두 종은 반문형태상 뚜렷한 차이가 있었고 유전자 분석결과에서도 두 종은 3개의 유전적 표식인자 (Me-1, Gp-4, Aco)를 가지는 별개의 분류군으로 확인되었다. 그러나 유전적 근연치는 S=0.813 , 유전적 차이치는 D=0.192로 종 수준 이하의 유전적 분화를 보였으며두 종의 동서하천에서 미세분포 상황 및 생식적 격리 수준을 조사한 결과, 두 종은 서식처 분리가 ENfut하여 검정망둑은 주로 염수역에, 민물검정망둑은 주로 담수역에 분포하며 이들 사이에 유\ulcorner 교환이 없는 것으로 확인되었으나 서식처 분리가 깨진 여천 방죽천 집단의 경우, 두 종간에는 유전자 교환이 일어나며 F2 이상의 잡종개체를 포함하여 높은 비율(25.6%) 의 자연잡종이 발생되는 것으로 보다 두종은 교배전 격리기작 (prmatign isolating mechanism) 이 불완전한 것으로 확인되었다. 그러나 F-statistics 분석결과 $F_{IS}$(inbredding coefficient) 값은 두 종간에 자유교배가 일어나지 않음을 보여 검정망둑과 민물검정망둑은 현재 아종에서 종으로 분화중에 있는 반종(semispecies)으로 추정되며 따라서 학명은 T.obscurus obscurus(검정망둑)와 T.obscurus brevispinis (민물검정망둑)을 사용하는 것이 타당하다고 사료된다.

• 한국콘텐츠학회논문지
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• 제11권10호
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• pp.41-48
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• 2011

최근 특징 선택에서 개미군집 최적화를 위한 선택적 평가 기법이 제안되었다. 이 기법은 불필요하거나 가능성이 적은 후보 해를 실제 평가 과정에서 제외함으로써 계산량을 줄인다. 실험을 통해 이 기법의 우수성을 보였으나, 하나의 데이터만을 사용하였으므로 통계적으로 충분한 신뢰성을 보여주지 못한다. 이 논문의 목적은 선택적 평가 기법의 수렴 특성을 분석하고 결론의 신뢰성을 높이는 것이다. 실험을 위해 UCI 데이터베이스에서 필기, 의료, 음성에 관련된 세가지 데이터를 선택하였다. 이들의 특징 집합 크기는 256부터 617까지 분포한다. 통계적으로 안정된 데이터를 얻기 위해, 이들 각각에 대해 프로그램을 독립적으로 12번 실행하였다. 긴 시간에 걸친 수렴을 관찰하기 위해, 각각의 프로그램 실행은 72시간 동안 이루어졌다. 실험 데이터의 분석을 바탕으로, 선택적 평가 기법의 우수성에 대한 이유와 이 기법의 적용 범위에 대해 기술한다.

• 정보처리학회논문지B
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• 제16B권3호
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• pp.195-202
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• 2009

논문에서는 개미 군집 최적화 알고리즘을 이용하여 뇌 자기공명 영상의 백질 및 회백질 영역을 분할하는 방법을 제안한다. 확률적 조합 최적화에 적합한 알고리즘으로 알려진 개미 군집 최적화 알고리즘은 실제 개미들이 집에서 먹이를 찾아가는 동안의 방법을 기억하는 습성을 적용한 것이다. 논문에서 제안하는 방법은 개미가 먹이를 찾아가는 동안의 방법을 기억하는 습성처럼 영상에서 원하는 픽셀을 찾아갈 수 있다는 것이다. 원하는 픽셀을 찾은 개미들은 페로몬을 픽셀에 축적하게 되는데 이 페로몬은 이후에 지나가는 개미들이 다음 경로를 선택할 때 영향을 준다. 그리고 각각의 반복단계에서 상태전이 법칙에 따라 영상의 위치를 바꿔가면서 최종 목적지에 도달하게 되며, 마지막으로 페로몬 분포의 분석을 통해 영상에서 분할 된 결과를 얻는다. 제안한 알고리즘을 기존의 임계치 기반의 분할 알고리즘인 Otsu 방법, 메타휴리스틱 계열의 대표적인 방법인 유전자알고리즘, 퍼지방법, 원래의 개미 군집 최적화 알고리즘등과 비교하였다. 비교 실험을 통해 제안한 방법이 뇌의 특정 영역을 더 정확하게 분할함을 알 수 있었다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 하계학술대회 논문집 Vol.9
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• pp.131-131
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• 2008

