• Journal of Veterinary Clinics
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• 제31권3호
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• pp.180-193
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• 2014

Allergic contact dermatitis (ACD) is an inflammatory skin disease and regarded as a prototype of T-cell mediated delayed-type hypersensitivity reactions. Aroma Oil Complex (AOC) is composed of lavender true oil, chamomile roman oil and tea tree oil. This study was performed to assess the effects of AOC in a canine model of ACD. ACD was induced on the back of dogs induced by sensitization and repeated application by 2,4-dinitro-1-chlorobenzene (DNCB). Topical treatment of AOC was applied once a day for 8 days and skin biophysical parameters including transepidermal water loss (TEWL), skin hydration, skin thickness and erythema index, were measured every two days during experimental periods. Histopathology and immunohistochemistry were performed to evaluate the anti-inflammatory effect. In skin biophysical parameters, TEWL, skin hydration, skin thickness and erythema index were significantly increased, with a maximum increase appeared on day 2 (p<0.05). After the completion of AOC treatment, skin biophysical parameters were significantly reached those of baseline in a time-dependent manner (p<0.05). In histopathology, marked increases of epidermal thicknesses were induced after DNCB challenge with numerous inflammatory cell infiltrations and edematous changes, decreases of connective tissue occupied regions in dermis. In addition, marked increases of cytokine - tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interferon-${\gamma}$ (IFN-${\gamma}$)-immunoreactivities in the dermis and of apoptotic markers - caspase-3 and PARP-immunoreactivities in the epidermis were observed in DNCB control as compared with intact control, respectively (p<0.01). The decrease of infiltrated inflammatory cells and related decreases of pro-inflammatory cytokine immunoreactivities were observed in AOC treated skin (p<0.01). Based on these findings, AOC may have anti-inflammatory and alleviatory effects in the allergic contact dermatitis.

• Korean Journal of Food Science and Technology
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• 제38권5호
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• pp.668-673
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• 2006

The effects of Acanthopanacis cortex water extract on allergic contact dermatitis (ACD) in Sprague-Dawley male rats treated with 2.5% 1-chloro-2,4-dinitrochlorobenzene (DNCB) on the dorsal skin were evaluated. The concentration of TBARS in plasma and liver was increased in ACD rats and was significantly decreased in Acanthopanacis cortex fed group (ACFG) compared to CG (control group). Serum Ig E level was significantly increased in CG compared to normal group, while that of ACFG was significantly decreased. The epidermal thickness of CG was significantly increased compared to that of normal group, while that of ACFG was significantly decreased compared to that of CG These results indicated that the Acanthopanacis cortex water extract administration improved lipid preoxidation, antioxidative activity, serum Ig E level and epidermal thickness in rats with ACD.

• Advances in Computational Design
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• 제2권4호
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• pp.333-348
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• 2017

Inspections of ancient metallic bridges have illustrated fatigue cracking in riveted connections. This paper presents a comparison between two alternative finite element (FE) models proposed to predict the fatigue strength of a single shear and single rivet connection. The first model is based on solid finite elements as well as on contact elements, to simulate contact between the components of the connection. The second model is built using shell finite elements in order to model the plates of the riveted connection. Fatigue life predictions are carried out for the shear splice, integrating both crack initiation and crack propagation lives, resulting from the two alternative FE models. Global fatigue results, taking into account several clamping stresses on rivet, are compared with available experimental results. Proposed comparisons between predictions and experimental data illustrated that the proposed two-stage model yields consistent results.

• Advances in Computational Design
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• 제4권4호
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• pp.367-379
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• 2019

Multiple Inputs and Multiple Outputs (MIMO) Fuzzy logic model is developed to predict the engine performance and emission characteristics of pongamia pinnata biodiesel with hydrogen injection. Engine performance and emission characteristics such as brake thermal efficiency (BTE), brake specific energy consumption (BSEC), hydrocarbon (HC), carbon monoxide (CO), carbon dioxide ($CO_2$) and nitrous oxides ($NO_X$) were considered. Experimental investigations were carried out by using four stroke single cylinder constant speed compression ignition engine with the rated power of 5.2 kW at variable load conditions. The performance and emission characteristics are measured using an Exhaust gas analyzer, smoke meter, piezoelectric pressure transducer and crank angle encoder for different fuel blends (Diesel, B10, B20 and B30) and engine load conditions. Fuzzy logic model uses triangular and trapezoidal membership function because of its higher predictive accuracy to predict the engine performance and emission characteristics. Computational results clearly demonstrate that, the proposed fuzzy model has produced fewer deviations and has exhibited higher predictive accuracy with acceptable determination correlation coefficients of 0.99136 to 1 with experimental values. The developed fuzzy logic model has produced good correlation between the fuzzy predicted and experimental values. So it is found to be useful for predicting the engine performance and emission characteristics with limited number of available data.

