Browse > Article

Effect of Acanthopanacis cortex Water Extract on Antioxidative Activity, Lipid Profile and Epidermal Thickness in DNCB-induced Allergic Contact Dermatitis Animal Model  

Kim, Yoon-Hee (Department of Food & Nutrition, Daegu University)
Park, Young-Sook (Department of Food & Nutrition, Daegu University)
Publication Information
Korean Journal of Food Science and Technology / v.38, no.5, 2006 , pp. 668-673 More about this Journal
Abstract
The effects of Acanthopanacis cortex water extract on allergic contact dermatitis (ACD) in Sprague-Dawley male rats treated with 2.5% 1-chloro-2,4-dinitrochlorobenzene (DNCB) on the dorsal skin were evaluated. The concentration of TBARS in plasma and liver was increased in ACD rats and was significantly decreased in Acanthopanacis cortex fed group (ACFG) compared to CG (control group). Serum Ig E level was significantly increased in CG compared to normal group, while that of ACFG was significantly decreased. The epidermal thickness of CG was significantly increased compared to that of normal group, while that of ACFG was significantly decreased compared to that of CG These results indicated that the Acanthopanacis cortex water extract administration improved lipid preoxidation, antioxidative activity, serum Ig E level and epidermal thickness in rats with ACD.
Keywords
allergic contact dermatitis; DNCB; Acanthopanacis cortex;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Afanasieva TN, Lebkova NP. Effect of Eleutherococcus on subcellular structures of the heart in experimental myocardial infarct. B. Exp. Biol. Med. 103: 212-215 (1987)
2 Kwon OS, Kim JT, Park IS, Ahn SH, Lee HP, Kim HH, Gang YH. The effect of Yunkyopaedosangamibang on allergic contact dermatitis. J. Institute Orient. Medicine. Dongguk Univ. 8: 77-91 (1999)
3 Hwang DY, Lee SC, Shin HD, Shin MK, Kim JH, Gil JJ, Song HJ. The effect of Radix Scutellariae water extract on the asthma induced by Ovalbumin. Korean J. Herbology 19: 117-125 (2004)
4 Brekhman. Eleutherococcu senticosus a new medicinal herb of the araliaceae family. Second International Pharmachological Meeting 7: 97-102 (1963)
5 Shin WT, Lee KS. The effect of Ogapi's ingestion exercise performance and SOD, MDA for 12 weeks. Korean Sport Res. 15: 1309-1320 (2004)
6 Friedwald WT. Levy Rl. Fedreicson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, with out was of the preparative ultracentrifuge. Clin Chem. 18: 499-506 (1972)
7 Yagi K. Lipid peroxides and related radicals in clinical medicine In: Free Radicals in Diagnostic Medicine, Armstrong DE (ed.). pp. 1-15. New York. Plenum Press, New York, USA (1994)
8 Lee YS, Jung SH, Lim SS, Ji J, Lee SH, Shin KH. Effects of the water extract from the stem bark of Acanthopanax senticosus on hyperlipidemia in rats. J. Korean Pharm. 32: 103-107 (2001)
9 Min YG. Effct of Sopoongsangagambang administration along with external spray treatment on atopic dermatitis development in NC/Nga mice. MS thesis, Dongsin University, Naju, Korea (2005)
10 Sale FO, Marchesimi SPH, Berra BA. Sensitive enzymatic assay for determination of cholesterol in lipid extracts. Anal. Biochem. 142: 347-350(1984)   DOI   ScienceOn
11 Kim HH, Kim DH. The effect of Yunkyopaedosangamibang on allergic contact dermatitis. J. Institute Orient Medicine. Semyoung Univ. 3: 67-80 (2001)
12 Paik IY, Park TS, Oh SW, Woo JH, Jin HE, Park HR. The effects of Eleutherococcus senticosus extract on human fatigue factors and oxidant-antioxidant system during maximal and sub-maximal exercise. Korean J. Physic. Edu. 41 : 305-315 (2002)
13 Aebi H. Catalase in vitro. Methods Enzymol. 105: 121-126 (1984)   DOI
14 Heinemann T, Axtmann G, Von Bergmann K. Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur. J. Clin. Invest. 23: 827-831 (1993)   DOI   ScienceOn
15 Szolomicki S, Samochowiec L, Wojcicki J. Drozdzik M. The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytotherapy Res. 14: 30-35 (2000)   DOI   ScienceOn
16 Son HH. Park MR and Rhee SJ. Effects of dietary xylooligosaccharides on lipoprotein lipase activity in epididymal adipose tissue and lipid composition in serum of rats fed high fat diets. J. Korean Nutri. Soc. 35: 1023-1030 (2002)   과학기술학회마을
17 Folch F, Lee GH. A simple method for the isolation and purification of total lipids from animal tissue. J. Biolchem. 226: 497-509 (1957)
18 Lowry OH, Rosenbrough NJ, Farr AL, & Randall JL. Protein measurement with the folin phenol regent. J. Biochem 193: 265-275 (1951)
19 Hirata F, Fujita K. Ishikura Y, Hosoda K, Ishikawa H. Hypocholesterolemic effect of sesame lignan in humans. Atherosclerosis 122: 135-136 (1996)   DOI   ScienceOn
20 Han YS. A study on the effect of antiinflammatory plant extracts on melanogenesis. Ph.D thesis. Ajou University, Suwon, Korea (2002)
21 Mayumi Ki, Motonobu M, Akihito F, Shinji H, Way W, Masaki S, Tadamitsu K, Toshio T. Persimmon leaf extract and astragalin inhibit development of dermatitis and Ig E elevation in NC/Nga mice. J. Allergy Clin. Immunol. 106: 159-166 (2000)   DOI   ScienceOn
22 Yoon JT, Seol IC, Kim DH, Kim SH, Kim HS. An experimental study of antiallergic activity of medicinal acupunture solution of Acanthopanax senticosus. J. Korean Acup. Moxi. Soc. 18: 136-149 (2001)
23 Balakrishnan SD, Anuradha CV, Exercise depletion of antioxidants and antioxidant anipulation. Cell Biol. 16: 269-275 (1998)
24 Sen CK. Oxidants and antioxidants in exercise. J. Appl. Physiol. 79: 675-686 (1995)   DOI
25 Yukie N, Yoshinori S. Plant self-defense mechanisms against oxidative injury and protection of the forest by planting trees of triploids and tetraploids. Ecotox. Environ. Sale. 55: 70-81 (2003)   DOI   ScienceOn
26 Jung KW. Studies on pharmacological activity of root bark of Acanthopanax Chiisanensis Nakai. Bull. Kyung Hee. Pharma. Sci. 9: 21-29 (1981)
27 Marklund S, Marklund G. Involvement of superoxide anion radical in the oxidation of pyrogallol and a convenient assay for supcroxide dismutase. Eur. J. Biochem. 47: 469-474 (1974)   DOI   ScienceOn