Silicon carbide (SiC) has attracted significant attention for high frequency, high temperature and high power devices due to its superior properties such as the large band gap, high breakdown electric field, high saturation velocity and high thermal conductivity. We performed Al ion implantation processes on n-type 4H-SiC substrate using a SILVACO ATHENA numerical simulator. The ion implantation model used a Monte-Carlo method. We studied the effect of channeling by Al implantation simulation in both 0 off-axis and 8 off-axis n-type 4H-SiC substrate. We have investigated the Al distribution in 4H-SiC through the variation of the implantation energies and the corresponding ratio of the doses. The implantation energies controlled 40, 60, 80, 100 and 120 keV and the implantation doses varied from $2\times10^{14}$ to $1\times10^{15}cm^{-2}$. In the simulation results, the Al ion distribution was deeper as increasing implantation energy and the doping level increased as increasing implantation doses. After the post-implantation annealing, the electrical properties of Al-implanted p-n junction diode were investigated by SILV ACO ATLAS numerical simulator.

• Journal of Ginseng Research
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• 제44권1호
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• pp.123-134
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• 2020

Background: The lepidopteran Asiatic corn borer (ACB), Ostrinia furnacalis (Guenee), has caused huge economic losses throughout the Asian-Western Pacific region. Usually, chemical pesticides are used for the control, but excessive use of pesticides has caused great harm. Therefore, the inartificial ecotypic pesticides to ACB are extremely essential. In our previous study, we found that panaxadiol saponins (PDS) can effectively reduce the harm of ACB by causing antifeedant activity. Therefore, it is necessary to reveal the biological molecular changes in ACB and the functionary mechanism of PDS. Methods: We analyzed the global transcription of ACB with different PDS concentration treatment (5 mg/mL, 10 mg/mL, and 25 mg/mL) by high-throughput sequencing and de novo transcriptome assembly method. Results: PDS treatment could cause the changes of many gene expressions which regulate its signal pathways. The genes in peroxisome proliferator-activated receptor (PPAR) signaling pathway were significantly downregulated, and then, the downstream fatty acid degradation pathway had also been greatly affected. Conclusion: Through this experiment, we hypothesized that the occurrence of antifeedant action of ACB is because the PDS brought about the downregulation of FATP and FABP, the key regulators in the PPAR, and the downregulation of FATP and FABP exerts further effects on the expression of SCD-1, ACBP, LPL, SCP-X, and ACO, which leads to the disorder of PPAR signaling pathway and the fatty acid degradation pathway. Not only that, PDS treatment leads to enzyme activity decrease by inhibiting the expression of genes associated with catalytic activity, such as cytochrome P450 and other similar genes.

• 한국통신학회논문지
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• 제36권4B호
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• pp.346-353
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• 2011

무선 센서 & 액터 네트워크에서 긴 네트워크의 수명을 유지하면서 다양한 지연시간을 요구하는 응용 프로그램들을 동시에 서비스하는 라우팅 방법이 요구되고 있다. 하지만 트리 기반 라우팅에서 네트워크 수명과 패킷 전송시의 평균 홉 수는 상충관계가 있다는 사실이 알려져 있다. 본 논문은 상충관계에 있는 두 가지 목적을 최적화하는 라우팅 트리들의 파레토 집합을 찾고자 파레토 개미 집단 최적화 알고리즘을 제시한다. 응용 프로그램이 요구하는 지연 시간에 따라 적절한 트리를 선택하여 라우팅에 사용할 수 있도록 함으로써 다양한 응용 프로그램의 요구 조건을 만족시킬 뿐 아니라 긴 네트워크의 수명을 보장한다. 그리고 모의실험을 통해 구해진 트리들이 대표적인 라우팅 트리인 최소신장트리 보다 파레토 최적에 근접한 트리들로 구성됨을 보인다.