• Advances in Computational Design
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• 제8권3호
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• pp.219-236
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• 2023

In this paper, finite element modeling of the laser ultrasonics (LU) process in ablation regime is of interest. The momentum resulting from the removal of material from the specimen surface by the laser beam radiation in ablation regime is modeled as a pressure pulse. To model this pressure pulse, two equations are required: one for the spatial distribution and one for the temporal distribution of the pulse. Previous researchers have proposed various equations for the spatial and temporal distributions of the pressure pulse in different laser applications. All available equations are examined and the best combination of the temporal and spatial distributions of the pressure pulse that provides the most accurate results is identified. This combination of temporal and spatial distributions has never been used for modeling laser ultrasonics before. Then by using this new model, the effects of variations in pulse duration and laser spot radius on the shape, amplitude, and frequency spectrum of ultrasonic waves are studied. Furthermore, the LU in thermoelastic regime is simulated by this model and compared with LU in ablation regime. The interaction of ultrasonic waves with a defect is also investigated in the LU process in ablation regime. Good agreement of the results obtained from the new finite element model and available experimental data confirms the accuracy of the proposed model.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• 제25권2호
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• pp.223-234
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• 2014

This paper describes the analysis results of channel characteristics in the operating area of satellite OTM(On-The-Move) terminal. The communication channel between the Koreasat-5 and OTM terminal on a test car is measured and recorded from Daejeon to Daecheon, using the downlink frequency of around 20 GHz. And the measurement data are divided into two classes ; highway environment and national road environment, and then are statistically analyzed. The statistical evaluation of satellite channel is conducted by using probability density function and Markov model and then presents average connection duration(ACD), average fade duration( AFD), and level crossing rate(LCR) of highway environment and national road environment. Finally the statistics data of the two environments are compared with each other.

• Advances in Computational Design
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• 제3권1호
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• pp.87-112
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• 2018

In this study, it is aimed to present engineering software to estimate the structural response of concrete arch dam. Type-1 concrete arch dam constructed in the laboratory is selected as a reference model. Finite element analyses and experimental measurements are conducted to show the accuracy of initial model. Dynamic analyses are carried out by spectrum analysis under empty reservoir case considering soil-structure interaction and fixed foundation condition. The displacements, principal stresses and strains are presented as an analysis results at all nodal points on downstream and upstream faces of dam body. It is seen from the analyses that there is not any specific ratio between prototype and scaled models for each nodal point with different scale values. So, dynamic analyses results cannot be generalized with a single formula. To eliminate this complexity, the regression analysis, which is a statistical method to obtain the real model results according to the prototype model by using fitting curves, is used. The regression analysis results are validated by numerical solutions using ANSYS software and the error percentages are examined. It is seen that 10% error rates are not exceeded.

• Advances in Computational Design
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• 제2권2호
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• pp.107-119
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• 2017

The Micro circular diaphragm (MCD) is the mechanical actuator part used in the micro electro-mechanical sensors (MEMS) that combine electrical and mechanical components. These actuators are working under harsh mechanical and thermal conditions, so it is very important to study the mechanical and thermal behaviors of these actuators, in order to do with its function successfully. The objective of this paper is to determine the thermo-mechanical behavior of MCD by developing the traditional bulge test technique to achieve the aims of this work. The specimen is first pre-stressed to ensure that is no initial deflection before applied the loads on diaphragm and then clamped between two plates, a differential pressure (P) and temperature ($T_b$) is leading to a deformation of the MCD. Analytical formulation of developed bulge test technique for MCD thermo-mechanical characterization was established with taking in-to account effect of the residual strength from pre-stressed loading. These makes the plane-strain bulge test ideal for studying the mechanical and thermal behavior of diaphragm in both the elastic and plastic regimes. The differential specimen thickness due to bulge effect to describe the mechanical behavior, and the temperature effect on the MCD material properties to study the thermal behavior under deformation were discussed. A finite element model (FEM) can be extended to apply for investigating the reliability of the proposed bulge test of MCD and compare between the FEM results and another one from analytical calculus. The results show that, the good convergence between the finite element model and analytical model.

• Advances in Computational Design
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• 제1권1호
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• pp.61-77
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• 2016

Seismic performance of structures depends on the force flow mechanism inside the structure. Discontinuity regions, like beam-column joints, are often affected during earthquake event due to the complex and discontinuous load paths. The evaluation of shear strength and identification of failure mode of the joint region are helpful to (i) define the strength hierarchy of the beam-column sub-assemblage, (ii) quantify the influence of different parameters on the behaviour of beam-column joint and, (iii) develop suitable and adequate strengthening scheme for the joints, if required, to obtain the desired strength hierarchy. In view of this, it is very important to estimate the joint shear strength and identify the failure modes of the joint region as it is the most critical part in any beam-column sub-assemblage. One of the most effective models is softened strut and tie model which was developed by incorporating force equilibrium, strain compatibility and constitutive laws of cracked reinforced concrete. In this study, softened strut and tie model, which incorporates force equilibrium equations, compatibility conditions and material constitutive relation of the cracked concrete, are used to simulate the shear strength behaviour and to identify failure mechanisms of the beam-column joints. The observations of the present study will be helpful to arrive at the design strategy of the joints to ensure the desired failure mechanism and strength hierarchy to achieve sustainability of structural systems under seismic loading.

• Advances in Computational Design
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• 제3권4호
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• pp.385-404
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• 2018

The study investigated an area of sustainable structural design that is often overlooked in practical engineering applications. Specifically, a novel method to simultaneously optimise the cost and embodied carbon performance of steel building structures was explored in this paper. To achieve this, a parametric design model was developed to analyse code compliant structural configurations based on project specific constraints and rigorous testing of various steel beam sections, floor construction typologies (precast or composite) and column layouts that could not be performed manually by engineering practitioners. Detailed objective functions were embedded in the model to compute the cost and life cycle carbon emissions of the different material types used in the structure. Results from a comparative numerical analysis of a real case study illustrated that the proposed optimisation approach could guide structural engineers towards areas of the solution space with realistic design configurations, enabling them to effectively evaluate trade-offs between cost and carbon performance. This significant contribution implied that the optimisation model could reduce the time required for the design and analysis of multiple structural configurations especially during the early stages of a project. Overall, the paper suggested that the deployment of automated design procedures can enhance the quality as well as the efficiency of the optimisation analysis.